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<1>
Accession Number
2013693188
Authors
Nocerino A.G. Achenbach S. Taylor A.J.
Institution
(Nocerino, Taylor) Georgetown University, School of Medicine, Washington,
DC, United States
(Achenbach) Department of Cardiology, University of Erlangen, Erlangen,
Germany
(Taylor) Division of Cardiology, Georgetown University Hospital, Medstar
Heart Institute, Washington, DC, United States
Title
Meta-analysis of effect of single versus dual antiplatelet therapy on
early patency of bypass conduits after coronary artery bypass grafting.
Source
American Journal of Cardiology. 112 (10) (pp 1576-1579), 2013. Date of
Publication: 15 Nov 2013.
Publisher
Elsevier Inc. (360 Park Avenue South, New York NY 10010, United States)
Abstract
Aspirin monotherapy represents a standard therapy for preserving patency
after coronary artery bypass grafting. Randomized trials addressing
whether dual antiplatelet therapy is superior to single antiplatelet
therapy to achieve graft patency early after coronary surgery have shown
inconsistent results. We performed a meta-analysis of randomized
controlled trials comparing single versus dual antiplatelet therapy after
coronary artery bypass grafting. In a systematic published works search, 5
randomized controlled trials meeting inclusion criteria were identified.
Pooled efficacy and safety data were abstracted and analyzed using a
fixed-effects model. The 5 trials included 958 patients and a total of
2,919 grafts with treatment up to 1 year after coronary bypass surgery.
Early occlusion was identified in 165 (6.5%) of 2,526 bypass grafts. Early
occlusion occurred in a greater proportion of grafts among patients
treated with single therapy (105 of 1,369; 7.7%) compared with dual
antiplatelet therapy (69 of 1,386; 5.0%; p = 0.005). The odds ratio for
graft occlusion with single versus dual therapy was 1.59 (95% confidence
interval 1.16 to 2.17). For vein grafts, single antiplatelet therapy was
associated with a significantly increased graft loss rate (91 of 846;
10.8%) versus dual antiplatelet therapy (57 of 860; 6.6%; odds ratio 1.70
[1.20 to 2.40]; p = 0.003). There was no effect on arterial graft patency.
Bleeding was noted in 3.3% and 4.9% of single and dual therapy treated
patients, respectively, with only 3 trials reporting bleeding outcomes. In
conclusion, among 958 patients randomly assigned to either single or dual
antiplatelet therapy for up to 1 year after coronary bypass surgery,
single antiplatelet therapy significantly increased the risk for graft
occlusion, an effect isolated to vein grafts, not arterial grafts. 2013
Elsevier Inc. All rights reserved.

<2>
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Accession Number
2013696706
Authors
Bayer O. Schwarzkopf D. Doenst T. Cook D. Kabisch B. Schelenz C. Bauer M.
Riedemann N.C. Sakr Y. Kohl M. Reinhart K. Hartog C.S.
Institution
(Bayer, Kabisch, Schelenz, Bauer, Riedemann, Sakr, Reinhart, Hartog)
Department of Anesthesiology and Intensive Care Medicine, Jena University
Hospital, Friedrich-Schiller-University, Jena, Germany
(Schwarzkopf, Bauer, Riedemann, Reinhart, Hartog) Center for Sepsis
Control and Care, Jena University Hospital, Jena, Germany
(Doenst) Department of Cardiothoracic Surgery, Jena University Hospital,
Friedrich-Schiller-University, Jena, Germany
(Cook) Department of Medicine, McMaster University, Hamilton, ON, Canada
(Cook) Department of Clinical Epidemiology and Biostatistics, McMaster
University, Hamilton, ON, Canada
(Kohl) Department of Mechanical and Process Engineering, Furtwangen
University, Villingen-Schwenningen, Germany
Title
Perioperative fluid therapy with tetrastarch and gelatin in cardiac
surgery - A prospective sequential analysis.
Source
Critical Care Medicine. 41 (11) (pp 2532-2542), 2013. Date of Publication:
November 2013.
Publisher
Lippincott Williams and Wilkins (530 Walnut Street,P O Box 327,
Philadelphia PA 19106-3621, United States)
Abstract
OBJECTIVES: To determine clinical outcomes of synthetic colloids,
tetrastarch, and gelatin, used before and after cardiac surgery. DESIGN:
Prospective observational cohort study. SETTING: Fifty-bed cardiac ICU.
PATIENTS: Six thousand four hundred seventy-eight consecutive patients
with cardiopulmonary bypass surgery. INTERVENTIONS: Fluid therapy in the
operating room and on the ICU directed at preset hemodynamic goals: 1)
hydroxyethyl starch (predominantly 6% hydroxyethyl starch 130/0.4) in
2004-2006, n = 2,137; 2) 4% gelatin in 2006-2008, n = 2,324; and 3) only
crystalloids in 2008-2010, n = 2,017. MEASUREMENTS AND MAIN RESULTS: Renal
replacement therapy was more common during periods when patients received
synthetic colloids compared to only crystalloids. Risk of renal
replacement therapy was greater after hydroxyethyl starch (odds ratio,
2.29; 95% CI, 1.47-3.60) and gelatin (odds ratio, 2.75; 95% CI, 1.84-4.16;
both p < 0.001) compared to crystalloid. Propensity score stratification
confirmed greater use of renal replacement therapy in the hydroxyethyl
starch and gelatin periods compared to the crystalloid period (odds ratio,
1.46 [1.08, 1.97]; p = 0.013 and odds ratio, 1.72 [1.33, 2.24]; p < 0.001,
respectively). Time to vasopressor cessation, normalization of serum
lactate, and mean arterial pressure did not differ among groups. Total
fluid requirement was 163 mL/kg in the hydroxyethyl starch period, 207
mL/kg in the gelatin period, and 224 mL/kg in the crystalloid period.
Fluid intake was higher in the crystalloid group only during the first 20
hours. CONCLUSIONS: In cardiac surgery patients, fluid therapy with
perioperative administration of synthetic colloids carries a high risk of
renal replacement therapy and is not more effective than treating with
only crystalloids. Copyright 2013 by the Society of Critical Care
Medicine and Lippincott Williams & Wilkins.

<3>
Accession Number
2013692715
Authors
Mahfouz R.A. Elawady W. Hossein E. Yosri A.
Institution
(Mahfouz, Elawady, Hossein, Yosri) Cardiology Department, Zagazig
University Hospital, Zagazig, Egypt
Title
Impact of atrioventricular compliance on clinical outcome of patients
undergoing successful percutaneous balloon mitral valvuloplasty.
Source
Echocardiography. 30 (10) (pp 1187-1193), 2013. Date of Publication:
November 2013.
Publisher
Blackwell Publishing Inc. (350 Main Street, Malden MA 02148, United
States)
Abstract
Objective We aimed to assess the impact of atrioventricular compliance
(Cn) on the clinical outcome, after successful percutaneous balloon mitral
valvuloplasty (PBMV). Methods and Results Using Doppler echocardiography
Cn was estimated from the equation that has been previously validated.
Mitral valve area (MVA), tricuspid annular plane systolic excursion
(TAPSE), pulmonary artery pressure (PAP), and degree of tricuspid
regurgitation (TR) severity were evaluated before, immediately, and every
6 months with a median duration of 32 months after successful PBMV in 150
consecutive patients. An immediate drop in PAP and significant improvement
of right ventricle (RV) function was observed after PBMV. Cn was
negatively correlated pre and post-PBMV, with the degree of pulmonary
artery systolic pressure (PAPs), TAPSE (P < 0.0001). Patients with Cn <=
3.75 mL/mmHg had higher incidence of adverse outcome (developing atrial
fibrillation [AF], worsening RV function, progressive left atrial
dilation, and redo intervention). Multivariate regression analysis showed
that the Cn was the strongest independent predictor of PAPs and RV
function before and after successful PBMV (P < 0.0001). Cn <= 3.75 mL/mmHg
was the cutoff value for prediction of clinical events at follow-up.
Conclusions Atrioventricular compliance was significantly lower in
patients with mitral stenosis (MS) with unfavorable outcome after
successful PBMV. The RV function and pulmonary hypertension were
significantly correlated with the degree of Cn. This suggests a
significant role of Cn in patients with MS, providing a good insight for
intervention and utilizing Cn as a noninvasive hemodynamic index for risk
stratification and proper timing for intervention in patients with MS.
2013, Wiley Periodicals, Inc.

<4>
Accession Number
2013687885
Authors
Panchal H.B. Ladia V. Desai S. Shah T. Ramu V.
Institution
(Panchal, Ladia, Desai, Ramu) Quillen College of Medicine, East Tennessee
State University, Johnson City, TN, United States
(Shah) Chicago Medical School, Rosalind Franklin University of Medicine
and Science, North Chicago, IL, United States
Title
A meta-analysis of mortality and major adverse cardiovascular and
cerebrovascular events following transcatheter aortic valve implantation
versus surgical aortic valve replacement for severe aortic stenosis.
Source
American Journal of Cardiology. 112 (6) (pp 850-860), 2013. Date of
Publication: 15 Sep 2013.
Publisher
Elsevier Inc. (360 Park Avenue South, New York NY 10010, United States)
Abstract
The purpose of this meta-analysis was to compare postprocedural mortality
and major adverse cardiovascular and cerebrovascular events between
transcatheter aortic valve implantation (TAVI) and surgical aortic valve
replacement (SAVR) for severe aortic stenosis. Seventeen studies (n =
4,659) comparing TAVI (n = 2,267) and SAVR (n = 2,392) were included. End
points were baseline logistic European System for Cardiac Operative Risk
Evaluation score, all-cause mortality, cardiovascular mortality,
myocardial infarction, stroke, transient ischemic attack, and major
bleeding events. Mean differences or risk ratios with 95% confidence
intervals were computed, and p values <0.05 were considered significant.
The population was matched for risk between the 2 groups on the basis of
logistic European System for Cardiac Operative Risk Evaluation score for
all outcomes except 30-day all-cause mortality, which had a high-risk
population in the TAVI group (p = 0.02). There was no significant
difference found in all-cause mortality at 30 days (p=0.97) and at an
average of 85 weeks (p=0.07). There was no significant difference in
cardiovascular mortality (p=0.54) as well as the incidence of myocardial
infarction (p=0.59), stroke (p=0.36), and transient ischemic attack (p =
0.85) at averages of 86, 72, 66, and 89 weeks, respectively. Compared with
patients who underwent TAVI, those who underwent SAVR had a significantly
higher frequency of major bleeding events (p <0.0001) at mean follow-up of
66 weeks. In conclusion, TAVI has similar cardiovascular and all-cause
mortality to SAVR at early and long-term follow-up. TAVI is superior to
SAVR for major bleeding complications and noninferior to SAVR for
postprocedural myocardial infarctions and cerebrovascular events. TAVI is
a safe alternative to SAVR in selected high-risk elderly patients with
severe aortic stenosis. 2013 Elsevier Inc. All rights reserved.

<5>
Accession Number
2013691988
Authors
Parkash R. Philippon F. Shanks M. Thibault B. Cox J. Low A. Essebag V.
Bashir J. Moe G. Birnie D.H. Larose E. Yee R. Swiggum E. Kaul P. Redfearn
D. Tang A.S. Exner D.V.
Institution
(Parkash, Cox) Faculty of Medicine, Dalhousie University, Halifax, NS,
Canada
(Philippon, Larose) Quebec Heart and Lung Institute, Laval University,
Quebec City, QC, Canada
(Shanks) Mazankowski Alberta Heart Institute, University of Alberta,
Edmonton, AB, Canada
(Thibault) Montreal Heart Institute, University of Montreal, Montreal, QC,
Canada
(Low) Chinook Regional Hospital, Lethbridge, AB, Canada
(Essebag) McGill University, Montreal, QC, Canada
(Bashir) University of British Columbia, Vancouver, BC, Canada
(Moe) St Michael's Hospital, University of Toronto, Toronto, ON, Canada
(Birnie) Ottawa Heart Institute, University of Ottawa, Ottawa, ON, Canada
(Yee) University of Western Ontario, London, ON, Canada
(Swiggum, Tang) Island Medical Program, Victoria, BC, Canada
(Kaul) University of Alberta, Edmonton, AB, Canada
(Redfearn) Queen's University, Kingston, ON, Canada
(Exner) Libin Cardiovascular Institute of Alberta, University of Calgary,
Calgary, AB, Canada
Title
Canadian cardiovascular society guidelines on the use of cardiac
resynchronization therapy: Implementation.
Source
Canadian Journal of Cardiology. 29 (11) (pp 1346-1360), 2013. Date of
Publication: November 2013.
Publisher
Pulsus Group Inc. (2902 South Sheridan Way, Oakville ONT L6J 7L6, Canada)
Abstract
Recent studies have provided the impetus to update the recommendations for
cardiac resynchronization therapy (CRT). This article provides guidance on
the implementation of CRT and is intended to serve as a framework for the
implementation of CRT within the Canadian health care system and beyond.
These guidelines were developed through a critical evaluation of the
existing literature, and expert consensus. The panel unanimously adopted
each recommendation. The 9 recommendations relate to patient selection in
the presence of comorbidities, delivery and optimization of CRT, and
resources required to deliver this therapy. The strength of evidence was
weighed, taking full consideration of any risk of bias, and any
imprecision, inconsistency, and indirectness of the available data. The
strength of each recommendation and the quality of evidence were
adjudicated. Trade-offs between desirable and undesirable consequences of
alternative management strategies were considered, as were values,
preferences, and resource availability. These guidelines were externally
reviewed by experts, modified based on those reviews, and will be updated
as new knowledge is acquired. 2013 Canadian Cardiovascular Society.

<6>
Accession Number
2013691137
Authors
Liistro F. Porto I. Angioli P. Grotti S. Ducci K. Falsini G. Bolognese L.
Institution
(Liistro, Porto, Angioli, Grotti, Ducci, Falsini, Bolognese)
Cardiovascular and Neurologic Department, San Donato Hospital, Via Pietro
Nenni 22, 52100 Arezzo, Italy
(Grotti) Department of Cardiovascular Diseases, University of Siena, Le
Scotte Hospital, Siena, Italy
Title
Elutax paclitaxel-eluting balloon followed by bare-metal stent compared
with Xience v drug-eluting stent in the treatment of de novo coronary
stenosis: A randomized trial.
Source
American Heart Journal. 166 (5) (pp 920-926), 2013. Date of Publication:
November 2013.
Publisher
Mosby Inc. (11830 Westline Industrial Drive, St. Louis MO 63146, United
States)
Abstract
Background Paclitaxel-eluting balloons (PEBs) are a promising alternative
to drug-eluting stent (DES) in the treatment of coronary stenoses. The aim
of our study was to compare the 9-month restenosis rates of a strategy of
predilatation with PEB followed by bare-metal CoCr stent (PEB + BMS group)
versus implantation of everolimus DES (DES group). Methods This
randomized, single-center study planned to enroll 366 patients with stable
angina (183 patients per arm) undergoing percutaneous coronary
intervention of a de novo, native coronary artery stenosis <= 15 mm in
length. Primary end point, in a noninferiority study design, was 9-month
binary angiographic restenosis. A frequency-domain optical coherence
tomography substudy investigated the percentage of uncovered stent struts
per lesion, the percentage of malapposed/uncovered struts per lesion, and
the percentage of net volume obstruction at 9-month follow-up among the
first consecutive 30 patients enrolled in the PEB + BMS group. Results The
study was prematurely halted after enrollment of 125 patients, 59 in the
PEB + BMS group and 66 in the DES group, because of excess of
ischemia-driven target lesion revascularization in the PEB + BMS group.
When all the enrolled patients completed their follow-up, IDLTR rates were
14% in the PEB + BMS versus 2% in DES group (P =.001). Binary restenosis,
either in-stent or in-segment, was significantly higher in the PEB + BMS
compared with DES group (17% vs 3% [P =.01] and 25% vs 4% [P =.009]
respectively). Frequency-domain optical coherence tomography demonstrated
important neointimal regrowth in the PEB + BMS group, similar to
historical BMS data. Conclusion In the treatment of de novo coronary
stenosis, a strategy of predilatation with PEB before BMS implantation was
significantly inferior to implantation of an everolimus DES stent in terms
of 9-month target lesion revascularization. Frequency-domain optical
coherence tomography data confirm the lack of efficacy of this strategy.
2013 Mosby, Inc.

<7>
Accession Number
2013687760
Authors
Lin D.M. Lin E.S. Tran M.-H.
Institution
(Lin) Lin Shin Hospital, Department of Medicine, Taichung City, Taiwan
(Republic of China)
(Lin) Department of Medicine, University of California, Irvine Medical
Center, Orange, CA, United States
(Tran) Department of Pathology and Laboratory Medicine, University of
California Irvine School of Medicine, Orange, CA, United States
(Tran) Transfusion Medicine Service, Orange, CA, United States
Title
Efficacy and safety of erythropoietin and intravenous iron in
perioperative blood management: A systematic review.
Source
Transfusion Medicine Reviews. 27 (4) (pp 221-234), 2013. Date of
Publication: October 2013.
Publisher
W.B. Saunders (Independence Square West, Philadelphia PA 19106-3399,
United States)
Abstract
The use of erythropoietin (EPO) and intravenous (IV) iron as bloodless
therapeutic modalities is being explored in the current era of restrictive
transfusion strategies and perioperative blood management. It is unclear,
however, whether the evidence in the literature supports their safety and
efficacy in reducing perioperative red cell transfusions. Adhering to the
Preferred Reporting Items for Systematic Reviews and Meta-Analysis
guidelines, we conducted a systematic review to evaluate their use in a
variety of perioperative settings. We performed a literature search of
English articles published between July 1997 and July 2012 in MEDLINE via
PubMed, The Cochrane Library, and CINAHL. Only studies with a comparator
group were eligible for inclusion. Twenty-four randomized controlled
trials (RCTs) and 15 nonrandomized studies were included in the final
review. Using the Cochrane risk of bias tool, 8 RCTs were assessed to be
at low risk for methodological bias. Of these, however, only 4 RCTs were
adequately powered to detect a reduction in transfusion rates. Patients
with preoperative iron deficiency anemia may have an earlier and more
robust hemoglobin recovery with preoperative IV iron therapy than with
oral iron supplementation. A short preoperative regimen of EPO, or a
single dose of EPO plus IV iron in the preoperative or intraoperative
period, may significantly reduce transfusion rates (number needed to treat
to avoid any transfusion ranged from 3 to 6). With regard to the safety of
erythropoietin-stimulating agent therapy, IV iron appears to be as well
tolerated as oral iron; however, the incidence of severe anaphylactic-type
reactions attributable to IV iron is difficult to estimate in prospective
trials because of its relatively infrequent occurrence. Furthermore, EPO
may increase the risk of thromboembolism in spinal surgery patients who
receive mechanical antithrombotic prophylaxis in the perioperative period
so pharmacological thromboprophylaxis is advised. Future low risk of bias,
adequately powered prospective efficacy, and safety trials in various
surgical settings that traditionally require red cell transfusions would
be required to make evidenced-based conclusions about the clinical
significance of erythropoietin-stimulating agent as a transfusion
avoidance strategy in perioperative blood management. 2013 Elsevier Inc.

<8>
Accession Number
2013691930
Authors
Conway A. Schadewaldt V. Clark R. Ski C. Thompson D.R. Doering L.
Institution
(Conway, Clark) School of Nursing and Institute of Health and Biomedical
Innovation, Queensland University of Technology, Level 7, 60 Musk Ave.,
Kelvin Grove, QLD 4059, Australia
(Schadewaldt) Faculty of Health Sciences, Australian Catholic University,
Melbourne, Australia
(Ski, Thompson) Cardiovascular Research Centre, Australian Catholic
University, Melbourne, Australia
(Doering) School of Nursing, University of California Los Angeles, CA,
United States
Title
The psychological experiences of adult heart transplant recipients: A
systematic review and meta-summary of qualitative findings.
Source
Heart and Lung: Journal of Acute and Critical Care. 42 (6) (pp 449-455),
2013. Date of Publication: November 2013.
Publisher
Mosby Inc. (11830 Westline Industrial Drive, St. Louis MO 63146, United
States)
Abstract
Background: Psychosocial factors and physical health are associated with
increased psychological distress post-heart transplant. Integrating
findings from qualitative studies could highlight mechanisms for how these
factors contribute to psychological well-being, thus aiding the
development of interventions. Objective: To integrate qualitative findings
regarding adult heart transplant recipients experiences, such as their
emotions, perceptions and attitudes. Methods: A systematic review and
meta-summary were conducted. Data from seven studies were categorized into
16 abstracted findings. Results: The most prominent finding across the
studies related to recipients' perceptions of the importance of social
support. Other prominent findings related to factors that promoted
psychological well-being, such as faith, optimism and sense of control.
Conclusions: Psychological well-being may be improved by enhancing
perceived control over health and daily life, promoting an optimistic
outlook by facilitating access to social support from other heart
transplant recipients and ensuring post-transplant recipient-caregiver
partnerships adequately support the transition back to independence. 2013
Elsevier Inc.

<9>
Accession Number
2013692007
Authors
Tashakkor A.Y. Mancini G.B.J.
Institution
(Tashakkor, Mancini) Department of Medicine (Division of Cardiology),
University of British Columbia, Vancouver, BC, Canada
Title
The relationship between skin cholesterol testing and parameters of
cardiovascular risk: A systematic review.
Source
Canadian Journal of Cardiology. 29 (11) (pp 1477-1487), 2013. Date of
Publication: November 2013.
Publisher
Pulsus Group Inc. (2902 South Sheridan Way, Oakville ONT L6J 7L6, Canada)
Abstract
Background: A potential correlation between skin cholesterol levels
obtained via skin biopsy and evidence of underlying atherosclerosis has
been reported. With the availability of a noninvasive method of skin
cholesterol measurement, multiple studies investigated the association of
skin cholesterol and traditional cardiovascular risk factors. We provide a
systematic review of clinical data to assist physicians counselling
patients that have undergone skin cholesterol testing and to provide a
framework for future research. Methods: Multiple electronic databases were
systematically searched for studies published from 1970 through February
2013. Selection criteria included English language, peer-reviewed studies
that quantitatively examined the relationship between noninvasively
measured skin cholesterol levels and indices of vascular disease or
cardiovascular risk factors in human subjects. Results: We identified 9
cohorts reported in 11 studies. The studies suggest that skin cholesterol
does not correlate with traditional markers of cardiovascular disease such
as serum lipid values and inflammatory markers, and integrated risk scores
(Framingham and Prospective Cardiovascular Munster [PROCAM]). Single
studies reported a significant relationship between skin cholesterol
levels and evidence of underlying atherosclerosis as implied by positive
exercise testing, invasive coronary angiography, increased calcium scores
in Caucasian patients, and presence of carotid plaque detected using
B-mode ultrasound. Two studies identified a significant relationship using
B-mode measurements of carotid intima medial thickening. Conclusions: Skin
cholesterol might be a marker of underlying vascular atherosclerosis.
Further prospective investigations are warranted to establish utility of
this point-of-care test for identifying subjects warranting formal
cardiovascular risk assessment. 2013 Canadian Cardiovascular Society.

<10>
Accession Number
2013652570
Authors
Grundeken M.J. Stella P.R. Bethencourt A. Asgedom S. Lesiak M. Norell M.S.
Koch K.T. Vis M.M. Henriques J.P. Onuma Y. Bartorelli A.L. Tijssen J.G.
Foley D.P. Garcia E. De Winter R.J. Wykrzykowska J.J.
Institution
(Grundeken, Koch, Vis, Henriques, Tijssen, De Winter, Wykrzykowska)
Department of Cardiology, Academic Medical Center, University of
Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands
(Stella) Department of Cardiology, University Medical Center Utrecht,
Utrecht University, Utrecht, Netherlands
(Bethencourt) Department of Cardiology, Hospital Son Espases, Palma de
Mallorca, Spain
(Asgedom, Foley) Beaumont Hospital, Dublin, Ireland
(Lesiak) 1st Department of Cardiology, Poznan University of Medical
Sciences, Poznan, Poland
(Norell) Heart and Lung Centre, Wolverhampton Hospital NHS Trust,
Wolverhampton, United Kingdom
(Onuma) Department of Interventional Cardiology, Thoraxcenter, Erasmus
Medical Center, Rotterdam, Netherlands
(Bartorelli) Department of Cardiovascular Sciences and Community Health,
Centro Cardiologico Monzino, University of Milan, Italy
(Garcia) Department of Cardiology, Hospital Clinico San Carlos, Madrid,
Spain
Title
Additional side branch stent placement in patients with long side branch
lesions treated with the Tryton dedicated bifurcation side branch stent.
Source
International Journal of Cardiology. 168 (3) (pp 3059-3062), 2013. Date of
Publication: 03 Oct 2013.
Publisher
Elsevier Ireland Ltd (P.O. Box 85, Limerick, Ireland)

<11>
Accession Number
2013652589
Authors
Chatterjee S. Sardar P.
Institution
(Chatterjee) Brown University, Providence, RI, United States
(Chatterjee) Providence VAMC, Providence, RI, United States
(Sardar) New York Medical College-Metropolitan Hospital Center, Department
of Medicine, New York, NY, United States
Title
Early surgery reduces mortality in patients with infective endocarditis:
Insight from a meta-analysis.
Source
International Journal of Cardiology. 168 (3) (pp 3094-3097), 2013. Date of
Publication: 03 Oct 2013.
Publisher
Elsevier Ireland Ltd (P.O. Box 85, Limerick, Ireland)

<12>
Accession Number
2013652595
Authors
Steib A. Collange O. Quessard A. Levy F. Zeisser M. Charles A.-L. Oltean
C. Kretz J.-G. Geny B. Borg J.
Institution
(Steib, Collange, Levy, Zeisser) Department of Anaesthesiology, Hopitaux
Universitaires de Strasbourg, 1 place de l'hopital, 67091 Strasbourg
cedex, France
(Quessard) Department of Anaesthesiology, La Pitie Hospital, AP-HP, Paris,
France
(Charles, Geny) Physiology Institute, Faculty of Medicine, Strasbourg
University, France
(Oltean, Kretz) Cardiovascular Surgery Department, University Hospital,
Strasbourg, France
(Borg) Biochemistry Laboratory, University Hospital, St Etienne, France
Title
Combined intraoperative use of Diltiazem and N-acetylcystein increases
myocardial damage and oxidative stress during off-pump cardiac surgery.
Source
International Journal of Cardiology. 168 (3) (pp 3107-3109), 2013. Date of
Publication: 03 Oct 2013.
Publisher
Elsevier Ireland Ltd (P.O. Box 85, Limerick, Ireland)

<13>
Accession Number
2013652768
Authors
Bielecka-Dabrowa A. Von Haehling S. Aronow W.S. Ahmed M.I. Rysz J. Banach
M.
Institution
(Bielecka-Dabrowa, Banach) Department of Hypertension, WAM University
Hospital in Lodz, Medical University of Lodz, Poland, Zeromskiego 113,
90-549 Lodz, Poland
(Von Haehling) Department of Cardiology, Charite Medical School, Campus
Virchow-Klinikum, Berlin, Germany
(Aronow) Cardiology Division, New York Medical College, Valhalla, United
States
(Ahmed) Division of Cardiovascular Medicine, Department of Medicine,
University of Alabama at Birmingham, Birmingham, AL, United States
(Rysz) Department of Nephrology, Hypertension and Family Medicine, Medical
University of Lodz, Poland
Title
Heart failure biomarkers in patients with dilated cardiomyopathy.
Source
International Journal of Cardiology. 168 (3) (pp 2404-2410), 2013. Date of
Publication: 03 Oct 2013.
Publisher
Elsevier Ireland Ltd (P.O. Box 85, Limerick, Ireland)
Abstract
Background We set out to evaluate the utility of selected heart failure
(HF) biomarkers in patients with dilated cardiomyopathy (DCM). Methods In
a prospective, randomized study, 68 DCM patients with left ventricular
ejection fraction (LVEF) <= 40% treated optimally were included. They were
observed for 5 years. Initial and control tests included full clinical
examination, measurement of tumor necrosis factor alpha (TNF-alpha),
interleukin 6 (IL-6) and IL-10, syndecan-4, cystatin C (CysC) and
N-terminal pro-brain natriuretic peptide (NT-proBNP), echocardiographic
examination, and the assessment of exercise capacity in 6-minute walk test
(6MWT). Results Finally, after 5-year follow-up we analyzed the data of 45
DCM patients. Concentration of syndecan-4 correlated negatively with LVEF
(R = - 0.36, p = 0.02) and positively with LV systolic (R = 0.57, p <
0.001) and diastolic diameters (R = 0.64, p < 0.001). A positive
correlation between CysC and right ventricular diastolic diameter (R =
0.38, p = 0.01), and negative correlations between CysC and glomerular
filtration rate (R = - 0.49, p < 0.001), LVEF (R = - 0.4, p = 0.02), and
6MWT (R = - 0.46, p < 0.001) were noted. Patients who had an increase in
LVEF during 5 years were characterized by lower levels of CysC (p = 0.01)
and NT-proBNP (p < 0.001). CysC <= 95 mg/l and NT-proBNP <= 32 pg/ml were
the best predictors of LVEF increase in DCM patients. Multivariate
regression analysis showed that 6MWT was the only independent predictor of
HF re-hospitalization (OR 0.989; p < 0.001), and NT-proBNP and LV
diastolic diameter were the only risk factors of increased mortality (OR
1.001; p = 0.007 and OR 2.960; p = 0.025, respectively) in DCM patients.
Conclusions CysC correlates negatively with both kidney function and
exercise capacity. Syndecan-4 may be a useful biomarker for predicting
adverse LV remodeling in DCM patients. 2013 Elsevier Ireland Ltd. All
rights reserved.

<14>
Accession Number
2013652541
Authors
Kwong J.S.W. Yu C.-M.
Institution
(Kwong, Yu) Department of Medicine and Therapeutics, Prince of Wales
Hospital, Chinese University of Hong Kong, Shatin, NT, Hong Kong
Title
Drug-eluting balloons for coronary artery disease: An updated
meta-analysis of randomized controlled trials.
Source
International Journal of Cardiology. 168 (3) (pp 2930-2932), 2013. Date of
Publication: 03 Oct 2013.
Publisher
Elsevier Ireland Ltd (P.O. Box 85, Limerick, Ireland)

<15>
Accession Number
2013578520
Authors
Lodi-Junqueira L. de Sousa M.R. da Paixao L.C. Kelles S.M.B. Amaral C.F.S.
Ribeiro A.L.
Institution
(Lodi-Junqueira, de Sousa, da Paixao, Kelles, Amaral, Ribeiro) Instituto
de Avaliacao de Tecnologias em Saude (IATS), Do Hospital das Clinicas da
Universidade Federal de Minas Gerais (UFMG), Avenida Alfredo Balena, 110,
CEP, 30130-100, Belo Horizonte, MG, Brazil
(Lodi-Junqueira) Setor de Hemodinamica do Hospital das Clinicas da UFMG,
Avenida Alfredo Balena, 110, CEP, 30130-100, Belo Horizonte, MG, Brazil
(de Sousa, Amaral, Ribeiro) Departamento de Clinica Medica, Faculdade de
Medicina da UFMG, Avenida Alfredo Balena, 190, CEP, 30130-100, Belo
Horizonte, MG, Brazil
Title
Does intravascular ultrasound provide clinical benefits for percutaneous
coronary intervention with bare-metal stent implantation? A meta-analysis
of randomized controlled trials.
Source
Systematic Reviews. 1 (1) , 2012. Article Number: 42. Date of Publication:
21 Sep 2012.
Publisher
BioMed Central Ltd. (Floor 6, 236 Gray's Inn Road, London WC1X 8HB, United
Kingdom)
Abstract
Background: The role of intravascular ultrasound (IVUS) in percutaneous
coronary interventions (PCI) is still controversial despite several
previously published meta-analyses. A meta-analysis to evaluate the
controversial role of IVUS-guided PCI with bare-metal stenting was
performed and a previous published meta-analysis was re-evaluated in order
to clarify the discrepancy between results of these studies.Methods: A
systematic review was performed by an electronic search of the PubMed,
Embase and Web of Knowledge databases and by a manual search of reference
lists for randomized controlled trials published until April 2011, with
clinical outcomes and, at least, six months of clinical follow-up. A
meta-analysis based on the intention to treat was performed with the
selected studies.Results: Five studies and 1,754 patients were included.
There were no differences in death (OR = 1.86; 95% CI = 0.88-3.95; p =
0.10), non-fatal myocardial infarction (OR = 0.65; 95% CI = 0.27-1.58; p =
0.35) and major adverse cardiac events (OR = 0.74; 95% CI = 0.49-1.13; p =
0.16). An analysis of the previous published meta-analysis strongly
suggested the presence of publication bias.Conclusions: There is no
evidence to recommend routine IVUS-guided PCI with bare-metal stent
implantation. This may be explained by the paucity and heterogeneity of
the studies published so far. 2012 Lodi-Junqueira et al.; licensee BioMed
Central Ltd.

<16>
Accession Number
2013578497
Authors
Mans C.M. Reeve J.C. Gasparini C.A. Elkins M.R.
Institution
(Mans) Physiotherapy Department, Waikato Hospital, Waikato District Health
Board, Hamilton, New Zealand
(Reeve) Division of Rehabilitation and Occupation Studies, Faculty of
Health and Environmental Studies, AUT University, Auckland, New Zealand
(Gasparini) Disability Service, Student Support Services, University of
Western Sydney, Sydney, Australia
(Elkins) Centre for Evidence-Based Physiotherapy, George Institute for
Global Health, Sydney, Australia
Title
Postoperative outcomes following preoperative inspiratory muscle training
in patients undergoing open cardiothoracic or upper abdominal surgery:
Protocol for a systematic review.
Source
Systematic Reviews. 1 (1) , 2012. Article Number: 63. Date of Publication:
18 Dec 2012.
Publisher
BioMed Central Ltd. (Floor 6, 236 Gray's Inn Road, London WC1X 8HB, United
Kingdom)
Abstract
Background: In patients undergoing open cardiothoracic and upper abdominal
surgery, postoperative pulmonary complications remain an important cause
of postoperative morbidity and mortality, impacting upon hospital length
of stay and health care resources. Adequate preoperative respiratory
muscle strength may help protect against the development of postoperative
pulmonary complications and therefore preoperative inspiratory muscle
training has been suggested to be of potential value in improving
postoperative outcomes.Methods/Design: A systematic search of electronic
databases will be undertaken to identify randomized trials of preoperative
inspiratory muscle training in patients undergoing elective open
cardiothoracic and upper abdominal surgery. From these trials, we will
extract available data for a list of predefined outcomes, including
postoperative pulmonary complications, hospital length of stay and
respiratory muscle strength. We will meta-analyze comparable results where
possible, and report a summary of the available pool of
evidence.Discussion: This review will provide the most comprehensive
answer available to the question of whether preoperative inspiratory
muscle training is clinically useful in improving postoperative outcomes
in patients undergoing cardiothoracic and upper abdominal surgery. It will
help inform clinicians working in the surgical arena of the likely
effectiveness of instituting preoperative inspiratory muscle training
programs to improve postoperative outcomes. 2012 Mans et al.; licensee
BioMed Central Ltd.

<17>
Accession Number
2013562743
Authors
Benson H.L. Wilkes D.S.
Institution
(Benson, Wilkes) Department of Medicine, Microbiology and Immunology,
Indiana University School of Medicine, Fairbanks Hall, Indianapolis, IN
46202, United States
(Benson, Wilkes) Center for Immunobiology, Indiana University School of
Medicine, Indianapolis, IN 46202, United States
Title
Matrix metalloproteinases in T cell mediated pulmonary diseases.
Source
Frontiers in Bioscience - Elite. 4 E (6) (pp 2162-2169), 2012. Date of
Publication: 01 Jan 2012.
Publisher
Frontiers in Bioscience (PO Box 160, Albertson NY 11507-0160, United
States)
Abstract
Lung transplantation is the only conclusive treatment for many patients
suffering from end-stage pulmonary disease. Unfortunately, the leading
cause of death in lung transplant recipients is the development of chronic
rejection known as obliterative bronchiolitis, characterized by extensive
remodeling. Matrix metalloproteinases (MMPs) are endopeptidases known for
their role in matrix remodeling and their involvement in many biological
processes including end-stage pulmonary disease and transplant rejection.
Our understanding of MMPs involvement in pulmonary immunity is rapidly
expanding. As a result there has been some focus on MMPs role in T
cell-associated pulmonary diseases, such as pulmonary fibrosis, emphysema,
asthma and bronchiolitis obliterans syndrome. However, not much is known
about the role of MMPs in regulating immune cell function. It is now
commonly known that MMP inhibition via, broad spectrum or specific
synthetic or naturally occurring inhibitors (TIMPs) can down regulated
many pulmonary disease states. In this review, we explore the idea that T
cell targeted MMP inhibition may provide a novel approach of immune
regulation in the treatment of T cell-mediated diseases.

<18>
Accession Number
2013686239
Authors
Ahangar A.G. Charag A.H. Lateef Wani M. Ganie F.A. Singh S. Qadri S.A.A.
Shah Z.A.
Institution
(Ahangar, Charag, Lateef Wani, Ganie, Singh, Qadri, Shah) Department of
Cardiovascular and Thoracic Surgery, Sheri Kashmir Institute of Medical
Science, Srinagar, Kashmir, India
Title
Comparing Aortic Valve Replacement through right anterolateral thoracotomy
with median sternotomy.
Source
International Cardiovascular Research Journal. 7 (3) , 2013. Date of
Publication: 2013.
Publisher
Iranian Cardiovascular Research Journal (Zand Ave., Shiraz, Iran, Islamic
Republic of)
Abstract
Background: Aortic Valve Replacement (AVR) is usually done through median
sternotomy. Te present study aimed to compare the right anterolateral
thoracotomy and median sternotomy approaches for AVR. Methods: Te present
prospective study was conducted on 60 patients who had aortic valve
disease and were subjected to AVR. Tirty patients underwent aortic valve
replacement via right anterolateral thoracotomy (study group) and thirty
patients via median sternotomy (control group). Statistical analysis was
done using Mann Whitney U test and Fischer's Exact test. Statistical
Package SPSS 17 was used for data analysis. Results: Te mean length of the
incision was 18.7+/-1.8 cm in the patients who had undergone AVR through
median sternotomy, while 7.8+/-0.9 cm in the study group patients.
Besides, the mean bypass time was 121.8+/-18.6 minutes for the patients
who had undergone AVR through median sternotomy, while 122.1+/-20.8
minutes for the study group. In addition, the mean aortic cross clamp time
was 67.7+/-13.4 minutes for the patients who had undergone AVR through
median sternotomy, while 68.0+/-8.9 minutes for the study group. Te mean
operating time was 181.6+/-31.5 minutes for the patients who had undergone
AVR through median sternotomy, while 190.8+/-29.8 minutes for the study
group. Patient satisfaction with respect to cosmesis was higher in the
study group. Only 50% of the patients who had undergone AVR through median
sternotomy in comparison to 73.3% of those in the study group were
satisfed with the cosmesis. Conclusions: Te right anterolateral
thoracotomy approach for aortic valve replacement proved to be easy to
perform whilst maintaining the maximum security for the patients. Besides
its better cosmetic result especially in female patients, this approach
proved to have several advantages.

<19>
Accession Number
2013652685
Authors
Beyer A.T. Ng R. Singh A. Zimmet J. Shunk K. Yeghiazarians Y. Ports T.A.
Boyle A.J.
Institution
(Beyer, Ng, Singh, Zimmet, Shunk, Yeghiazarians, Ports, Boyle) Division of
Cardiology, University of California San Francisco, San Francisco, CA,
United States
Title
Topical nitroglycerin and lidocaine to dilate the radial artery prior to
transradial cardiac catheterization: A randomized, placebo-controlled,
double-blind clinical trial: The PRE-DILATE Study.
Source
International Journal of Cardiology. 168 (3) (pp 2575-2578), 2013. Date of
Publication: 03 Oct 2013.
Publisher
Elsevier Ireland Ltd (P.O. Box 85, Limerick, Ireland)
Abstract
Background/Objectives Transradial access (TRA) is being increasingly used
for both diagnostic and interventional cardiac procedures. Use of TRA
offers many advantages: decreased bleeding, vascular complications,
reduced length of hospital stay, and reduced cost. However, the small size
of the radial artery limits the size of the equipment that can be used via
this approach. We sought to determine whether pre-procedural
administration of topical nitroglycerin and lidocaine increases the size
of the radial artery. Methods Patients undergoing transradial cardiac
catheterization were randomized in a double-blind fashion to a topical
combination of nitroglycerin + lidocaine or placebo ointment. The primary
endpoint was change in radial artery size. Secondary endpoints included
radial artery spasm and radial artery patency. Results 86 patients were
enrolled (43 allocated to treatment group and 43 to placebo group).
Patients underwent ultrasound of the radial artery at baseline and before
the catheterization. Complications were rare: one hematoma (placebo group)
and one radial artery occlusion (placebo group). Baseline demographic and
clinical characteristics were similar. The baseline radial artery
cross-sectional area (CSA) was similar in both groups (4.95 +/- 0.24
mm² in placebo group and 5.14 +/- 0.34 mm² in the
treatment group). However, the final CSA decreased to 4.66 +/- 0.25
mm² in the placebo group and increased to 5.78 +/- 0.38
mm² in the treatment group (p = 0.02), which corresponded to a
decrease in CSA by - 5.6 +/- 2.1% and an increase in CSA by 16.5 +/- 4.2%
(p < 0.0001), respectively. Conclusions Pre-procedural administration of
topical mixture of nitroglycerin + lidocaine increases the size of the
radial artery in patients undergoing transradial cardiac catheterization.
ClinicalTrials.gov Identifier NCT01155167 2013 Elsevier Ireland Ltd. All
rights reserved.

<20>
Accession Number
2013652743
Authors
Lu M. Liu S. Zheng Z. Yin G. Song L. Chen H. Chen X. Chen Q. Jiang S. Tian
L. He Z. Hu S. Zhao S.
Institution
(Lu, Liu, Zheng, Yin, Song, Chen, Chen, Jiang, He, Hu, Zhao) State Key
Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of
Medical Sciences, Beijing, 100037, China
(Chen, Tian) Department of Cardiology, Queen Mary Hospital, Hong Kong,
Hong Kong
Title
A pilot trial of autologous bone marrow mononuclear cell transplantation
through grafting artery: A sub-study focused on segmental left ventricular
function recovery and scar reduction.
Source
International Journal of Cardiology. 168 (3) (pp 2221-2227), 2013. Date of
Publication: 03 Oct 2013.
Publisher
Elsevier Ireland Ltd (P.O. Box 85, Limerick, Ireland)
Abstract
Background Our preliminary study suggested that patients with chronic
myocardial infarction (MI) and heart failure could potentially benefit
from CABG combined with aBM-MNC by improving global left ventricular (LV)
function. The purpose of this sub-study was to quantitatively evaluate the
effectiveness of aBM-MNC transplantation during CABG in patients with
chronic MI by intensively analyzing the global and segmental LV function,
the scar, and the relationships between the function recovery and the scar
transmural extent. Methods A randomized, double-blinded,
placebo-controlled study was performed in 50 patients with chronic MI. The
patients were randomly allocated into CABG with stem cell transplantation
(group A) and CABG only (group B) groups. CMR assessments of global and
segmental left ventricular function and scar tissue were performed before
surgery and repeated at 12 months after CABG and aBM-MNC transplantation.
Results The left ventricular ejection fraction (LVEF) improved by 13.5%
and 8.0% in group A and B respectively (P = 0.04). Segmental analysis of
regional LV function recovery indicated that more improvement in
contractility was found in group A within the same degree of the infarct
transmurality (P = 0.017) and showed a predominant interaction in the most
severely affected segments (76-100%, P = 0.016). Decrease in infarct size
between the two groups did not reach statistical difference (9.4% vs.
6.0%, P = 0.100). Conclusions CMR assessments revealed reversed
ventricular remodeling and improved systolic function and scar reduction
in patients who underwent aBM-MNC transplantation during CABG. And the
conjunctional use of CABG and stem cell therapy could improve the left
ventricular function in patients with chronic MI. 2013 Elsevier Ireland
Ltd. All rights reserved.

<21>
Accession Number
2013637738
Authors
Van De Bruaene A. De Meester P. Voigt J.-U. Delcroix M. Pasquet A. De
Backer J. De Pauw M. Naeije R. Vachiery J.-L. Paelinck B.P. Morissens M.
Budts W.
Institution
(Van De Bruaene, De Meester, Voigt, Delcroix, Budts) Congenital and
Structural Cardiology, University Hospitals Leuven, Herestraat 49, B-3000
Leuven, Belgium
(Pasquet) University Hospitals St Luc Brussels, Brussels, Belgium
(De Backer, De Pauw) Ghent University Hospital, Ghent, Belgium
(Naeije, Vachiery) Erasme University Hospital, Brussels, Belgium
(Paelinck) University Hospital Antwerp, Belgium
(Morissens) CHU Brugman, Brussels, Belgium
Title
Worsening in oxygen saturation and exercise capacity predict adverse
outcome in patients with Eisenmenger syndrome.
Source
International Journal of Cardiology. 168 (2) (pp 1386-1392), 2013. Date of
Publication: 30 Sep 2013.
Publisher
Elsevier Ireland Ltd (P.O. Box 85, Limerick, Ireland)
Abstract
Objectives: To evaluate (1) changes in clinical, biochemical and
echocardiographic parameters, (2) whether deterioration in exercise
capacity and resting oxygen saturation (SatO2-rest) are related with
adverse outcome and (3) its additional value in predicting outcome in
Eisenmenger patients. Methods: Seventy-seven (36+/-14 years, 30% male)
patients were included and prospectively followed. Changes between
baseline and final visit were evaluated. Clinical deterioration was
defined as a deterioration in exercise capacity or SatO2-rest. Univariate
and multivariate analyses were performed to evaluate predictors of outcome
defined as the need for hospitalization due to right heart failure,
transplantation, or all-cause mortality. Finally, the additional
prognostic value of deterioration in exercise capacity and SatO2-rest was
evaluated. Results: During amean follow-up period of 4.0+/-2.1 years, 27
(35%) events occurred. Patients in the event-group presented with an
deterioration in NYHA class (Pb0.0001), 6 minute walk distance (P=0.006)
and SatO2-rest (Pb0.0001). After adjustment for baseline variables,
multivariate Cox regression analysis indicated that clinical deterioration
was independently associated with adverse outcome. Conclusions: Clinical
deterioration, defined as a deterioration in exercise capacity or
SatO2-restwas associated with adverse outcome in Eisenmenger
patients.Moreover, these parameters provided additional information
onwhich patients would develop an event and may benefit from initiation or
escalation of disease targeting therapy. 2012 Elsevier Ireland Ltd. All
rights reserved.

<22>
Accession Number
2013644949
Authors
Gao F. Zhou Y.J. Shen H. Wang Z.J. Yang S.W. Liu X.L.
Institution
(Gao, Zhou, Shen, Wang, Yang, Liu) Department of Cardiology, An Zhen
Hospital, Capital Medical University, Anzhenli Avenue, Chao Yang District,
Beijing 100029, China
Title
Meta-analysis of percutaneous coronary intervention versus coronary artery
bypass graft surgery in patients with diabetes and left main and/or
multivessel coronary artery disease.
Source
Acta Diabetologica. 50 (5) (pp 765-773), 2013. Date of Publication: 2013.
Publisher
Springer Milan (Via Podgora 4, Milan I-20122, Italy)
Abstract
The optimal coronary revascularization strategy for patients with diabetes
and left main and/or multivessel disease is undetermined. The aim of our
study was to evaluate percutaneous coronary intervention (PCI) versus
coronary artery bypass graft (CABG) in those patients. We identified 13
articles, published before October 2011, enrolling 6992 patients, whose
follow-up period ranged from 1 to 5 years. Patients with PCI had a
significant reduction in cerebral vascular attack (CVA) (OR, 0.29; 95 %
CI, 0.16-0.51; p < 0.0001, I ² = 0 %) as compared with CABG,
whereas there was a fourfold increased risk of repeat revascularization
associated with PCI even using drug-eluting stent (OR, 4.44; 95 % CI,
3.42-5.78; X² = 4.92, p < 0.00001, I ² = 0 %). The
overall mortality (OR, 0.97; 95 % CI, 0.81-1.15; p = 0.70, I ²
= 0 %) was comparable between the PCI and CABG. However, in subgroup
analysis, the composite outcome (death/myocardial infarction/CVA) was
significantly reduced in favor of DES implantation (OR, 0.79; 95 % CI,
0.63-0.99; X² = 1.07, p = 0.04, I ² = 0 %). Our
study confirmed the cerebral vascular benefits of PCI by significantly
reducing CVA risks, and the composite outcome was better in patients
undergoing PCI with drug-eluting stent, despite a higher repeat
revascularization rate. It poses imperative demands for future prospective
randomized studies to define the optimal strategy in patients with
diabetes and left main and/or multivessel disease. 2012 Springer-Verlag.

<23>
Accession Number
2013686548
Authors
Qu C.-Z. Zhang R.-Y. Xiang K.-F.
Institution
(Qu, Zhang, Xiang) General Hospital of Ningxia Medical University,
Yinchuan 750004, Ningxia Hui Autonomous Region, China
Title
Blood glucose control in the perioperative stage of cardiac value
replacement influences levels of blood lactic acid.
Source
Chinese Journal of Tissue Engineering Research. 16 (53) (pp 9955-9959),
2012. Date of Publication: 2012.
Publisher
Journal of Clinical Rehabilitative (P.O. Box 1200, Shenyang 110004, China)
Abstract
BACKGROUND: Hyperglycemia after cardiac-valve replacement can happen
easily that is unfavorable on the prognosis. However, the perioperative
blood glucose has close relationship with the level of lactic acid in
patients. OBJECTIVE: To observe the changes of blood glucose and blood
lactic acid levels in the patients with cardiac-valve replacement, and to
perform the correlation analysis. METHODS: Sixty-three patients with
cardiac-valve replacement were randomly divided into two groups. The
control group received traditional standard therapy, and the blood glucose
concentration was maintained at 7. 5-11. 1 mmol/L. The experimental group
received intensive therapy by subcutaneous infusion or continuous insulin
infusion, and the blood glucose concentration was maintained at 3. 6-7. 5
mmol/L. RESULTS AND CONCLUSION: The concentration of blood glucose during
cardiopulmonary bypass and after valve replacement in experimental group
was lower than that in the control group (P < 0. 05); with the time of the
cardiac-valve replacement increased, the blood lactic acid levels of two
groups were significantly increased, and the hyperlactacidemia could be
seen, the incidence of complications in the experimental group was lower
than that in the control group (P < 0. 05). The blood glucose and blood
lactic acid levels in two groups were gradually increased and returned to
the normal levels, the blood glucose and blood lactic acid levels were
highest at 6 hours after replacement. The changes of blood glucose level
and blood lactic acid level were the same. One variant linear regression
analysis showed the correlation coefficient of blood glucose and lactic
acid was 0. 838 and P < 0. 01 in one side, which proved that there was a
linear relationship between the two variables. Strict application of
insulin is beneficial to the control intraoperative and postoperative
blood glucose and blood lactic acid levels of cardiac-valve replacement
and can reduce the incidence of complication after replacement.
Perioperative blood glucose and blood lactic acid levels are positively
correlated.

<24>
Accession Number
2013676383
Authors
Mohty D. Damy T. Cosnay P. Echahidi N. Casset-Senon D. Virot P. Jaccard A.
Institution
(Mohty, Echahidi, Virot) Service de Cardiologie, Pole Coeur-poumon-rein,
Hopital Dupuytren, CHU de Limoges, 87042 Limoges, France
(Jaccard) Service d'Hematologie Clinique et de Therapie Cellulaire Pole
Onco-hematologie, Ctr. Natl. de Ref. Pour l'Amylose AL et Autres Maladies
de Depots d'Immunoglobulines Monoclonales, CHU de Limoges, Limoges, France
(Damy) Service de Cardiologie, CHU Henri-Mondor, Creteil, France
(Cosnay) Service de Cardiologie, CHU Trousseau, Tours, France
(Casset-Senon) Service de Medecine Nucleaire, CHU Trousseau, Tours, France
(Jaccard) UMR, CNRS 7276, Laboratoire d'Immunologie, Limoges, France
Title
Cardiac amyloidosis: Updates in diagnosis and management.
Source
Archives of Cardiovascular Diseases. 106 (10) (pp 528-540), 2013. Date of
Publication: October 2013.
Publisher
Elsevier Masson SAS (62 rue Camille Desmoulins, Issy les Moulineaux Cedex
92442, France)
Abstract
Amyloidosis is a severe systemic disease. Cardiac involvement may occur in
the three main types of amyloidosis (acquired monoclonal light-chain,
hereditary transthyretin and senile amyloidosis) and has a major impact on
prognosis. Imaging the heart to characterize and detect early cardiac
involvement is one of the major aims in the assessment of this disease.
Electrocardiography and transthoracic echocardiography are important
diagnostic and prognostic tools in patients with cardiac involvement.
Cardiac magnetic resonance imaging better characterizes myocardial
involvement, functional abnormalities and amyloid deposition due to its
high spatial resolution. Nuclear imaging has a role in the diagnosis of
transthyretin amyloid cardiomyopathy. Cardiac biomarkers are now used for
risk stratification and staging of patients with light-chain systemic
amyloidosis. Different types of cardiac complications may occur, including
diastolic followed by systolic heart failure, atrial and/or ventricular
arrhythmias, conduction disturbances, embolic events and sometimes sudden
death. Senile amyloid and hereditary transthyretin amyloid cardiomyopathy
have better prognoses than light-chain amyloidosis. Cardiac treatment of
heart failure is usually ineffective and is often poorly tolerated because
of its hypotensive and bradycardiac effects. The three main types of
amyloid disease, despite their similar cardiac appearance, have specific
new aetiological treatments that may change the prognosis of this disease.
Cardiologists should be aware of this disease to allow early treatment.
2013 Elsevier Masson SAS.

<25>
Accession Number
2013637808
Authors
Takagi H. Niwa M. Mizuno Y. Goto S.-N. Umemoto T.
Title
Incidence, predictors, and prognosis of acute kidney injury after
transcatheter aortic valve implantation: A summary of contemporary studies
using Valve Academic Research Consortium definitions.
Source
International Journal of Cardiology. 168 (2) (pp 1631-1635), 2013. Date of
Publication: 30 Sep 2013.
Publisher
Elsevier Ireland Ltd (P.O. Box 85, Limerick, Ireland)

<26>
Accession Number
2013637786
Authors
Takagi H. Niwa M. Mizuno Y. Yamamoto H. Goto S.-N. Umemoto T.
Institution
(Takagi, Niwa, Mizuno, Yamamoto, Goto, Umemoto) Department of
Cardiovascular Surgery, Shizuoka Medical Center, 762-1 Nagasawa,
Shimizu-cho, Sunto-gun, Shizuoka 411-8611, Japan
Title
A meta-analysis comparing observed 30-day all-cause mortality with the
society of thoracic surgeons predicted risk of mortality in contemporary
studies using valve academic research consortium definitions.
Source
International Journal of Cardiology. 168 (2) (pp 1598-1602), 2013. Date of
Publication: 30 Sep 2013.
Publisher
Elsevier Ireland Ltd (P.O. Box 85, Limerick, Ireland)

<27>
Accession Number
2013637692
Authors
Kabir S. Hjortshoj S. Schmidt E.B. Arya A. Christensen J.H.
Lundbye-Christensen S. Riahi S.
Institution
(Kabir, Hjortshoj, Schmidt, Lundbye-Christensen, Riahi) Department of
Cardiology, Center for Cardiovascular Research, Aarhus University
Hospital, Hobrovej 16-18, Postbox 365, DK-9100 Aalborg, Denmark
(Arya) Department of Electrophysiology, University of Leipzig, Heart
Center, Leipzig, Germany
(Christensen) Department of Nephrology, Center for Cardiovascular
Research, Aarhus University Hospital, Denmark
(Riahi) Department of Health Science and Technology, Faculty of Medicine,
Aalborg University, Denmark
Title
High dose atorvastatin therapy and QTc interval in patients treated with
coronary bypass surgery.
Source
International Journal of Cardiology. 168 (2) (pp 1526-1528), 2013. Date of
Publication: 30 Sep 2013.
Publisher
Elsevier Ireland Ltd (P.O. Box 85, Limerick, Ireland)