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<1>
Accession Number
2018735572
Title
Optimal cut-off value for endocardial bipolar voltage mapping using a
multipoint mapping catheter to characterize the scar regions described in
cardio-CT with myocardial thinning.
Source
Journal of Cardiovascular Electrophysiology. 33(10) (pp 2174-2180), 2022.
Date of Publication: October 2022.
Author
Ene E.; Halbfass P.; Nentwich K.; Sonne K.; Berkovitz A.; Cochet H.; Jais
P.; Lehmkuhl L.; Foldyna B.; Deneke T.
Institution
(Ene, Nentwich, Sonne, Berkovitz, Lehmkuhl, Foldyna, Deneke) Clinic for
Invasive Electrophysiology, Heart Center Bad Neustadt, Bad Neustadt an der
Saale, Germany
(Halbfas) Klinikum Oldenburg, Universitatsklinik fur Innere
Medizin-Kardiologie, Oldenburg, Germany
(Cochet, Jais) LIRYC, CHU Bordeaux, Bordeaux University, Talence, France
Publisher
John Wiley and Sons Inc
Abstract
Introduction: To investigate whether the current standard voltage cut-off
of <0.5 for dense scar definition on endocardial bipolar voltage mapping
(EBVM), using a high-resolution multipoint mapping catheter with
microelectrodes (HRMMC), correctly identifies the actual scar area
described on CT with myocardial thinning (CT MT). Method(s): Forty
patients (39 men; 67.0 +/- 9.0 y/o) with a history of transmural
myocardial infarction (mean time interval since MI 15.0 +/- 7.9 years) and
sustained ventricular tachycardia (VT) were consecutively enrolled. A CT
MT was performed in each patient before VT ablation. The CT MT 3D
anatomical model, including MT layers, was merged with the 3D
electroanatomical and EBVM. Different predefined cut-off settings for scar
definition on EBVM were used to identify the optimal ones, which showed
the best overlap in terms of scar area with the different MT layers.
 Result(s): A cut-off value of <0.2 mV demonstrated the best
correlation in terms of scar area with the 2 mm thinning on CT MT (p =.04)
and a cut-off of <1 mV best overlapped with the 5 mm thinning (p =.003).
The currently used <0.5 mV cut-off for scar definition on EBVM proved to
be the best area correlation with 3 mm thinning (p =.0002).
 Conclusion(s): In order to better identify the real extent of scar
areas after transmural MI as described on preprocedural CT MT, higher
cut-off values for scar definition should be applied if the EBVM is
performed using a HRMMC. Copyright © 2022 Wiley Periodicals LLC.

<2>
Accession Number
2018695669
Title
Evaluate Short-Term Outcomes of abciximab in ST-Segment Elevation
Myocardial Infarction Patients Undergoing Percutaneous Coronary
Intervention: A Meta-Analysis of Randomized Clinical Trials.
Source
Journal of Interventional Cardiology. 2022 (no pagination), 2022. Article
Number: 3911414. Date of Publication: 2022.
Author
Bai N.; Niu Y.; Ma Y.; Shang Y.-S.; Zhong P.-Y.; Wang Z.-L.
Institution
(Bai, Niu, Ma, Shang, Zhong) The First Clinical Medical College of Lanzhou
University, Lanzhou, China
(Wang) Department of Cardiology, The First Hospital of Lanzhou University,
Lanzhou, China
Publisher
Hindawi Limited
Abstract
Objectives. This meta-analysis was to verify the short-time efficacy and
safety of abciximab in patients with ST-segment elevation myocardial
infarction (STEMI) undergoing percutaneous coronary intervention (PCI).
Background. Abciximab has long-term efficacy in patients with STEMI
undergoing PCI, but the short-term efficacy is still controversial.
Methods. We conducted a systematic review and meta-analysis compared with
or without abciximab in patients with STEMI undergoing PCI. The relevant
randomized controlled trials were included by searching PubMed, EMBASE,
Cochrane Library, and Web of Science databases and other sources. The
relative risk (RR) and 95% confidence intervals (CI) of outcomes were
calculated by the fixed-effects model. Results. Ten randomized controlled
trials with 5008 patients met inclusion criteria. There were no
significant differences in risk of all-cause death at 30-day (RR 0.79, CI
0.55-1.12, P=0.18), major bleeding (1.37, 0.93-2.03, P=0.11), and
transfusion (1.23, 0.94-1.61, P=0.13) between the two groups. However,
there were significant differences in risk of all-cause death at 6 months
(0.57, 0.36-0.90, P=0.02), recurrent myocardial infarction (0.55,
0.33-0.92, P=0.02), repeat revascularization (0.58, 0.43-0.78, P=0.0004),
final TIMI flow <3 (0.77, 0.62-0.96, P=0.02), minor bleeding (1.29,
1.02-1.63, P=0.04), and thrombocytopenia (2.04, 1.40-2.97, P=0.0002).
Conclusions. The application of abciximab can lead to a lower risk of
reinfarction, revascularization, and all-cause death at 6 months, but a
higher risk of minor bleeding, and thrombocytopenia. Copyright ©
2022 Nan Bai et al.

<3>
Accession Number
2018458775
Title
Peer-mentor support for older vulnerable myocardial infarction patients
referred to cardiac rehabilitation: single-arm feasibility study.
Source
Pilot and Feasibility Studies. 8(1) (no pagination), 2022. Article Number:
172. Date of Publication: December 2022.
Author
Pedersen M.; Bennich B.; Boateng T.; Beck A.M.; Sibilitz K.; Andersen I.;
Overgaard D.
Institution
(Pedersen, Bennich, Overgaard) Department of Nursing and Nutrition,
University College Copenhagen, Tagensvej 86, Copenhagen N 2200, Denmark
(Boateng, Beck) Department of Nursing and Nutrition, University College
Copenhagen, Sigurdsgade 26, Copenhagen N 2200, Denmark
(Beck) The Dietetic and Nutritional Research Unit, EFFECT, Herlev and
Gentofte University Hospital, Borgmester Ib Juuls Vej 50, Herlev 2730,
Denmark
(Sibilitz) Department of Cardiology, Rigshospitalet, The Heart Centre,
Copenhagen University Hospital, Blegdamsvej 9, Copenhagen O 2100, Denmark
(Andersen) Section of Social Medicine, Department of Public Health,
Faculty of Health and Medical Sciences, University of Copenhagen, Oster
Farimagsgade 5, Copenhagen K 1353, Denmark
Publisher
BioMed Central Ltd
Abstract
Background: The positive effects of cardiac rehabilitation are well
established. However, it has an inherent challenge, namely the low
attendance rate among older vulnerable patients, which illustrates the
need for effective interventions. Peer mentoring is a low-cost
intervention that has the potential to improve cardiac rehabilitation
attendance and improve physical and psychological outcomes among older
patients. The aim of this study was to test the feasibility and
acceptability of a peer-mentor intervention among older vulnerable
myocardial infarction patients referred to cardiac rehabilitation.
 Method(s): The study was conducted as a single-arm feasibility study
and designed as a mixed methods intervention study. Patients admitted to a
university hospital in Denmark between September 2020 and December 2020
received a 24-week peer-mentor intervention. The feasibility of the
intervention was evaluated based on five criteria by Orsmond and Cohn: (a)
recruitment capability, (b) data-collection procedures, (c) intervention
acceptability, (d) available resources, and (e) participant responses to
the intervention. Data were collected through self-administrated
questionnaires, closed-ended telephone interviews, semi-structured
interviews, and document sheets. Result(s): Twenty patients were
offered the peer-mentor intervention. The intervention proved feasible,
with a low dropout rate and high acceptability. However, the original
inclusion criteria only involved vulnerable women, and this proved not to
be feasible, and were therefore revised to also include vulnerable male
patients. Peer mentors (n = 17) were monitored during the intervention
period, and the findings indicate that their mentoring role did not cause
any harm. The peer-mentor intervention showed signs of effectiveness, as a
high rate of cardiac rehabilitation attendance was achieved among
patients. Quality of life also increased among patients. This was the case
for emotional, physical, and global quality of life measures at 24-week
follow-up. Conclusion(s): The peer-mentor intervention is a feasible
and acceptable intervention that holds the potential to increase both
cardiac rehabilitation attendance and quality of life in older vulnerable
patients. This finding paves the way for peer-mentor interventions to be
tested in randomized controlled trials, with a view toward reducing
inequality in cardiac rehabilitation attendance. However, some of the
original study procedures were not feasible, and as such was revised.
Trial registration: The feasibility study was registered at
ClinicalTrials.gov (ClinicalTrials.gov identification number:
NCT04507529), August 11, 2020. Copyright © 2022, The Author(s).

<4>
Accession Number
2020513523
Title
A Comparative Study Between Ultrasound-Guided Erector Spinae Plane Block
and Paravertebral Block in Thoracic Surgeries For Postoperative Analgesia.
Source
Journal of Cellular and Molecular Anesthesia. 7(4) (pp 203-212), 2022.
Date of Publication: 01 Oct 2022.
Author
Jain A.; Singh P.; Tiwari T.; Digraskar V.
Institution
(Jain, Singh, Tiwari, Digraskar) Department of Anaesthesiology and
Critical Care, King George's Medical University, Uttar Pradesh, Lucknow,
India
Publisher
Shahid Beheshti University of Medical Sciences, Anesthesiology Research
Center
Abstract
Background: Regional analgesia has an important role in the multimodal
analgesia approach for postoperative pain management. Recently, the use of
PVB is increased for providing effective analgesia. ESP block is a
comparatively newer modality, established as a good analgesic technique.
This study aimed to compare the postoperative analgesic efficacy of
ultrasound-guided ESP block and PVB in thoracic surgeries.
 Material(s) and Method(s): This prospective randomized comparative
double-blinded study involved 60 patients who underwent different thoracic
surgeries and were randomized to receive ultrasound-guided ESP block
(group A) or PVB (group B) with 20 ml 0.25% bupivacaine before induction
of general anesthesia. Postoperatively, all patients received 1gm
intravenous paracetamol injection every 8 hours. The primary outcome was
to compare VAS scores at 0, 1, 3, 6, 12, and 24h, and secondary outcomes
were assessed in terms of analgesic consumption and hemodynamic stability
postoperatively Results: Group A had a significantly lower VAS score at
0h, 1h, 3h, and 6h postoperatively (p=0.026, 0.003, 0.003, and 0.002,
respectively) than group B. Thereafter, comparable VAS scores were found
at 12 and 24h. However, the mean VAS in either of the group was <4
postoperatively. Rescue analgesic consumption was found comparable
(p>0.05) in both groups. All patients exhibited stable hemodynamic
profiles postoperatively. Conclusion(s): Ultrasound-guided ESP block
along with round-the-clock NSAIDs can be a better and safe alternative to
PVB in thoracic surgeries with reduced analgesic consumption and
hemodynamic stability. Copyright © 2022 The authors.

<5>
[Use Link to view the full text]
Accession Number
2020420135
Title
Prognostic factors associated with left ventricular non-compaction: A
PRISMA-compliant meta-analysis.
Source
Medicine (United States). 101(37) (pp E30337), 2022. Date of Publication:
16 Sep 2022.
Author
Yang Z.-G.; Liu Z.-J.; Zhang X.-X.; Wang L.
Institution
(Yang, Wang) Department of Cardiology, The First Affiliated Hospital,
School of Medicine, Shihezi University, Xinjiang, Shihezi City, China
(Liu) Department of Dermatology, The First Affiliated Hospital School of
Medicine, Shihezi University, Xinjiang, Shihezi City, China
(Zhang) Department of Cardiothoracic Surgery, The First Affiliated
Hospital School of Medicine, Shihezi University, Xinjiang, Shihezi City,
China
Publisher
Lippincott Williams and Wilkins
Abstract
Background: Left ventricular non-compaction (LVNC) is a rare disease with
a poor prognosis. Efforts to improve prognosis are limited by the quality
and scope of the available evidence on prognostic factors. Method(s):
Pubmed, Embase, China National Knowledge Infrastructure, Cochrane Library,
Wanfang, and Baidu Scholar were searched and all relevant studies that
examined factors related to LVNC prognosis, published before January 2021,
were retrieved. Study quality evaluation and data extraction were
independently completed by two authors. Statistical analyses were
performed using STATA 15.0 software. Result(s): A total of 20 cohort
studies were included in this study, with a total of 1910 patients. The
results of the meta-analysis are as follows: New York Heart Function
Association (NYHA) class III/IV (hazard ratio [HR] = 3.93, 95% confidence
interval [CI]: 1.66-9.29), (NT-proBNP) increased (HR = 1.98, 95% CI:
1.10-3.58), left ventricular ejection fraction (LVEF) decreased (HR =
1.04, 95% CI: 1.03-1.06), left ventricular end-diastolic diameter (LVEDD)
increased (HR = 1.03, 95% CI: 1.01-1.06) was an independent poor
prognostic factor, and body mass index (HR = 0.80, 95% CI: 0.64-0.98) was
an independent protective factor. Creatinine (CR) level (HR = 1.09, 95%
CI: 0.95-1.25) and late gadolinium-enhanced (LGE) imaging (HR = 3.1, 95%
CI: 0.85-11.31) has no statistical significance in the prognosis of LVNC.
 Conclusion(s): In LVNC patients, NYHA class III/IV, elevated
N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, decreased
LVEF, and increased LVEDD may lead to poor prognosis, and increased body
mass index may improve the prognosis of LVNC. Further clinical research
with large sample sizes and long-term follow-ups should be conducted.
PROSPERO Registration Number: 42020152706. © Copyright 2022 the
Author(s).

<6>
Accession Number
2015266473
Title
Patient Adherence to Lung CT Screening Reporting & Data System-Recommended
Screening Intervals in the United States: A Systematic Review and
Meta-Analysis.
Source
Journal of Thoracic Oncology. 17(1) (pp 38-55), 2022. Date of Publication:
January 2022.
Author
Lin Y.; Fu M.; Ding R.; Inoue K.; Jeon C.Y.; Hsu W.; Aberle D.R.; Prosper
A.E.
Institution
(Lin, Ding, Hsu, Aberle) Department of Bioengineering, University of
California Los Angeles, Los Angeles, CA, United States
(Lin, Ding, Hsu, Aberle, Prosper) Medical & Imaging Informatics Group,
Department of Radiological Sciences, University of California Los Angeles,
Los Angeles, CA, United States
(Fu) Medical Informatics Home Area, Department of Bioinformatics,
University of California Los Angeles, Los Angeles, CA, United States
(Inoue) Department of Social Epidemiology, Graduate School of Medicine,
Kyoto University, Kyoto, Japan
(Inoue, Jeon) Department of Epidemiology, UCLA Fielding School of Public
Health, University of California Los Angeles, Los Angeles, CA, United
States
(Jeon) Department of Medicine, Samuel Oschin Cancer Institute,
Cedars-Sinai Medical Center, Los Angeles, CA, United States
(Aberle, Prosper) Department of Radiological Sciences, David Geffen School
of Medicine at UCLA, Los Angeles, CA, United States
Publisher
Elsevier Inc.
Abstract
Lung cancer screening (LCS) is effective in reducing mortality,
particularly when patients adhere to follow-up recommendations
standardized by the Lung CT Screening Reporting & Data System (Lung-RADS).
Nevertheless, patient adherence to recommended intervals varies,
potentially diminishing benefit from screening. We conducted a systematic
review and meta-analysis of patient adherence to Lung-RADS-recommended
screening intervals. We systematically searched MEDLINE, EMBASE, Web of
Science, the Cochrane Central Register of Controlled Trials, and major
radiology and oncology conference archives between April 28, 2014, and
December 17, 2020. Eligible studies mentioned patient adherence to the
recommendations of Lung-RADS. The review protocol was registered with
PROSPERO (CRD42020189326). We identified 24 eligible studies for
qualitative summary, of which 21 were suitable for meta-analysis. The
pooled adherence rate was 57% (95% confidence interval: 46%-69%) for
defined adherence (e.g., an annual incidence screen was performed within
15 mo) among 6689 patients and 65% (95% confidence interval: 55%-75%) for
anytime adherence among 5085 patients. Large heterogeneity in adherence
rates between studies was observed (I2 = 99% for defined
adherence, I2 = 98% for anytime adherence). Heterogeneous
adherence rates were associated with Lung-RADS scores, with significantly
higher adherence rates among Lung-RADS 3 to 4 than Lung-RADS 1 to 2 (p <
0.05). Patient adherence to Lung-RADS-recommended screening intervals is
suboptimal across clinical LCS programs in the United States, especially
among patients with results of Lung-RADS categories 1 to 2. To improve
adherence rates, future research may focus on implementing tailored
interventions after identifying barriers to LCS. We also propose a minimum
standardized set of data elements for future pooled analyses of LCS
adherence on the basis of our findings. Copyright © 2021
International Association for the Study of Lung Cancer

<7>
Accession Number
2004251979
Title
Prenatal risk factors for urgent atrial septostomy at birth in fetuses
with transposition of the great arteries: a systematic review and
meta-analysis.
Source
Journal of Maternal-Fetal and Neonatal Medicine. 35(3) (pp 598-606), 2022.
Date of Publication: 2022.
Author
Buca D.; Winberg P.; Rizzo G.; Khalil A.; Liberati M.; Makatsariya A.;
Greco F.; Nappi L.; Acharya G.; D'Antonio F.
Institution
(Buca, Liberati) Department of Obstetrics and Gynaecology, University of
Chieti, Chieti, Italy
(Winberg) Department of Paediatric Cardiology, Astrid Lindgrens Children's
Hospital/Karolinska University Hospital, Stockholm, Sweden
(Rizzo) Department of Maternal Fetal Medicine, Ospedale Cristo Re Roma,
University of Rome "Tor Vergata", Rome, Italy
(Rizzo, Makatsariya) Department of Obstetrics and Gynaecology, The First
I.M. Sechenov Moscow State Medical University, Moscow, Russian Federation
(Khalil) Fetal Medicine Unit, St. George's Hospital, London, United
Kingdom
(Greco, Nappi, D'Antonio) Department of Obstetrics and Gynaecology,
Ospedali Riuniti, University of Foggia, Foggia, Italy
(Acharya) Department of Clinical Sciences, Intervention and Technology,
Karolinska Institute, Stockholm, Sweden
(Acharya) Center for Fetal Medicine, Karolinska University Hospital,
Stockholm, Sweden
(Acharya) Department of Clinical Medicine, Faculty of Health Sciences,
UiT-The Arctic University of Norway, Tromso, Norway
Publisher
Taylor and Francis Ltd.
Abstract
Purpose of the article. To explore the role of fetal echocardiography in
predicting the risk of urgent balloon atrial septostomy (BAS) at birth in
fetuses diagnosed with transposition of the great arteries (TGA).
 Material(s) and Method(s): Medline, Embase, and Cochrane databases
were searched. The primary aim was to explore the differences in prenatal
echocardiographic parameters among fetuses diagnosed with TGA that
required urgent BAS within 24 h of birth due to life-threatening cyanosis
compared to those who did not require such procedure. Random-effect
meta-analyses were used to compute the data. Result(s): Six studies
(292 fetuses) were included. Restrictive appearance of the FO was present
in 64.5% (95% CI = 39.8-85.7) of fetuses with TGA requiring BAS at birth
compared to 7.9% (95% CI = 2.1-16.8) not requiring such procedure (OR =
71.1; 95% CI = 8.3-608.5, p <.0001). Hypermobile appearance of the atrial
septum was present in 39.1% (95% CI = 26.4-56.5) of fetuses requiring BAS
at birth compared to 9.8% (95% CI = 1.4-24.3) of those which did (OR 3.6;
95% CI = 1.4-9.0, p =.05). There was no difference in the prevalence of
redundant (p =.374) or fixed (p =.051) atrial septum, bidirectional flow
in the DA (p =.26) or an abnormal size of the DA (p =.06) in fetuses
requiring urgent BAS at birth compared to those which did not. Mean
(+/-SD) size of the right atrium was smaller in the fetuses with TGA
undergoing urgent BAS at birth (23.4 +/- 6.7) compared to those which did
not (29.2 +/- 6.2, p =.01). The mean (+/-SD) ratio between the FO and the
aortic valve diameters (1.01 +/- 0.41 versus 1.41 +/- 0.43, p =.009) and
the mean (+/-SD) ratio between the FO diameter and the septal length (0.36
+/- 0.13 versus 0.51 +/- 0.14, p =.001) were significantly smaller in
fetuses requiring compared to those not undergoing urgent BAS at birth.
The diagnostic accuracy of each independent ultrasound marker of the need
for urgent BAS showed an overall good specificity but a low sensitivity.
 Conclusion(s): Fetal echocardiography prior to birth can stratify the
risk of BAS in fetuses with TGA. Further studies are needed to validate
these findings and build individualized multiparametric predictive models
in order to more accurately identify those fetuses with TGA at a higher
risk of urgent BAS after birth. Copyright © 2020 Informa UK
Limited, trading as Taylor & Francis Group.

<8>
Accession Number
2017746468
Title
Immune Response to SARS-CoV-2 Vaccine among Heart Transplant Recipients: A
Systematic Review.
Source
Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary
Medicine. 16 (no pagination), 2022. Date of Publication: 2022.
Author
Shoar S.; Prada-Ruiz A.C.C.; Patarroyo-Aponte G.; Chaudhary A.; Sadegh
Asadi M.
Institution
(Shoar) Department of Clinical Research, Scientific Collaborative
Initiative, Houston, TX, United States
(Prada-Ruiz) Division of Pediatric Cardiology, Department of Pediatrics,
University of Texas Health Science Center at Houston, Houston, TX, United
States
(Patarroyo-Aponte) Division of Pulmonary and Critical Care Medicine,
Department of Internal Medicine, McGovern Medical School, University of
Texas Health Science Center at Houston, Houston, TX, United States
(Chaudhary) Department of Internal Medicine, Griffin Hospital, Derby, CT,
United States
(Sadegh Asadi) Division of Cardiology, Department of Medicine, University
of Maryland School of Medicine, Baltimore, MD, United States
Publisher
SAGE Publications Ltd
Abstract
Background: Heart transplant (HTX) recipients are at a significantly
higher risk of adverse clinical outcomes, due to chronic immunosuppression
and co-existence of other chronic conditions, when contracting the
SARS-CoV-2 infection. Although vaccination against SARS-CoV-2 is currently
the most promising measure for the prevention of severe Coronavirus
Disease 2019 (COVID-19) among solid organ transplant recipients, the
extent of immune response and its protective efficacy among patients
receiving HTX has not been sufficiently studied. Method(s): We
performed a systematic review of the literature by inquiring
PubMed/Medline to identify original studies among HTX recipients, who had
received at least one dose of the SARS-CoV-2 vaccine. Data on the measured
humoral or cellular immune response was collected from all the eligible
studies. Factors associated with a poor immune response were further
investigated within these studies. Result(s): A total of 12 studies
comprising 563 HTX recipients were included. The average age of the study
participants was 60.8 years. Sixty four percent of the study population
were male. Ninety percent of the patients had received an mRNA vaccine
(Pfizer/ BNT162b2 or Moderna/mRNA-1273). A positive immune response to
SARS-CoV-2 vaccine was variably reported in 0% to 100% of the patients.
Older age (> 65 years), vaccine dose (first, second, or third), time since
HTX to the first dose of the vaccine, the time interval between the latest
dose of the vaccine and measurement of the immune response, and the type
of immunosuppressive regimen were all indicated as potential determinants
of a robust immune response to the SARS-CoV-2 vaccination.
 Conclusion(s): HTX recipients demonstrate a weaker immune response to
the vaccination against SARS-CoV-2 compared to the general population.
Older age, anti-metabolite agents such as mycophenolate mofetil, and
vaccination during the first year following the HTX have been indicated as
potential determinants of a poor immune response. Copyright © The
Author(s) 2022.

<9>
Accession Number
2018878356
Title
Influence of intensive lipid-lowering on CT derived fractional flow
reserve in patients with stable chest pain: Rationale and design of the
FLOWPROMOTE study.
Source
Clinical Cardiology. 45(10) (pp 986-994), 2022. Date of Publication:
October 2022.
Author
Mortensen M.B.; Sand N.-P.; Busk M.; Jensen J.M.; Grove E.L.; Dey D.;
Iraqi N.; Updegrove A.; Fonte T.; Mathiassen O.N.; Hosbond S.; Botker
H.E.; Leipsic J.; Narula J.; Norgaard B.L.
Institution
(Mortensen, Jensen, Grove, Iraqi, Mathiassen, Botker, Norgaard) Department
of Cardiology, Aarhus University Hospital, Aarhus, Denmark
(Sand) Department of Cardiology, Southwestern Hospital, Esbjerg, Denmark
(Busk, Hosbond) Department of Cardiology, Lillebaelt Hospital,
Vejle-Kolding, Denmark
(Grove, Botker, Norgaard) Department Clinical Medicine, Faculty of Health,
Aarhus University, Aarhus, Denmark
(Dey) Biomedical Imaging Research Institute, Cedars-Sinai Medical Center,
Los Angeles, CA, United States
(Updegrove, Fonte) HeartFlow, Redwood City, CA, United States
(Leipsic) Division of Cardiology and Radiology, St Paul's Hospital,
Vancouver, BC, Canada
(Narula) Icahn School of Medicine, Mount Sinai, NY, United States
Publisher
John Wiley and Sons Inc
Abstract
Introduction: Coronary CT angiography (CTA) derived fractional flow
reserve (FFR<inf>CT</inf>) shows high diagnostic performance when compared
to invasively measured FFR. Presence and extent of low attenuation plaque
density have been shown to be associated with abnormal physiology by
measured FFR. Moreover, it is well established that statin therapy reduces
the rate of plaque progression and results in morphology alterations
underlying atherosclerosis. However, the interplay between lipid lowering
treatment, plaque regression, and the coronary physiology has not
previously been investigated. Aim(s): To test whether lipid lowering
therapy is associated with significant improvement in FFR<inf>CT</inf>,
and whether there is a dose-response relationship between lipid lowering
intensity, plaque regression, and coronary flow recovery. Method(s):
Investigator driven, prospective, multicenter, randomized study of
patients with stable angina, coronary stenosis >=50% determined by
clinically indicated first-line CTA, and FFR<inf>CT</inf> <= 0.80 in whom
coronary revascularization was deferred. Patients are randomized to
standard (atorvastatin 40 mg daily) or intensive (rosuvastatin 40 mg +
ezetimibe 10 mg daily) lipid lowering therapy for 18 months. Coronary CTA
scans with blinded coronary plaque and FFR<inf>CT</inf> analyses will be
repeated after 9 and 18 months. The primary endpoint is the 18-month
difference in FFR<inf>CT</inf> using (1) the FFR<inf>CT</inf> value 2 cm
distal to stenosis and (2) the lowest distal value in the vessel of
interest. A total of 104 patients will be included in the study.
 Conclusion(s): The results of this study will provide novel insights
into the interplay between lipid lowering, and the pathophysiology in
coronary artery disease. Copyright © 2022 The Authors. Clinical
Cardiology published by Wiley Periodicals, LLC.

<10>
Accession Number
2020668456
Title
Using Music for the Prevention of Delirium in Patients After Coronary
Artery Bypass Graft Surgery: A Randomized Clinical Trial.
Source
Journal of Cardiothoracic and Vascular Anesthesia. (no pagination), 2022.
Date of Publication: 2022.
Author
Esfahanian F.; Mirmohammadsadeghi A.; Gholami H.; Neshat S.; Mansouri M.;
Sadeghi M.; Bathaie S.R.; Heidari Z.; Mirmohammadsadeghi M.
Institution
(Esfahanian, Gholami, Neshat, Bathaie) School of Medicine, Isfahan
University of Medical Sciences, Isfahan, Iran, Islamic Republic of
(Mansouri) Cardiac Anesthesia Research Center, Department of
Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Iran,
Islamic Republic of
(Sadeghi) Cardiac Rehabilitation Research Center, Isfahan Cardiovascular
Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran,
Islamic Republic of
(Heidari) School of Health, Isfahan University of Medical Sciences,
Isfahan, Iran, Islamic Republic of
(Mirmohammadsadeghi, Mirmohammadsadeghi) Chamran Cardiovascular Medical
and Research Hospital, Isfahan University of Medical Sciences, Isfahan,
Iran, Islamic Republic of
Publisher
W.B. Saunders
Abstract
Objective: The aim was to evaluate the effect of music on preventing
delirium after coronary artery bypass grafting, to analyze vital signs and
blood gas parameters, and to determine risk factors affecting delirium.
 Design(s): A randomized clinical trial. Setting(s): A
single-center, tertiary hospital. Participant(s): In total, 200
patients who underwent coronary artery bypass grafting surgery from April
2020 to April 2021. Intervention(s): A one-hour session of new-age
music was administered twice a day postoperatively for 7 days using a
headphone. Delirium was assessed using the Confusion Assessment Method for
the Intensive Care Unit before and after each session. Vital signs and
blood gas parameters were compared to evaluate the effect of music. All
assessments were conducted blindly by a different researcher.
 Measurements and Main Results: Twelve participants who were
delirium-positive were in the control group, and there were 3 in the case
group, which suggested a statistically significant effect of music in
preventing delirium (p = 0.016). The mean age of patients was 64.7 +/- 7.9
years old in the control group and 62.2 +/- 7.5 years old in the case
group. There was a significant difference among the control and case
groups in terms of the surgery time; surgery time in the control group was
significantly lower than in the case group (242.4 +/- 42.3 v 261.6 +/-
48.9, respectively; p = 0.03 < 0.05). Blood pressure and heart rate in the
case group were lower, similar to the respiratory rate and venous blood
gas parameters; Blood pressure differences were not statistically
significant (p > 0.05); Conclusion(s): Relaxation music, including
bird, water, and wind, significantly prevents delirium after coronary
artery bypass grafting. Copyright © 2022 Elsevier Inc.

<11>
Accession Number
2020740832
Title
Sonographic Measurement of the Optic Nerve Sheath Diameter to Improve
Detection of Elevated Intracranial Pressure.
Source
Biomedical and Pharmacology Journal. 15(3) (pp 1677-1685), 2022. Date of
Publication: September 2022.
Author
Awdallah F.F.; Abulnaga I.H.; Michael S.F.; Nagi H.K.; Abdallah M.H.
Institution
(Awdallah, Michael, Nagi, Abdallah) Department of Critical care, Cairo
University, Cairo, Egypt
(Abulnaga) Department of Critical care, National heart institute, Cairo,
Egypt
Publisher
Oriental Scientific Publishing Company
Abstract
Rapid recognition of elevated intracranial pressure (ICP) is essential to
avoid brain stem herniation and death. Brain stem herniation is a very
serious disorder in which an excess of intracranial pressure causes part
of the brain to be squeezed through the foramen magnum at the base of the
skull. Increased pressure on the brain stem can lead to blood pressure and
breathing problems and brain death, respiratory or cardiac arrest,
permanent brain damage, coma and death. The aim of this work was to
evaluate the diagnostic accuracy of using Optic Nerve Sheath Diameter
(ONSD) measurements to detect elevated ICP compared to computed tomography
(CT) brain scanning. A prospective, observational cross-sectional study of
100 randomly selected ICU patients with suspected elevated ICP at Cairo
university hospitals and cardiothoracic surgical ICU of the National Heart
Institute (NHI), Cairo, Egypt. Optic nerve ultrasonography (US) was
performed on all patients; CT brain scanning was chosen as the gold
standard for detecting elevated ICP. Result(s): the cause of elevated
ICP, 51.3% of patients were admitted with head trauma P-value = 0.000,
clinical signs of elevated ICP, 31.3% of patients developed convulsions
and 26.3% showed Cushing reflex (P=0.004 and 0.010 respectively). Besides
the Glasgow Coma Scale (GCS), patients with elevated ICP had a mean GCS
score of 7 and patients without elevated ICP had mean GCS of 13 (P?0.001).
Regarding ONSD, mean average ONSD was 6 in patients with elevated ICP and
3.1 in patients without elevated ICP (P?0.01), receiver operating
characteristic (ROC) curve analysis revealed that ONSD greater than 4.31
mm was significant in prediction of elevated ICP compared to CT brain
scanning with 94.8% sensitivity and 90.11% specificity.
 Conclusion(s): patients' ONSD is a simple bedside technique that can
accurately diagnose of elevated ICP compared to CT brain scanning. The
diagnostic accuracy of ONSD using a 4.31 mm cut-off value can diagnose of
elevated ICP with 94.8% sensitivity and 90.11% specificity. Copyright
© 2022 Oriental Scientific Publishing Company. All rights reserved.

<12>
Accession Number
2019627586
Title
Should nasogastric tube be used routinely in patients undergoing cardiac
surgery? A narrative review.
Source
Journal of Cardiac Surgery. (no pagination), 2022. Date of Publication:
2022.
Author
Paleczny S.; Fatima R.; Amador Y.; El Diasty M.
Institution
(Paleczny, Fatima, El Diasty) Department of Surgery, Division of Cardiac
Surgery, Kingston General Hospital, Queen's University, Kingston, ON,
Canada
(Amador) Department of Anesthesiology and Perioperative Medicine, Kingston
General Hospital, Queen's University, Kingston, ON, Canada
Publisher
John Wiley and Sons Inc
Abstract
Background and Aim: Nasogastric tube (NGT) use has been common in the
immediate postoperative period in surgical patients for decades. Potential
advantages include the decompression of gastric contents and the early
administration of time-sensitive medications. However, its routine use
after cardiac surgery has not been established as a gold standard yet. The
NGT use for prevention of postoperative nausea and vomiting has been a
matter of debate in literature. Also, NGT use has also been associated
with the incidence of some respiratory and gastrointestinal complications
and it may be a source of significant pain and discomfort to patients. In
this article, we review the current available literature regarding the use
of NGT during and immediately after cardiac surgery, with particular
emphasis on its potential role in enhanced postoperative recovery.
 Method(s): We performed a database search in October 2021 using
Embase, Cochrane Library, and Medline to identify studies that examined
the use of NGT in patients that underwent cardiac surgery. Data and
literature about NGT's impact on post-operative nausea and vomiting, early
administration of medications, interference with imaging, post-operative
complications, respiratory complications, gastrointestinal complications,
pain and discomfort, and enhanced recovery after surgery were examined.
 Result(s): Three reports investigating the use of NGT to reduce
post-operative nausea and vomiting were examined with sample sizes of 114,
104, and 202. The use of NGT did not significantly reduce the incidence of
post-operative nausea and vomiting in 2/3 of the studies: a 2% nausea
reduction with NGT (p < 0.05), a 7.7% nausea reduction with NGT (p = 0.6),
and a 14% vomiting reduction with NGT (p = 0.007). The prevalence of
pneumonia following NGT use has been shown to vary ranging from 4 to 95%
with associated mortality rates of 17 to 62%. Conclusion(s): Based on
our findings, there is currently not sufficient evidence to support the
routine use of NGT during cardiac surgery. Further research is needed to
establish the role of NGT in this patient population. Copyright ©
2022 Wiley Periodicals LLC.

<13>
Accession Number
2015309263
Title
ST-Segment Elevation Myocardial Infarction: Sex Differences in Incidence,
Etiology, Treatment, and Outcomes.
Source
Current Cardiology Reports. 24(5) (pp 529-540), 2022. Date of Publication:
May 2022.
Author
Shah T.; Kapadia S.; Lansky A.J.; Grines C.L.
Institution
(Shah, Lansky) Yale University School of Medicine, New Haven, CT, United
States
(Kapadia) Yale University, New Haven, CT, United States
(Grines) Northside Hospital Cardiovascular Institute, Atlanta, GA, United
States
Publisher
Springer
Abstract
Purpose: Although there have been marked improvements in the standard of
care for treatment of ST-elevation myocardial infarction, women,
especially younger women, continue to have significantly worse outcomes
than men. Recent Findings: This review highlights the current sex
differences in presentation, etiology, treatment, and outcomes among these
patients in order to make providers aware of the heterogeneous entities
that cause ST-elevation myocardial infarction particularly in women and of
disparities in treatment that lead to poorer outcomes in women.
 Summary: Furthermore, it emphasizes evidence-based strategies
including standardized protocols for early revascularization, mechanical
circulatory support, and access methodology that can reduce sex-based
disparities in treatments and outcomes. Copyright © 2022, The
Author(s), under exclusive licence to Springer Science+Business Media,
LLC, part of Springer Nature.

<14>
Accession Number
2015104620
Title
Cardiovascular disease in hereditary haemophilia: The challenges of
longevity.
Source
British Journal of Haematology. 197(4) (pp 397-406), 2022. Date of
Publication: May 2022.
Author
Shapiro S.; Benson G.; Evans G.; Harrison C.; Mangles S.; Makris M.
Institution
(Shapiro) Oxford University Hospitals NHS Foundation Trust, Oxford NIHR
Biomedical Research Centre, Oxford, United Kingdom
(Shapiro) Radcliffe Department of Medicine, Oxford University, Oxford,
United Kingdom
(Benson) Belfast City Hospital, Belfast, United Kingdom
(Evans) Kent Haemophilia and Thrombosis Centre, East Kent Hospitals
University Foundation NHS Trust, Canterbury, United Kingdom
(Harrison, Makris) Sheffield Haemophilia and Thrombosis Centre, Royal
Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust,
Sheffield, United Kingdom
(Mangles) Haemophilia, Haemostasis and Thrombosis Centre, Hampshire
Hospitals NHS Foundation Trust, Basingstoke, United Kingdom
(Makris) Department of Infection, Immunity and Cardiovascular Disease,
University of Sheffield, Sheffield, United Kingdom
Publisher
John Wiley and Sons Inc
Abstract
The development of effective and safe treatments has significantly
increased the life expectancy of persons with haemophilia (PWH). This has
been accompanied by an increase in the comorbidities of ageing including
cardiovascular disease, which poses particular challenges due to the
opposing risks of bleeding from haemophilia and antithrombotic treatments
versus thrombosis. Although mortality secondary to coronary artery disease
in PWH is less than in the general population, the rate of atherosclerosis
appears similar. The prevalence of atrial fibrillation in PWH and risk of
secondary thromboembolic stroke are not well established. PWH can be
safely supported through acute coronary interventions but data on the
safety and efficacy of long-term antithrombotics are scarce. Increased
awareness and research on cardiovascular disease in PWH will be crucial to
improve primary prevention, acute management, secondary prevention and to
best support ageing PWH. Copyright © 2022 The Authors. British
Journal of Haematology published by British Society for Haematology and
John Wiley & Sons Ltd.

<15>
[Use Link to view the full text]
Accession Number
2020554670
Title
Sugammadex for reversing neuromuscular blockages after lung surgery: A
systematic review and meta-analysis.
Source
Medicine (United States). 101(39) (pp E30876), 2022. Date of Publication:
30 Sep 2022.
Author
Yang J.-L.; Chen K.-B.; Shen M.-L.; Hsu W.-T.; Lai Y.-W.; Hsu C.-M.
Institution
(Yang, Chen, Hsu, Hsu) Department of Anesthesiology, China Medical
University Hospital, 40447 No.2, Yude Rd., North Dist., Taichung City
40447, Taiwan (Republic of China)
(Yang, Chen, Shen, Hsu, Lai, Hsu) Department of Anesthesiology, College of
Medicine, China Medical University, Taichung, Taiwan (Republic of China)
(Shen) Department of Anesthesiology, Taichung Tzu-Chi Hospital, Taichung,
Taiwan (Republic of China)
(Lai) Department of Nursing, China Medical University Hospital, Taichung,
Taiwan (Republic of China)
Publisher
Lippincott Williams and Wilkins
Abstract
Background: This study determined whether sugammadex was associated with a
lower risk of postoperative pulmonary complications and improved outcomes
in lung surgeries. Method(s): A systematic literature search was
conducted using PubMed, Embase, Web of Science, and the Cochrane Library
from January 2000 to March 2022. The characteristics of lung surgeries
using sugammadex treatment compared with control drugs and postoperative
outcomes were retrieved. The primary outcome was estimated through a
pooled odds ratio (OR) and its 95% confidence interval (CI) was identified
using a random-effects model. Result(s): From 465 citations, 7
studies with 453 patients receiving sugammadex and 452 patients receiving
a control were included. The risk of postoperative pulmonary complication
(PPCs) was lower in the sugammadex group than in the control group. Also,
it showed that the effect of sugammadex on PPCs in the subgroup analysis
was significantly assessed on the basis of atelectasis or non-atelectasis.
Furthermore, subgroup analysis based on the relationship between high body
mass index (BMI) and PPCs also showed that sugammadex had less occurrence
in both the high BMI (defined as BMI>=25) and low BMI groups. No
difference in length of hospital stay (LOS) between the two groups was
observed. Conclusion(s): This study observed that although reversing
neuromuscular blockages with sugammadex in patients undergoing thoracic
surgery recorded fewer PPCs and shorter extubation periods than
conventional reversal agents, no difference in LOS, postanaesthesia care
unit (PACU) stay length and chest tube insertion duration in both groups
was observed. Copyright © 2022 the Author(s).

<16>
Accession Number
2020527440
Title
Advanced Cardiovascular Imaging for the Diagnosis of Mycobacterium
chimaera Prosthetic Valve Infective Endocarditis After Open-heart Surgery:
A Contemporary Systematic Review.
Source
Current Problems in Cardiology. 47(12) (no pagination), 2022. Article
Number: 101392. Date of Publication: December 2022.
Author
Sanchez-Nadales A.; Diaz-Sierra A.; Mocadie M.; Asher C.; Gordon S.; Xu B.
Institution
(Sanchez-Nadales, Asher) Department of Cardiovascular Disease, Cleveland
Clinic Florida, Weston, FL
(Diaz-Sierra) Department of Medicine, Advocate Illinois Masonic Medical
Center, Chicago, IL
(Mocadie) Department of Infectious Diseases, University Hospitals,
Cleveland, OH
(Gordon) Department of Infectious Diseases, Cleveland Clinic, Cleveland,
OH
(Xu) Section of Cardiovascular Imaging, Robert and Suzanne Tomsich
Department of Cardiovascular Medicine, Sydell and Arnold Miller Family
Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH
Publisher
Elsevier Inc.
Abstract
Mycobacterium chimaera is an opportunistic and emerging pathogen, which
has been recognized to cause prosthetic valve infective endocarditis and
disseminated infection following open-chest cardiac surgery with certain
contaminated heater-cooler systems. Diagnostic evaluation of suspected
prosthetic valve infective endocarditis due to M chimaera is challenging
and requires a very high index of suspicion. This systematic review aims
to evaluate prosthetic valve infective endocarditis due to M chimaera.
Based on the current literature review, transesophageal echocardiography
and 18F-fluorodeoxyglucose positron emission tomography/computed
tomography are the most common imaging modalities used to establish the
diagnosis. Based on 22 published cases, the reported cases of M chimaera
endocarditis have occurred almost entirely in males. Within this cohort,
the patients developed endocarditis on average 2.7 years after exposure to
contaminated heater-cooler systems during cardiac surgery. M chimaera
infection is associated with significant morbidity and
mortality. Copyright © 2022 Elsevier Inc.

<17>
Accession Number
2020520250
Title
Research Progress on Coping Strategies of Cognitive Impairment after
Cardiac Surgery: A Systematic Review of Literature.
Source
Heart Surgery Forum. 25(1) (pp E118-E123), 2022. Date of Publication: 12
Jan 2022.
Author
Yan Y.; Sandeep B.; Ding W.; Ma C.; Peng S.; Xiao Z.
Institution
(Yan, Ding, Peng) Zunyi Medical University, Guizhou, Zunyi, China
(Sandeep, Ma) Department of Cardio-Thoracic Surgery, Chengdu Second
People's Hospital, Sichuan, Chengdu, China
(Xiao) Department of Cardio-Thoracic Surgery, Zunyi Medical University,
Chengdu Second People's Hospital, Sichuan, Chengdu, China
Publisher
Forum Multimedia Publishing LLC
Abstract
Postoperative cognitive dysfunction (POCD) refers to a complication of
neurological dysfunction after surgery, including one or more changes that
are significantly lower than those before surgery. The purpose of this
study was to review the coping strategies and risk factors of POCD.
Systemic research was conducted searching Pubmed, Web of Science, MEDLINE,
and other websites with the keywords of cardiac surgery, cognitive
impairment, and POCD. Multiple factors have been associated with the
treatment of POCD, including anesthetic, choice of analgesic drugs,
anti-inflammatory drugs, erythropoietin, atherosclerosis, emotional
factors, surgical, and other factors. Targeted treatments are carried out
for risk factors that may affect POCD prevention, such as anesthetic drug
prevention, anti-inflammatory drug prevention, and intraoperative
prevention and other preventive measures are aimed at reducing the
incidence of POCD after cardiac surgery. Copyright © 2022 Forum
Multimedia Publishing, LLC.

<18>
Accession Number
2017048257
Title
Transfemoral Tricuspid Valve Replacement in Patients With Tricuspid
Regurgitation: TRISCEND Study 30-Day Results.
Source
JACC: Cardiovascular Interventions. 15(5) (pp 471-480), 2022. Date of
Publication: 14 Mar 2022.
Author
Kodali S.; Hahn R.T.; George I.; Davidson C.J.; Narang A.; Zahr F.;
Chadderdon S.; Smith R.; Grayburn P.A.; O'Neill W.W.; Wang D.D.; Herrmann
H.; Silvestry F.; Elmariah S.; Inglessis I.; Passeri J.; Lim D.S.; Salerno
M.; Makar M.; Mack M.J.; Leon M.B.; Makkar R.
Institution
(Kodali, Hahn, George, Leon) Columbia University Irving Medical Center,
New York, NY, United States
(Hahn) Cardiovascular Research Foundation, New York, NY, United States
(Davidson, Narang) Northwestern University, Chicago, IL, United States
(Zahr, Chadderdon) Oregon Health and Science University, Portland, OR,
United States
(Smith, Grayburn, Mack) Baylor Scott and White The Heart Hospital Plano,
Plano, TX, United States
(O'Neill, Wang) Henry Ford Hospital, Detroit, MI, United States
(Herrmann, Silvestry) Hospital of the University of Pennsylvania,
Philadelphia, PA, United States
(Elmariah, Inglessis, Passeri) Massachusetts General Hospital, Boston, MA,
United States
(Lim, Salerno) University of Virginia, Charlottesville, VA, United States
(Makar, Makkar) Cedars-Sinai Medical Center, Los Angeles, CA, United
States
Publisher
Elsevier Inc.
Abstract
Objectives: The TRISCEND study (Edwards EVOQUE Tricuspid Valve
Replacement: Investigation of Safety and Clinical Efficacy after
Replacement of Tricuspid Valve with Transcatheter Device) is evaluating
the safety and performance of transfemoral transcatheter tricuspid valve
replacement in patients with clinically significant tricuspid
regurgitation (TR) and elevated surgical risk. Background(s):
Transcatheter valve replacement could lead to a paradigm shift in treating
TR and improving patient quality of life. Method(s): In the
prospective, single-arm, multicenter TRISCEND study, patients with
symptomatic moderate or greater TR, despite medical therapy, underwent
percutaneous transcatheter tricuspid valve replacement with the EVOQUE
system. A composite rate of major adverse events, echocardiographic
parameters, and clinical, functional, and quality-of-life measures were
assessed at 30 days. Result(s): Fifty-six patients (mean age of 79.3
years, 76.8% female, 91.1% TR severe or greater, 91.1% atrial
fibrillation, and 87.5% New York Heart Association functional class III or
IV) were treated. At 30 days, TR was reduced to mild or less in 98%. The
composite major adverse events rate was 26.8% at 30 days caused by 1
cardiovascular death in a patient with a failed procedure, 2
reinterventions after device embolization, 1 major access site or vascular
complication, and 15 severe bleeds, of which none were life-threatening or
fatal. No myocardial infarction, stroke, renal failure, major cardiac
structural complications, or device-related pulmonary embolism were
observed. New York Heart Association significantly improved to functional
class I or II (78.8%; P < 0.001), 6-minute walk distance improved 49.8 m
(P < 0.001), and Kansas City Cardiomyopathy Questionnaire score improved
19 points (P < 0.001). Conclusion(s): Early experience with the
transfemoral EVOQUE system in patients with clinically significant TR
demonstrated technical feasibility, acceptable safety, TR reduction, and
symptomatic improvement at 30 days. The TRISCEND II randomized trial
(NCT04482062) is underway. Copyright © 2022

<19>
Accession Number
2017039819
Title
Outcomes of heart transplantation in cardiac amyloidosis: an updated
systematic review.
Source
Heart Failure Reviews. 27(6) (pp 2201-2209), 2022. Date of Publication:
November 2022.
Author
Lakhdar S.; Buttar C.; Nassar M.; Ciobanu C.; Patel R.; Munira M.S.
Institution
(Lakhdar, Nassar) Department of Medicine, Icahn School of Medicine at
Mount Sinai/NYC H+H/Queens, 82-68 164th St. Queens, New York, NY 11432,
United States
(Buttar) Department of Cardiology, Ochsner Medical Center, New Orleans,
LA, United States
(Ciobanu) St. Barnabas Hospital/Albert Einstein College of Medicine, New
York, NY, United States
(Patel, Munira) Division of Cardiology, Icahn School of Medicine at Mount
Sinai/NYC H+H/Queens, New York, NY, United States
(Munira) Division of Cardiology, Icahn School of Medicine at Mount Sinai,
New York, NY, United States
Publisher
Springer
Abstract
Cardiac amyloidosis is one of the most common infiltrative
cardiomyopathies that is characterized by the extracellular deposition of
misfolded fibrillar protein. Several studies have previously found that
patients with amyloid in the past have performed poorly after heart
transplantation. Recent advancements in treatments have been made that
have significantly improved outcomes in these patients. The study aimed to
evaluate the outcomes of heart transplantation in cardiac amyloidosis. We
systematically searched EMBASE, PubMed/MEDLINE, and Cochrane Library
databases on 30 December 2021 following the Preferred Reporting Items for
Systematic Reviews and Meta-analyses (PRISMA) guidelines. We identified 22
studies that examined 42,951 patients with cardiac amyloidosis of which
only 1,329 patients underwent isolated heart transplantation. Seven
studies reported individual patient data. The results of 123 patients have
been pooled for analysis. There were 70 male patients, 45 female patients,
and eight patients who did not report their gender. Among the types of
amyloids, 63 (51%) patients were found to have light chain amyloidosis
(AL) and 33 (27%) patients had transthyretin amyloidosis (ATTR). Only 41
patients (33.3%) reported a monoclonal component. There were 30 patients
with AL that underwent autologous hematopoietic stem cell transplant
(ASCT). The mean survival of 24 out of 30 patients was 4.33 years. In
addition, the reported data include 13 patients requiring intra-aortic
balloon pump (IABP), six with cardiac resynchronization therapy (CRT), and
four with implantable cardioverter defibrillator (ICD). With the current
advancements in treatments in combination with a multidisciplinary
approach and careful patient selection, patients undergoing heart
transplantation for amyloidosis may have encouraging results in the
current era. Further studies will be needed to evaluate the outcomes of
heart transplantation in amyloidosis patients now that several advances
have been made in the field. Copyright © 2022, The Author(s),
under exclusive licence to Springer Science+Business Media, LLC, part of
Springer Nature.

<20>
Accession Number
2019182053
Title
Health and Well-Being in Surviving Congenital Heart Disease Patients: An
Umbrella Review With Synthesis of Best Evidence.
Source
Frontiers in Cardiovascular Medicine. 9 (no pagination), 2022. Article
Number: 870474. Date of Publication: 10 Jun 2022.
Author
Cocomello L.; Taylor K.; Caputo M.; Cornish R.P.; Lawlor D.A.
Institution
(Cocomello, Taylor, Cornish, Lawlor) MRC Integrative Epidemiology Unit,
Population Health Sciences, Bristol Medical School, University of Bristol,
Oakfield House, Bristol, United Kingdom
(Caputo) Bristol Heart Institute, Bristol, United Kingdom
Publisher
Frontiers Media S.A.
Abstract
Background: Advances in the management of congenital heart disease (CHD)
patients have enabled improvement in long-term survival even for those
with serious defects. Research priorities (for patients, families and
clinicians) have shifted from a focus on how to improve survival to
exploring long-term outcomes in patients with CHD. A comprehensive
appraisal of available evidence could inform best practice to maximize
health and well-being, and identify research gaps to direct further
research toward patient and clinical need. We aimed to critically appraise
all available published systematic reviews of health and well-being
outcomes in adult patients with CHD. Method(s): We conducted an
umbrella review, including any systematic reviews that assessed the
association of having vs. not having CHD with any long-term health
(physical or mental), social (e.g., education, occupation) or well-being
[e.g., quality of life (QoL)] outcome in adulthood (>=18-years).
 Result(s): Out of 1330 articles screened, we identified five
systematic reviews of associations of CHD with adult outcomes. All but one
(which studied QoL) explored health outcomes: one cardiovascular, two
mental, and one mortality after transplant. CHD patients had a higher risk
of stroke, coronary heart disease and heart failure, with the pooled
relative risk (RR) for any outcome of 3.12 (95% CI: 3.01 to 3.24), with
substantial heterogeneity (I2 = 99%) explained by the outcome
being studied (stronger association for heart failure) and geography
(stronger in Europe compared with other regions). CHD patients had a
higher risk of anxiety (OR = 2.58 (1.45 to 4.59)], and higher mean scores
for depression/anxiety symptoms (difference in means = -0.11 SD (-0.28 to
0.06), I2 = 94%)]. Compared with patients having a cardiac
transplant for other (non-CHD) diseases, CHD patients had higher
short-term mortality (RR at 30-days post-transplant = 2.18 [1.62 to
2.93)], with moderate heterogeneity (I2 = 41%) explained by
previous surgery (higher mortality with prior Fontan/Glenn operation). All
domains of QoL were lower in patients with Fontan's circulation than
non-CHD adults. Conclusion(s): Adults with CHD have poorer
cardiovascular, mental health and QoL outcomes, and higher short-term
mortality after transplant. The paucity of systematic reviews, in
particular for outcomes such as education, occupation and lifestyles,
highlights the need for this to be made a priority by funders and
researchers. Systematic Review Registration:
[www.crd.york.ac.uk/prospero], identifier [CRD42020175034]. Copyright
© 2022 Cocomello, Taylor, Caputo, Cornish and Lawlor.

<21>
Accession Number
2017603659
Title
The use of steroids in treating chylothorax following cardiac surgery in
children: a unique perspective.
Source
Cardiology in the Young. 32(4) (pp 525-530), 2022. Date of Publication: 01
Apr 2022.
Author
Saad D.; Makarem A.; Fakhri G.; Al Amin F.; Bitar F.; El Rassi I.; Arabi
M.
Institution
(Saad, Fakhri) Department Of Pediatrics And Adolescent Medicine, American
University Of Beirut Medical Center, Beirut, Lebanon
(Makarem) Faculty Of Medicine, American University Of Beirut Medical
Center, Beirut, Lebanon
(Al Amin, Bitar, Arabi) Division Of Pediatric Cardiology, Department Of
Pediatrics And Adolescent Medicine, American University Of Beirut Medical
Center, Beirut, Lebanon
(El Rassi) Department Of Cardiothoracic Surgery, American University Of
Beirut Medical Center, Beirut, Lebanon
Publisher
Cambridge University Press
Abstract
Background: Chylothorax is the accumulation of chyle fluid in the pleural
space. The incidence of chylothorax is quite common post-cardiac surgeries
in pediatrics especially in Fontan procedures. Although several treatment
lines are known for the management of chylothorax, steroids were scarcely
reported as a treatment option. We present a unique case of a 4-year-old
child who underwent Fontan procedure and suffered a long-term consequence
of chylothorax. The chylothorax only fully resolved after introducing
corticosteroids as part of her management. Method(s): A literature
review about management of chylothorax post-cardiac surgery in children
using Ovid Medline (19462021), PubMed, and google scholar was performed.
 Conclusion(s): Conservative management without additional surgical
intervention is adequate in most patients. Additionally, somatostatin can
be used with variable success rate. However, a few cases mentioned using
steroids in such cases. More research and reporting on the use of steroids
in the treatment of chylothorax post-cardiac surgeries in children is
needed to prove its effectivity. In this article, we describe a case of
chylothorax post-Fontan procedure that supports the use of
steroids. Copyright ©

<22>
Accession Number
639232562
Title
Plasma microRNA-221-3p as a biomarker for POCD after non-cardiac surgery.
Source
PloS one. 17(10) (pp e0275917), 2022. Date of Publication: 2022.
Author
Fan D.; Chen X.; Zhou H.; Hu N.; Chen C.; Yao Y.; Bai Y.; Feng J.; Jia J.;
Wang X.
Institution
(Fan, Chen, Zhou, Hu, Chen, Yao, Bai, Wang) Department of Anesthesiology,
Affiliated Hospital of Southwest Medical University, Sichuan Province,
China
(Feng, Jia) Laboratoryof Anesthesiology, Southwest Medical University,
Sichuan Province, China
Publisher
NLM (Medline)
Abstract
Our previous study showed that the plasma microRNA-221-3p level could
serve as a biomarker for major depression or mood. This study aimed to
further investigate the role of plasma microRNA-221-3p level in
postoperative cognitive dysfunction (POCD). Patients undergoing
non-cardiac surgery were randomly assigned according to the inclusion and
exclusion criteria. POCD was diagnosed by the Z score method. The relative
level of plasma microRNA-221-3p was decided by quantitative real-time
polymerase chain reaction. Multiple logistic regression analysis and
receiver operating characteristic(ROC) curves were used for the analysis
of plasma microRNA-221-3p prediction performance for POCD. At 7 days
post-surgery, the rate of POCD was 34.04%. Patients in the POCD group had
a higher preoperative depression score, older age, and longer operation
duration than that in the NPOCD group. The relative level of plasma
microRNA-221-3p in the POCD group was 1.78 and 2.73 times higher than that
in the NPOCD group at 1 day before and 7 days after the surgery,
respectively. The relative content of plasma microRNA-221-3p at 7 days
after operation was an independent risk factor for POCD. The ROC curves
showed that the area under the curve was 0.938 for plasma microRNA-221-3p
at postoperative 7 days, and the threshold for POCD detection was 12.33
with a sensitivity and specificity of 81.3% and 96.3%, respectively. Our
results indicate that the plasma postoperative microRNA-221-3p levels
could be an effective predictor for POCD after non-cardiac surgery.

<23>
Accession Number
638142039
Title
Effect of Ascorbic Acid on Cardiac Surgery-Associated Acute Kidney Injury
Incidence.
Source
The Thoracic and cardiovascular surgeon. 70(7) (pp 566-574), 2022. Date of
Publication: 01 Oct 2022.
Author
Djordjevic A.; Susak S.; Kotnik P.; Gorenjak M.; Knez Z.; Antonic M.
Institution
(Djordjevic, Antonic) Department of Cardiac Surgery, University Medical
Centre Maribor, Maribor, Slovenia
(Susak) Department of Cardiovascular Surgery, Institute of Cardiovascular
Diseases of Vojvodina, Sremska Kamenica, Vojvodina, Serbia
(Kotnik, Gorenjak, Knez) Faculty of Medicine, University of Maribor,
Maribor, Slovenia
Publisher
NLM (Medline)
Abstract
OBJECTIVES: Acute kidney injury (AKI) is associated with higher
perioperative mortality and morbidity. Oxidative stress has been proposed
as a cause of postoperative AKI. Ascorbic acid (AA) supplementation was
suggested as a novel and promising antioxidant. The aim of this study was
to evaluate the capability of AA to reduce the incidence of postoperative
AKI in cardiac surgery patients. METHOD(S): A prospective randomized
trial was conducted in patients scheduled for on-pump cardiac surgery.
Subjects in the AA group received 2g of AA intravenously during the
induction of anesthesia, 2g before aortic cross-clamp removal and 1g every
8hours for five postoperative days (the JERICA protocol). Postoperatively,
the patients were monitored for AKI and other complications.
Malondialdehyde levels were monitored in a subpopulation of 100 patients
to evaluate the effect of AA on oxidative stress level. RESULT(S):
The AA and control group consisted of 163 and 169 patients, respectively.
The groups were well matched for baseline demographics and had similar
intraoperative characteristics. The incidence of AKI in the AA and control
group was 20.9 and 28.4%, respectively (p=0.127). The estimated glomerular
filtration rate did not differ between the study groups in the entire
postoperative period. There was a trend toward higher malondialdehyde
values with statistical significance on postoperative day 1 and lower
in-hospital mortality in the AA group (0.6 vs. 4.1%, p=0.067).
 CONCLUSION(S): Our results do not support the effectiveness of AA
supplementation in reducing the incidence of postoperative AKI in on-pump
cardiac surgery patients. CLINICAL REGISTRATION NUMBER: This study was
registered with the ISRCTN Registry under the trial registration number
ISRCTN98572043. Copyright The Author(s). This is an open access
article published by Thieme under the terms of the Creative Commons
Attribution-NonDerivative-NonCommercial License, permitting copying and
reproduction so long as the original work is given appropriate credit.
Contents may not be used for commercial purposes, or adapted, remixed,
transformed or built upon.
(https://creativecommons.org/licenses/by-nc-nd/4.0/

<24>
Accession Number
2020663009
Title
Meta-Analysis on the Anesthetic Effects of Remifentanil plus
Dexmedetomidine versus Remifentanil Alone in Cardiac Surgery.
Source
Computational and Mathematical Methods in Medicine. 2022 (no pagination),
2022. Article Number: 1077980. Date of Publication: 2022.
Author
Zeng X.-L.; Liao J.-H.; Zhong H.-S.; Yin X.-H.; Wang R.; Liang J.-P.;
Zhang Z.-S.
Institution
(Zeng, Yin, Wang) Department of Cardiology, Shenzhen University General
Hospital, Shenzhen, China
(Liao) Guangzhou Yujia Biotechnology Co., Ltd., Guangzhou, China
(Zhong) Cardiac Surgery Center, The First Affiliated Hospital of Gannan
Medical University, Jiangxi, China
(Liang) Department of Radiology, Shenzhen bao'An District Songgang
People's Hospital, Shenzhen, China
(Zhang) Department of Cardiology, Pingshan District People's Hospital of
Shenzhen, Pingshan General Hospital, Southern Medical University,
Guangdong, Shenzhen, China
Publisher
Hindawi Limited
Abstract
In this study, we performed a meta-analysis to investigate the anesthesia
effects of remifentanil plus dexmedetomidine versus remifentanil alone in
cardiac surgery. Literature search was performed on PubMed, Web of
Science, Embase, China Knowledge Infrastructure, Wanfang Data, and other
databases for relevant literature published in English or Chinese before
October 2021. A total of 17 studies, consisting of 1350 patients, were
included in this study. Of these, 10 studies showed that remifentanil plus
dexmedetomidine had a good anesthesia effect in cardiac surgery (OR=3.61,
95% CI: 1.73, 7.52, P<0.001), and 8 studies showed that the Ramsay score
test of anesthesia (SMD=0.88; 95% CI: -0.77, 2.53; P<0.001) in the
experimental group was better than that in the control group. In addition,
changes in the hemodynamic heart rate (SMD=-0.74; 95% CI: -1.41, -0.07;
P<0.001) and mean arterial pressure (SMD=-0.18; 95% CI: -0.72, 0.36;
P<0.001) of the two groups of anesthesia were counted in 17 studies, which
also showed that the anesthesia effect of remifentanil plus
dexmedetomidine was good. Thus, remifentanil plus dexmedetomidine may be a
more promising option for cardiac surgery anesthesia than remifentanil
alone. Copyright © 2022 Xiao-Lin Zeng et al.

<25>
Accession Number
2020576604
Title
Safety and performance of a novel cerebral embolic protection device for
transcatheter aortic valve implantation: the PROTEMBO C Trial.
Source
EuroIntervention. 18(7) (pp 590-597), 2022. Date of Publication: September
2022.
Author
Jagielak D.; Targonski R.; Frerker C.; Abdel-Wahab M.; Wilde J.; Werner
N.; Lauterbach M.; Leick J.; Grygier M.; Misterski M.; Erglis A.; Narbute
I.; Ryszard Witkowski A.; Adam M.; Frank D.; Gatto F.; Schmidt T.; Lansky
A.J.
Institution
(Jagielak, Targonski) Department of Cardiac & Vascular Surgery,
Uniwersyteckie Centrum Kliniczne, Gdansk, Poland
(Frerker, Schmidt) Universitatsklinikum Lubeck, Lubeck, Germany
(Abdel-Wahab, Wilde) Heart Center Leipzig, University of Leipzig, Leipzig,
Germany
(Werner, Lauterbach, Leick) Krankenhaus der Barmherzigen Bruder Trier,
Trier, Germany
(Grygier, Misterski) Department of Cardiology, Poznan University of
Medical Sciences, Poznan, Poland
(Erglis, Narbute) Paul Stradins Clinical University Hospital, University
of Latvia, Riga, Latvia
(Ryszard Witkowski) National Institute of Cardiology, Warsaw, Poland
(Adam) University Hospital Cologne, Cologne, Germany
(Frank) UKSH University Medical Center Schleswig-Holstein, Kiel, Germany
(Frank) DZHK Partner Site Hamburg/Kiel, Lubeck, Germany
(Gatto) HerzZentrum Saar, Volklingen, Germany
(Lansky) Section of Cardiovascular Medicine, Yale School of Medicine, New
Haven, CT, United States
Publisher
Europa Group
Abstract
Background: Stroke remains a feared complication associated with
transcatheter aortic valve implantation (TAVI). Embolic cerebral injury
occurs in the majority of TAVI cases and can lead to cognitive
dysfunction. Aim(s): The PROTEMBO C Trial evaluated the safety and
performance of the ProtEmbo Cerebral Protection System in TAVI patients.
 Method(s): Forty-one patients were enrolled in this single-arm study
conducted at 8 European centres. The primary safety endpoint was the rate
of VARC 2-defined major adverse cardiac and cerebrovascular events (MACCE)
at 30 days; the primary performance endpoint was the composite rate of
technical success versus performance goals (PG). Secondary endpoints
included brain diffusion-weighted magnetic resonance imaging (DW-MRI), new
lesion volume, and the rate of death or all strokes compared to historical
data. Result(s): Thirty-seven of 41 enrolled patients underwent TAVI
with the ProtEmbo device (intention-to-treat [ITT] population). Both
primary endpoints were met. MACCE at 30 days was 8.1% (upper limit of the
95% confidence interval [CI]: 21.3% vs PG 25%; p=0.009), and technical
success was 94.6% (lower limit of the 95% CI: 82.3% vs PG 75%; p=0.003).
New DW-MRI lesion volumes with ProtEmbo were smaller than in historical
data, and 87% of patients completing MRI follow-up had no single lesion
>150 mm3. There was 1 stroke in a patient in whom the device
was removed prematurely before TAVI completion. Conclusion(s): The
PROTEMBO C Trial met its primary safety and performance endpoints compared
to prespecified historical PGs. Patients had smaller brain lesion volumes
on DW-MRI compared to prior series and no larger single lesions. These
results warrant further evaluation of the ProtEmbo in a larger randomised
controlled trial (RCT). Copyright © 2022 CSIC Consejo Superior de
Investigaciones Cientificas. All Rights Reserved.

<26>
Accession Number
2020555094
Title
The effect of aggressive management of intraoperative body temperature on
postoperative APACHE II score and prognosis in high-risk patients
undergoing thoracoscopic surgery.
Source
Journal of Thoracic Disease. 14(9) (pp 3429-3437), 2022. Date of
Publication: September 2022.
Author
Li W.; Hu Z.; Liu J.; Yuan Y.; Li K.
Institution
(Li, Hu, Liu, Yuan, Li) Department of Anesthesiology, China-Japan Union
Hospital, Jilin University, Changchun, China
Publisher
AME Publishing Company
Abstract
Background: Intraoperative hypothermia is related with postoperative
complication, longer length of stay (LoS) and mortality. Acute Physiology
and Chronic Health Evaluation II (APACHE II) it the most commonly used
evaluation system for assessing the severity and clinical prognosis of
patients. This study sought to examine the effect of intraoperative body
temperature on postoperative APACHE II scores and the prognosis of
high-risk patients undergoing thoracoscopic surgery. Method(s): This
study used the clinical data of patients from a multicenter randomized
controlled trial who had undergone thoracoscopic surgery at our center
(NCT03111875). In our center were randomly assigned (1:1) to receive
either aggressive warming to a target core temperature of 37 or routine
thermal management to a target of 35.5 during non-cardiac surgery.
Randomisation was computer-generated. Eligible patients (aged >=45 years)
had at least one cardiovascular risk factor, were scheduled for inpatient
noncardiac surgery expected to last 2-6 h with general anaesthesia. We
retrieved medical information through the electronic medical record
system. The primary outcome was the postoperative APACHE II scores, APACHE
II score variation. The secondary outcome was Quality of Recovery-15
(QoR-15) scores, LoS in hospital, postoperative complications, infections,
and deaths of the patients were recorded, and a logistic regression
analysis was conducted to stratify the risk factors for the APACHE II
score. Result(s): Group R comprised 121 patients and Group A
comprised 84 patients. Group A had lower postoperative APACHE II scores
(P=0.046) and a lower probability of a grade increase than Group R
(P=0.005). However, no significant differences were found in terms of the
QoR-15 scores, LoS, postoperative complications, infections, and deaths
between the 2 groups. The logistic regression showed that aggressive
warming, age, and the American Society of Anesthesiologists (ASA) grade
were risk factors for the deterioration of postoperative APACHE II scores.
 Conclusion(s): The active adoption of various passive and aggressive
warming strategies to keep the core body temperature >=37 during
thoracoscopic surgery significantly reduced increases in APACHE II scores,
which is different from age and ASA grade, and was the only intervention
factor. Copyright © Journal of Thoracic Disease. All rights
reserved.

<27>
Accession Number
2015978516
Title
Percutaneous coronary intervention with drug-eluting stents versus
coronary artery bypass grafting in left main coronary artery disease: an
individual patient data meta-analysis.
Source
The Lancet. 398(10318) (pp 2247-2257), 2021. Date of Publication: 18 Dec
2021.
Author
Sabatine M.S.; Bergmark B.A.; Murphy S.A.; O'Gara P.T.; Smith P.K.;
Serruys P.W.; Kappetein A.P.; Park S.-J.; Park D.-W.; Christiansen E.H.;
Holm N.R.; Nielsen P.H.; Stone G.W.; Sabik J.F.; Braunwald E.
Institution
(Sabatine, Bergmark, Murphy, Braunwald) Thrombolysis in Myocardial
Infarction Study Group, Brigham and Women's Hospital and Harvard Medical
School, Boston, MA, United States
(Sabatine, Bergmark, Murphy, O'Gara, Braunwald) Division of Cardiovascular
Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston,
MA, United States
(Smith) Department of Surgery (Cardiothoracic), Duke University School of
Medicine, Duke Clinical Research Institute, Durham, NC, United States
(Serruys) Department of Cardiology, National University of Ireland Galway,
Galway, Ireland
(Serruys) National Heart and Lung Institute, Imperial College London,
London, UK, United Kingdom
(Kappetein) Department of Cardiothoracic Surgery, Erasmus University
Medical Centre, Rotterdam, Netherlands
(Kappetein) Medtronic, Maastricht, Netherlands
(Park, Park) Department of Cardiology, Asan Medical Center, Seoul, South
Korea
(Christiansen, Holm) Department of Cardiology, Aarhus University Hospital,
Aarhus, Denmark
(Nielsen) Department of Cardiothoracic and Vascular Surgery, Aarhus
University Hospital, Aarhus, Denmark
(Stone) The Zena and Michael A Wiener Cardiovascular Institute, Icahn
School of Medicine at Mount Sinai, New York, NY, United States
(Stone) Cardiovascular Research Foundation, New York, NY, United States
(Sabik) Department of Surgery, University Hospitals Cleveland Medical
Center, Cleveland, OH, United States
Publisher
Elsevier B.V.
Abstract
Background: The optimal revascularisation strategy for patients with left
main coronary artery disease is uncertain. We therefore aimed to evaluate
long-term outcomes for patients treated with percutaneous coronary
intervention (PCI) with drug-eluting stents versus coronary artery bypass
grafting (CABG). Method(s): In this individual patient data
meta-analysis, we searched MEDLINE, Embase, and the Cochrane database
using the search terms "left main", "percutaneous coronary intervention"
or "stent", and "coronary artery bypass graft*" to identify randomised
controlled trials (RCTs) published in English between database inception
and Aug 31, 2021, comparing PCI with drug-eluting stents with CABG in
patients with left main coronary artery disease that had at least 5 years
of patient follow-up for all-cause mortality. Two authors (MSS and BAB)
identified studies meeting the criteria. The primary endpoint was 5-year
all-cause mortality. Secondary endpoints were cardiovascular death,
spontaneous myocardial infarction, procedural myocardial infarction,
stroke, and repeat revascularisation. We used a one-stage approach; event
rates were calculated by use of the Kaplan-Meier method and treatment
group comparisons were made by use of a Cox frailty model, with trial as a
random effect. In Bayesian analyses, the probabilities of absolute risk
differences in the primary endpoint between PCI and CABG being more than
0.0%, and at least 1.0%, 2.5%, or 5.0%, were calculated. Finding(s):
Our literature search yielded 1599 results, of which four RCTs-SYNTAX,
PRECOMBAT, NOBLE, and EXCEL-meeting our inclusion criteria were included
in our meta-analysis. 4394 patients, with a median SYNTAX score of 25.0
(IQR 18.0-31.0), were randomly assigned to PCI (n=2197) or CABG (n=2197).
The Kaplan-Meier estimate of 5-year all-cause death was 11.2% (95% CI
9.9-12.6) with PCI and 10.2% (9.0-11.6) with CABG (hazard ratio 1.10, 95%
CI 0.91-1.32; p=0.33), resulting in a non-statistically significant
absolute risk difference of 0.9% (95% CI -0.9 to 2.8). In Bayesian
analyses, there was an 85.7% probability that death at 5 years was greater
with PCI than with CABG; this difference was more likely than not less
than 1.0% (<0.2% per year). The numerical difference in mortality was
comprised more of non-cardiovascular than cardiovascular death.
Spontaneous myocardial infarction (6.2%, 95% CI 5.2-7.3 vs 2.6%, 2.0-3.4;
hazard ratio [HR] 2.35, 95% CI 1.71-3.23; p<0.0001) and repeat
revascularisation (18.3%, 16.7-20.0 vs 10.7%, 9.4-12.1; HR 1.78,
1.51-2.10; p<0.0001) were more common with PCI than with CABG. Differences
in procedural myocardial infarction between strategies depended on the
definition used. Overall, there was no difference in the risk of stroke
between PCI (2.7%, 2.0-3.5) and CABG (3.1%, 2.4-3.9; HR 0.84, 0.59-1.21;
p=0.36), but the risk was lower with PCI in the first year after
randomisation (HR 0.37, 0.19-0.69). Interpretation(s): Among patients
with left main coronary artery disease and, largely, low or intermediate
coronary anatomical complexity, there was no statistically significant
difference in 5-year all-cause death between PCI and CABG, although a
Bayesian approach suggested a difference probably exists (more likely than
not <0.2% per year) favouring CABG. There were trade-offs in terms of the
risk of myocardial infarction, stroke, and revascularisation. A heart team
approach to communicate expected outcome differences might be useful to
assist patients in reaching a treatment decision. Funding(s): No
external funding. Copyright © 2021 Elsevier Ltd

<28>
Accession Number
2011863847
Title
A randomized prospective multicenter trial for stroke prevention by
prophylactic surgical closure of the left atrial appendage in patients
undergoing bioprosthetic aortic valve surgery--LAA-CLOSURE trial protocol.
Source
American Heart Journal. 237 (pp 127-134), 2021. Date of Publication: July
2021.
Author
Kiviniemi T.; Bustamante-Munguira J.; Olsson C.; Jeppsson A.; Halfwerk
F.R.; Hartikainen J.; Suwalski P.; Zindovic I.; Copa G.R.; van Schaagen
F.R.N.; Hanke T.; Cebotari S.; Malmberg M.; Fernandez-Gutierrez M.;
Bjurbom M.; Schersten H.; Speekenbrink R.; Riekkinen T.; Ek D.; Vasankari
T.; Lip G.Y.H.; Airaksinen K.E.J.; van Putte B.
Institution
(Kiviniemi, Malmberg, Vasankari, Airaksinen) Turku University Hospital and
University of Turku, Finland
(Kiviniemi) Brigham and Women's Hospital, Harvard Medical School, Boston,
MA, United States
(Bustamante-Munguira, Fernandez-Gutierrez) Hospital Clinico Universitario
de Valladolid, Valladolid, Spain
(Olsson, Bjurbom) Karolinska University Hospital and The Karolinska
Institutet, Stockholm, Sweden
(Jeppsson, Schersten) Sahlgrenska University Hospital, Gothenburg, Sweden;
and Department of Molecular and Clinical Medicine, Institute of Medicine.
Sahlgrenska Academy, University of Gothenburg, Sweden
(Halfwerk, Speekenbrink) Medisch Spectrum Twente, Thoraxcentrum Twente,
Enschede, Netherlands
(Hartikainen, Riekkinen) Kuopio University Hospital, University of Eastern
Finland, Kuopio, Finland
(Suwalski) Central Clinical Hospital of the Ministry of the Interior and
Administration in Warsaw, Warsaw, Poland
(Zindovic, Ek) Lund University, Skane University Hospital, Department of
Clinical Sciences, Lund, Department of Cardiothoracic Surgery, Lund,
Sweden
(Copa) Hospital Universitario La Princesa, Madrid, Spain
(van Putte) St. Antonius Ziekenhuis, Nieuwegein, Netherlands
(van Schaagen) University Medical Center Rotterdam, Rotterdam, Netherlands
(Hanke) Asklepios Klinik Harburg, Hamburg, Germany
(Cebotari) Medizinische Hochschule, Hannover, Germany
(Lip) Liverpool Centre for Cardiovascular Science, University of Liverpool
and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom
(Lip) Department of Clinical Medicine, Aalborg University, Aalborg,
Denmark
Publisher
Elsevier Inc.
Abstract
Patients undergoing surgical aortic valve replacement (SAVR) are at high
risk for atrial fibrillation (AF) and stroke after surgery. There is an
unmet clinical need to improve stroke prevention in this patient
population. The LAA-CLOSURE trial aims to assess the efficacy and safety
of prophylactic surgical closure of the left atrial appendage for stroke
and cardiovascular death prevention in patients undergoing bioprosthetic
SAVR. This randomized, open-label, prospective multicenter trial will
enroll 1,040 patients at 13 European sites. The primary endpoint is a
composite of cardiovascular mortality, stroke and systemic embolism at 5
years. Secondary endpoints include cardiovascular mortality, stroke,
systemic embolism, bleed fulfilling academic research consortium (BARC)
criteria, hospitalization for decompensated heart failure and health
economic evaluation. Sample size is based on 30% risk reduction in time to
event analysis of primary endpoint. Prespecified reports include 30-day
safety analysis focusing on AF occurrence and short-term outcomes and
interim analyses at 1 and 3 years for primary and secondary outcomes.
Additionally, substudies will be performed on the completeness of the
closure using transesophageal echocardiography/cardiac computed tomography
and long-term ECG recording at one year after the operation. Copyright
© 2021 The Author(s)

<29>
Accession Number
2020555047
Title
Anesthetic (r)evolution from the conventional concept to the minimally
invasive techniques in thoracic surgery-narrative review.
Source
Journal of Thoracic Disease. 14(8) (pp 3045-3060), 2022. Date of
Publication: August 2022.
Author
Szabo Z.; Fabo C.; Oszlanyi A.; Hawchar F.; Geczi T.; Lantos J.; Furak J.
Institution
(Szabo) Tritonlife Szeged Hospital, Szeged, Hungary
(Fabo, Hawchar) Department of Anesthesiology and Intensive Care,
University of Szeged, Szeged, Hungary
(Oszlanyi) Department of Cardiac Surgery, Zala County St. Raphael
Hospital, Zalaegerszeg, Hungary
(Geczi, Furak) Department of Surgery, University of Szeged, Szeged,
Hungary
(Lantos) Department of Neurology, Bacs-Kiskun County Hospital, Kecskemet,
Hungary
Publisher
AME Publishing Company
Abstract
Background and Objective: Thanks to the growing experience with the
non-intubated anesthetic and surgical techniques, most pulmonary
resections can now be performed by using minimally invasive techniques.
The conventional method, i.e., surgery on the intubated, ventilated
patient under general anesthesia with one-lung ventilation (OLV) was
considered necessary for the major thoracoscopic lung resections for all
patients. An adequate analgesic approach (regional or epidural anesthesia)
allows video-assisted thoracoscopy (VATS) to be performed in anesthetized
patients and thus the potential adverse effects related to general
anesthesia and mechanical OLV can be minimized. Method(s): Multiple
medical literature databases (PubMed, Google Scholar, Scopus) were
searched, using the terms [(non-intubated) OR (nonintubated) OR (tubeless)
OR (awake)] AND [(thoracoscopic surgery)] from 2004 to December 2021.
Thirty hundred and six scientific papers were collected. The editorials,
commentaries, letters, and papers were excluded, that focus on other than
the non-intubated (aka awake or tubeless) VATS technique, as well as the
full text scientific papers available in languages other than English. Key
Content and Findings: After reviewing the literature, we identified
"schools" with different techniques but with very similar results. Most of
the differences were in the anesthetic technique, oxygenation and
analgesia, however, the immunological results, and the qualitative
parameters (inpatient hospital care days, complication rate, mortality) of
the perioperative period showed great similarity, in addition, all three
schools identified the same risk factors (hypoxia, hypercapnia, airway
safety). The combination of spontaneous ventilation with double lumen tube
intubation, called VATS-spontaneous ventilation with intubation (SVI)
method seems to be suitable for reducing these risk factors, which may
serve as an alternative for patients not suitable for the non-intubated
technique in the near future. Conclusion(s): Based on the results,
non-intubated thoracic surgery appears to be an increasingly widespread,
safe procedure, that will be available to a wider range of patients as
experience expands and by the implication of the constantly evolving new
processes. Copyright © Journal of Thoracic Disease. All rights
reserved.

<30>
Accession Number
2017684293
Title
Remifentanil versus Dexmedetomidine in Cardiac Surgery Patients with
Noninvasive Ventilation Intolerance: Protocol for the REDNIVI Trial.
Source
Reviews in Cardiovascular Medicine. 23(3) (no pagination), 2022. Article
Number: rcm2303084. Date of Publication: March 2022.
Author
Luo M.-H.; Hao G.-W.; Liu K.; Yin K.; Yu S.-J.; Wang H.; Su Y.; Luo J.-C.;
Wei Y.-Q.; Wang Y.-H.; Pan W.-Q.; Tu G.-W.; Luo Z.
Institution
(Luo, Wei, Wang, Pan) Shanghai Medical College, Fudan University, Shanghai
200032, China
(Hao, Liu, Yu, Wang, Su, Luo, Tu, Luo) Department of Critical Care
Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
(Yin) Department of Surgery, Massachusetts General Hospital, Harvard
Medical School, Boston, MA 02114, United States
(Luo) Department of Critical Care Medicine, Xiamen Branch, Zhongshan
Hospital, Fudan University, Fujian, Xiamen 361015, China
Publisher
IMR Press Limited
Abstract
Background: Respiratory failure is one of the most common complications
following cardiac surgery. Although noninvasive ventilation (NIV) has been
an effective treatment, it has a high rate of intolerance. Both
remifentanil and dexmedetomidine are used as sedatives in cardiac surgery
(CS) patients with NIV intolerance. However, no randomized controlled
trials have compared the effects of these drugs in relieving the
intolerance. Method(s): REDNIVI will be a multicenter, prospective,
single-blind, randomized controlled trial carried out in six clinical
sites in China. Subjects with NIV intolerance will be randomized to
receive remifentanil or dexmedetomidine in a ratio of 1:1. Primary
outcomes of intolerance remission rate at different timings (15 minutes,
1, 3, 6, 12, 24, 36, 48, 60, 72 hours after initiation of treatment) and
72 h average remission rate will be determined. In addition, secondary
outcomes such as mortality, duration of intensive care unit (ICU) stay,
duration of mechanical ventilation (MV), the need for endotracheal
intubation, hemodynamic changes, and delirium incidence will also be
determined. Conclusion(s): This trial will provide evidence to
determine the effects of remifentanil and dexmedetomidine in patients with
NIV intolerance after cardiac surgery. Copyright © 2022 The
Author(s).

<31>
Accession Number
2019788424
Title
Randomized controlled trial between conventional versus sutureless
bioprostheses for aortic valve replacement: Impact of mini and full
sternotomy access at 1-year follow-up.
Source
International Journal of Cardiology. 368 (pp 56-61), 2022. Date of
Publication: 01 Dec 2022.
Author
Fischlein T.; Caporali E.; Folliguet T.; Kappert U.; Meuris B.; Shrestha
M.L.; Roselli E.E.; Bonaros N.; Fabre O.; Corbi P.; Troise G.; Andreas M.;
Pinaud F.; Pfeiffer S.; Kueri S.; Tan E.; Voisine P.; Girdauskas E.; Rega
F.; Garcia-Puente J.; Lorusso R.
Institution
(Fischlein, Pfeiffer) Klinikum Nurnberg, Cardiovascular Center, Paracelsus
Medical University, Nuremberg, Germany
(Caporali) Cardiology, Istituto Cardiocentro Ticino, EOC, Lugano,
Switzerland
(Caporali) Cardiac Surgery, Istituto Cardiocentro Ticino, EOC, Lugano,
Switzerland
(Folliguet) Department of Cardiac Surgery, Hopital Henri Mondor,
Universite Paris 12, Creteil, Paris, France
(Kappert) Herzzentrum Dresden GmbH Universitatsklinik, Dresden, Germany
(Meuris, Rega) UZ Gasthuisberg Leuven, University Hospital, Leuven,
Belgium
(Shrestha) Hannover Medical School, Hannover, Germany
(Roselli) Heart, Vascular and Thoracic Institute, Cleveland Clinic,
Cleveland, OH, United States
(Bonaros) Medical University of Innsbruck, Innsbruck, Austria
(Fabre) Lens Hospital and Bois Bernard Private Hospital, Lens, France
(Corbi) Poitiers University Hospital, Poitiers, France
(Troise) Cardiac Surgery, Poliambulanza Foundation Hospital, Brescia,
Italy
(Andreas) Medical University of Vienna, Vienna, Austria
(Pinaud) Department of Cardiac Surgery, University Hospital Angers,
Angers, France
(Kueri) University Heart Center Freiburg, Bad Krozingen, Germany
(Tan) Catharina Ziekenhuis, Eindhoven, Netherlands
(Voisine) Division of Cardiac Surgery, Quebec Heart and Lung Institute,
Quebec, Canada
(Girdauskas) University Heart Center Hamburg, Universitatsklinikum Hamburg
Eppendorf (UKE), Hamburg, Germany
(Garcia-Puente) University General Hospital Virgen de la Arrixaca, Murcia,
Spain
(Lorusso) Cardio-Thoracic Surgery Department, Heart and Vascular Center,
Maastricht University Medical Center (MUMC+), Cardiovascular Research
Institute Maastricht (CARIM), Maastricht, Netherlands
Publisher
Elsevier Ireland Ltd
Abstract
Background: The present study is a sub-analysis of the multicenter,
randomized PERSIST-AVR trial (PERceval Sutureless Implant versus Standard
Aortic Valve Replacement) comparing the in-hospital and 1-year results of
sutureless versus conventional stented bioprostheses in isolated surgical
aortic valve replacement (SAVR) within two different surgical approaches:
mini-sternotomy (MS) and full-sternotomy (FS). Method(s): A total of
819 patients (per-protocol population) underwent preoperative
randomization to sutureless or stented biological valve at 47 centers
worldwide. Sub-analysis on isolated SAVR was performed. Results were
compared between sutureless and stented within the two different surgical
approaches. Result(s): 285 patients were implanted with Perceval (67%
in MS) and 293 with stented valves (65% in MS). Sutureless group showed
significantly reduced surgical times both in FS and MS. In-hospital
results show no differences between Perceval and stented valves in FS,
while a lower incidence of new-onset of atrial fibrillation (3.7% vs
10.8%) with Perceval in MS. After 1-year, use of sutureless valve showed a
significant reduction of MACCE (5.2% vs 10.8%), stroke rate (1.0% vs
5.4%), new-onset of atrial fibrillation (4.2% vs 11.4%) and
re-hospitalizations (21.8 days vs 47.6 days), compared to stented valves
but presented higher rate of pacemaker implantation (11% vs 1.6%).
 Conclusion(s): Sutureless bioprosthesis showed significantly reduced
procedural times during isolated SAVR in both surgical approaches.
Patients with sutureless valves and MS access showed also better 1-year
outcome regarding MACCEs, stroke, re-hospitalization and new-onset atrial
fibrillation, but presented a higher rate of permanent pacemaker
implantation compared to patients with stented
bioprosthesis. Copyright © 2022 Elsevier B.V.

<32>
Accession Number
2018982962
Title
Comparison of the analgesic effect of inhaled lavender vs vanilla
essential oil for neonatal frenotomy: a randomized clinical trial
(NCT04867824).
Source
European Journal of Pediatrics. 181(11) (pp 3923-3929), 2022. Date of
Publication: November 2022.
Author
Maya-Enero S.; Fabregas-Mitjans M.; Llufriu-Marques R.M.; Candel-Pau J.;
Garcia-Garcia J.; Lopez-Vilchez M.A.
Institution
(Maya-Enero, Fabregas-Mitjans, Llufriu-Marques, Candel-Pau, Garcia-Garcia,
Lopez-Vilchez) Department of Neonatology, Service of Pediatrics, Hospital
del Mar, Parc de Salut Mar, Universitat Pompeu Fabra, Passeig Maritim
25-29, Barcelona 08003, Spain
Publisher
Springer Science and Business Media Deutschland GmbH
Abstract
It is necessary to treat neonatal pain because it may have short- and
long-term adverse effects. Frenotomy is a painful procedure where sucking,
a common strategy to relieve pain, cannot be used because the technique is
performed on the tongue. In a previous randomized clinical trial, we
demonstrated that inhaled lavender essential oil (LEO) reduced the signs
of pain during neonatal frenotomy. We aimed to find out whether inhaled
vanilla essential oil (VEO) is more effective in reducing pain during
frenotomy than LEO. Randomized clinical trial with neonates who underwent
a frenotomy for type 3 tongue-ties between May and October 2021. Pain was
assessed using pre and post-procedure heart rate (HR) and oxygen
saturation (SatO2), crying time, and NIPS score. Neonates were randomized
into "experimental" and "control" group. In both groups, we performed
swaddling, administered oral sucrose, and let the newborn suck for 2 min.
We placed a gauze pad with one drop of LEO (control group) or of VEO
(experimental group) under the neonate's nose for 2 min prior to and
during the frenotomy. We enrolled 142 neonates (71 per group). Both groups
showed similar NIPS scores (2.02 vs 2.38) and crying times (15.3 vs 18.7
s). We observed no differences in HR increase or in SatO2 decrease between
both groups. We observed no side effects in either of the groups.
 Conclusion(s): We observed no appreciable difference between LEO and
VEO; therefore, we cannot conclude which of them was more effective in
treating pain in neonates who underwent a frenotomy. Trial registration:
This clinical trial is registered with www.clinicaltrials.gov with
NCT04867824.What is Known:* Pain management is one of the most important
goals of neonatal care as it can have long-term neurodevelopmental
effects.* Lavender essential oil can help relieve pain due to its
sedative, antispasmodic, and anticolic properties.What is New:* Lavender
and vanilla essential oils are safe, beneficial, easy to use, and cheap in
relieving pain in neonates who undergo a frenotomy for type 3
tongue-ties. Copyright © 2022, The Author(s), under exclusive
licence to Springer-Verlag GmbH Germany, part of Springer Nature.

<33>
Accession Number
2018964118
Title
Health-related quality of life after restrictive versus liberal RBC
transfusion for cardiac surgery: Sub-study from a randomized clinical
trial.
Source
Transfusion. 62(10) (pp 1973-1983), 2022. Date of Publication: October
2022.
Author
Hu R.T.; Royse A.G.; Royse C.; Scott D.A.; Bowyer A.; Boggett S.; Summers
P.; Mazer C.D.
Institution
(Hu, Royse, Royse, Scott, Bowyer, Boggett) Department of Surgery,
University of Melbourne, Parkville, VIC, Australia
(Hu) Department of Anaesthesia, Austin Health, Heidelberg, VIC, Australia
(Royse, Royse, Bowyer) Department of Anaesthesia and Pain Management,
Royal Melbourne Hospital, Parkville, VIC, Australia
(Royse) Outcomes Research Consortium, The Cleveland Clinic, Cleveland, OH,
United States
(Scott) Department of Anaesthesia and Acute Pain Medicine, St Vincent's
Hospital Melbourne, Fitzroy, VIC, Australia
(Summers) Statistical Consulting Centre, University of Melbourne,
Parkville, VIC, Australia
(Summers) Melbourne Disability Institute, University of Melbourne,
Parkville, VIC, Australia
(Summers) Centre for Health Analytics, Murdoch Children's Research
Institute, Royal Children's Hospital, Parkville, VIC, Australia
(Mazer) Department of Anaesthesia, St. Michael's Hospital, University of
Toronto, Toronto, ON, Canada
Publisher
John Wiley and Sons Inc
Abstract
Background: Transfusion Requirements in Cardiac Surgery III (TRICS III), a
multi-center randomized controlled trial, demonstrated clinical
non-inferiority for restrictive versus liberal RBC transfusion for
patients undergoing cardiac surgery. However, it is uncertain if
transfusion strategy affects long-term health-related quality of life
(HRQOL). Study Design and Methods: In this planned sub-study of Australian
patients in TRICS III, we sought to determine the non-inferiority of
restrictive versus liberal transfusion strategy on long-term HRQOL and to
describe clinical outcomes 24 months postoperatively. The restrictive
strategy involved transfusing RBCs when hemoglobin was <7.5 g/dl; the
transfusion triggers in the liberal group were: <9.5 g/L intraoperatively,
<9.5 g/L in intensive care, or <8.5 g/dl on the ward. HRQOL assessments
were performed using the 36-item short form survey version 2 (SF-36v2).
Primary outcome was non-inferiority of summary measures of SF-36v2 at 12
months, (non-inferiority margin: -0.25 effect size; restrictive minus
liberal scores). Secondary outcomes included non-inferiority of HRQOL at
18 and 24 months. Result(s): Six hundred seventeen Australian
patients received allocated randomization; HRQOL data were available for
208/311 in restrictive and 217/306 in liberal group. After multiple
imputation, non-inferiority of restrictive transfusion at 12 months was
not demonstrated for HRQOL, and the estimates were directionally in favor
of liberal transfusion. Non-inferiority also could not be concluded at 18
and 24 months. Sensitivity analyses supported these results. There were no
differences in quality-adjusted life years or composite clinical outcomes
up to 24 months after surgery. Discussion(s): The non-inferiority of
a restrictive compared to a liberal transfusion strategy was not
established for long-term HRQOL in this dataset. Copyright © 2022
AABB.

<34>
Accession Number
2018960497
Title
Adverse complications of frozen elephant trunk, do we have enough quality
data?.
Source
Journal of Cardiac Surgery. 37(11) (pp 3863-3864), 2022. Date of
Publication: November 2022.
Author
Howard C.; Al-Tawil M.; Geragotellis A.; Abdelhaliem A.
Institution
(Howard) Faculty of Biology, Medicine and Health, The University of
Manchester, Manchester, United Kingdom
(Al-Tawil) Faculty of Medicine, Al-Quds University, Jerusalem, Palestine
(Geragotellis) Faculty of Health Sciences, University of Cape Town, Cape
Town, South Africa
(Abdelhaliem) Department of Vascular and Endovascular Surgery, Royal
Blackburn Teaching Hospital, Blackburn, United Kingdom
Publisher
John Wiley and Sons Inc
Abstract
Background: Frozen elephant trunk has in recent times become a mainstay
for total arch replacement in aortovascular surgery and is indicated to
treat a spectrum of complex aortic pathologies. However, despite
associated excellent postoperative results it is incredibly important to
recognize potential adverse complications such as negative aortic
remodeling, endoleak, and distal stent-graft induced new entry so that
outcomes can be further improved. Aim of the study: Below we provide
commentary on a recent article in the Journal of Cardiac Surgery
discussing the topic. Conclusion(s): Despite the fascinating outcomes
of this systematic review and meta-analysis the heterogeneity of the
literature regarding these adverse outcomes remains an issue which can
only be solved with large multicenter trials directly comparing graft
types as well as indications for surgery. Copyright © 2022 Wiley
Periodicals LLC.

<35>
Accession Number
2018167276
Title
Prophylactic low dose furosemide infusion effect on cardiac surgery
patients with renal dysfunction: A randomized controlled trial.
Source
Critical Care and Shock. 25(5) (pp 253-262), 2022. Date of Publication:
October 2022.
Author
Adriane P.; Hidayat J.; Sugiarto A.; Susilo A.R.
Institution
(Adriane, Hidayat, Sugiarto) Department of Anesthesiology and Intensive
Therapy, Medical Faculty, University of Indonesia, Jakarta, Indonesia
(Susilo) Department of Anesthesiology and Intensive Therapy, National
Cardiovascular Center Harapan Kita, Jakarta, Indonesia
Publisher
The Indonesian Foundation of Critical Care Medicine
Abstract
Objectives: Preoperative renal dysfunction in-creases the risk of
postoperative renal failure and mortality in cardiac surgery patients.
Stud-ies investigating the protective effect of furo-semide in cardiac
surgery were mostly conducted in patients with normal renal function. This
study aimed to evaluate the effect of prophylactic low-dose furosemide in
cardiac surgery patients with mild to moderate renal dys-function.
 Design(s): Double-blind randomized controlled trial. Setting(s):
This study was conducted at a cardiovascular surgery center. Patients and
participants: Eighty-seven patients of elective cardiac surgery with mild
to moderate renal dysfunction (estimated glomerular filtration rate [eGFR]
30-89 ml/min/1.73 m2). Intervention(s): Prophylactic
furosemide infusion (2 mg/h) or 0.9% NaCl infusion (2 ml/h) was
ad-ministered and continued for a total of 12 hours. Measurement and
results: We examined blood samples at 12, 24, 48, and 120 hours after
infusion started to measure the change in eGFR. A decrease in eGFR 320%
was considered a worsening of renal function, while 320% increase in eGFR
was recovering of renal function. We compared the requirement for
therapeutic furo-semide infusion and renal replacement therapy in both
groups. The incidence of decreasing eGFR at the 12th, 24th, and 48th-hour
was higher in the control compared to the furosemide group. Increasing
eGFR at the 120th-hour was the same in both groups. Subjects in the
furosemide group re-quired less administration of therapeutic furo-semide
infusion than the control group. Renal replacement therapy was needed more
in the furo-semide group than in the control group. Conclusion(s):
Low-dose furosemide infusion can reduce the incidence of worsening renal
function, and the need for therapeutic furosemide infu-sion, but does not
prevent the usage of renal replacement therapy. Copyright © 2022,
The Indonesian Foundation of Critical Care Medicine. All rights reserved.

<36>
Accession Number
2018145475
Title
Transcranial electric stimulation motor evoked potentials for cervical
spine intraoperative monitoring complications: systematic review and
illustrative case of cardiac arrest.
Source
European Spine Journal. 31(10) (pp 2723-2732), 2022. Date of Publication:
October 2022.
Author
Revilla-Pacheco F.; Watanabe S.; Rodriguez-Reyes J.; Sanchez-Torres C.;
Shkurovich-Bialik P.; Herrada-Pineda T.; Rodriguez-Salgado P.;
Franco-Granillo J.; Calderon-Juarez M.
Institution
(Revilla-Pacheco, Watanabe, Herrada-Pineda, Rodriguez-Salgado) Department
of Neurosurgery, ABC Medical Center, Mexico City, Mexico
(Rodriguez-Reyes, Sanchez-Torres) Department of Anesthesiology, ABC
Medical Center, Mexico City, Mexico
(Shkurovich-Bialik) Department of Neurophysiology, ABC Medical Center,
Mexico City, Mexico
(Franco-Granillo) Intensive Care Unit, ABC Medical Center, Mexico City,
Mexico
(Calderon-Juarez) Plan de Estudios Combinados en Medicina, Faculty of
Medicine, National Autonomous University of Mexico, Circuto Escolar 411A,
Coyoacan, Mexico City 04360, Mexico
Publisher
Springer Science and Business Media Deutschland GmbH
Abstract
Purpose: We show a systematic review of known complications during
intraoperative neuromonitoring (IONM) using transcranial electric
stimulation motor evoked potentials (TES-MEP) on cervical spine surgery,
which provides a summary of the main findings. A rare complication during
this procedure, cardiac arrest by cardioinhibitory reflex, is also
described. Method(s): Findings of 523 scientific papers published
from 1995 onwards were reviewed in the following databases: CENTRAL,
Cochrane Library, Embase, Google Scholar, Ovid, LILACS, PubMed, and Web of
Science. This study evaluated only complications on cervical spine surgery
undergoing TES-MEP IONM. Result(s): The review of the literature
yielded 13 studies on the complications of TES-MEP IONM, from which three
were excluded. Five studies are case series; the rest are case reports.
Overall, 169 complications on 167 patients were reported in a total of
38,915 patients, a global prevalence of 0.43%. The most common
complication was tongue-bite in 129 cases, (76.3% of all complication
events). Tongue-bite had a prevalence of 0.33% (CI 95%, 0.28-0.39%) in all
patients on TES-MEP IONM. A relatively low prevalence of severe
complications was found: cardiac-arrhythmia, bradycardia and seizure, the
prevalence of this complications represents only one case in all the
sample. Alongside, we report the occurrence of cardiac arrest attributable
to TES-MEP IONM. Conclusion(s): This systematic review shows that
TES-MEP is a safe procedure with a very low prevalence of complications.
To our best knowledge, asystole is reported for the first time as a
complication during TES-MEP IONM. Copyright © 2022, The
Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part
of Springer Nature.

<37>
Accession Number
2004977747
Title
Maintenance immunosuppression in heart transplantation: insights from
network meta-analysis of various immunosuppression regimens.
Source
Heart Failure Reviews. 27(3) (pp 869-877), 2022. Date of Publication: May
2022.
Author
Ueyama H.; Kuno T.; Takagi H.; Alvarez P.; Asleh R.; Briasoulis A.
Institution
(Ueyama, Kuno) Department of Medicine, Mount Sinai Beth Israel, Icahn
School of Medicine at Mount Sinai, New York, NY, United States
(Takagi) Department of Cardiovascular Surgery, Shizuoka Medical Center,
Shizuoka, Japan
(Alvarez, Briasoulis) Division of Cardiovascular Diseases, Section of
Heart Failure and Transplant, University of Iowa Hospitals and Clinics,
200 Hawkins Dr, Iowa City, IA 52242, United States
(Asleh) Division of Cardiovascular Medicine, Mayo Clinic, Rochester, MN,
United States
Publisher
Springer
Abstract
Previous studies have reported superiority of mechanistic
target-of-rapamycin (mTOR) antagonists (mTA) over calcineurin inhibitors
(CNI) as part of maintenance immunosuppression (IS) in mitigating cardiac
allograft vasculopathy (CAV) after heart transplantation (HT). MEDLINE and
EMBASE were searched through October 2019 for studies comparing
maintenance IS with mTA + antimetabolites (AM), CNI + mTA or CNI + AM post
HT. The main outcomes were all-cause mortality, CAV, acute rejection, CMV
infections, and change in eGFR. To compare different IS antagonists, a
random-effects network meta-analysis was performed. We used p-scores to
rank best treatments per outcome. Our search identified fifteen eligible
studies (5 studies comparing mTA + AM vs. CNI + AM, 9 comparing CNI + mTA
vs. CNI + AM, 1 comparing mTA + AM vs. CNI + mTA, 8 using everolimus and 7
sirolimus as mTA) reporting the selected outcomes. We did not identify any
statistical difference in all-cause mortality among the three IS regimens
without heterogeneity among studies. CAV rates were significantly lower
with CNI + mTA (odds ratio [OR] 0.53, 95% confidence interval [CI]
0.3-0.92). Acute rejection rates were significantly lower with CNI + AM
(OR 0.26, 95% CI 0.12-0.56) and with CNI + mTA (OR 0.16, 95% CI 0.07-0.33)
compared with mTA + AM without significant heterogeneity (I2 =
43%, p = 0.9). CMV infections were significantly lower with mTA + AM (OR
0.13, 95% CI 0.03-0.46) and with CNI + mTA (OR 0.27, 95% CI 0.2-0.38)
compared with CNI + AM without heterogeneity. mTA + AM led to higher eGFR
compared with CNI + AM (9.06 ml/min/1.73 m2, 95% CI 3.15-14.97) and CNI +
Mta (9.64 ml/min/1.73 m2, 95% CI 0.91-18.36), but the heterogeneity among
studies was significant. CNI + mTA ranked better for CAV (p = 0.78), and
acute rejection (p = 0.99) while mTA + AM for CMV infection (p = 0.94) and
improvement in renal function (p = 0.93) than other regimens. Different IS
regimens have similar effects on survival post HT, but CNI + mTA was
associated with lower CAV rates, and acute rejection, while mTA + AM with
less CMV infection post HT. Copyright © 2020, Springer
Science+Business Media, LLC, part of Springer Nature.

<38>
Accession Number
2019505354
Title
Complementary medicine usage in surgery: a cross-sectional survey in
Germany.
Source
BMC Complementary Medicine and Therapies. 22(1) (no pagination), 2022.
Article Number: 263. Date of Publication: December 2022.
Author
Lederer A.-K.; Samstag Y.; Simmet T.; Syrovets T.; Huber R.
Institution
(Lederer, Huber) Center for Complementary Medicine, Department of Medicine
II, Faculty of Medicine, Medical Center-University of Freiburg, University
of Freiburg, Hugstetter Strase 55 - Haus Frerichs, Freiburg 79106, Germany
(Lederer) Department of General, Visceral and Transplantation Surgery,
University Medical Center, Mainz, Germany
(Samstag) Institute of Immunology, Section Molecular Immunology,
University Hospital of Heidelberg, Heidelberg, Germany
(Simmet, Syrovets) Institute of Pharmacology of Natural Products &
Clinical Pharmacology, Ulm University, Ulm, Germany
Publisher
BioMed Central Ltd
Abstract
Background: Complementary medicine (CM) is frequently used by patients,
but little is known about the usage of CM in surgical patients. The study
aimed to elucidate the relevance of CM in surgery. Method(s): This
cross-sectional, multi-center survey utilized a paper-based questionnaire
consisting of 21 questions to capture CM usage and interest as well as CM
communication in visceral and thoracic surgical patients being
hospitalized at the corresponding departments of surgery at the University
Medical Centers in Freiburg, Heidelberg und Ulm, Germany. Result(s):
Overall, 151 patients consented to the survey. On average, current CM
usage was stated by 44% of patients. Most frequently used CM approaches
were physical exercise (63%), nutritional supplements (59%) and herbal
medicine (56%). Strong interest in CM counselling was stated by 51% of
patients. Almost 80% of patients wanted to be treated in a holistic manner
and desired for reliable information about CM as well as CM informed
physicians. Only 12% of patients communicated CM usage and interest with
their attending physician. Review of literature revealed similar results
showing an overall CM usage of 43%, preferring nutritional supplements and
herbal medicine. Conclusion(s): The results of our cross-sectional
study indicate a high percentage of CM users and a strong interest in CM
among surgical patients. Indeed, the current communication about CM
between patients and surgeons is poor. With respect to safety and quality
reasons, but also to pay attention to patients' demands, physicians should
be aware of patients' CM usage in surgery. Trial registration: German
Clinical Trial register (DRKS00015445). Copyright © 2022, The
Author(s).

<39>
Accession Number
639054079
Title
Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement.
Source
The New England journal of medicine. 387(14) (pp 1253-1263), 2022. Date of
Publication: 06 Oct 2022.
Author
Kapadia S.R.; Makkar R.; Leon M.; Abdel-Wahab M.; Waggoner T.; Massberg
S.; Rottbauer W.; Horr S.; Sondergaard L.; Karha J.; Gooley R.; Satler L.;
Stoler R.C.; Messe S.R.; Baron S.J.; Seeger J.; Kodali S.; Krishnaswamy
A.; Thourani V.H.; Harrington K.; Pocock S.; Modolo R.; Allocco D.J.;
Meredith I.T.; Linke A.
Institution
(Kapadia, Makkar, Leon, Abdel-Wahab, Waggoner, Massberg, Rottbauer, Horr,
Sondergaard, Karha, Gooley, Satler, Stoler, Messe, Baron, Seeger, Kodali,
Krishnaswamy, Thourani, Harrington, Pocock, Modolo, Allocco, Meredith,
Linke) From the Department of Cardiovascular Medicine (S.R.K.), Cleveland
Clinic Foundation (A.K.), Cleveland; Smidt Heart Institute, Cedars-Sinai
Medical Center, Los Angeles (R. Makkar); Columbia Interventional
Cardiovascular Care (M.L.), Columbia University Medical Center (S.K.), New
York; Leipzig Heart Center, University of Leipzig, Leipzig (M.A.-W.),
Medizinische Klinik und Poliklinik I, Klinikum der Universitat Munchen and
German Center for Cardiovascular Research (DZHK), Munich Heart Alliance,
Munich (S.M.), Universitaetsklinikum Ulm, Ulm (W.R.), Medical Campus Lake
Constance, Friedrichshafen (J.S.), and the Clinic for Internal Medicine
and Cardiology, Technische Universitat Dresden, Herzzentrum, Dresden
(A.L.) - all in Germany; Pima Heart and Vascular, Tucson Medical Center
Healthcare, Tucson, AZ (T.W.); Centennial Medical Center, Nashville
(S.H.); Rigshospitalet, Copenhagen University Hospital, Copenhagen (L.
Sondergaard); Heart Hospital of Austin, Austin (J.K.), Baylor Heart and
Vascular Hospital, Dallas (R.C.S.), and Baylor Scott and White the Heart
Hospital-Plano, Plano (K.H.) - all in Texas; Monash Medical Centre,
Clayton, VIC, Australia (R.G.); Washington Hospital Center, Washington, DC
(L. Satler); the Department of Neurology, University of Pennsylvania,
Philadelphia (S.R.M.); Lahey Hospital and Medical Center, Burlington
(S.J.B.), and Boston Scientific, Marlborough (R. Modolo, D.J.A., I.T.M.) -
both in Massachusetts; Piedmont Heart Institute, Atlanta (V.H.T.); and the
London School of Hygiene and Tropical Medicine, London (S.P.)
Publisher
NLM (Medline)
Abstract
BACKGROUND: Transcatheter aortic-valve replacement (TAVR) for the
treatment of aortic stenosis can lead to embolization of debris. Capture
of debris by devices that provide cerebral embolic protection (CEP) may
reduce the risk of stroke. METHOD(S): We randomly assigned patients
with aortic stenosis in a 1:1 ratio to undergo transfemoral TAVR with CEP
(CEP group) or without CEP (control group). The primary end point was
stroke within 72 hours after TAVR or before discharge (whichever came
first) in the intention-to-treat population. Disabling stroke, death,
transient ischemic attack, delirium, major or minor vascular complications
at the CEP access site, and acute kidney injury were also assessed. A
neurology professional examined all the patients at baseline and after
TAVR. RESULT(S): A total of 3000 patients across North America,
Europe, and Australia underwent randomization; 1501 were assigned to the
CEP group and 1499 to the control group. A CEP device was successfully
deployed in 1406 of the 1489 patients (94.4%) in whom an attempt was made.
The incidence of stroke within 72 hours after TAVR or before discharge did
not differ significantly between the CEP group and the control group (2.3%
vs. 2.9%; difference, -0.6 percentage points; 95% confidence interval,
-1.7 to 0.5; P=0.30). Disabling stroke occurred in 0.5% of the patients in
the CEP group and in 1.3% of those in the control group. There were no
substantial differences between the CEP group and the control group in the
percentage of patients who died (0.5% vs. 0.3%); had a stroke, a transient
ischemic attack, or delirium (3.1% vs. 3.7%); or had acute kidney injury
(0.5% vs. 0.5%). One patient (0.1%) had a vascular complication at the CEP
access site. CONCLUSION(S): Among patients with aortic stenosis
undergoing transfemoral TAVR, the use of CEP did not have a significant
effect on the incidence of periprocedural stroke, but on the basis of the
95% confidence interval around this outcome, the results may not rule out
a benefit of CEP during TAVR. (Funded by Boston Scientific; PROTECTED TAVR
ClinicalTrials.gov number, NCT04149535.). Copyright © 2022
Massachusetts Medical Society.

<40>
Accession Number
2014723469
Title
Comparative evaluation of high-flow nasal cannula oxygenation vs nasal
intermittent ventilation in postoperative paediatric patients operated for
acyanotic congenital cardiac defects.
Source
Medical Journal Armed Forces India. 78(4) (pp 454-462), 2022. Date of
Publication: October 2022.
Author
Kumar A.; Joshi S.; Tiwari N.; Kumar V.; Ramamurthy H.R.; Kumar G.; Sharma
V.
Institution
(Kumar) Classified Specialist (Anaesthesia & Cardio-Thoracic Anaesthesia),
Army Hospital (R&R), New Delhi, India
(Joshi) Senior Advisor (Anaesthesia) & Trained in Paediatric Anaesthesia,
Army Hospital (R&R), New Delhi, India
(Tiwari) Senior Advisor (Surgery) & Cardio-Thoracic Surgeon, Army Hospital
(R&R), New Delhi, India
(Kumar) Classified Specialist (Paediatric) & Trained in Paediatric
Cardiology, Army Hospital (R&R), New Delhi, India
(Ramamurthy) Senior Advisor (Paediatric) & Trained in Paediatric
Cardiology, Army Hospital (R&R), New Delhi, India
(Kumar) Senior Consultant (Paediatric Cardiac Surgery), Fortis Hospital,
Delhi, India
(Sharma) Professor (Cardiac Anaesthesia), Dr. D.Y. Patil Medical College,
Pune, India
Publisher
Elsevier B.V.
Abstract
Background: This study aimed to compare high-flow nasal cannula (HFNC)
oxygenation vs nasal intermittent ventilation (NIV) oxygenation for
respiratory care after extubation in postoperative paediatric cardiac
patients. Method(s): This study was a randomised controlled trial.
One hundred twenty-one paediatric patients with acyanotic congenital heart
disease undergoing corrective cardiac surgery on cardiopulmonary bypass
were included in the study. Patients were randomised to receive either
HFNC (AIRVO) or NIV (RAM Cannula) postextubation. Arterial blood gas was
analysed at different time points perioperatively. Result(s):
Patients in both the groups were matched with respect to diagnosis and
demographic profiles. Baseline hemodynamic and respiratory parameters were
also similar in both the groups. Patients in HFNC/AIRVO group did not show
improved carbon dioxide (CO<inf>2</inf>) washout but showed improved
pO<inf>2</inf> and pO<inf>2</inf>/FiO<inf>2</inf> ratio immediate
postextubation. Reintubation rate and other intensive care unit (ICU)
complications were similar in both the groups. Conclusion(s):
Postcardiopulmonary bypass respiratory complications in paediatric
patients with congenital acyanotic heart disease can be minimised with
newer oxygen therapy devices such as AIRVO (HFNC) or RAM cannula (NIV). In
comparison between these two, AIRVO did not show improved CO<inf>2</inf>
washout over RAM cannula; however, it did provide better oxygenation as
measured by pO<inf>2</inf> in arterial blood and
pO<inf>2</inf>/FiO<inf>2</inf> ratio immediate postextubation. Also,
long-term results such as duration of mechanical ventilation and ICU stay
were not affected by the choice of device. Copyright © 2021

<41>
Accession Number
639214485
Title
Right displacement of trachea to reduce right bronchial misplacement of
left double lumen tube: a prospective, double-blind, randomized study.
Source
BMC anesthesiology. 22(1) (pp 312), 2022. Date of Publication: 06 Oct
2022.
Author
Guan J.; Zhu W.; Xiao X.; Huang Z.; Xing J.; Hei Z.; Zhang Y.; Yao W.
Institution
(Guan, Zhu, Xiao, Huang, Xing, Hei, Zhang, Yao) Department of
Anesthesiology, Third Affiliated Hospital of Sun Yat-Sen University,
Guangzhou 510630, China
Publisher
NLM (Medline)
Abstract
BACKGROUND: Misplacement of double-lumen endobronchial tubes (DLTs) during
bronchial intubation, especially when bronchoscopy guidance is not
applicable, threatens effective lung isolation and brings about airway
injury during reposition. We aimed to examine whether a novel maneuver
called right tracheal displacement (RTD) can reduce left-sided DLT
misplacement during first-attempt intubation without bronchoscopy
guidance. METHOD(S): Patients that underwent thoracic surgeries
requiring one-lung ventilation during November 2020 to January 2021 were
recruited and randomized into control and RTD group, with 54 cases in each
group. The primary outcomes included the incidence of DLT misplacement and
the time to complete desired bronchial intubation. The secondary outcomes
included mucosal injury, sore throat and hoarseness upon emergence and at
24 h post-operatively. RESULT(S): The incidence of DLT misplacement
in RTD group was significantly lower compared to control group (0% vs.
16.7%) The time to complete bronchial intubation was also significantly
shortened in RTD group compared to control (52.88+/-9.36 s vs.
63.04+/-20.02 s). The incidence of mucosal injury, sore throat and
hoarseness were comparable between two groups. CONCLUSION(S): RTD
maneuver can effectively improve the success rate of first-attempt proper
DLT positioning and shorten the time required by bronchial intubation.
TRIAL REGISTRATION: This prospective, double-blind, randomized study has
completed the registration of the Chinese Clinical Trial Center at
2/11/2020 with the registration number ChiCTR2000040212. It was conducted
from 26/11/2020 to 31/7/2021 in third affiliated hospital of Sun Yat-sen
university. Copyright © 2022. The Author(s).

<42>
Accession Number
2020659407
Title
Meta-Resolve of Risk Factors for Nosocomial Infection in Patients
Undergoing Thoracic Surgery.
Source
Contrast Media and Molecular Imaging. 2022 (no pagination), 2022. Article
Number: 2836014. Date of Publication: 2022.
Author
Chen J.; Zhang W.; Yang D.
Institution
(Chen, Zhang, Yang) Department of Cardiothoracic Surgery, Chongqing
Emergency Medical Center, Chongqing University Central Hospital,
Chongqing, China
Publisher
Hindawi Limited
Abstract
As we all know, various complications may occur after surgery, and
postoperative bleeding and infection are the most common in clinical
practice. Postoperative infection mainly manifests as abdominal abscess,
peritonitis, and fungal infection. Thoracic surgery is a very common
clinical operation. It can directly deal with the relevant lesions, so a
better curative effect can usually be obtained. However, patients
undergoing thoracic surgery are generally more severely ill, with low
immune resistance, long duration, and complicated surgical treatment
process. Therefore, the probability of nosocomial infection is high, and
there are many risk factors for infection. After the occurrence of HAI, it
not only increases the suffering and economic burden of patients and the
workload of medical staff but also prolongs the hospitalization time of
patients, reduces the turnover rate of hospital beds, causes unnecessary
economic losses, and affects the social and economic benefits of
hospitals. Based on this, this paper proposes to analyze the risk factors
of nosocomial infection in patients undergoing thoracic surgery, so as to
provide a reference for the prevention or control of nosocomial infection.
This paper analyzes the actual situation of nosocomial infection in a city
hospital and then uses meta-analysis to determine the factors of
nosocomial infection from the perspective of relevant research literature.
Meta-analysis results show that patients older than 60 years have twice
the risk of postoperative infection compared with patients younger than 60
years. Copyright © 2022 Junjian Chen et al.

<43>
[Use Link to view the full text]
Accession Number
2020580164
Title
Effect of a balanced colloid on acute kidney injury in paediatric cardiac
surgery: A post hoc analysis of a randomised controlled trial.
Source
European Journal of Anaesthesiology. 39(11) (pp 895-897), 2022. Date of
Publication: 01 Nov 2022.
Author
Willems A.; Arend S.; Schmartz D.; Van Der Linden P.
Institution
(Willems) Paediatric Intensive Care Unit, Department of Intensive Care,
Leiden University Medical Centre, Leiden, Netherlands
(Arend, Schmartz, Van Der Linden) Department of Anaesthesiology,
University Hospital Brugmann, Queen Fabiola University Children's
Hospital, Brussels, Belgium
Publisher
Lippincott Williams and Wilkins

<44>
Accession Number
2020641533
Title
Pathophysiology of High Output Arteriovenous Fistula with Heart Failure: A
Systematic Review and Meta-analysis.
Source
Journal of Clinical and Diagnostic Research. 16(9) (pp OE07-OE12), 2022.
Date of Publication: September 2022.
Author
Bhaskaran A.P.; Bhaskaran I.P.; Bhaskaran P.
Institution
(Bhaskaran, Bhaskaran) Department of Cardiovascular Surgery, Imperial
College, London, United Kingdom
(Bhaskaran) Department of Cardiothoracic Surgery, Imperial College,
London, United Kingdom
Publisher
Journal of Clinical and Diagnostic Research
Abstract
Introduction: Arteriovenous Fistula (AVF) is extensively used as vascular
access for haemodialysis patients. It induces a high output state, which
is associated with cardiac remodeling. With High Output Heart Failure
(HOHF), the AVF occupies a low pressure; reduced vascular resistance and
increased venous return. The High Output Arteriovenous Fistula with Heart
Failure (HOHF-AVF) patients often undergo a comprehensive assessment of
type of underlying diseases, the degree of vasodilatation along with
laboratory investigations and cardiac imaging. Hence identification of the
pathophysiological determinants of HOHF-AVF is intriguing. Aim(s): To
identify the pathophysiological determinants of HOHF-AVF. Material(s)
and Method(s): This systematic review was conducted from May 2021 to
December 2021 at the Department of Cardiovascular Surgery, Imperial
College, United Kingdom. Randomised Controlled Trials (RCTs), cohort,
case-control, cross-sectional and descriptive studies, conducted on adult
patients who underwent AVF creation or ligation and addressed the
pathophysiological determinants of HOHF-AVF were included. Studies
conducted among Paediatric cases, case reports, and case series were
excluded. Medline (PubMed), EMBASE, ProQuest, and the Cochrane database
were searched, by utilising the key words {[("HOHF" OR "High output heart
failure") AND ("AVF" OR "Arteriovenous fistula")] AND ("LV parameters" OR
"Structural Characteristics" OR "Echocardiographic indices)}. The searches
were restricted from January 2000 to October 2021 with studies published
in the English language. All the included studies were subjected to
critical appraisal using the "Cochrane risk of bias assessment tool" for
RCTs, and the "Joanna Briggs Institute (JBI) checklist" for cohort,
case-control, cross-sectional and descriptive studies. For meta-analysis
Mantel-Haenszel Odds Ratio (M.H. O.R.) with its 95% Confidence Interval
(C.I), Mean Difference (M.D) with its 95 % C.I were computed. The Review
Manager Software (Rev Man 5, Cochrane collabouration, Oxford, England) was
used for data analytics. Result(s): Overall, 115 citations were
identified from the initial search, of which 29 studies were retrieved.
Later, 14 studies were excluded. Of the remaining 15 studies, 12 were
subjected to meta-analysis. There was a change in Left Ventricular (LV)
end diastolic diameter (M.D=2.0; p<0.001; 95% C.I=1.13 to 2.86), and
cardiac index (M.D=0.63; p<0.001, 95% C.I=0.46 to 0.79) from baseline to
atleast three months of postsurgery among HOHF-AVF patients. According to
the AVF flow, there was a change in LV systolic diameter (M.D=-18.90;
p<0.01; 95% C.I=-22.84 to-14.96), cardiac index (M.D=0.50; p=0.007; 95%
C.I=0.14 to 0.86) and tricuspid annular plane systolic excursion
(M.D=3.90; p=0.03; 95% C.I=0.30 to 7.50). Conclusion(s): Left
ventricular end diastolic diameter and cardiac index were found to be the
major determinants for a HOHF-AVF. The left ventricular mass index,
ejection fraction, posterior wall thickness, interventricular septum were
not associated with HOHF-AVF. Left ventricular systolic diameter, cardiac
index and tricuspid annular plane systolic excursion were the determinants
of AVF flow. Copyright © 2022 Journal of Clinical and Diagnostic
Research. All rights reserved.

<45>
Accession Number
2019467118
Title
The hotspots and publication trends in postoperative delirium: A
bibliometric analysis from 2000 to 2020.
Source
Frontiers in Aging Neuroscience. 14 (no pagination), 2022. Article Number:
982154. Date of Publication: 26 Sep 2022.
Author
Lin X.; Cao Y.; Liu X.; Yu K.; Miao H.; Li T.
Institution
(Lin, Cao, Liu, Yu, Miao, Li) Department of Anesthesiology, Beijing
Shijitan Hospital, Capital Medical University, Beijing, China
Publisher
Frontiers Media S.A.
Abstract
Background: Postoperative delirium (POD) is a common aging-associated
postoperative complication that has received increasing attention in the
context of the aging global population and the number of articles
published on POD is gradually increasing. This study aimed to quantify the
basic information of scholarly publications on POD and identify the most
impactful literature, trends, and hotspots in POD research.
 Material(s) and Method(s): We searched articles on POD through the
Science Citation Index Expanded databases published from 2000 to 2020.
Bibliographic information, including year, country, authorship, type,
journal, funding, affiliations, subject areas, and hotspots, was collected
for further analysis. Result(s): A total of 2,114 articles on POD
from 2000 to 2020 were identified. The highest number of studies (n = 748)
were published in the United States, comprising the most total citations
(13,928), followed by China (n = 278), and Germany (n = 209). Inouye,
Sharon K. was the most productive author, with 66 publications on POD. The
Journal of the American Geriatrics Society published the highest number of
articles (n = 80), with the most total citations (4,561) and average
(57.01), followed by Anesthesia and Analgesia (n = 52), and the British
Journal of Anaesthesia (n = 43). Harvard University was the most
productive institute, with the highest H-index (n = 46) and highest degree
centrality (n = 191). The top hotspots in the field of POD during this
period were "elderly," "cardiac surgery," "cognitive impairment," "hip
fracture," and "intensive care unit." Conclusion(s): This study
provides an overview of developments in the field of POD over the past 20
years using bibliometric analysis. Overall, research on POD has flourished
worldwide. The United States (US) has a relatively high academic impact
owing to its productive expertise and institutions in this field. Despite
much research illustrating the diagnosis and management of POD in clinical
practice, more basic research is needed. Copyright © 2022 Lin,
Cao, Liu, Yu, Miao and Li.

<46>
Accession Number
2018194167
Title
Derivation and Validation a Risk Model for Acute Kidney Injury and
Subsequent Adverse Events After Cardiac Surgery: A Multicenter Cohort
Study.
Source
International Journal of General Medicine. 15 (pp 7751-7760), 2022. Date
of Publication: 2022.
Author
Zhang H.; Yu M.; Wang R.; Fan R.; Zhang K.; Chen W.; Chen X.
Institution
(Zhang, Wang, Fan, Chen, Chen) Department of Thoracic and Cardiovascular
Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing
210006, China
(Zhang) Department of Thoracic Surgery, Shanghai General Hospital,
Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China
(Yu) Department of Cardiovascular Surgery, Shanghai General Hospital,
Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
(Zhang) Department of Thoracic and Cardiovascular Surgery, Changzhou
Second People's Hospital, Nanjing Medical University, Changzhou 213003,
China
Publisher
Dove Medical Press Ltd
Abstract
Purpose: To establish a risk model for acute kidney injury and subsequent
adverse events in Chinese cardiac patients. Patients and Methods:
This study included 11,740 patients who had cardiac surgery at 14
institutions in China. Patients were randomly assigned to a derivation
cohort (n = 8197) or a validation cohort (n = 3543). Variables ascertained
during hospitalization were screened using least absolute shrinkage and
selection operator and logistic regression to construct a nomogram model.
Model performance was evaluated using C-statistic, calibration curve, and
Brier score. The nomogram was further compared with the five conventional
models: Mehta score, Ng score, AKICS score, SRI score, and Cleveland
Clinic score. Acute kidney injury was defined according to the Kidney
Disease Improving Global Outcomes criteria. Subsequent adverse events
included mid-term outcomes: death from all causes and major adverse kidney
events (defined as composite outcome of death from renal failure,
dialysis, and advanced chronic kidney disease). Result(s): Acute
kidney injury occurred in 3237 (27.6%) patients. The model included 12
predictors. The total score generated from the nomogram ranged from 0 to
556. The nomogram achieved a C-statistic of 0.825 and 0.804 in the
derivation and validation cohorts, respectively, and had well-fitted
calibration curves. The model performance of the nomogram was better than
other five conventional models. After risk stratification, moderate-risk
or high-risk groups were associated with significantly higher rates of
death from all causes and major adverse kidney events compared with
low-risk group during 7-year follow-up. Conclusion(s): The nomogram
could serve as an effective tool for predicting acute kidney injury and
evaluating its subsequent adverse events after cardiac
surgery. Copyright © 2022 Zhang et al.

<47>
Accession Number
2020648013
Title
The Impact of Cognitive Impairment on Clinical Outcomes After
Transcatheter Aortic Valve Implantation (from a Systematic Review and
Meta-Analysis).
Source
American Journal of Cardiology. (no pagination), 2022. Date of
Publication: 2022.
Author
Sim J.J.L.; Ling R.R.; Neo V.S.Q.; Tan F.L.; Djohan A.H.; Yeo L.L.L.; Chan
K.A.; Lim Y.; Tan B.Y.Q.; Yeo T.-C.; Chan M.Y.; Poh K.-K.; Kong W.K.F.;
Yip J.W.L.; Chong Y.F.; Sharma V.K.; Kuntjoro I.; Sia C.-H.
Institution
(Sim, Ling, Neo, Tan, Yeo, Tan, Yeo, Chan, Poh, Kong, Yip, Chong, Sharma,
Sia) Yong Loo Lin School of Medicine, National University of Singapore,
Singapore
(Djohan, Lim, Yeo, Chan, Poh, Kong, Yip, Kuntjoro, Sia) Department of
Cardiology, National University Heart Centre, Singapore
(Yeo, Tan, Chong, Sharma) Division of Neurology, Department of Medicine,
National University Hospital, Singapore
(Chan) Section of Adult Cardiology, Chong Hua Heart Institute, Chong Hua
Hospital, Cebu, Philippines
Publisher
Elsevier Inc.
Abstract
This study sought to investigate the impact of pre-existing cognitive
impairment on outcomes after transcatheter aortic valve implantation
(TAVI). TAVI has been increasingly used in seniors, and evidence suggests
better outcomes than surgical aortic valve replacement. Although frailty
has been shown to be associated with poorer outcomes after TAVI, the
effect of pre-existing cognitive impairment on patient outcomes after TAVI
remains unclear. We searched the Medline, Embase, Scopus and Cochrane
databases until May 14, 2022. The risk of bias was assessed using the
Newcastle-Ottawa scale. The primary outcome was short-term (6 months to 1
year) mortality, and secondary outcomes included long-term (1 year to 3
years) mortality, in-hospital mortality, and postoperative delirium. A
total of 14 studies with 32,746 patients (5,098 patients with cognitive
impairment at baseline, 27,648 without) were included in our
meta-analysis. Among studies that reported the raw proportion of patients
with mortality of postoperative delirium, cognitive impairment
significantly increased mortality (risk ratio 2.10, 95% confidence
intervals [CIs] 1.43 to 3.08, p = 0.0002) and postoperative delirium (risk
ratio 2.27, 95% CI 1.76 to 2.93, p <0.0001). Studies which reported the
hazards for mortality (pooled hazards ratio 1.97, 95% CI 1.50 to 2.60, p
<0.0001) and odds of postoperative delirium (pooled odds ratio 2.40, 95%
CI: 1.51 to 3.80, p = 0.0002) yielded results consistent with the primary
meta-analysis. In conclusion, pre-existing cognitive impairment is a
significant risk factor for poorer outcomes after TAVI and should be
carefully considered in this group of patients. Guidelines and future
studies should take cognitive impairment into consideration for
preoperative risk stratification. Copyright © 2022 Elsevier Inc.

<48>
Accession Number
2020610915
Title
Depth of anaesthesia and mortality after cardiac or noncardiac surgery: a
systematic review and meta-analysis of randomised controlled trials.
Source
British Journal of Anaesthesia. (no pagination), 2022. Date of
Publication: 2022.
Author
Payne T.; Braithwaite H.; McCulloch T.; Paleologos M.; Johnstone C.;
Wehrman J.; Taylor J.; Loadsman J.; Wang A.Y.; Sanders R.D.
Institution
(Payne, Wehrman, Taylor, Loadsman, Sanders) Central Clinical School
Faculty of Medicine and Health, The University of Sydney, Sydney, NSW,
Australia
(Payne, Braithwaite, McCulloch, Paleologos, Johnstone, Loadsman, Wang,
Sanders) Department of Anaesthetics, Royal Prince Alfred Hospital, Sydney
Local Health District, Sydney, NSW, Australia
(Wang) Northern Clinical School, Faculty of Medicine and Health, The
University of Sydney, NSW, Australia
(Sanders) NHMRC Clinical Trials Centre, University of Sydney, NSW,
Australia
(Sanders) Institute of Academic Surgery, Royal Prince Alfred Hospital,
Sydney Local Health District, Sydney, NSW, Australia
Publisher
Elsevier Ltd
Abstract
Background: Recent randomised controlled trials have failed to show a
benefit in mortality by using processed electroencephalography (pEEG) to
guide lighter anaesthesia. We performed a meta-analysis of mortality data
from randomised trials of pEEG monitoring to assess the evidence of any
protective effect of pEEG-guided light anaesthesia compared with deep
anaesthesia in adults aged >=18 yr. Method(s): Our study followed the
Preferred Reporting Items for Systematic Reviews and Meta-analyses
(PRISMA) guidelines. In February 2022, we searched three databases
(Cochrane CENTRAL, OVID Medline, EMBASE) for RCTs of pEEG monitoring that
provided mortality data at 30 days, 90 days, and/or 1 yr or longer.
 Result(s): We included 16 articles from 12 RCTs with 48 827 total
participants. We observed no statistically significant mortality reduction
with light anaesthesia compared with deep anaesthesia in patients aged
>=18 yr when all studies were pooled (odds ratio [OR]=0.99; 95% confidence
interval (CI), 0.92-1.08). This result did not change significantly when
analysing mortality at 30 days, 90 days, 1 yr or longer. We observed no
mortality benefit for pEEG monitoring compared with usual care (OR=1.02;
95% CI, 0.89-1.18), targeting higher pEEG index values compared with lower
values (OR=0.89; 95% CI, 0.60-1.32), or low pEEG index value alerts
compared with no alerts (OR=1.02; 95% CI, 0.41-2.52). Conclusion(s):
pEEG-guided lighter anaesthesia does not appear to reduce the risk of
postoperative mortality. The absence of a plausible rationale for why
deeper anaesthesia should increase mortality has hampered appropriate
design of definitive clinical trials. Clinical trial registration:
CRD42022285195 (PROSPERO). Copyright © 2022 British Journal of
Anaesthesia

<49>
Accession Number
639254423
Title
Routine revascularization with percutaneous coronary intervention in
patients with coronary artery disease undergoing transcatheter aortic
valve implantation - the third Nordic Aortic Valve Intervention Trial -
NOTION-3.
Source
American heart journal. (no pagination), 2022. Date of Publication: 08
Oct 2022.
Author
Sabbah M.; Veien K.; Niemela M.; Freeman P.; Linder R.; Ioanes D.;
Terkelsen C.J.; Kajander O.A.; Koul S.; Savontaus M.; Karjalainen P.;
Erglis A.; Minkkinen M.; Jorgensen T.; Sondergaard L.; De Backer O.;
Engstrom T.; Lonborg J.
Institution
(Sabbah, Jorgensen, De Backer, Lonborg) Department of Cardiology,
Copenhagen University Hospital - Rigshospitalet, Denmark
(Veien) Department of Cardiology, Odense University Hospital, Odense,
Denmark
(Niemela) Department of Cardiology, University of Oulu, Oulu University
Hospital, Finland
(Freeman) Department of Cardiology, Aalborg University Hospital, Denmark
(Linder) Department of Medicine, Karolinska Institutet, Stockholm, Sweden;
Division of Cardiovascular Medicine, Department of Clinical Sciences,
Karolinska Institutet, Danderyd University Hospital, Stockholm, Sweden
(Ioanes) Department of Cardiology, Sahlgrenska University Hospital,
Gothenburg, Sweden
(Terkelsen) The Danish Heart Foundation; Department of Cardiology, Aarhus
University Hospital, Aarhus, Denmark
(Kajander, Karjalainen, Minkkinen) Heart and Lung Center, Helsinki
University Hospital and Helsinki University, Helsinki, Finland
(Koul) Department of Cardiology, Clinical Sciences, Lund University, Skane
University Hospital, Lund, Sweden
(Savontaus) Heart Center, Turku University Hospital, Finland
(Erglis) University of Latvia, Riga, Latvia
(Sondergaard, Engstrom) Department of Cardiology, Copenhagen University
Hospital - Rigshospitalet, Denmark; Department of Clinical Medicine,
University of Copenhagen, Denmark
Publisher
NLM (Medline)
Abstract
BACKGROUND: Coronary artery disease (CAD) frequently coexists with severe
aortic valve stenosis (AS) in patients planned for transcatheter aortic
valve implantation (TAVI). How to manage CAD in this patient population is
still an unresolved question. In particular, it is still not known whether
fractional flow reserve (FFR) guided revascularization with percutaneous
coronary intervention (PCI) is superior to medical treatment for CAD in
terms of clinical outcomes. STUDY DESIGN: The third Nordic Aortic Valve
Intervention (NOTION-3) Trial is an open-label investigator-initiated,
multicenter multinational trial planned to randomize 452 patients with
severe AS and significant CAD to either FFR-guided PCI or medical
treatment, in addition to TAVI. Patients are eligible for the study in the
presence of at least one significant PCI-eligible coronary stenosis. A
significant stenosis is defined as either FFR <=0.80 and/or diameter
stenosis >90%. The primary endpoint is a composite of first occurring
all-cause mortality, myocardial infarction, or urgent revascularization
(PCI or coronary artery bypass graft performed during unplanned hospital
admission) until the last included patient have been followed for 1 year
after the TAVI. SUMMARY: NOTION-3 is a multicenter, multinational
randomized trial aiming at comparing FFR-guided revascularization vs
medical treatment of CAD in patients with severe AS planned for
TAVI. Copyright © 2022. Published by Elsevier Inc.

<50>
Accession Number
639238907
Title
Routine Ultrasonography Guidance for Femoral Vascular Access for Cardiac
Procedures: The UNIVERSAL Randomized Clinical Trial.
Source
JAMA Cardiology. (no pagination), 2022. Date of Publication: 2022.
Author
Jolly S.S.; Alrashidi S.; D'Entremont M.-A.; Alansari O.; Brochu B.;
Heenan L.; Skuriat E.; Tyrwhitt J.; Raco M.; Tsang M.; Valettas N.;
Velianou J.L.; Sheth T.; Sibbald M.; Mehta S.R.; Pinilla-Echeverri N.;
Schwalm J.D.; Natarajan M.K.; Kelly A.; Akl E.; Tawadros S.; Camargo M.;
Faidi W.; Bauer J.; Moxham R.; Nkurunziza J.; Dutra G.; Winter J.
Institution
(Jolly, D'Entremont, Heenan, Skuriat, Tyrwhitt, Sheth, Mehta,
Pinilla-Echeverri, Schwalm, Natarajan) Population Health Research
Institute, Hamilton, ON, Canada
(Jolly, Alrashidi, Alansari, Raco, Tsang, Valettas, Velianou, Sheth,
Sibbald, Mehta, Pinilla-Echeverri, Schwalm, Natarajan, Kelly, Nkurunziza,
Dutra) McMaster University, Hamilton, ON, Canada
(Jolly, Alrashidi, Alansari, Raco, Tsang, Valettas, Velianou, Sheth,
Sibbald, Mehta, Pinilla-Echeverri, Schwalm, Natarajan, Kelly, Tawadros,
Camargo, Faidi, Bauer, Moxham, Nkurunziza, Dutra) Hamilton Health
Sciences, Hamilton, ON, Canada
(Jolly, Alrashidi, Alansari, Raco, Tsang, Valettas, Velianou, Sheth,
Sibbald, Mehta, Pinilla-Echeverri, Schwalm, Natarajan, Kelly, Nkurunziza)
Niagara Health, ON, Canada
(D'Entremont) Centre Hospitalier Universitaire de Sherbrooke (CHUS),
Sherbrooke, QC, Canada
(Brochu) CK Hui Heart Centre, Royal Alexandra Hospital Edmonton, Edmonton,
AB, Canada
(Akl) McGill University, Faculty of Medicine and Health Sciences,
Montreal, QC, Canada
(Winter) Departamento de Enfermedades Cardiovasculares, Clinica Alemana de
Santiago, Universidad Del Desarrollo, Chile
Publisher
American Medical Association
Abstract
Importance: A significant limitation of femoral artery access for cardiac
interventions is the increased risk of vascular complications and bleeding
compared with radial access. Strategies to make femoral access safer are
needed. Objective(s): To determine whether routinely using
ultrasonography guidance for femoral arterial access for coronary
angiography/intervention reduces bleeding or vascular complications.
 Design, Setting, and Participant(s): The Routine Ultrasound Guidance
for Vascular Access for Cardiac Procedures (UNIVERSAL) randomized clinical
trial is a multicenter, prospective, open-label trial of
ultrasonography-guided femoral access vs no ultrasonography for coronary
angiography or intervention with planned femoral access. Patients were
randomized from June 26, 2018, to April 26, 2022. Patients with
ST-elevation myocardial infarction were not eligible.
 Intervention(s): Ultrasonography guidance vs no ultrasonography
guidance for femoral arterial access on a background of fluoroscopic
landmarking. Main Outcomes and Measures: The primary composite
outcome is the composite of major bleeding based on the Bleeding Academic
Research Consortium 2, 3, or 5 criteria or major vascular complications
within 30 days. Result(s): A total of 621 patients were randomized at
2 centers in Canada (mean [SD] age, 71 [10.24] years; 158 [25.4%] female).
The primary outcome occurred in 40 of 311 patients (12.9%) in the
ultrasonography group vs 50 of 310 patients (16.1%) without
ultrasonography (odds ratio, 0.77 [95% CI, 0.49-1.20]; P =.25). The rates
of Bleeding Academic Research Consortium 2, 3, or 5 bleeding were 10.0%
(31 of 311) vs 10.7% (33 of 310) (odds ratio, 0.93 [95% CI, 0.55-1.56]; P
=.78). The rates of major vascular complications were 6.4% (20 of 311) vs
9.4% (29 of 310) (odds ratio, 0.67 [95% CI, 0.37-1.20]; P =.18).
Ultrasonography improved first-pass success (277 of 311 [86.6%] vs 222 of
310 [70.0%]; odds ratio, 2.76 [95% CI, 1.85-4.12]; P <.001) and reduced
the number of arterial puncture attempts (mean [SD], 1.2 [0.5] vs 1.4
[0.8]; mean difference, -0.26 [95% CI, -0.37 to -0.16]; P <.001) and
venipuncture (10 of 311 [3.1%] vs 37 of 310 [11.7%]; odds ratio, 0.24 [95%
CI, 0.12-0.50]; P <.001) with similar times to access (mean [SD], 114
[185] vs 129 [206] seconds; mean difference, -15.1 [95% CI, -45.9 to
15.8]; P =.34). All prerandomization prespecified subgroups were
consistent with the overall finding. Conclusions and Relevance: In
this randomized clinical trial, use of ultrasonography for femoral access
did not reduce bleeding or vascular complications. However,
ultrasonography did reduce the risk of venipuncture and number of
attempts. Larger trials may be required to demonstrate additional
potential benefits of ultrasonography-guided access. Trial Registration:
ClinicalTrials.gov Identifier: NCT03537118. Copyright © 2022
American Medical Association. All rights reserved.

<51>
Accession Number
2002560975
Title
Comparison of early and delayed invasive strategies in short-medium term
among patients with non-ST segment elevation acute coronary syndrome: A
systematic review and meta-analysis.
Source
PLoS ONE. 14(8) (no pagination), 2019. Article Number: e0220847. Date of
Publication: 01 Aug 2019.
Author
Zhang M.-B.; Guo C.; Li M.; Lv Y.-H.; Fan Y.-D.; Wang Z.-L.
Institution
(Zhang, Guo, Li, Lv, Wang) First Medical Clinical College of Lanzhou
University, Lanzhou, China
(Fan) Department of Cardiology, Emergency General Hospital, Beijing, China
(Wang) Department of Cardiology, First Hospital of Lanzhou University,
Lanzhou, China
Publisher
Public Library of Science
Abstract
Background and objectives An invasive approach is recommended as the
treatment of patients with non-ST elevated acute coronary syndromes
(NSTE-ACS). However, it remains unclear that the optimal time of
angiography and intervention for patients with NSTE-ACS at present. This
study was designed to compare the effect of early and delayed invasive
strategies on short-medium term prognosis in patients with those. Methods
Pubmed, Cochrane Library and Embase were searched up to Dec-30-2018.
Randomized clinical trials comparing an early versus a delayed invasive
strategy in patients with NSTEACS were included. The primary endpoint
(all-cause death and recurrent myocardial infarction) and secondary
endpoint (major bleeding and recurrent revascularization), as well as
composite endpoint were assessed by random or fixed effected meta-analysis
with software RevMan 5.3 version after short-medium term follow up. Result
A total of six randomized clinical trials involving 4,277 early or delayed
invasive strategies patients with NSTE-ACS were included in the
meta-analysis. Time to coronary angiography varied from 0.5 to 24 h in the
early invasive strategy and from 18.6 to 72 h in the delayed invasive
strategy. There was a statistical difference in the primary endpoint of
all-cause death among patients with NSTE-ACS between early and delayed
invasive strategies (4.6% vs 6%; OR:0.76; 95% CI:0.58 to 1.00; P = 0.05;
I2 = 0%), but not for recurrent myocardial infarction (6.0% vs 6.3%; OR:
0.94; 95% CI: 0.55 to 1.61; P = 0.82; I2 = 60%). The major bleeding in
patients with NSTE-ACS was similar between both invasive strategies (2.7%
vs 3.1%; OR:0.88; 95% CI:0.59 to 1.31; P = 0.54; I2 = 0%). However, the
composite endpoint in the early invasive strategy patients with NSTE-ACS
was significantly lower than that of the delayed invasive strategy (10.9%
vs 13.9%; OR:0.76; 95% CI:0.63 to 0.92; P = 0.006; I2 = 0%), and the
recurrent revascularization between both strategies was just the opposite
(8.7% vs 5.9%; OR:1.5; 95%CI:1.15 to 1.97; P = 0.003; I2 = 0%). Conclusion
The systematic review and meta-analysis demonstrated that the early
invasive strategy had a beneficial trend on all-cause death and
significantly reduced the composite endpoint in patients with NSTE-ACS,
but increased the rate of revascularization. These data could provide a
solution for patients with those. Copyright © 2019 Zhang et al.

<52>
Accession Number
2001693337
Title
Transfusion of standard-issue packed red blood cells induces pulmonary
vasoconstriction in critically ill patients after cardiac surgery-A
randomized, double-blinded, clinical trial.
Source
PLoS ONE. 14(3) (no pagination), 2019. Article Number: e0213000. Date of
Publication: March 2019.
Author
Baron-Stefaniak J.; Leitner G.C.; Kuntzel N.K.I.; Meyer E.L.; Hiesmayr
M.J.; Ullrich R.; Baron D.M.
Institution
(Baron-Stefaniak, Kuntzel, Hiesmayr, Ullrich, Baron) Department of
Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University
of Vienna, Vienna, Austria
(Leitner) Department of Blood Group Serology and Transfusion Medicine,
Medical University of Vienna, Vienna, Austria
(Meyer) Section for Medical Statistics, Center for Medical Statistics,
Informatics, and Intelligent Systems, Medical University of Vienna,
Vienna, Austria
Publisher
Public Library of Science
Abstract
Background Experimental and volunteer studies have reported pulmonary
vasoconstriction during transfusion of packed red blood cells (PRBCs)
stored for prolonged periods. The primary aim of this study was to
evaluate whether transfusion of PRBCs stored over 21 days (standard-issue,
siPRBCs) increases pulmonary artery pressure (PAP) to a greater extent
than transfusion of PRBCs stored for less then 14 days (fresh, fPRBCs) in
critically ill patients following cardiac surgery. The key secondary aim
was to assess whether the pulmonary vascular resistance index (PVRI)
increases after transfusion of siPRBCs to a greater extent than after
transfusion of fPRBCs. Methods The study was performed as a single-center,
double-blinded, parallel-group, randomized clinical trial. Leukoreduced
PRBCs were transfused while continuously measuring hemodynamic parameters.
Systemic concentrations of syndecan-1 were measured to assess glycocalyx
injury. After randomizing 19 patients between January 2014 and June 2016,
the study was stopped due to protracted patient recruitment. Results Of 19
randomized patients, 11 patients were transfused and included in
statistical analyses. Eight patients were excluded prior to transfusion, 6
patients received fPRBCs (10+/-3 storage days), whereas 5 patients
received siPRBCs (33+/-4 storage days). The increase in PAP (7 +/-3 vs.
2+/-2 mmHg, P = 0.012) was greater during transfusion of siPRBCs than
during transfusion of fPRBCs. In addition, the change in PVRI (150+/-89
vs. -4+/-37 dynscm-5m2, P = 0.018) was greater after
transfusion of siPRBCs than after transfusion of fPRBCs. The increase in
PAP correlated with the change of systemic syndecan-1 concentrations at
the end of transfusion (R = 0.64,P = 0.034). Conclusion Although this
study is underpowered and results require verification in larger clinical
trials, our findings suggest that transfusion of siPRBCs increases PAP and
PVRI to a greater extent than transfusion of fPRBCs in critically ill
patients following cardiac surgery. Glycocalyx injury might contribute to
pulmonary vasoconstriction associated with transfusion of stored
blood. Copyright: © 2019 Baron-Stefaniak et al. This is an open
access article distributed under the terms of the Creative Commons
Attribution License, which permits unrestricted use, distribution, and
reproduction in any medium, provided the original author and source are
credited.

<53>
[Use Link to view the full text]
Accession Number
2020420650
Title
Intravenous lidocaine for the management of traumatic rib fractures: A
double-blind randomized controlled trial (INITIATE program of research).
Source
Journal of Trauma and Acute Care Surgery. 93(4) (pp 496-502), 2022. Date
of Publication: 01 Oct 2022.
Author
Patton P.; Vogt K.; Priestap F.; Parry N.; Ball I.M.
Institution
(Patton, Ball) Department of Medicine
(Vogt) Department of Surgery
(Vogt, Priestap) Western University; Trauma Program, London Health
Sciences Centre, United Kingdom
(Parry, Ball) Office of Academic Military Medicine
(Ball) Department of Epidemiology and Biostatistics, Western University,
London, ON, Canada
Publisher
Lippincott Williams and Wilkins
Abstract
BACKGROUND Traumatic rib fractures (TRFs) are common with a 10% incidence
in all trauma patients and are associated with significant morbidity and
mortality. Adequate analgesia is paramount for preventing pulmonary
complications and death. Evidence exists for intravenous (IV) lidocaine's
effectiveness and safety in postoperative thoracic and abdominal surgery,
and we hypothesized that it would be effective in patients with TRFs.
METHODS We conducted a single-center, double-blind, randomized control
trial comparing IV lidocaine plus usual analgesics to placebo infusion
plus usual analgesics for 72 hours to 96 hours. Participants were adult
trauma patients diagnosed with two or more TRFs requiring hospital
admission. The primary outcome was mean pain score at rest and with
movement, as measured on the visual analog scale. Secondary outcomes
included patient satisfaction and opioid requirements (standardized total
morphine equivalents). The study was powered to detect a 20% reduction in
pain scores, which has been deemed clinically meaningful. RESULTS
Thirty-six patients were enrolled and randomized to IV lidocaine or
placebo. Comparison of the mean visual analog scale pain scores
demonstrated significant pain reduction with movement in the lidocaine
group compared with placebo (7.05 +/- 1.72 vs. 8.22 +/- 1.28, p = 0.042).
Although pain scores at rest were reduced in the lidocaine group, this
difference was not statistically significant (3.37 +/- 2.00 vs. 3.82 +/-
1.97; p = 0.519). Patient satisfaction was higher in the lidocaine group
than the placebo group, although this did not reach statistical
significance (8.3; interquartile range [IQR], 7.0-9.6 vs. 6.3; IQR,
5.2-7.1; p = 0.105). Total morphine equivalents were lower in the
lidocaine group than the placebo group, but this difference did not reach
statistical significance (167; IQR, 60-340 vs. 290; IQR 148-390; p =
0.194). CONCLUSION These results demonstrate that lidocaine has a
beneficial analgesic effect in patients with TRFs. Future work is needed
to evaluate lidocaine's ability to reduce patient important consequences
of inadequate analgesia. LEVEL OF EVIDENCE Therapeutic/Care Management;
Level II. Copyright © Wolters Kluwer Health, Inc. All rights
reserved.

<54>
Accession Number
2019734952
Title
A Comparative Study of Bilateral Erector Spinae Block Versus Intravenous
Dexmedetomidine for Perioperative Pain Management in Patients Undergoing
Off-Pump Coronary Artery Bypass Grafting - A Single-Blind Randomized
Controlled Trial.
Source
Journal of Cardiothoracic and Vascular Anesthesia. 36(11) (pp 4085-4092),
2022. Date of Publication: November 2022.
Author
Kodali V.R.K.; Shree S.; Prasad M.; Sambandam K.K.G.; Karthekeyan R.B.;
Vakamudi M.
Institution
(Kodali, Vakamudi) Department of Anaesthesiology, Sri Ramachandra
Institute of Higher Education and Research (SRIHER), Chennai, India
(Shree, Prasad, Sambandam, Karthekeyan) Department of Cardiac
Anaesthesiology, Sri Ramachandra Institute of Higher Education and
Research (SRIHER), Chennai, India
Publisher
W.B. Saunders
Abstract
Objective: Regional analgesia, along with general anesthesia, reduce
postoperative pain. In this study, the authors compared the erector spinae
plane (ESP) block having dexmedetomidine as an adjuvant with conventional
pain management along with intravenous dexmedetomidine. Design(s):
Prospective randomized single-blinded trial. Setting(s): Tertiary
care teaching hospital. Participant(s): All of the patients scheduled
for elective off-pump coronary artery bypass grafting with an ejection
fraction of >45%. Intervention(s): After obtaining institutional
ethical committee approval, 130 patients were randomized into Group E and
Group D. Group E patients received ESP block bilaterally with 25 mL of
bupivacaine plus 0.5 mug/kg of dexmedetomidine. The patients in Group D
received conventional intravenous analgesia, as well as a 0.7 mug/kg of
dexmedetomidine bolus, followed by a 0.3 mug/kg dexmedetomidine infusion
during surgery and continued postoperatively for 24 hours. Group E
patients received 8 mL/h of bupivacaine infusion bilaterally for 24 hours.
Measurements: The primary outcome assessed was pain scores in the
postoperative period. The secondary outcomes assessed were postoperative
rescue analgesic consumption, time to first rescue analgesia,
intraoperative fentanyl consumption, duration of mechanical ventilation,
and duration of intensive care unit (ICU) stay. Result(s): Both
groups were comparable in demographic characteristics. The postoperative
pain scores from 4 hours to 12 hours were lower in Group E compared with
Group D. The pain scores at 24 hours were not significantly different
between groups. Postoperative fentanyl consumption in Group E (99.23 +/-
50.19 mug) was significantly lower than in Group D (181.15 +/- 82.92 mug),
with a p value of 0.001. Time to first rescue analgesia was significantly
longer in Group E, with a median score of 8 hours when compared with that
of 4 hours in Group D, with a p value of 0.01. Intraoperative fentanyl
consumption was significantly lower in Group E (392.15 +/- 55.36 mug)
compared with Group D (604.00 +/- 131.87 mug; p = 0.001). There were no
significant differences in the duration of mechanical ventilation in both
groups. Duration of ICU stay was significantly lower in Group E (51.95 +/-
8.54 hours) when compared with Group D (59.06 +/- 8.68 hours) (p = 0.001).
 Conclusion(s): Erector spinae fascial plane blocks appeared to reduce
postoperative pain scores in off-pump coronary artery bypass graft
patients. Furthermore, ESP block was beneficial in terms of less
intraoperative and postoperative opioid consumption, longer time to first
rescue analgesia, and shorter ICU stay. Copyright © 2022 Elsevier
Inc.

<55>
Accession Number
2018962374
Title
Effect of ventilation mode on postoperative pulmonary complications
following lung resection surgery: a randomised controlled trial.
Source
Anaesthesia. 77(11) (pp 1219-1227), 2022. Date of Publication: November
2022.
Author
Li X.-F.; Jin L.; Yang J.-M.; Luo Q.-S.; Liu H.-M.; Yu H.
Institution
(Li, Liu, Yu) Department of Anaesthesiology, West China Hospital of
Sichuan University, Chengdu, China
(Jin, Yang, Luo) Department of Anaesthesiology, Leshan People's Hospital,
Leshan, China
Publisher
John Wiley and Sons Inc
Abstract
The effect of intra-operative mechanical ventilation modes on pulmonary
outcomes after thoracic surgery with one-lung ventilation has not been
well established. We evaluated the impact of three common ventilation
modes on postoperative pulmonary complications in patients undergoing lung
resection surgery. In this two-centre randomised controlled trial, 1224
adults scheduled for lung resection surgery with one-lung ventilation were
randomised to one of three groups: volume-controlled ventilation;
pressure-controlled ventilation; and pressure-control with volume
guaranteed ventilation. Enhanced recovery after surgery pathways and
lung-protective ventilation protocols were implemented in all groups. The
primary outcome was a composite of postoperative pulmonary complications
within the first seven postoperative days. The outcome occurred in 270
(22%), with 87 (21%) in the volume control group, 89 (22%) in the pressure
control group and 94 (23%) in the pressure-control with volume guaranteed
group (p = 0.831). The secondary outcomes also did not differ across study
groups. In patients undergoing lung resection surgery with one-lung
ventilation, the choice of ventilation mode did not influence the risk of
developing postoperative pulmonary complications. This is the first
randomised controlled trial examining the effect of three ventilation
modes on pulmonary outcomes in patients undergoing lung resection
surgery. Copyright © 2022 Association of Anaesthetists.

<56>
Accession Number
2018846516
Title
Comparing mid-term outcomes of Cox-Maze procedure and pulmonary vein
isolation for atrial fibrillation after concomitant mitral valve surgery:
A systematic review.
Source
Journal of Cardiac Surgery. 37(11) (pp 3801-3810), 2022. Date of
Publication: November 2022.
Author
Sef D.; Trkulja V.; Raja S.G.; Hooper J.; Turina M.I.
Institution
(Sef, Raja) Department of Cardiac Surgery, Harefield Hospital, Royal
Brompton and Harefield Hospitals, Part of Guy's and St. Thomas' NHS
Foundation Trust, London, United Kingdom
(Trkulja) Department of Pharmacology, Zagreb University School of
Medicine, Zagreb, Croatia
(Hooper) Bristol Royal Infirmary, University Hospitals Bristol and Weston
NHS Foundation Trust, Bristol, United Kingdom
(Turina) University of Zurich, Zurich, Switzerland
Publisher
John Wiley and Sons Inc
Abstract
Background: Although concomitant pulmonary vein isolation (PVI) is used
more frequently than the Cox-Maze procedure, which is currently the gold
standard treatment for atrial fibrillation (AF), data on the comparative
effectiveness of the two procedures after concomitant mitral valve (MV)
surgery are still limited. Objective(s): We conducted a systematic
review to identify randomized controlled trials (RCTs) and observational
studies comparing the mid-term mortality and recurrence of AF after
concomitant Cox-Maze and PVI in patients with AF undergoing MV surgery
based on 12-month follow-up. Method(s): Medline, EMBASE databases,
and the Cochrane Library were searched from 1987 up to March 2022 for
studies comparing concomitant Cox-Maze and PVI. Additionally, a
meta-analysis of RCTs was performed to compare the mid-term clinical
outcomes between these two surgical ablation techniques. Result(s):
Three RCTs and three observational studies meeting the inclusion criteria
were included in this systematic review with 790 patients in total (532
concomitant Cox-Maze and 258 PVI during MV surgery). Most studies reported
that the concomitant Cox-Maze procedure was associated with higher freedom
from AF at 12-month follow-up than PVI. Regarding AF recurrence, estimates
pooled across the three RCTs indicated large heterogeneity and high
uncertainty. In the largest and highest quality RCT, 12-month AF
recurrence was higher in the PVI arm (risk ratio = 1.58, 95% CI:
0.91-2.73). In two out of three higher-quality observational studies,
12-month AF recurrence was higher in PVI than in the Cox-Maze arm
(estimated adjusted probabilities 11% vs. 8% and 35% vs. 17%,
respectively). RCTs demonstrated comparable 12-month mortality between
concomitant Cox-Maze and PVI, while observational studies demonstrated the
survival benefit of Cox-Maze. Conclusion(s): Concomitant Cox-Maze in
AF patients undergoing MV surgery is associated with better mid-term
freedom from AF when compared to PVI with comparable mid-term survival.
Large observational studies suggest that there might be a mid-term
survival benefit among patients after concomitant Cox-Maze. Further large
RCTs with longer standardized follow-up are required to clarify the
benefits of concomitant Cox-Maze in AF patients during MV
surgery. Copyright © 2022 The Authors. Journal of Cardiac Surgery
published by Wiley Periodicals LLC.

<57>
Accession Number
2017680339
Title
Perioperative Cefazolin Prophylaxis in Pediatric Cardiac Surgery: A
Prospective, Cohort Study.
Source
Annals of Thoracic Surgery. 114(4) (pp 1434-1440), 2022. Date of
Publication: October 2022.
Author
Suna J.; Moloney G.; Marathe S.P.; Bierbach B.; Roberts J.A.; Parker S.;
Ungerer J.P.J.; McWhinney B.; Dorofaeff T.; Venugopal P.; Alphonso N.
Institution
(Suna) University of Queensland, Brisbane, Australia
(Suna) Queensland Paediatric Cardiac Research, Queensland Children's
Hospital, Brisbane, Australia
(Moloney) Department of Anaesthetics, Queensland Children's Hospital,
Brisbane, Australia
(Marathe, Dorofaeff, Venugopal) University of Queensland Clinical School,
Queensland Children's Hospital, University of Queensland, Brisbane,
Australia
(Marathe, Venugopal, Alphonso) Queensland Paediatric Cardiac Service,
Queensland Children's Hospital, Brisbane, Australia
(Bierbach) Department of Paediatric Cardiac Surgery, University Hospital
Bonn, Bonn, Germany
(Roberts, Parker) University of Queensland Centre for Clinical Research,
The University of Queensland, Brisbane, Australia
(Roberts) Pharmacy Department and Department of Intensive Care Medicine,
Royal Brisbane and Women's Hospital, Brisbane, Australia
(Roberts) Division of Anaesthesiology Critical Care Emergency and Pain
Medicine, Nimes University Hospital, University of Montpellier, Nimes,
France
(Ungerer, McWhinney) Pathology Queensland, Queensland Health, Brisbane,
Australia
(Ungerer) School of Biomedical Sciences, University of Queensland,
Brisbane, Australia
(Dorofaeff) Paediatric Intensive Care Unit, Queensland Children's
Hospital, Brisbane, Australia
(Alphonso) Child Health Research Centre, University of Queensland,
Brisbane, Australia
Publisher
Elsevier Inc.
Abstract
Background: This study's objective was to determine the effect of age,
prolonged bypass, and hypothermia on serum cefazolin concentrations in
children undergoing cardiac surgery. Method(s): A prospective,
single-center, observational study was conducted, examining children
undergoing cardiac surgery. Participants received cefazolin intravenously
approximately 1 hour before skin incision, 3 hourly intraoperatively, and
8 hourly postoperatively. Blood samples were collected at 6 to 8 time
points intraoperatively and at 6 time points in the first 24 hours
postoperatively. Target unbound serum cefazolin concentrations were 2
mg/L. Result(s): Sixty-eight patients were enrolled in the study, and
64 were included in the analysis. All maintained concentrations >= 2 mg/L
throughout the operation. Nineteen patients (30%) did not maintain
concentrations >= 2 mg/L in the first 24 hours after surgery. Older,
larger children (P < .0001) were significantly less likely to achieve
target unbound serum cefazolin concentrations. Conclusion(s):
Intraoperative cefazolin concentrations reached the target concentration
in all pediatric cardiac surgical cases. Postoperative cefazolin dosing
appears to be insufficient to achieve minimum inhibitory concentrations in
many patients. Copyright © 2022 The Society of Thoracic Surgeons

<58>
Accession Number
2017205988
Title
A physiology-based trigger score to guide perioperative transfusion of
allogeneic red blood cells: A multicentre randomised controlled trial.
Source
Transfusion Medicine. 32(5) (pp 375-382), 2022. Date of Publication:
October 2022.
Author
Lu K.; Huang Z.; Liang S.; Pan F.; Zhang C.; Wei J.; Wei H.; Wang Y.; Liao
R.; Huang A.; Huang Y.
Institution
(Lu, Liang, Wei, Huang) Department of Anesthesiology, The Third Affiliated
Hospital of Guangxi Medical University, Guangxi, Nanning, China
(Huang, Pan, Zhang) Department of Anesthesiology, Affiliated Hospital of
Youjiang Medical University for Nationalities, Guangxi, Baise, China
(Wei, Wang, Huang) Department of Anesthesiology, People's Hospital of
Guangxi Zhuang Autonomous Region, Guangxi, Nanning, China
(Liao) Department of Anesthesiology, West China Hospital, Sichuan
University, Sichuan, Chengdu, China
Publisher
John Wiley and Sons Inc
Abstract
Background: Restrictive blood transfusion is recommended by major
guidelines for perioperative management, but requires objective assessment
at 7-10 g/dl haemoglobin (Hb). A scoring system that considers the
physiological needs of the heart may simply the practice and reduce
transfusion. Method(s): Patients (14-65 years of age) undergoing
non-cardiac surgery were randomised at a 1:1 ratio to a control group
versus a Perioperative Transfusion Trigger Score (POTTS) group. POTTS
(maximum of 10) was calculated as 6 plus the following: adrenaline
infusion rate (0 for no infusion, 1 for <=0.05
mug.kg-1.min-1, and 2 for higher rate),
FiO<inf>2</inf> to keep SpO<inf>2</inf> at >=95% (0 for <=35%, 1 for
36%-50%, and 2 for higher), core temperature (0 for <38degreeC, 1 for
38-40degreeC, and 2 for higher), and angina history (0 for no, 1 for
exertional, and 2 for resting). Transfusion is indicated when actual Hb is
lower than the calculated POTTS in individual patients. Transfusion in the
control group was based on the 2012 American Association for Blood Banks
(AABB) guideline. The primary outcome was the proportion of the patients
requiring transfusion of allogeneic red blood cells (RBCs) during the
perioperative period (until discharge from hospital), as assessed in the
intention-to-treat (ITT) population (all randomised subjects).
 Result(s): A total of 864 patients (mean age 44.4 years, 244 men and
620 women) were enrolled from December 2017 to January 2021 (433 in the
control and 431 in the POTTS group). Baseline Hb was 9.2 +/- 1.8 and 9.2
+/- 1.7 g/dl in the control and POTTS groups, respectively. In the ITT
analysis, the proportion of the patients receiving allogeneic RBCs was
43.9% (190/433) in the control group versus 36.9% (159/431) in the POTTS
group (p = 0.036). Lower rate of allogeneic RBCs transfusion in the POTTS
group was also evident in the per-protocol analysis (42.8% vs. 35.5%, p =
0.030). Transfusion volume was 4.0 (2.0, 6.0) and 3.5 (2.0, 5.5) units
(200 ml/unit) in the control and POTTS groups, respectively (p = 0.25).
The rate of severe postoperative complications (Clavien-Dindo grade IIIa
and higher) was 3.9% in the control group versus 1.2% in the POTTS group
(p = 0.010). Conclusion(s): Transfusion of allogeneic RBCs based on
the POTTS was safe and reduced the transfusion requirement in patients
undergoing non-cardiac surgery. Copyright © 2022 The Authors.
Transfusion Medicine published by John Wiley & Sons Ltd on behalf of
British Blood Transfusion Society.

<59>
Accession Number
2016984191
Title
Remote Cardiac Rehabilitation in Older Cardiac Disease: A Randomized Case
Series Feasibility Study.
Source
Cardiology Research. 13(1) (pp 57-64), 2022. Date of Publication: February
2022.
Author
Saitoh M.; Takahashi T.; Morisawa T.; Honzawa A.; Yokoyama M.; Abulimiti
A.; Kagiyama N.; Kasai T.; Minamino T.; Asai T.; Fujiwara T.; Daida H.
Institution
(Saitoh, Takahashi, Morisawa, Fujiwara, Daida) Department of Physical
Therapy, Faculty of Health Science, Juntendo University, Tokyo, Japan
(Honzawa, Yokoyama) Cardiovascular Rehabilitation and Fitness, Juntendo
University Hospital, Tokyo, Japan
(Yokoyama, Abulimiti, Kagiyama, Kasai, Minamino, Daida) Department of
Cardiovascular Biology and Medicine, Juntendo University Graduate School
of Medicine, Tokyo, Japan
(Abulimiti) Sportology Center, Juntendo University Graduate School of
Medicine, Tokyo, Japan
(Kagiyama, Kasai) Department of Digital Health and Telemedicine R&D,
Faculty of Health Science, Juntendo University, Tokyo, Japan
(Asai) Department of Cardiovascular Surgery, Juntendo University Graduate
School of Medicine, Tokyo, Japan
(Fujiwara) Department of Rehabilitation Medicine, Juntendo University
Graduate School of Medicine, Tokyo, Japan
Publisher
Elmer Press
Abstract
Background: Cardiac rehabilitation (CR) in the long term is fundamental to
achieve better outcomes. However, most patients may find it difficult to
maintain healthy lifestyle behavior after ambulatory CR program. We aimed
to investigate the feasibility on remote CR support program (Remote-CR) in
older patients with cardiac disease. Method(s): Between October 2020
and February 2021, we enrolled older patients with cardiac disease after
at least over 5 months of ambulatory CR program. The study was conducted
as a randomized controlled case series to compare Remote-CR vs.
center-based CR (CBCR) after ambulatory CR in older patients with cardiac
disease. The core component of Remote-CR is a web application, which
evaluates vital sign and receives feedback through real-time video
consultation once a week. We evaluated the satisfaction of Remote-CR, and
impact of Remote-CR on adherence to exercise and physical activity
management. Moreover, we assessed the change in functional status using
handgrip strength, usual gait speed, short physical performance battery
(SPPB), and Kihon checklist (KCL) before the intervention, at the end of
the 4-week intervention, and cardiovascular-related hospital discharge
within 6 months after completion of ambulatory CR. Result(s): Eleven
patients were enrolled (six for Remote-CR and five for CB-CR). All
participants completed the intervention without serious adverse event in
each group. After the on-site initial remote system set up, all the
patients completed the Remote-CR session without on-site assistance.
Patients' satisfaction with Remote-CR was generally high. Remote-CR helps
to maintain healthy lifestyle behavior. In addition, Remote-CR and CB-CR
seem to be equally successful in maintaining functional status and
preventing cardiovascular-related hospital readmission.
 Conclusion(s): This trial suggested the Remote-CR comprising a hybrid
of information and communication technology and strategy for health
behavior change may be a feasible and safe intervention option in selected
older patients with cardiac disease after completion of ambulatory
CR. Copyright © The authors Journal compilation Cardiol Res
and Elmer Press IncTM www.cardiologyres.org This article is
distributed under the terms of the Creative Commons Attribution
Non-Commercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided
the original work is properly cited

<60>
Accession Number
2020515905
Title
Limb Remote Ischemic Preconditioning Applied During Sevoflurane Anesthesia
Does Not Protect the Lungs in Patients Undergoing Adult Heart Valve
Surgery.
Source
Heart Surgery Forum. 24(5) (pp E916-E924), 2021. Date of Publication: 08
Sep 2021.
Author
Li T.-Y.; Zeng Q.-S.; She S.-Z.
Institution
(Li) Department of Anesthesiology, The First Affiliated Hospital of
Nanchang University, Jiangxi, Nanchang, China
(Zeng) Department of Anesthesiology, Guangdong General Hospital,
Guangdong, Guangzhou, China
(She) Department of Anesthesiology, Guangzhou First People's Hospital,
Guangzhou, China
Publisher
Forum Multimedia Publishing LLC
Abstract
Background: Two consistent overall cell protective preconditioning
treatments should provide more protection. We hypothesized that limb
remote ischemic preconditioning (RIPC, second preconditioning stimulus)
applied during sevoflurane inhalation (first preconditioning stimulus)
would provide more protection to the lungs of patients undergoing adult
heart valve surgery. Method(s): In this randomized,
placebo-controlled, double-blind trial, 50 patients were assigned to the
RIPC group or the placebo group (1:1). Patients in the RIPC group received
three 5-min cycles of 300 mmHg cuff inflation/deflation of the left-side
lower limb before aortic cross-clamping. Anesthesia consisted of opioids
and propofol for induction and sevoflurane for maintenance. The primary
end point was comparison of the postoperative arterial-alveolar oxygen
tension ratio (a/A ratio) between groups. Secondary end points included
comparisons of pulmonary variables, postoperative morbidity and mortality
and regional and systemic inflammatory cytokines between groups.
 Result(s): In the RIPC group, the a/A ratio and other pulmonary
variables exhibited no significant differences throughout the study period
compared with the placebo group. No significant differences in either
plasma or bronchoalveolar lavage levels of TNF- alpha were noted between
the groups at 10 min after anesthetic induction and 1 h after cross-clamp
release. The percentage of neutrophils at 12 h postoperation was
significantly increased in the RIPC group compared with the placebo group
(91.34+/-0.00 vs. 89.42+/-0.10, P = 0.023). Conclusion(s): Limb RIPC
applied during sevoflurane anesthesia did not provide additional
significant pulmonary protection following adult valvular cardiac
surgery. Copyright © 2021 Forum Multimedia Publishing, LLC.

<61>
Accession Number
2019504140
Title
Modified Warden procedure using aortic homograft for superior vena caval
translocation: Where is the evidence?.
Source
Journal of Cardiac Surgery. (no pagination), 2022. Date of Publication:
2022.
Author
Williams I.M.; Jubouri M.; Bailey D.M.; Bashir M.
Institution
(Williams) Department of Vascular Surgery, University Hospital of Wales,
Cardiff, United Kingdom
(Jubouri) Hull York Medical School, University of York, York, United
Kingdom
(Bailey) Neurovascular Research Laboratory, Faculty of Life Sciences and
Education, University of South Wales, Pontypridd, United Kingdom
(Bashir) Vascular and Endovascular Surgery, Velindre University NHS Trust,
Health Education and Improvement Wales (HEIW), Cardiff, United Kingdom
Publisher
John Wiley and Sons Inc
Abstract
Background: Partial anomalous pulmonary venous connection (PAPVC) occurs
when at least one pulmonary vein drains into the right atrium or its
tributaries rather than the left atrium, most commonly connecting with the
superior vena cava (SVC). The Warden procedure involves transecting the
SVC proximal to the uppermost connection of the pulmonary vein followed by
proximal SVC reattachment to the right atrial appendage. However,
descending thoracic aortic homograft replacement for SVC translocation has
recently been introduced as a modified technique. Aim(s): This
commentary aims to discuss the recent study by Said et al. who reported
their experiences with six PAPVC cases undergoing a modified Warden
procedure using thoracic aortic homograft SVC translocation.
 Method(s): A comprehensive literature search was performed using
multiple electronic databases to collate the relevant research evidence.
 Result(s): The Warden procedure is associated with a 10% incidence of
SVC obstruction with many requiring reintervention. Meanwhile, using the
aortic homograft for SVC translocation, Said et al. observed no SVC
obstructions. In addition, this modified technique does not require
anticoagulation and has demonstrated an improvement in long-term SVC
patency. Nevertheless, it can be considered an expensive procedure.
Moreover, since the thoracic aortic homograft utilized is biological
tissue, only long-term follow-up will determine whether calcification and
graft degeneration is an issue. Conclusion(s): It can be concluded
that the modified Warden procedure is a safe and effective method to
reconstruct the systemic venous drainage into the right atrium when a
direct anastomosis under tension might be prone to
re-stenosis. Copyright © 2022 Wiley Periodicals LLC.

<62>
Accession Number
2002368801
Title
Pre-operative stress testing in the evaluation of patients undergoing
non-cardiac surgery: A systematic review and meta-analysis.
Source
PLoS ONE. 14(7) (no pagination), 2019. Article Number: e0219145. Date of
Publication: 01 Jul 2019.
Author
Kalesan B.; Nicewarner H.; Intwala S.; Leung C.; Balady G.J.
Institution
(Kalesan) Department of Medicine and Community Health Sciences, Boston
University, School of Medicine and Public Health, Boston, MA, United
States
(Nicewarner, Intwala, Leung, Balady) Department of Medicine, Boston
Medical Center, Boston University Medical Campus, Boston, MA, United
States
Publisher
Public Library of Science
Abstract
Background Pre-operative stress testing is widely used to evaluate
patients for non-cardiac surgeries. However, its value in predicting
peri-operative mortality is uncertain. The objective of this study is to
assess the type and quality of available evidence in a comprehensive and
statistically rigorous evaluation regarding the effectiveness of
pre-operative stress testing in reducing 30-day post -operative mortality
following non -cardiac surgery. Methods The databases of MEDLINE, EMBASE,
and CENTRAL databases (from inception to January 27, 2016) were searched
for all studies in English. We included studies with pre-operative stress
testing prior to 10 different non-cardiac surgery among adults and
excluded studies with sample size<15. The data on study characteristics,
methodology and outcomes were extracted independently by two observers and
checked by two other observers. The primary outcome was 30-day mortality.
We performed random effects meta-analysis to estimate relative risk (RR)
and 95% confidence intervals (95% CI) in two-group comparison and pooled
the rates for stress test alone. Heterogeneity was assessed using I2 and
methodological quality of studies using Newcastle-Ottawa Quality
Assessment Scale. The predefined protocol was registered in PROSPERO
#CRD42016049212. Results From 1807 abstracts, 79 studies were eligible
(297,534 patients): 40 had information on 30- day mortality, of which 6
studies compared stress test versus no stress test. The risk of 30- day
mortality was not significant in the comparison of stress testing versus
none (RR: 0.79, 95% CI = 0.35-1.80) along with weak evidence for
heterogeneity. For the studies that evaluated stress testing without a
comparison group, the pooled rates are 1.98% (95% CI = 1.25- 2.85) with a
high heterogeneity. There was evidence of potential publication bias and
small study effects. Conclusions Despite substantial interest and research
over the past 40 years to predict 30-day mortality risk among patients
undergoing non-cardiac surgery, the current body of evidence is
insufficient to derive a definitive conclusion as to whether stress
testing leads to reduced perioperative mortality. Copyright ©
2019 Kalesan et al. This is an open access article distributed under the
terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.

<63>
[Use Link to view the full text]
Accession Number
2020580411
Title
Early Peritoneal Dialysis and Postoperative Outcomes in Infants After
Pediatric Cardiac Surgery: A Systematic Review and Meta-Analysis*.
Source
Pediatric Critical Care Medicine. 23(10) (pp 793-800), 2022. Date of
Publication: 01 Oct 2022.
Author
Namachivayam S.P.; Law S.; Millar J.; D'Udekem Y.
Institution
(Namachivayam, Law, Millar) Intensive Care Unit, The Royal Children's
Hospital, Melbourne, VIC, Australia
(Namachivayam, Millar) Clinical Sciences, Murdoch Children's Research
Institute, Melbourne, VIC, Australia
(Namachivayam) Department of Critical Care, University of Melbourne,
Melbourne, VIC, Australia
(Law) Department of Pediatrics, Faculty of Medicine Siriraj Hospital,
Mahidol University, Bangkok, Thailand
(Millar, D'Udekem) Department of Paediatrics, University of Melbourne,
Melbourne, VIC, Australia
(D'Udekem) Cardiac Surgery, Children's National Heart Institute,
Children's National Hospital, Washington, DC, United States
Publisher
Lippincott Williams and Wilkins
Abstract
Objective: Peritoneal dialysis (PD) is used in several cardiac surgical
units after cardiac surgery, and early initiation of PD after surgery may
have the potential to influence postoperative outcomes. This systematic
review and meta-analysis aims to summarize the evidence for the
association between early PD after cardiac surgery and postoperative
outcomes. Data Sources: MEDLINE, Embase, and PubMed from 1981 to
November 1, 2021. Study Selection: Observational studies and randomized
trials reporting on early PD after pediatric cardiac surgery. Data
Extraction: Random-effects meta-analysis was used to estimate the pooled
odds ratios (ORs) and their 95% CIs for postoperative mortality and pooled
mean difference (MD) (95% CI) for duration of mechanical ventilation and
ICU length of stay. Data Synthesis: We identified nine studies from
the systematic review, and five were considered suitable for
meta-analysis. Early initiation of PD after cardiac surgery was associated
with a reduction in postoperative mortality (OR, 0.43 (95% CI, 0.23-0.80);
number of estimates = 4). Early commencement of PD shortened duration of
mechanical ventilation (MD [95% CI], -1.09 d [-1.86 to -0.33 d];
I2= 56.1%; p = 0.06) and intensive care length of stay (MD [95%
CI], -2.46 d [-3.57 to -1.35 d]; I2= 18.7%; p = 0.30],
respectively. All three estimates had broad 95% prediction intervals
(crossing null) denoting major heterogeneity between studies and wide
range of possible study estimates in similar future studies. Overall,
studies reporting on the effects of early PD included only a subset of
infants undergoing cardiac surgery (typically high-risk infants), so
selection bias may be a major issue in published studies.
 Conclusion(s): This review suggests that early initiation of PD may
be associated with beneficial postoperative outcomes in infants after
cardiac surgery. However, these results were based on studies of varying
qualities and risk of bias. Early identification of high-risk infants
after cardiac surgery is important so that prevention or early mitigation
strategies can be applied to this cohort. Future prospective studies in
high-risk populations are needed to study the role of early PD in
influencing postoperative outcomes. Copyright © 2022 Lippincott
Williams and Wilkins. All rights reserved.

<64>
Accession Number
2020490447
Title
Does quality of life improve in octogenarians following cardiac surgery? A
systematic review.
Source
BMJ Open. 5(4) (no pagination), 2015. Article Number: e006904. Date of
Publication: 2015.
Author
Abah U.; Dunne M.; Cook A.; Hoole S.; Brayne C.; Vale L.; Large S.
Institution
(Abah, Dunne, Hoole, Large) Papworth Hospital NHS Foundation Trust,
Cambridge, United Kingdom
(Cook) Wessex Institute, University of Southampton, Southampton, United
Kingdom
(Brayne) Department of Public Health and Primary Care, Cambridge Institute
of Public Health, University of Cambridge, Cambridge, United Kingdom
(Vale) Institute of Health and Society, Newcastle University, Newcastle
upon Tyne, United Kingdom
Publisher
BMJ Publishing Group
Abstract
Objectives: Current outcome measures in cardiac surgery are largely
described in terms of mortality. Given the changing demographic profiles
and increasingly aged populations referred for cardiac surgery this may
not be the most appropriate measure. Postoperative quality of life is an
outcome of importance to all ages, but perhaps particularly so for those
whose absolute life expectancy is limited by virtue of age. We undertook a
systematic review of the literature to clarify and summarise the existing
evidence regarding postoperative quality of life of older people following
cardiac surgery. For the purpose of this review we defined our population
as people aged 80 years of age or over. Method(s): A systematic
review of MEDLINE, EMBASE, Cochrane Library, trial registers and
conference abstracts was undertaken to identify studies addressing quality
of life following cardiac surgery in patients 80 or over. Result(s):
Forty-four studies were identified that addressed this topic, of these
nine were prospective therefore overall conclusions are drawn from largely
retrospective observational studies. No randomised controlled data were
identified. Conclusion(s): Overall there appears to be an improvement
in quality of life in the majority of elderly patients following cardiac
surgery, however there was a minority in whom quality of life declined
(8-19%). There is an urgent need to validate these data and if correct to
develop a robust prediction tool to identify these patients before
surgery. Such a tool could guide informed consent, policy development and
resource allocation. Copyright © 2015 BMJ Publishing Group. All
rights reserved.

<65>
Accession Number
639232327
Title
Evaluation of Rhomboid Intercostal and Subserratus Plane Block Under
Direct Vision For Postoperative Analgesia in Thoracic Surgeries: A
Prospective, Randomized Controlled Trial.
Source
European journal of cardio-thoracic surgery : official journal of the
European Association for Cardio-thoracic Surgery. (no pagination), 2022.
Date of Publication: 11 Oct 2022.
Author
Kozanhan B.; Semerkant T.; Esme H.; Canitez A.; Iyisoy M.S.
Institution
(Kozanhan) University of Health Sciences, Konya City Hospital, Department
of Anesthesiology and Reanimation, Konya, Turkey
(Semerkant, Esme) University of Health Sciences, Konya City Hospital,
Department of Thorax Surgery, Konya, Turkey
(Canitez) Abdulkadir Yuksel City Hospital, Department of Anesthesiology
and Reanimation, Gaziantep, Turkey
(Iyisoy) Necmettin Erbakan University, Department of Medical Education and
Informatics, Konya, Turkey
Publisher
NLM (Medline)
Abstract
OBJECTIVES: This study is designed to evaluate the efficacy of rhomboid
intercostal and subserratus plane (RISS) block under the surgeon's direct
vision for providing postoperative pain relief after thoracic surgeries.
 METHOD(S): Forty patients who underwent thoracotomy were
prospectively recruited and randomly assigned to group R (intravenous
patient-controlled analgesia (IVPCA)+continued RISS block; n=20) and group
C (IVPCA; n=20). Numeric rating scale (NRS) at rest and cough, at
post-anesthetic care unit, 1, 2, 6, 9, 12, 24, and 48hours was used as the
primary outcome measure. Secondary outcome measures were the amount of
tramadol consumption, the number of patients required rescue analgesia,
the occurrence of postoperative adverse effects, pulmonary functions, and
the overall satisfaction with pain management. RESULT(S): NRS scores
both at rest and during coughing were significantly lower in group R than
the group C group at all time intervals (p<0.001 in each). Tramadol
consumption at 24h and 48h was significantly lower in the group R block
than group C (p<0.001 for each). None of the patients in group R require
rescue analgesia. The incidence of nausea and vomiting was similar among
the groups. Compared with group C, change in lung function from baseline
levels was significantly less in group R (p=0.047 and p=0.04 for FEV1 and
FVC, respectively). The satisfaction scores in group R were significantly
higher than group C (p<0.001). CONCLUSION(S): Continuous RISS block
improved postoperative outcomes of thoracic surgery in terms of reduced
postoperative pain scores, sparing opioid consumption, pulmonary function,
and patient satisfaction. CLINICAL TRIAL REGISTRATION: NCT04443556
(https://clinicaltrials.gov/ct2/show/NCT04443556). Copyright ©
The Author(s) 2022. Published by Oxford University Press on behalf of the
European Association for Cardio-Thoracic Surgery. All rights reserved.

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