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<1>
Accession Number
2035266535
Title
The safety and efficacy of NeVa mechanical thrombectomy device in acute
ischemic stroke: A systematic review and meta-analysis.
Source
Journal of Clinical Neuroscience. 130 (no pagination), 2024. Article
Number: 110892. Date of Publication: December 2024.
Author
Habibi M.A.; Mirjnani M.S.; Kargar-Soleimanabad S.; Akbari Javar M.T.;
Diyanati M.; Ahmadvand M.H.; Berglar I.K.; Dmytriw A.A.
Institution
(Habibi) Department of Neurosurgery, Shariati Hospital, Tehran University
of Medical Sciences, Tehran, Iraq
(Mirjnani) Student Research Committee, Qom University of Medical Sciences,
Qom, Iraq
(Kargar-Soleimanabad) Student Research Committee, Mazandaran University of
Medical Sciences, Sari, Iraq
(Akbari Javar, Diyanati) Student Research Committee, Rafsanjan University
of Medical Sciences, Rafsanjan, Iran, Islamic Republic of
(Ahmadvand) Faculty of Medicine, Tehran University of Medical Science,
Tehran, Iraq
(Berglar, Dmytriw) Neuroendovascular Program, Massachusetts General
Hospital, Harvard Medical School, Boston, MA, United States
Publisher
Churchill Livingstone
Abstract
Background: Recent favorable cohort studies on endovascular therapy for
ischemic stroke have predominantly utilized NeVa thrombectomy
(NeVa^TM) stent retrievers. We carried out a systematic review
and meta-analysis to investigate the efficacy and safety of this
second-generation stent retriever in acute ischemic stroke patients.
<br/>Method(s): We conducted the study according to the Preferred
Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)
guidelines. The electronic databases of PubMed, Embase, and Scopus were
searched until 26 November 2023 and was updated on August 1, 2024.
<br/>Result(s): This meta-analysis systematically investigated 11 studies
with a total of 805 patients suffering from ischemic stroke. The mean age
of participants across the studies ranged from 65 to 77 years with a male
preponderance of 50.16 %. While ten studies reported on the etiology of
strokes, some studies reported the risk factors such as hypertension,
dyslipidemia, diabetes, history of coronary artery disease, and previous
stroke. The results of our study indicate that the all-hemorrhagic
complications rate was 0.32 (95 %CI: 0.18-0.45), while the complete
arterial recanalization rate was 0.76 [95 %CI: 0.49-1.04]. The overall
recanalization rate was found to be 0.97 [95 %CI: 0.94-1.00]. Moreover,
the postoperative hemorrhage rate was 0.28 [95 %CI: 0.14-0.41], while the
repeated re-thrombosis rate was 0.01 [95 %CI: -0.01-0.03]. Lastly, the
vasospasm rate was calculated to be 0.09 [95 %CI: -0.03-0.21].
<br/>Conclusion(s): NeVaTM is a safe option capable of achieving a high
rate of recanalization and functional independence. Abbreviations: PRISMA,
Preferred Reporting Items for Systematic Reviews and Meta-Analyses;
PROSPERO, International Prospective Register of Systematic Reviews;
NeVaTM, NeVa Thrombectomy; ICH, Intracranial Hemorrhage; mTICI, modified
Thrombolysis in Cerebral Infarction; mRS, modified Rankin Scale; ACA,
Anterior Cerebral Artery; MCA, Middle Cerebral Artery; PCA, Posterior
Cerebral Artery; ICA, Internal Carotid Artery; NIHSS, National Institutes
of Health Stroke Scale.<br/>Copyright &#xa9; 2024 Elsevier Ltd

<2>
Accession Number
2035260196
Title
Current evidence of unicuspid aortic valve in young adults: A systematic
review and metanalysis.
Source
Current Problems in Cardiology. 50(1) (no pagination), 2025. Article
Number: 102884. Date of Publication: January 2025.
Author
Carbone A.; Ferrara F.; Bottino R.; Russo V.; Rega S.; Limongelli G.;
Bossone E.; Evangelista A.
Institution
(Carbone, Rega, Bossone) Department of Public Health, University of Naples
"Federico II", Via Pansini, 5, Naples 80131, Italy
(Carbone, Bottino) Unit of Cardiology, University of Campania "Luigi
Vanvitelli", Naples, Italy
(Ferrara) Heart Department, University Hospital of Salerno, Salerno, Italy
(Russo) Radiology Department, University Hospital of Salerno, Salerno,
Italy
(Limongelli) Inherited and Rare Cardiovascular Diseases, Department of
Translational Medical Sciences, Monaldi Hospital, University of Campania
"Luigi Vanvitelli", Naples, Italy
(Limongelli) Institute of Cardiovascular Science, University College
London, London, United Kingdom
(Evangelista) Teknon Medical Center, Heart Institute, Barcelona, Spain
Publisher
Elsevier Inc.
Abstract
Unicuspid aortic valve (UAV) is a rare congenital valvular anomaly, often
misdiagnosed as the more prevalent bicuspid aortic valve (BAV). The aim of
this study was to explore demographic, clinical characteristics,
diagnosis, surgical options, short and long term outcomes of young adults
with UAV. A systematic review and meta-analysis of literature were
conducted for studies (1971-2024) including patients (>= 14 years old)
with diagnosis of UAV. Among the 2953 studies retrieved, 67 case reports,
6 case series (n = 130) and 13 retrospective studies (n = 918), were
included in the analysis. Data from retrospective studies were aggregated
using a random effects model for estimating the pooled risk ratio and mean
difference. UAV is mostly unicommissural in adults (mean age 36 years old
at diagnosis, 76-79 % males). The most common conditions associated in UAV
patients were aortic coarctation (from 3.8 to 12 %), ventricular septal
defect (3 %) and Turner syndrome (3 %). In general, the diagnosis was
performed with TTE and confirmed with TEE (+/- 3D-TEE). The most common
types of surgery were AVR. Dilated ascending aorta was described in 44 %
and 35 % of retrospective studies and case reports, respectively.
Concomitant ascending aorta replacement/repair was reported 38 % and 27 %
of retrospective studies and case reports, respectively. Overall survival
was reported in 3 studies, ranging from 95 to 98 % at 10 years. UAV should
be considered a separate entity from BAV. Further investigations with
regards to the possibility of a familial incidence, associated
histopathological changes in the aorta, and ideal follow up and
intervention are needed.<br/>Copyright &#xa9; 2024 The Author(s)

<3>
Accession Number
2035319992
Title
Lived experiences of persons with heart transplantation: A systematic
literature review and meta-synthesis.
Source
Heart and Lung. 69 (pp 174-184), 2025. Date of Publication: 01 Jan 2025.
Author
Nour El Hadi S.; Zanotti R.; Danielis M.
Institution
(Nour El Hadi) Department of Anesthesia and Intensive Care, University
Hospital of Padua, Padua, Italy
(Zanotti, Danielis) Laboratory of Studies & Evidence Based Nursing,
Department of Cardiac, Thoracic, Vascular Sciences and Public Health,
University of Padua, Padua, Italy
Publisher
Elsevier Inc.
Abstract
Background: Heart transplantation (HT) recipients often report improved
quality of life and increased overall happiness, viewing the
transplantation as a rebirth and a second chance at life. However,
interpretations of normality vary among individuals. Understanding
patients' and caregivers' experiences in depth is crucial to adjust
clinical care paths and avoid complications. <br/>Objective(s): To examine
the experiences of patients and caregivers after cardiac transplantation.
<br/>Method(s): A systematic search of the literature was performed from
January 1, 2013, to September 30, 2023, using the MEDLINE (PubMed), CINHAL
(EBSCO), SCOPUS, Web of Science, and Embase (OVID) databases. Full-text,
primary qualitative articles written in English, which reported patients'
experiences of daily life after HT, were included. <br/>Result(s): The
search yielded 5,114 articles; 13 articles that fully met the inclusion
criteria were selected for extraction and synthesis. The inductive
approach led to the identification of 28 codes, which were then grouped
into seven categories and three themes: 1) Undergoing an emotionally
charged journey, 2) Balancing personal health and social dynamics, and 3)
Fostering existential reflection. <br/>Conclusion(s): This review
underscores the importance of further research and the development of a
standardized assessment framework for post-HT patients, emphasizing the
need to consider not just clinical factors but also psychological and
personal aspects to improve outcomes and quality of life. Additionally,
the review identified a lack of comprehensive information about the
experiences of caregivers, highlighting the need for further studies to
better understand and support their roles in the post-transplant
journey.<br/>Copyright &#xa9; 2024 The Author(s)

<4>
Accession Number
2031629278
Title
Efficacy and Safety of Jiuxin Pill in the Treatment of Patients with
Stable Angina Pectoris: A Protocol for a Randomized, Double-Blind,
Placebo-Controlled, Multicenter Clinical Trial.
Source
International Journal of General Medicine. 17 (pp 4711-4722), 2024. Date
of Publication: 2024.
Author
Liu T.; Zhang J.; Zhao Z.; Bi Y.; Zheng Y.; Wang S.; Dai X.; Li J.; Lin
Q.; Ni D.; Wang C.; Wu J.; Xue Y.; Zhu M.; Wang X.; Mao J.
Institution
(Liu, Zhang, Zhao, Bi, Zheng, Wang, Wang, Mao) Cardiovascular Department,
First Teaching Hospital of Tianjin University of Traditional Chinese
Medicine, National Clinical Research, Center for Chinese Medicine
Acupuncture and Moxibustion, Tianjin, China
(Liu, Zhang) Graduate School, Tianjin University of Traditional Chinese
Medicine, Tianjin, China
(Dai) Cardiovascular Department, The First Affiliated Hospital of Anhui
University of Chinese Medicine, Anhui, China
(Li) Cardiovascular Department, Guang'anmen Hospital of China Academy of
Chinese Medicine Science, Beijing, China
(Lin) Cardiovascular Department, Dongzhimen Hospital of Beijing University
of Chinese Medicine, Beijing, China
(Ni) Cardiovascular Department, Taihe Hospital of Traditional Chinese
Medicine Affiliated to Anhui University of Chinese Medicine, Anhui, China
(Wang) Cardiovascular Department, Xiyuan Hospital of China Academy of
Chinese Medical Sciences, Beijing, China
(Wu) Cardiovascular Department, Affiliated Hospital of Jiangxi University
of Chinese Medicine, Jiangxi, China
(Xue) Cardiovascular Department, Affiliated Hospital of Shandong
University of Traditional Chinese Medicine, Shandong, China
(Zhu) Cardiovascular Department, The First Affiliated Hospital of He'nan
University of Traditional Chinese Medicine, Henan, China
Publisher
Dove Medical Press Ltd
Abstract
Background: Stable angina pectoris (SAP), as a common type of coronary
heart disease (CHD), is characterized by transient retrosternal squeezing
pain or suffocation induced by exercise, mood swings, or other stress.
Most patients with stable angina pectoris do not benefit from
interventional therapy and medication, so optimizing treatment plans has
important clinical significance. Jiuxin pill is a Chinese patent medicine
developed by Huatuo Chinese Medicine Co. Ltd. (Bozhou, China) to relieve
the symptoms of stable angina pectoris (SAP). However, there is a lack of
evidence support from high-quality clinical studies. <br/>Method(s): In
this randomized, double-blind, placebo-controlled, multicenter clinical
trial, 170 patients with SAP were recruited from 11 centers in China. The
patients were randomized to either the treatment group (Jiuxin pill, 2
pills, bid) or the control group (Jiuxin pill simulant, 2 pills, bid)
without changing the original conventional western medicine. The trial was
set up with a run-in period of 7 days, a treatment period of 28 +/- 2
days, and a follow-up period of 28 +/- 2 days. Total exercise time (TED)
in the treadmill test and Seattle Angina Questionnaire (SAQ) scores were
set as the main efficacy outcomes, and the 1-minute heart rate recovery
(HRR1), metabolic equivalents (METs), maximum ST segment depression, Borg
perceived exertion after exercise, the average number of angina attacks
per week, usage of nitroglycerin, drug withdrawal and reduction rate,
information scoring of four diagnostic methods in traditional Chinese
medicine and incidence of major adverse cardiovascular events were set as
the secondary efficacy outcomes. Adverse events were monitored throughout
the trial. <br/>Discussion(s): In China, the use of Chinese patent
medicine in the treatment of stable angina pectoris is more common. This
trial evaluated the efficacy and safety of the Jiuxin pill in the
treatment of patients with SAP, and the trial results provide high-quality
research evidence for its clinical application. Trial Registration: This
trial has been registered in the China Clinical Trial Registry on 11 June
2022 (Registration No.: ChiCTR2200060780,
https://www.chictr.org.cn/showproj.html?proj=172352).<br/>Copyright &#xa9;
2024 Liu et al.

<5>
Accession Number
2015117362
Title
Cerebral near-infrared spectroscopy monitoring (NIRS) in children and
adults: a systematic review with meta-analysis.
Source
Pediatric Research. 96(4) (pp 856-867), 2024. Date of Publication:
September 2024.
Author
Hansen M.L.; Hyttel-Sorensen S.; Jakobsen J.C.; Gluud C.; Kooi E.M.W.;
Mintzer J.; de Boode W.P.; Fumagalli M.; Alarcon A.; Alderliesten T.;
Greisen G.; Lemmers P.; Rhee C.J.; Wong F.; Wolf M.; Urlesberger B.;
Szczapa T.; Schwarz C.E.; Roll C.; Roehr C.C.; Pichler G.; Pellicer A.;
Neunhoeffer F.; Naulaers G.; Martini S.; Liem K.D.; Levy P.T.; Gucuyener
K.; Ergenekon E.; Dempsey E.; Bruckner M.; Austin T.
Institution
(Hansen, Greisen) Department of Neonatology, Copenhagen University
Hospital - Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark
(Hyttel-Sorensen) Department of Intensive Care, Copenhagen University
Hospital - Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark
(Jakobsen, Gluud) Copenhagen Trial Unit, Centre for Clinical Intervention
Research, The Capital Region, Copenhagen University Hospital -
Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark
(Jakobsen, Gluud) Department of Regional Health Research, The Faculty of
Health Sciences, University of Southern Denmark, Odense, Denmark
(Kooi) Division of Neonatology, University of Groningen, University
Medical Center Groningen, Beatrix Children's Hospital, Groningen,
Netherlands
(Mintzer) Department of Pediatrics, Division of Newborn Medicine,
Mountainside Medical Center, Montclair, NJ, United States
(de Boode) Division of Neonatology, Department of Pediatrics, Radboud
University Medical Center, Radboud Institute for Health Sciences, Amalia
Children's Hospital, Nijmegen, Netherlands
(Fumagalli) Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Via Francesco Sforza 35, Milano 20122, Italy
(Fumagalli) Department of Clinical Sciences and Community Health,
University of Milan, Via Festa del Perdono 7, Milano 20122, Italy
(Alarcon) Department of Neonatology, Hospital Sant Joan de Deu, Passeig de
Sant Joan de Deu 2, Barcelona, Esplugues de Llobregat 08950, Spain
(Alderliesten) Department of Neonatology, University Medical Center
Utrecht Brain Center, Utrecht University, Utrecht, Netherlands
(Austin) Topun Austin, Neonatal Intensive Care Unit, Cambridge University
Hospitals NHS Foundation Trust, Cambridge, United Kingdom
(Bruckner) Research Unit for Neonatal Micro- and Macrocirculation,
Department of Pediatrics and Adolescent Medicine, Medical University of
Graz, Graz, Austria
(Schwarz, Dempsey) Department of Paediatrics and Child Health, INFANT
Centre, University College Cork, Cork, Ireland
(Ergenekon) Division of Newborn Medicine, Department of Pediatrics, Gazi
University Hospital, Ankara, Turkey
(Gucuyener) Department of Pediatric Neurology, Gazi University Hospital,
Ankara, Turkey
(Levy) Boston Children's Hospital, Harvard Medical School, Harvard
University, Boston, MA, United States
(Liem) Department of Neonatology, Radboud University Medical Center,
Radboud Institute for Health Sciences, Amalia Children's Hospital,
Nijmegen, Netherlands
(Martini) Department of Medical and Surgical Sciences, Neonatal Intensive
Care Unit, S. Orsola-Malpighi University Hospital, University of Bologna,
Bologna, Italy
(Naulaers) Department of Development and Regeneration, Woman and Child, KU
Leuven, Leuven, Belgium
(Neunhoeffer) Department of Pediatric Cardiology, Pulmonology and
Pediatric Intensive Care Medicine, University Children's Hospital
Tubingen, Tubingen, Germany
(Pellicer) Department of Neonatology, La Paz University Hospital, Madrid,
Spain
(Pichler) Department of Pediatrics, Medical University of Graz, Graz,
Austria
(Roehr) Newborn Services, Southmead Hospital, North Bristol Trust,
Bristol, United Kingdom
(Roehr) National Perinatal Epidemiology Unit Clinical Trials Unit,
Nuffield Department of Population Health, Medical Sciences Division,
University of Oxford, Oxford, United Kingdom
(Roehr) Faculty of Health Sciences, University of Bristol, Bristol, United
Kingdom
(Roll) Department of Neonatology, Pediatric Intensive Care, Sleep
Medicine, Vest Children's Hospital Datteln, University Witten-Herdecke,
Datteln, Germany
(Schwarz) Department of Neonatology, University Children's Hospital
Tubingen, Tubingen, Germany
(Szczapa) Department of Neonatology, Biophysical Monitoring and
Cardiopulmonary Therapies Research Unit, Poznan University of Medical
Sciences, Poznan, Poland
(Urlesberger) Division of Neonatology, Department of Pediatrics and
Adolescent Medicine, Medical University of Graz, Graz, Austria
(Wolf) Biomedical Optics Research Laboratory, Department of Neonatology,
University Hospital Zurich, Zurich, Switzerland
(Wong) Monash Newborn, Monash Children's Hospital, Hudson Institute of
Medical Research, Department of Paediatrics, Monash University, Melbourne,
VIC, Australia
(Rhee) Section of Neonatology, Baylor College of Medicine, Texas
Children's Hospital, Houston, TX, United States
(Lemmers) Department of Neonatology, Wilhelmina Children's Hospital,
University Medical Center, Utrecht, Netherlands
Publisher
Springer Nature
Abstract
Background: Cerebral oxygenation monitoring utilising near-infrared
spectroscopy (NIRS) is increasingly used to guide interventions in
clinical care. The objective of this systematic review with meta-analysis
and Trial Sequential Analysis is to evaluate the effects of clinical care
with access to cerebral NIRS monitoring in children and adults versus care
without. <br/>Method(s): This review conforms to PRISMA guidelines and was
registered in PROSPERO (CRD42020202986). Methods are outlined in our
protocol (doi: 10.1186/s13643-021-01660-2). <br/>Result(s): Twenty-five
randomised clinical trials were included (2606 participants). All trials
were at a high risk of bias. Two trials assessed the effects of NIRS
during neonatal intensive care, 13 during cardiac surgery, 9 during
non-cardiac surgery and 1 during neurocritical care. Meta-analyses showed
no significant difference for all-cause mortality (RR 0.75, 95% CI
0.51-1.10; 1489 participants; I² = 0; 11 trials; very low
certainty of evidence); moderate or severe, persistent cognitive or
neurological deficit (RR 0.74, 95% CI 0.42-1.32; 1135 participants;
I² = 39.6; 9 trials; very low certainty of evidence); and
serious adverse events (RR 0.82; 95% CI 0.67-1.01; 2132 participants;
I² = 68.4; 17 trials; very low certainty of evidence).
<br/>Conclusion(s): The evidence on the effects of clinical care with
access to cerebral NIRS monitoring is very uncertain. Impact: The evidence
of the effects of cerebral NIRS versus no NIRS monitoring are very
uncertain for mortality, neuroprotection, and serious adverse events.
Additional trials to obtain sufficient information size, focusing on
lowering bias risk, are required. The first attempt to systematically
review randomised clinical trials with meta-analysis to evaluate the
effects of cerebral NIRS monitoring by pooling data across various
clinical settings. Despite pooling data across clinical settings, study
interpretation was not substantially impacted by heterogeneity. We have
insufficient evidence to support or reject the clinical use of cerebral
NIRS monitoring.<br/>Copyright &#xa9; The Author(s) 2022.

<6>
Accession Number
2034302246
Title
Cardiac Papillary Fibroelastoma and Cerebrovascular Events: A Systematic
Review.
Source
CJC Open. 6(11) (pp 1259-1273), 2024. Date of Publication: November 2024.
Author
Neupane G.; Sharma R.; Parajuli R.; Mathews A.; Khalili H.
Institution
(Neupane) Department of Internal Medicine, Mercy Hospital, Springfield,
MO, United States
(Sharma) Department of Internal Medicine, Florida Atlantic University,
Boca Raton, FL, United States
(Parajuli) Odum School of Ecology, University of Georgia, Athens, GA,
United States
(Parajuli) Department of Geosciences, Florida Atlantic University, Boca
Raton, FL, United States
(Mathews) Department of Cardiology, Tampa General Hospital, FL, United
States
(Khalili) Department of Cardiology, Memorial Healthcare System, FL, United
States
Publisher
Elsevier Inc.
Abstract
Background: Cardiac papillary fibroelastomas (CPFs) are benign endocardial
tumours with embolic potential. This article is a systematic review to
identify the clinical profile, diagnosis, tumour characteristics, and
treatment modalities in patients with CPF presenting with stroke or
transient ischemic attack (TIA). <br/>Method(s): This systematic review
was conducted using the PubMed and Embase databases, including case
reports and/or series and observational studies (for a search period of up
until April 2022). A descriptive summary of case reports and/or series,
and a narrative summary of observational studies, were completed.
<br/>Result(s): A total of 161 cases were identified from 133 case reports
and 11 case series. The mean age of patients was 54.8 years, and 46.6%
were male. TIA and stroke were reported in 32.3% and 67.8%, respectively.
The most common stroke territory was multiple brain sites (36.6%). The
mean tumour size was 11.8 mm. Most of the tumours were left-sided (98.7%).
The mitral valve was the most involved valve (38.9%), with the anterior
leaflet being the commonest site (61.3%). A total of 91.4% of tumours were
independently mobile; 10.6% of tumours missed by transthoracic
echocardiography were identified on transesophageal echocardiography.
Antiplatelet and anticoagulation treatment were used in 87.9% and 12.1% of
cases, respectively. Simple excision, valve repair, and valve replacement
were performed in 66.7%, 16.7%, and 16.7%, respectively. The logistic
regression model revealed that age was the only significant predictor; an
increase in the log-odds of recurrent cerebrovascular events occurred with
increasing age. <br/>Conclusion(s): CPFs are a differential diagnosis of
cryptogenic stroke, especially if the initial workup for stroke is
negative. Transesophageal echocardiography serves as a better imaging
tool, compared to transthoracic echocardiography, in identifying CPF.
Although the consensus for CPF management remains controversial, surgical
excision is the primary approach for left-sided CPF presenting as stroke
or TIA.<br/>Copyright &#xa9; 2024 The Authors

<7>
Accession Number
645299542
Title
The effect of eye mask on sleep quality and pain in patients undergoing
coronary artery bypass graft surgery: A double-blind randomized controlled
trial.
Source
Nursing in critical care. 29(6) (pp 1346-1354), 2024. Date of Publication:
01 Nov 2024.
Author
Dagcan Sahin N.; Nal B.; Gurol Arslan G.; Astarcioglu M.A.; Parlar A.I.
Institution
(Dagcan Sahin, Nal) Faculty of Health Sciences, Kutahya Health Sciences
University, Kutahya, Turkey
(Gurol Arslan) Fundamentals of Nursing Department, Nursing Faculty, Dokuz
Eylul University, Izmir, Turkey
(Astarcioglu) Department of Cardiology, Kutahya Health Science University,
Kutahya, Turkey
(Parlar) Department of Cardiovascular Surgery, Kutahya Health Science
University, Kutahya, Turkey
Abstract
BACKGROUND: Pain is one of the common postoperative issues that impair
recovery and quality of life in patients undergoing coronary artery bypass
graft (CABG) surgery. It leads to prolonged recovery and sleep
disturbances in patients. AIM: This study was conducted to examine the
effect of eye mask use on sleep quality and pain in patients undergoing
CABG surgery. STUDY DESIGN: A double-blind randomized trial design was
employed. The study included 60 patients undergoing CABG surgery. They
were divided into intervention and control groups through block
randomization. Data were collected using a 'Demographic Characteristics
Form', the 'Richards-Campbell Sleep Questionnaire (RCSQ)' and a 'Visual
Analogue Scale' (VAS) through face-to-face interviews. While patients in
the control group received standard care throughout the night, patients in
the intervention group received standard care and used eye mask. All
patients were followed up for three nights. The CONSORT was used to report
the study. <br/>RESULT(S): The main outcome of the study, the RCSQ score,
was higher in the intervention group at baseline. The intervention group
had higher RCSQ scores than the control group at time 1 and time 2. There
were no differences between the groups in the secondary outcome, pain
levels. The control group had higher pain scores at time 1 and time 2 than
the intervention group. <br/>CONCLUSION(S): The use of an eye mask after
CABG surgery is an effective, safe and simple nursing intervention to
improve sleep quality and control pain. RELEVANCE TO CLINICAL PRACTICE:
Because the use of an eye mask is an independent and unique nursing
intervention, nurses should be supported and allowed to practise
it.<br/>Copyright &#xa9; 2024 The Author(s). Nursing in Critical Care
published by John Wiley & Sons Ltd on behalf of British Association of
Critical Care Nurses.

<8>
Accession Number
645660568
Title
Diagnostic accuracy of NT-proBNP to predict the incidence of CSA-AKI: A
systematic review and meta-analysis.
Source
Medicine. 103(43) (pp e39479), 2024. Date of Publication: 25 Oct 2024.
Author
Zhang J.; Li X.; Yu X.
Institution
(Zhang) Department of Nephrology, Third Hospital of Mianyang/Sichuan
Mental Health Center, Mianyang, Sichuan, China
(Li) Department of Neurosurgery, Chengdu Third People's Hospital, Chengdu,
Sichuan, China
(Yu) Department of Cardiology, Third Hospital of Mianyang/Sichuan Mental
Health Center, Mianyang, Sichuan, China
Abstract
BACKGROUND: Cardiac surgery-associated acute kidney injury (CSA-AKI) is a
severe complication following cardiac surgery. Early identification and
diagnosis are critical. In this study, we aim to systematically assess the
diagnostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP)
for CSA-AKI. <br/>METHOD(S): The PubMed, Embase, Web of Science, and
Cochrane Library databases were searched from January 1971 to October 2023
to identify prospective observational and retrospective observational
studies. Data extraction and study screening were carried out
independently by 2 authors. The methodological quality of the included
studies was evaluated by the Quality Assessment of Diagnostic Accuracy
Studies 2 standards, and all statistical analyses were conducted by Stata
15.0. <br/>RESULT(S): Seven studies including 37,200 patients were
identified. The pooled sensitivity of 0.67 (95% credible interval [CI] =
0.56-0.77), specificity of 0.55 (95% CI = 0.45-0.64), area under the
summary receiver operating characteristic curve of 0.65 (95% CI =
0.60-0.69), positive likelihood ratio of 1.5 (95% CI = 1.2-1.8), negative
likelihood ratio of 0.60 (95% CI = 0.46-0.79), and diagnostic odds ratio
of 2 (95% CI = 2-4) suggested that patients with higher preoperative
NT-proBNP levels (pg/mL) are at higher risk of developing acute kidney
injury after cardiac surgery. However, NT-proBNP lacks sufficient
sensitivity and specificity to reliably predict CSA-AKI.
<br/>CONCLUSION(S): Our findings suggest that the diagnostic accuracy of
NT-proBNP to predict the incidence of CSA-AKI is limited. However, we
provide novel perspectives on the early detection of CSA-AKI biomarkers,
and it is urgent to identify more precise and practical biomarkers for the
early diagnosis of CSA-AKI.<br/>Copyright &#xa9; 2024 the Author(s).
Published by Wolters Kluwer Health, Inc.

<9>
Accession Number
645659740
Title
Transplant Trial Watch.
Source
Transplant international : official journal of the European Society for
Organ Transplantation. 37 (pp 13860), 2024. Date of Publication: 2024.
Author
Knight S.R.; O'Callaghan J.M.
Institution
(Knight, O'Callaghan) Centre for Evidence in Transplantation, Nuffield
Department of Surgical Sciences, University of Oxford, Oxford, United
Kingdom
(Knight) Oxford Transplant Centre, Churchill Hospital, Oxford, United
Kingdom
(O'Callaghan) University Hospitals Coventry & Warwickshire, Coventry,
United Kingdom

<10>
Accession Number
2035507729
Title
Predictive potential of pre-procedural cardiac and inflammatory biomarkers
regarding mortality following transcatheter aortic valve implantation: A
systematic review and meta-analysis.
Source
Heart and Lung. 69 (pp 229-240), 2025. Date of Publication: 01 Jan 2025.
Author
AziziKia H.; Mousavi A.; Shojaei S.; Shaker F.; Salabat D.; Bahri R.A.;
Dolama R.H.; Radkhah H.
Institution
(AziziKia) Student Research Committee, School of Medicine, Shahroud
University of Medical Sciences, Shahroud, Iran, Islamic Republic of
(Mousavi, Shojaei, Shaker, Salabat, Bahri, Dolama) School of Medicine,
Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of
(Mousavi, Shojaei, Shaker, Salabat, Dolama) Tehran Heart Center,
Cardiovascular Diseases Research Institute, Tehran University of Medical
Sciences, Tehran, Iran, Islamic Republic of
(Radkhah) Sina Hospital Department of Internal Medicine, Tehran, Iran,
Islamic Republic of
Publisher
Elsevier Inc.
Abstract
Background: Aortic stenosis (AS) is a common heart valve disease,
especially in aging populations. While surgical aortic valve replacement
(SAVR) is the standard treatment, many patients are ineligible.
Transcatheter aortic valve implantation (TAVI) offers an alternative,
especially for high-risk patients, but is not without complications.
Identifying biomarkers that predict post-TAVI mortality is essential for
optimizing outcomes. <br/>Objective(s): The purpose of this systematic
review and meta-analysis is to evaluate the role of cardiac and
inflammatory biomarkers in predicting short-term and mid to long-term
mortality following TAVI. <br/>Method(s): We searched PubMed, Scopus,
Embase, and Web of Science for studies examining the impact of
inflammatory and cardiac biomarkers on mortality following TAVI. Mean
differences (MDs) and 95 % confidence interval (CI) were calculated using
a random-effect model. <br/>Result(s): Twenty-eight studies involving
10,560 patients were included, with 1867 in the mortality group. Mortality
was significantly associated with higher pre-procedural levels of
creatinine (0.41; 95 % CI: [0.35, 0.48]), brain natriuretic peptide (0.58;
95 % CI: [0.43, 0.73]), C-reactive protein (0.55; 95 % CI: [0.45, 0.64]),
and white blood cell count (0.18; 95 % CI: [0.06, 0.31]), and lower
pre-procedural levels of hemoglobin (-0.49; 95 % CI: [-0.60, -0.38]) and
albumin (-0.18; 95 % CI: [-0.24, -0.13]). These associations remained
statistically significant in subgroup analyses for both mid to long-term
mortality and short-term mortality, except for WBC levels, which were not
significantly associated with short-term mortality, and Hb, for which
short-term data were insufficient. Platelet count showed no significant
difference. <br/>Conclusion(s): These findings highlight the importance of
inflammatory and cardiac biomarkers in risk stratification and patient
management in TAVI procedures.<br/>Copyright &#xa9; 2024 Elsevier Inc.

<11>
Accession Number
2032069119
Title
Evaluation of preoperative cardiopulmonary reserve and surgical risk of
patients undergoing lung cancer resection.
Source
Therapeutic Advances in Respiratory Disease. 18 (no pagination), 2024.
Date of Publication: January-December 2024.
Author
Petrella F.; Cara A.; Cassina E.M.; Faverio P.; Franco G.; Libretti L.;
Pirondini E.; Raveglia F.; Sibilia M.C.; Tuoro A.; Vaquer S.; Luppi F.
Institution
(Petrella, Faverio, Franco, Luppi) Division of Thoracic Surgery,
Fondazione IRCCS San Gerardo dei Tintori, Via GB Pergolesi 33, MB, Monza
20090, Italy
(Cara, Cassina, Faverio, Franco, Libretti, Pirondini, Raveglia, Sibilia,
Tuoro, Vaquer, Luppi) Division of Thoracic Surgery, Fondazione IRCCS San
Gerardo dei Tintori, Monza, Italy
(Faverio, Franco, Luppi) Division of Respiratory Disease, Fondazione IRCCS
San Gerardo dei Tintori, Monza, Italy
(Faverio, Franco, Luppi) School of Medicine and Surgery, University of
Milano-Bicocca, Milan, Italy
Publisher
SAGE Publications Ltd
Abstract
Lung cancer represents the second most frequent neoplasm and the leading
cause of neoplastic death among both women and men, causing almost 25% of
all cancer deaths. Patients undergoing lung resection-both for primary and
secondary tumors-require careful preoperative cardiopulmonary functional
evaluation to confirm the safety of the planned resection, to assess the
maximum tolerable volume of resection or to exclude surgery, thus shifting
the therapeutic approach toward less invasive options. Cardiopulmonary
reserve, pulmonary lung function and mechanical respiratory function
represent the cornerstones of preoperative assessment of patients
undergoing major lung resection. Spirometry with carbon monoxide diffusing
capacity, split function tests, exercise tests and cardiologic evaluation
are the gold standard instruments to safely assess the entire
cardiorespiratory function before pulmonary resection. Although pulmonary
mechanical and parenchymal function, together with cardiorespiratory
compliance represent the mainstay of preoperative evaluation in thoracic
surgery, the variables that are responsible for fitness in patients who
have undergone lung resection have expanded and are being continually
investigated. Nevertheless, because of the shift to older patients who
undergo lung resection, a global approach is required, taking into
consideration variables like frailty status and likelihood of
postoperative functional deterioration. Finally, the decision to go ahead
with surgery in fragile patients being consideredfor lung resection should
be evaluated in a multispecialty preoperative discussion to provide a
personalized risk stratification. The aim of this review is to focus on
preoperative evaluation of cardiopulmonary reserve and surgical risk
stratification of patients candidate for lung cancer resection. It does so
by a literature search of clinical guidelines, expert consensus
statements, meta-analyses, clinical recommendations, book chapters and
randomized trials (1980-2022).<br/>Copyright &#xa9; The Author(s), 2024.

<12>
Accession Number
2032035491
Title
Transplant Trial Watch.
Source
Transplant International. 37 (no pagination), 2024. Article Number: 13860.
Date of Publication: 2024.
Author
Knight S.R.; O'Callaghan J.M.
Institution
(Knight, O'Callaghan) Centre for Evidence in Transplantation, Nuffield
Department of Surgical Sciences, University of Oxford, Oxford, United
Kingdom
(Knight) Oxford Transplant Centre, Churchill Hospital, Oxford, United
Kingdom
(O'Callaghan) University Hospitals Coventry & Warwickshire, Coventry,
United Kingdom
Publisher
Frontiers Media SA

<13>
Accession Number
2035502617
Title
The effects of thoracic epidural blockade on ventilation-perfusion
matching during one-lung ventilation: An exploratory study.
Source
Journal of Clinical Anesthesia. 99 (no pagination), 2024. Article Number:
111678. Date of Publication: December 2024.
Author
Wang Y.; Wei Y.; Chen G.; Wang Z.; Fan Y.; Wang J.; Yang Y.; Zhou D.;
Zhong M.
Institution
(Wang, Chen, Yang, Zhong) Department of Critical Care Medicine, Zhongshan
Hospital, Fudan University, Shanghai, China
(Wei, Zhong) Shanghai Institute of Infectious Disease and Biosecurity,
School of Public Health, Fudan University, Shanghai, China
(Wang, Fan, Wang, Zhou) Department of Anesthesiology, Zhongshan Hospital,
Fudan University, Shanghai, China
(Zhong) Shanghai Key Laboratory of Lung Inflammation and Injury, Shanghai,
China
Publisher
Elsevier Inc.
Abstract
Objective: Electrical impedance tomography (EIT) enables continuous image
acquisition, facilitating real-time measurements of ventilation and
perfusion at the clinical bedside. Experimental and clinical studies on
controversial effects of thoracic epidural blockade (TEB) with local
anesthetics on ventilation-perfusion(V/Q) matching and hypoxia during one
lung ventilation (OLV) are rare. The aim of this study was to use EIT to
investigate the effects of TEB combined with general anesthesia on
pulmonary perfusion distribution and V/Q matching during one-lung
ventilation. <br/>Design(s): Single-centered, prospective, unblinded,
randomized, parallel-group clinical trial. <br/>Setting(s): Surgical suite
of a university-affiliated teaching hospital. <br/>Patient(s): Thirty
patients prepared for thoracic surgery were randomly assigned to either
the control group or the TEB group, which received a combination of
thoracic epidural blockade and general anesthesia. Measurements: EIT
measurements and blood gas analysis were conducted in the lateral position
during two-lung ventilation(T<inf>0</inf>), 15 min after
OLV(T<inf>1</inf>), and 15 min after administration of 0.25 % ropivacaine
or 0.9 % saline via epidural delivery during OLV(T<inf>2</inf>).
Hemodynamic and respiratory parameters were recorded, and Dead Space%,
Shunt%, and V/Q Match% were calculated based on blood gas analysis and EIT
images. <br/>Result(s): Mean arterial pressure (p < 0.05) significantly
decreased 15 min after TEB, while there were no significant changes in
heart rate among the 30 patients (p = 0.547). OLV resulted in a
significant decrease in arterial oxygen partial pressure/inspired oxygen
fraction (PaO<inf>2</inf>/FiO<inf>2</inf>) from T<inf>0</inf> to
T<inf>1</inf> in both groups. The PaO<inf>2</inf>/FiO<inf>2</inf> in the
TEB group was significantly lower after epidural administration of the
local anesthetic (p < 0.05). Shunt- ABG (%) was significantly higher in
the TEB group compared to the control group at T<inf>2</inf> (p < 0.05).
TEB increased non-ventilated perfusion distribution(p < 0.05), and
Shunt-EIT % (p < 0.05) and reduced Matched Region % (p < 0.05), while Dead
Space-EIT % remained (p = 0.499). <br/>Conclusion(s): Based on the
contrast-enhanced EIT evaluation of pulmonary perfusion and ventilation,
TEB appears to induce a V/Q mismatch in patients undergoing OLV in the
lateral position for thoracic surgery. Trial registration:
ClinicalTrials.gov, NCT04730089. Registration on January 25th,
2021.<br/>Copyright &#xa9; 2024

<14>
Accession Number
2035403118
Title
Surgical Treatment of Atrial Septal Defects.
Source
Reviews in Cardiovascular Medicine. 25(10) (no pagination), 2024. Article
Number: 350. Date of Publication: 2024.
Author
Grieshaber P.; Jaschinski C.; Farag M.; Fonseca-Escalante E.; Gorenflo M.;
Karck M.; Loukanov T.
Institution
(Grieshaber, Jaschinski, Farag, Fonseca-Escalante, Loukanov) Division of
Congenital Cardiac Surgery, Department of Cardiac Surgery, University
Hospital Heidelberg, Heidelberg 69120, Germany
(Gorenflo) Department of Pediatric Cardiology and Congenital Heart
Disease, University Hospital Heidelberg, Heidelberg 69120, Germany
(Karck) Department of Cardiac Surgery, University Hospital Heidelberg,
Heidelberg 69120, Germany
Publisher
IMR Press Limited
Abstract
Atrial septal defects (ASDs) are among the most prevalent congenital
cardiac malformations. Closure of the defect and repair of associated
cardiac malformations are typically indicated if an ASD is hemodynamically
significant or symptomatic. This narrative review aims to summarize key
aspects of surgical ASD closures. A non-systematic literature review was
conducted to cover surgically relevant aspects of (developmental) anatomy,
morphology, and treatment. ASDs result from diverse developmental
alterations, leading to subtype-specific associated cardiac malformations,
meaning surgical therapy varies accordingly. Presently, surgical repair
yields excellent outcomes for all ASD subtypes, with minimally invasive
approaches, especially in adults, increasingly employed for ASD closure.
Surgical ASD repair is safe with excellent results. However, familiarity
with ASD subtypes and typically associated lesions is crucial for optimal
patient management.<br/>Copyright &#xa9; 2024 The Author(s).

<15>
Accession Number
2035222764
Title
Meta-Analysis of Lowering LDL Cholesterol and its Impact on the
Cardiovascular System.
Source
Pakistan Journal of Medical and Health Sciences. 17(5) (pp 8-12), 2023.
Date of Publication: May 2023.
Author
Badalyan S.S.; Markosyan S.V.; Tariq H.; Malik Z.; Asghar A.
Institution
(Badalyan) (Organization) I.M. Sechenov First Moscow State Medical
University, Sechenov University, Russian Federation
(Markosyan) Yerevan State Medical University after Mkhitar Heratsi,
Armenia
(Tariq) Benazir Bhutto Shaheed Medical College, AJK, Pakistan
(Malik) University of Lahore, Pakistan
(Asghar) Institute of Pharmaceutical Sciences, University of Veterinary
and Animal Sciences, Lahore 54000, Pakistan
Publisher
Lahore Medical And Dental College
Abstract
Background: By lowering LDL cholesterol levels, the risk of coronary heart
disease (CHD) and other serious vascular events can be significantly
reduced. In order to prevent cardiovascular illnesses (CVD), mainly
coronary heart disease, LDL-cholesterol (LDL-C) levels must be tightly
controlled on both a primary and secondary level (CHD). Despite the fact
that patients in primary prevention experience a higher absolute number of
atherosclerotic cardiovascular (CV) events than those in secondary
prevention of CVD, subjects in primary prevention frequently receive
little attention when it comes to the clinical management of LDL-C levels.
<br/>Aim(s): To summarise the research supporting LDL cholesterol
reduction treatments for elderly people. <br/>Method(s): For this
meta-analysis, we searched PubMed, GOOGLE SCHOLAR, SCI.HUB, MEDLINE, and
Embase for publications released between January 1, 2017, and December 28,
2021. As recommended by the 2018 American Academy of Cardiology and
American Heart Association guidelines, randomised controlled trials
evaluating cardiovascular outcomes of an LDL cholesterol-lowering medicine
with a median follow-up of at least 2 years and data on older patients
(aged 75 years).The search for literature source was limited to randomized
controlled trials (human being). This meta-analysis, comprised of 24
trials from the Cholesterol Therapy Trialists' Collaboration meta-analysis
plus five other trials, used data from six journals. 21492 (8%) of the
244090 participants in 29 studies, were over the age of 75. Among them,
11750 (54%) came from statin trials, 6209 (28%) from ezetimibe trials, and
3533 (16%) from PCSK9 inhibitor trials. We conducted network meta-analyses
for the statins and non statin treatments. <br/>Result(s): Of the 244090
participants in 29 studies, 21492(8%) were over 75. These included 3533
(16%) from PCSK9 inhibitor studies, 11750 (54%) from statin trials, and
6209 (28%) from ezetimibe trials. A median follow-up period of 2 to 6
years was used. Without statistically differentiating from the risk
reduction in patients under the age of 75 (085 [078-092];
pinteraction=037), LDL cholesterol lowering significantly reduced the risk
of major vascular events (n=3519) by 26% for 1 mmol/L reduction in LDL
cholesterol (RR 074 [95% CI 061-089]; p=00019).In older patients, there
was no statistically significant difference in the RRs for statin (0.82
[0.73-0.91] and non-statin (0.67 [0.47-0.95]; pinteraction=0.64)
treatment. Reduced LDL cholesterol in older persons was shown to benefit
all components of the composite, including coronary revascularization (080
[066-096], stroke (073 [061-087], and myocardial infarction (080
[071-090]. Practical implication: This meta analysis can be used to
improve the treatment of people withlowering LDL cholesterol.
<br/>Conclusion(s): The viability and security of diminishing LDL
cholesterol in more seasoned adults are now supported by further research
provided by this meta-analysis. By non-statin and statin LDL
cholesterol-bringing down medication, we identified a risk reduction for
major vascular events that were at least as effective as that observed in
younger patients<br/>Copyright &#xa9; 2023 Lahore Medical And Dental
College. All rights reserved.

<16>
Accession Number
2035131688
Title
Study protocol for a single-centre randomised controlled trial to
investigate the effect of lung recruitment in paediatric patients after
cardiac surgery.
Source
BMJ Open. 12(5) (no pagination), 2022. Article Number: e063278. Date of
Publication: 17 May 2022.
Author
Gu M.; Deng N.; Xia W.; Deng L.; Liang G.
Institution
(Gu, Deng, Deng, Liang) Department of Critical Care Medicine, West China
Hospital of Sichuan University, Chengdu, China
(Xia) Department of Respiratory and Critical Care Medicine, West China
Hospital of Sichuan University, Chengdu, China
Publisher
BMJ Publishing Group
Abstract
Introduction A number of published studies have revealed that lung
recruitment can improve oxygenation, shorten the duration of mechanical
ventilation (MV) and decrease mortality in adults with acute hypoxaemic
respiratory failure, especially patients with acute respiratory distress
syndrome. However, few articles have assessed lung recruitment in
paediatric patients, especially after cardiac surgery. This clinical trial
aimed to determine whether lung recruitment can reduce the duration of MV
in paediatric patients with hypoxaemic respiratory failure after cardiac
surgery. Method and analysis In this trial, we will randomly assign 234
paediatric patients (aged 28 days to 14 years) within 72 hours after
cardiac surgery with an arterial oxygen tension (PaO<inf>2</inf>) to
fraction of inspired oxygen (FiO<inf>2</inf>) ratio (PaO<inf>2</inf>
/FiO<inf>2</inf>) of <300 to either a lung recruitment group or a
conventional group. The primary endpoint will be the duration of MV. The
secondary endpoints will be ventilator-free days, PaO<inf>2</inf>
/FiO<inf>2</inf>, respiratory system compliance, duration of non-invasive
ventilation, reintubation rate, length of intensive care unit stay, length
of hospital stay, occurrence of serious adverse events (barotrauma,
persistent hypotension and arrhythmia), postoperative pulmonary
complications. Ethics and dissemination The ethics committee of West China
Hospital of Sichuan University granted ethics approval for this study (20
August 2019). The results will be published in peer-reviewed journals and
presented at conferences. <br/>Copyright &#xa9; Author(s) (or their
employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use.
See rights and permissions. Published by BMJ.

<17>
Accession Number
2032120492
Title
Association of physical function with hospital readmissions among older
adults: A systematic review.
Source
Journal of Hospital Medicine. (no pagination), 2024. Date of Publication:
2024.
Author
Thomas E.M.; Smith J.; Curry A.; Salsberry M.; Ridgeway K.; Hunt B.;
Desanto K.; Falvey J.R.
Institution
(Thomas, Salsberry) School of Health and Rehabilitation Sciences, The Ohio
State University, Columbus, OH, United States
(Smith) Kinesiology Department, University of Connecticut, Storrs, CT,
United States
(Curry) Rehabilitation Services Department, Washington Hospital Healthcare
System, Fremont, CA, United States
(Ridgeway) Rehabilitation Therapy Services Department, University of
Colorado Hospital, UCHealth, Aurora, CO, United States
(Ridgeway) Physical Therapy Program, School of Medicine, University of
Colorado Anschutz Medical Campus, Aurora, CO, United States
(Hunt) Rehabilitation Services Department, Intermountain Health, Canyons
Region, Salt Lake, UT, United States
(Desanto) Strauss Health Sciences Library, University of Colorado Anschutz
Medical Campus, Aurora, CO, United States
(Falvey) Department of Physical Therapy and Rehabilitation Science and
Department of Epidemiology and Public Health, University of Maryland
School of Medicine, Baltimore, MD, United States
Publisher
John Wiley and Sons Inc
Abstract
Background: Hospital readmissions pose significant burdens on healthcare
systems, particularly among older adults. While efforts to reduce
readmissions have historically focused on medical management, emerging
evidence suggests physical function may also play a role in successful
care transitions. However, there is a limited understanding of the
relationship between functional measures and readmission risk. This
systematic review aims to assess the association between physical function
impairments and hospital readmissions. <br/>Objective(s): This systematic
review aims to assess the association between physical function
impairments and hospital readmissions. <br/>Method(s): A systematic review
was conducted following PRISMA guidelines, with studies identified through
databases including PubMed, CINAHL, Embase, and others published January
1, 2010-December 31, 2022. Inclusion criteria encompassed observational
studies of adults aged 50 and older in the United States, reporting
readmissions within 90 days of discharge and assessing physical function
across domains of the International Classification of Function model. Data
extraction and risk of bias assessment were independently conducted by two
authors using theScottish Intercollegiate Guidelines Network (SIGN) tool.
<br/>Result(s): Seventeen studies, representing 80,008 participants, were
included in this systematic review. Patient populations included a wide
array of medical populations, including general medical inpatients and
those undergoing cardiac surgery. Across various functional measures
assessed before or during admission, impairments were consistently
associated with increased risk for hospital readmissions up to 90 days
after admission. Measures of participation, including life-space mobility,
were also associated with increased readmission risk. <br/>Conclusion(s):
Functional impairments are robust predictors of hospital readmissions in
older adults. Routine assessment of physical function during
hospitalization can improve risk stratification and may support successful
care transitions, particularly in older adults.<br/>Copyright &#xa9; 2024
The Author(s). Journal of Hospital Medicine published by Wiley Periodicals
LLC on behalf of Society of Hospital Medicine.

<18>
Accession Number
2032095893
Title
Ectopic Calcification in Congenital Heart Surgery: A Material-Centric
Review.
Source
Pediatric Cardiology. (no pagination), 2024. Date of Publication: 2024.
Author
Watanabe T.; Yuhara S.; Leland J.T.; Spiess J.L.; Thodla A.; Ramachandiran
R.; Kelly J.M.; Shinoka T.; Breuer C.K.
Institution
(Watanabe, Yuhara, Leland, Spiess, Thodla, Ramachandiran, Kelly, Shinoka,
Breuer) Center for Regenerative Medicine, Research Institute at Nationwide
Children's Hospital, Columbus, OH, United States
(Kelly, Shinoka) The Heart Center, Nationwide Children's Hospital,
Columbus, OH, United States
(Shinoka) Department of Cardiothoracic Surgery, Nationwide Children's
Hospital, Columbus, OH, United States
(Breuer) Department of Surgery, Nationwide Children's Hospital, Columbus,
OH, United States
(Breuer) Department of Surgery, The Ohio State University College of
Medicine, Columbus, OH, United States
Publisher
Springer
Abstract
The modern congenital heart surgeon has an array of materials available
for cardiovascular repair. With advancements in the surgical outcomes for
pediatric cardiac defects, choice of material has become increasingly
dependent on late-term complications associated with each material.
Calcification is a leading long-term complication and is increasing in
prevalence with materials lasting longer in patients. Material
calcification can impair functionality, lead to subsequent complications,
and require additional interventions. A comprehensive literature review
was conducted to investigate ectopic calcification of commonly used
materials for congenital heart defect repair. Mechanisms of ectopic
calcification among commonly used materials were investigated. Ectopic
calcification is initiated by material-specific immunological reactions.
Recent efforts have focused on developing new materials that are not prone
to calcification. ePTFE was widely used in cardiovascular applications but
still has reported instances of calcification in various situations, such
as long-term use. Tissue engineering techniques have shown reduced
calcification in reports. Calcification can occur in all conventional
materials we reviewed and, in some cases, has led to life-threatening
complications. Favorable outcomes have been reported with
tissue-engineered materials, with the expectation of continued positive
results in future reports. With an array of synthetic and biological
materials now displaying acceptable surgical and short-term outcomes,
there is a pressing need to review the long-term viability of these
materials, especially considering improved patient survival to adulthood.
Furthermore, developing new materials to mitigate calcification remains a
promising avenue of research in this field.<br/>Copyright &#xa9; The
Author(s), under exclusive licence to Springer Science+Business Media,
LLC, part of Springer Nature 2024.

<19>
Accession Number
645658527
Title
Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis
and Myocardial Fibrosis: The EVOLVED Randomized Clinical Trial.
Source
JAMA. (no pagination), 2024. Date of Publication: 28 Oct 2024.
Author
Loganath K.; Craig N.J.; Everett R.J.; Bing R.; Tsampasian V.; Molek P.;
Botezatu S.; Aslam S.; Lewis S.; Graham C.; White A.C.; MacGillivray T.;
Tuck C.E.; Rayson P.; Cranley D.; Irvine S.; Armstrong R.; Milne L.; Chin
C.W.L.; Hillis G.S.; Fairbairn T.; Greenwood J.P.; Steeds R.; Leslie S.J.;
Lang C.C.; Bucciarelli-Ducci C.; Joshi N.V.; Kunadian V.; Vassiliou V.S.;
Dungu J.N.; Hothi S.S.; Boon N.; Prasad S.K.; Keenan N.G.; Dawson D.;
Treibel T.A.; Motwani M.; Miller C.A.; Mills N.L.; Rajani R.; Ripley D.P.;
McCann G.P.; Prendergast B.; Singh A.; Newby D.E.; Dweck M.R.
Institution
(Loganath, Craig, White, Tuck, Mills, Newby, Dweck) British Heart
Foundation Centre of Research Excellence, University of Edinburgh,
Edinburgh, United Kingdom
(Craig, Everett, Bing, White, Mills, Newby, Dweck) Edinburgh Heart Centre,
Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
(Tsampasian, Vassiliou) Norwich Medical School, University of East Anglia,
Norwich, United Kingdom
(Tsampasian, Vassiliou) Department of Cardiology, Norfolk and Norwich
University Hospital, Norwich, United Kingdom
(Molek) Department of Coronary Disease and Heart Failure, Jagiellonian
University Medical College, Krakow, Poland
(Botezatu) University of Medicine and Pharmacy Carol Davila, Cardiology
Department, Bucharest, Romania
(Aslam, McCann, Singh) Department of Cardiovascular Sciences, University
of Leicester and the NIHR Leicester Biomedical Research Centre, Glenfield
Hospital, Leicester, United Kingdom
(Lewis, Rayson, Cranley, Irvine, Armstrong, Milne) Edinburgh Clinical
Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, United
Kingdom
(Graham) Edinburgh Clinical Research Facility, University of Edinburgh,
Edinburgh, United Kingdom
(MacGillivray) University of Edinburgh, Edinburgh, United Kingdom
(Chin) Department of Cardiology, National Heart Centre Singapore,
Singapore
(Chin) Cardiovascular Medicine ACP Duke NUS Medical School, Singapore
(Hillis) Medical School, University of Western Australia, Perth, WA,
Australia
(Hillis) Department of Cardiology, Royal Perth Hospital, Perth, WA,
Australia
(Fairbairn) Department of Cardiology, Liverpool Centre for Cardiovascular
Science, Liverpool Heart and Chest Hospital, Liverpool, United Kingdom
(Greenwood) Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
(Greenwood) Baker Heart and Diabetes Institute, Melbourne, VIC, Australia
(Steeds) Department of Cardiology, Queen Elizabeth Hospital Birmingham,
University Hospitals of Birmingham NHS Foundation Trust, Birmingham,
United Kingdom
(Leslie) Cardiac Unit, Raigmore Hospital, Inverness, United Kingdom
(Lang) Division of Molecular and Clinical Medicine, School of Medicine,
University of Dundee, Dundee, United Kingdom
(Lang) National University of Malaysia, Malaysia
(Bucciarelli-Ducci, Joshi) Bristol Heart Institute, University Hospitals
Bristol NHS Foundation Trust, Bristol, United Kingdom
(Bucciarelli-Ducci, Prasad) Royal Brompton and Harefield Hospitals, Guys'
and St Thomas NHS Foundation Trust, London, United Kingdom
(Kunadian) Translational and Clinical Research Institute, Faculty of
Medical Sciences, Newcastle, United Kingdom
(Kunadian) University and Cardiothoracic Centre, Freeman Hospital,
Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne,
United Kingdom
(Dungu) Essex Cardiothoracic Centre, Nethermayne, Basildon, Essex, United
Kingdom
(Dungu) Anglia Ruskin University, Chelmsford, Essex, United Kingdom
(Hothi) Department of Cardiology, Royal Wolverhampton NHS Trust, Institute
of Cardiovascular Sciences, University of Birmingham, Wolverhampton,
United Kingdom
(Boon) Retired, Hertfordshire, United Kingdom
(Keenan) Department of Cardiology, West Hertfordshire Hospitals NHS Trust,
Watford, United Kingdom
(Keenan) Imperial College, London, United Kingdom
(Dawson) Aberdeen Cardiovascular and Diabetes Centre, University of
Aberdeen, Aberdeen, United Kingdom
(Treibel) Institute of Cardiovascular Sciences, University College London,
and St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield,
London, United Kingdom
(Motwani) Department of Cardiology, Manchester Royal Infirmary, Manchester
University NHS Foundation Trust, Manchester, United Kingdom
(Miller) Division of Cardiovascular Sciences, School of Medical Sciences,
Faculty of Biology, Medicine and Health, Manchester Academic Health
Science Centre, University of Manchester, Manchester, United Kingdom
(Mills) Usher Institute, University of Edinburgh, Edinburgh, United
Kingdom
(Rajani) Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
(Ripley) Cardiology, Northumbria Healthcare NHS Foundation Trust,
Newcastle upon Tyne, United Kingdom
(Prendergast) Cleveland Clinic London and St Thomas' Hospital, London,
United Kingdom
Abstract
Importance: Development of myocardial fibrosis in patients with aortic
stenosis precedes left ventricular decompensation and is associated with
an adverse long-term prognosis. <br/>Objective(s): To investigate whether
early valve intervention reduced the incidence of all-cause death or
unplanned aortic stenosis-related hospitalization in asymptomatic patients
with severe aortic stenosis and myocardial fibrosis. <br/>Design, Setting,
and Participant(s): This prospective, randomized, open-label, masked end
point trial was conducted between August 2017 and October 2022 at 24
cardiac centers across the UK and Australia. Asymptomatic patients with
severe aortic stenosis and myocardial fibrosis were included. The final
date of follow-up was July 26, 2024. <br/>Intervention(s): Early valve
intervention with transcatheter or surgical aortic valve replacement or
guideline-directed conservative management. <br/>Main Outcomes and
Measures: The primary outcome was a composite of all-cause death or
unplanned aortic stenosis-related hospitalization in a time-to-first-event
intention-to-treat analysis. There were 9 secondary outcomes, including
the components of the primary outcome and symptom status at 12 months.
<br/>Result(s): The trial enrolled 224 eligible patients (mean [SD] age,
73 [9] years; 63 women [28%]; mean [SD] aortic valve peak velocity of 4.3
[0.5] m/s) of the originally planned sample size of 356 patients. The
primary end point occurred in 20 of 113 patients (18%) in the early
intervention group and 25 of 111 patients (23%) in the guideline-directed
conservative management group (hazard ratio, 0.79 [95% CI, 0.44-1.43];
P=.44; between-group difference, -4.82% [95% CI, -15.31% to 5.66%]). Of 9
prespecified secondary end points, 7 showed no significant difference.
All-cause death occurred in 16 of 113 patients (14%) in the early
intervention group and 14 of 111 (13%) in the guideline-directed group
(hazard ratio, 1.22 [95% CI, 0.59-2.51]) and unplanned aortic stenosis
hospitalization occurred in 7 of 113 patients (6%) and 19 of 111 patients
(17%), respectively (hazard ratio, 0.37 [95% CI, 0.16-0.88]). Early
intervention was associated with a lower 12-month rate of New York Heart
Association class II-IV symptoms than guideline-directed conservative
management (21 [19.7%] vs 39 [37.9%]; odds ratio, 0.37 [95% CI,
0.20-0.70]). <br/>Conclusions and Relevance: In asymptomatic patients with
severe aortic stenosis and myocardial fibrosis, early aortic valve
intervention had no demonstrable effect on all-cause death or unplanned
aortic stenosis-related hospitalization. The trial had a wide 95% CI
around the primary end point, with further research needed to confirm
these findings. Trial Registration: ClinicalTrials.gov Identifier:
NCT03094143.

<20>
Accession Number
645654663
Title
Subcostal transversus abdominis plane block for epigastric cardiac
pacemaker operation: A randomised controlled trial.
Source
European journal of anaesthesiology. (no pagination), 2024. Date of
Publication: 28 Oct 2024.
Author
Kim J.-T.; Min J.; Park J.-B.; Jang Y.-E.
Institution
(Kim) From the Department of Anaesthesiology and Pain Medicine, Republic
of Korea (J-TK, Department of Thoracic and Cardiovascular Surgery, Seoul
National University Hospital, Seoul National University College of
Medicine, Seoul, South Korea

<21>
Accession Number
2035247758
Title
A Qualitative Study of Electronic Patient-Reported Outcome Symptom
Monitoring After Thoracic Surgery.
Source
Journal of Surgical Research. 303 (pp 744-755), 2024. Date of Publication:
November 2024.
Author
Boisson-Walsh A.; Cox C.; O'Leary M.; Shrestha S.; Carr P.; Gentry A.L.;
Hill L.; Newsome B.; Long J.; Haithcock B.; Stover A.M.; Basch E.; Leeman
J.; Mody G.N.
Institution
(Boisson-Walsh, Stover) Gillings School of Public Health, University of
North Carolina at Chapel Hill, Chapel Hill, NC, United States
(Cox, Gentry, Hill, Newsome, Long, Haithcock, Mody) Department of Surgery,
University of North Carolina at Chapel Hill, Chapel Hill, NC, United
States
(O'Leary, Shrestha, Carr, Stover, Basch, Mody) Lineberger Comprehensive
Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill,
NC, United States
(Leeman) School of Nursing, University of North Carolina at Chapel Hill,
Chapel Hill, NC, United States
Publisher
Academic Press Inc.
Abstract
Introduction: Thoracic surgery is a mainstay of therapy for lung cancer
and other chronic pulmonary conditions, but recovery is often complicated.
Digital health systems can facilitate remote postoperative symptom
management yet obstacles persist in their routine clinical adoption. This
study aimed to identify patient-perceived barriers and facilitators to
using an electronic patient-reported outcome (ePRO) monitoring platform
specially designed to detect complications from thoracic surgery
postdischarge. <br/>Method(s): Patients (n = 16) who underwent thoracic
surgery and participated in an ePRO parent study completed semistructured
interviews, which were analyzed using thematic content analysis and
iterative team-based coding. Themes were mapped onto the three domains of
the Capability, Opportunity, and Motivation Model of behavior framework to
inform ePRO design and implementation improvements. <br/>Result(s):
Analysis demonstrated seven dominant themes, including barriers (1.
postoperative patient physical and mental health, 2. lack of access to
email and poor internet connectivity, 3. lack of clarity on ePRO use in
routine clinical care, and 4. symptom item redundancy) as well as
facilitators (5. ease of the ePRO assessment completion, 6. engagement
with the surgical care team on ePRO use, and 7. increased awareness of
symptom experience through ePRO use). Suggested ePRO improvements included
offering alternatives to web-based completion, tailoring symptom
assessments to individual patients, and the need for patient education on
ePROs for perioperative care. <br/>Conclusion(s): Addressable barriers and
facilitators to implementation of ePRO symptom monitoring in the thoracic
surgical patient population postdischarge have been identified. Future
work will test the impact of design improvements on implementation
outcomes of feasibility and acceptability.<br/>Copyright &#xa9; 2024
Elsevier Inc.

<22>
[Use Link to view the full text]
Accession Number
2034969058
Title
Projection of visual material on postoperative delirium in patients
undergoing cardiac surgery: A double blind randomized clinical trial.
Source
Medicine (United States). 103(40) (pp e39470), 2024. Date of Publication:
04 Oct 2024.
Author
Mendez-Martinez C.; Casado-Verdejo I.; Fernandez-Fernandez J.A.;
Sanchez-Valdeon L.; Bello-Corral L.; Mendez-Martinez S.; Sandoval-Diez A.;
Gomez-Salgado J.; Garcia-Suarez M.; Fernandez-Garcia D.
Institution
(Mendez-Martinez, Casado-Verdejo, Fernandez-Fernandez, Sanchez-Valdeon,
Bello-Corral, Garcia-Suarez, Fernandez-Garcia) Health Research Nursing
Group (GREIS), University of Leon, Leon, Spain
(Mendez-Martinez, Mendez-Martinez, Sandoval-Diez, Garcia-Suarez)
University Hospital of Leon, Leon, Spain
(Casado-Verdejo, Fernandez-Fernandez, Sanchez-Valdeon, Bello-Corral,
Fernandez-Garcia) Department of Nursing and Physiotherapy, University of
Leon, Leon, Spain
(Gomez-Salgado) Department of Sociology, Social Work and Public Health,
Faculty of Labour Sciences, University of Huelva, Huelva, Spain
(Gomez-Salgado) Safety and Health Postgraduate Program, Universidad
Espiritu Santo, Guayaquil, Ecuador
Publisher
Lippincott Williams and Wilkins
Abstract
Background: Postoperative delirium is a neurobehavioral disorder that can
appear after surgery. It is characterized by an altered level of
consciousness and impaired cognitive function. The aim of this study was
to evaluate the impact of visual projection of images of relatives or
loved ones in patients undergoing cardiac surgery in the immediate
postoperative period, and its influence on the incidence and development
of postoperative delirium. <br/>Method(s): A randomized, double-blind
clinical trial was designed in the immediate postoperative period of adult
patients undergoing cardiac surgery. Consolidated Statement of Reporting
Trials guidelines were followed. A control group (CG) and an intervention
group (IG) were established. In the IG, the patients underwent a visual
projection, while the usual unit treatment was carried out with the CG.
Sociodemographic, anthropometric, anesthetic, and surgical variables were
also recorded. The postoperative delirium assessment scale used was the
confusion assessment method for diagnosing delirium in intensive care unit
patients. <br/>Result(s): Information was collected from 104 patients
undergoing cardiac surgery. Most of the patients included in the study
were men (66.35%) and the most performed surgical intervention was aortic
valve replacement (34.62%). In the CG, positive patients in postoperative
delirium increased from 19.23% to 25%, while in the IG they decreased from
5.77% to 1.92%. The logistic regression analysis presents a prediction
model where the variables that influence the model are gender and group
membership, meaning that being female and belonging to the IG
significantly reduce the presence of delirium. <br/>Conclusion(s): The
projection of visual material reduced the incidence of postoperative
delirium in patients undergoing cardiac surgery, although it cannot be
established that it is effective as a treatment once the pathology is
already established.<br/>Copyright &#xa9; 2024 the Author(s). Published by
Wolters Kluwer Health, Inc.

<23>
Accession Number
2032016922
Title
Stylet-driven leads compared with lumenless leads for left bundle branch
area pacing: a systematic review and meta-analysis.
Source
BMC Cardiovascular Disorders. 24(1) (no pagination), 2024. Article Number:
598. Date of Publication: December 2024.
Author
Chen X.; Dong J.
Institution
(Chen, Dong) Department of Cardiology, Capital Medical University
Affiliated Anzhen Hospital, No.2 of Anzhen Road, Chaoyang District,
Beijing 100029, China
(Chen) Department of Cardiology, Peking University International Hospital,
Beijing, China
Publisher
BioMed Central Ltd
Abstract
Objective: Left bundle branch area pacing (LBBAP) is a novel physiological
pacing method for treating left ventricular dyssynchrony. LBBAP is often
delivered using lumenless leads (LLL). However, recent studies have also
reported the use of style-driven leads (SDL). This study is the first
systematic review comparing the outcomes of LBBAP with SDL vs. LLL.
<br/>Method(s): The review and meta-analysis included all available
comparative studies published on Embase, PubMed, Web of Science, CENTRAL,
and Scopus up to 6th March 2024. <br/>Result(s): Eight observational
studies were included in the review. Meta-analysis showed that success
rates of LBBAP performed with LLL and SDL were comparable (OR: 1.72 95%
CI: 0.94, 3.17 I² = 38%). Duration of implantation and total
procedural duration were significantly lower in LBBAP performed with SDL.
The pacing threshold was significantly higher, while pacing impedance was
significantly lower in the SDL compared to the LLL group. Pacing QRS
interval, R-wave amplitude, and stimulus to peak left ventricular
activation time were similar in the two groups. Intra-operative and
post-operative dislodgement were significantly higher in the SDL group,
but no difference was noted in intra-operative perforation and
pneumothorax risk. <br/>Conclusion(s): Limited evidence from observational
studies with inherent selection bias shows that success rates for LBBAP
may not differ between SDL and LLL. While implantation of SDL may be
significantly faster, it carries a higher risk of lead dislodgement. Both
SDL and LLL are associated with comparable pacing characteristics except
for reduced pacing impedance with SDL.<br/>Copyright &#xa9; The Author(s)
2024.

<24>
Accession Number
2035429857
Title
Timing of Aortic Valve Intervention in the Management of Aortic Stenosis.
Source
JACC: Cardiovascular Interventions. 17(21) (pp 2502-2514), 2024. Date of
Publication: 11 Nov 2024.
Author
Maznyczka A.; Prendergast B.; Dweck M.; Windecker S.; Genereux P.;
Hildick-Smith D.; Bax J.; Pilgrim T.
Institution
(Maznyczka, Windecker, Pilgrim) Department of Cardiology, Inselspital,
Bern University Hospital, University of Bern, Bern, Switzerland
(Prendergast) St Thomas' Hospital and Cleveland Clinic London, London,
United Kingdom
(Dweck) British Heart Foundation Centre for Cardiovascular Science,
University of Edinburgh, Edinburgh, United Kingdom
(Genereux) Department of Cardiology, Gagnon Cardiovascular Institute,
Morristown Medical Center, Morristown, NJ, United States
(Hildick-Smith) Sussex Cardiac Centre, Royal Sussex County Hospital,
University Hospitals Sussex NHS Foundation Trust, Brighton, United Kingdom
(Bax) Department of Cardiology, Leiden University Medical Center, Leiden,
Netherlands
Publisher
Elsevier Inc.
Abstract
Aortic stenosis (AS) affects about 12% of people aged >=75 years.
Accumulating evidence on the prognostic importance of cardiac damage in
patients with asymptomatic and less than severe AS supports the
proposition of advancing aortic valve replacement (AVR) to earlier disease
stages. Potential benefits of earlier treatment, including prevention of
cardiac damage progression and reduced cardiovascular hospitalizations,
need to be balanced against the earlier procedural risk and subsequent
lifetime management after AVR. Two small, randomized trials indicate that
early surgical AVR may improve survival in patients with asymptomatic
severe AS, and observational data suggest that AVR may reduce mortality
even in patients with moderate AS. A clear understanding of the
pathophysiology of cardiac damage secondary to AS is needed to develop
strategies to select patients for earlier AVR. Noninvasive imaging can
detect early cardiac damage, and indices such as fibrosis, global
longitudinal strain, and myocardial work index have potential use to guide
stratification of patients for earlier AVR. Ongoing randomized trials are
investigating the safety and efficacy of AVR for patients with
asymptomatic severe AS and those with moderate AS who have
symptoms/evidence of cardiac damage. Pathophysiological considerations and
accumulating evidence from clinical studies that support earlier timing of
AVR for AS will need to be corroborated by the results of these trials.
This review aims to evaluate the evidence for earlier AVR, discuss
strategies to guide stratification of patients who may benefit from this
approach, highlight the relevant ongoing randomized trials, and consider
the consequences of earlier intervention.<br/>Copyright &#xa9; 2024 The
Authors

<25>
Accession Number
2035239677
Title
The effect of omentoplasty in various surgical operations: systematic
review and meta-analysis.
Source
International Journal of Surgery. 110(6) (pp 3778-3794), 2024. Date of
Publication: June 2024.
Author
Peng Y.; Xiong S.; Ding Y.; Xie L.; Wang Y.; Mei Y.; Liu W.; Deng T.
Institution
(Peng, Xiong, Ding, Xie, Wang, Mei, Deng) National Clinical Research
Center for Metabolic Diseases, Department of Metabolism and Endocrinology,
Hunan, Changsha, China
(Peng, Xiong, Ding, Xie, Wang, Mei, Deng) Key Laboratory of Diabetes
Immunology, Ministry of Education, Metabolic Syndrome Research Center,
Hunan, Changsha, China
(Liu) Department of Biliopancreatic Surgery and Bariatric Surgery, Hunan,
Changsha, China
(Deng) Clinical Immunology Center, The Second Xiangya Hospital of Central
South University, Hunan, Changsha, China
Publisher
Wolters Kluwer Health Inc
Abstract
Background: Omentoplasty is commonly used in various surgeries. However,
its effectiveness is unsure due to lack of convincing data and research.
To clarify the impact of omentoplasty on postoperative complications of
various procedures, this systematic review and meta-analysis was
performed. <br/>Method(s): A systematic review of published literatures
from four databases: PubMed, Web of Science, Cochrane Library, and Embase
before 14 July 2022. The authors primarily included publications on five
major surgical operations performed in conjunction with omentoplasty:
thoracic surgery, esophageal surgery, gastrointestinal surgery,
pelvi-perineal surgery, and liver surgery. The protocol was registered in
PROSPERO. <br/>Result(s): This review included 25 273 patients from 91
studies (n = 9670 underwent omentoplasty). Omentoplasty was associated
with a lower risk of overall complications particularly in
gastrointestinal [relative risk (RR) 0.53; 95% CI: 0.39-0.72] and liver
surgery (RR 0.54; 95% CI: 0.39-0.74). Omentoplasty reduced the risk of
postoperative infection in thoracic (RR 0.38; 95% CI: 0.18-0.78) and liver
surgery (RR 0.39; 95% CI: 0.29-0.52). In patients undergoing esophageal
(RR 0.89; 95% CI: 0.80-0.99) and gastrointestinal (RR 0.28; 95% CI:
0.23-0.34) surgery with a BMI greater than 25, omentoplasty is
significantly associated with a reduced risk of overall complications
compared to patients with normal BMI. No significant differences were
found in pelvi-perineal surgery, except infection in patients whose BMI
ranged from 25 kg/m² to 29.9 kg/m² (RR 1.25; 95% CI:
1.04-1.50) and anastomotic leakage in patients aged over 60 (RR 0.59; 95%
CI: 0.39-0.91). <br/>Conclusion(s): Omentoplasty can effectively prevent
postoperative infection. It is associated with a lower incidence of
multiple postoperative complications in gastrointestinal and liver
surgery.<br/>Copyright &#xa9; 2024 The Author(s).

<26>
Accession Number
2034768992
Title
Effect of Delayed Remote Ischemic Preconditioning on Acute Kidney Injury
and Outcomes in Patients Undergoing Cardiac Surgery: A Randomized Clinical
Trial.
Source
Circulation. 150(17) (pp 1366-1376), 2024. Date of Publication: 22 Oct
2024.
Author
Jia P.; Ji Q.; Zou Z.; Zeng Q.; Ren T.; Chen W.; Yan Z.; Shen D.; Li Y.;
Peng F.; Su Y.; Xu J.; Shen B.; Luo Z.; Wang C.; Ding X.
Institution
(Jia, Zou, Zeng, Ren, Chen, Yan, Shen, Li, Peng, Xu, Shen, Ding)
Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai
Medical Center of Kidney, Shanghai Key Laboratory of Kidney and Blood
Purification, China
(Ji, Wang) Department of Cardiovascular Surgery, Zhongshan Hospital, Fudan
University, Shanghai, China
(Su, Luo) Cardiac Intensive Care Center, Zhongshan Hospital, Fudan
University, Shanghai, China
Publisher
Lippincott Williams and Wilkins
Abstract
BACKGROUND: Remote ischemic preconditioning (RIPC) has 2 time windows for
organ protection: acute and delayed. Previous studies have mainly focused
on the organoprotective effects of acute RIPC. We aimed to determine
whether delayed RIPC can reduce the occurrence of acute kidney injury
(AKI) and postoperative complications in patients undergoing cardiac
surgery. <br/>METHOD(S): This prospective, single-center, double-blind,
randomized controlled trial involved 509 patients at high risk for AKI who
were scheduled for elective cardiac surgery requiring cardiopulmonary
bypass. Patients were randomized to receive RIPC (4 cycles of 5-minute
inflation and 5-minute deflation on 1 upper arm with a blood pressure
cuff) 24 hours before surgery or a sham condition (control group) that was
induced by 4 cycles of 5-minute inflation to a pressure of 20 mm Hg
followed by 5-minute cuff deflation. The primary end point was the
incidence of AKI within the prior 7 days after cardiac surgery. The
secondary end points included renal replacement therapy during
hospitalization, change in urinary biomarkers of AKI and markers of
myocardial injury, duration of intensive care unit stay and mechanical
ventilation, and occurrence of nonfatal myocardial infarction, stroke, and
all-cause mortality by day 90. <br/>RESULT(S): A total of 509 patients
(mean age, 65.2+/-8.2 years; 348 men [68.4%]) were randomly assigned to
the RIPC group (n=254) or control group (n=255). AKI was significantly
reduced in the RIPC group compared with the control group (69/254 [27.2%]
versus 90/255 [35.3%]; odds ratio, 0.68 [95% CI, 0.47-1.00]; P=0.048).
There were no significant between-group differences in the secondary end
points of perioperative myocardial injury (assessed by the concentrations
of cardiac troponin T, creatine kinase myocardial isoenzyme, and NT-proBNP
[N-terminal pro-brain natriuretic peptide]), duration of stay in the
intensive care unit and hospital, and occurrence of nonfatal myocardial
infarction, stroke, and all-cause mortality by day 90. <br/>CONCLUSION(S):
Among high-risk patients undergoing cardiac surgery, delayed RIPC
significantly reduced the occurrence of AKI.<br/>Copyright &#xa9; 2024 The
Authors.

<27>
Accession Number
2034583066
Title
Complete vs Culprit-Only Revascularization in Older Patients With
Myocardial Infarction With or Without ST-Segment Elevation.
Source
Journal of the American College of Cardiology. 84(20) (pp 2014-2022),
2024. Date of Publication: 12 Nov 2024.
Author
Cocco M.; Campo G.; Guiducci V.; Casella G.; Cavazza C.; Cerrato E.;
Sacchetta G.; Moreno R.; Menozzi A.; Amat Santos I.; Diez Gil J.L.;
Scarsini R.; Picchi A.; Vadala G.; Pilato G.; Colaiori I.; Barbierato M.;
Arioti M.; Pavasini R.; Lanzilotti V.; Menozzi M.; Varbella F.; Erriquez
A.; Biscaglia S.
Institution
(Cocco, Campo, Pavasini, Erriquez, Biscaglia) Cardiology Unit, Azienda
Ospedaliero Universitaria di Ferrara, Ferrara, Italy
(Guiducci) Cardiology Unit, Azienda USL-IRCCS Reggio Emilia, S. Maria
Nuova Hospital, Reggio Emilia, Italy
(Casella, Lanzilotti) Cardiology Unit, Ospedale Maggiore, Bologna, Italy
(Cavazza, Menozzi) Cardiovascular Department, Infermi Hospital, Rimini,
Italy
(Cerrato, Varbella) Interventional Cardiology Unit, San Luigi Gonzaga
University Hospital, Orbassano, and Rivoli Infermi Hospital ASLTO3, Turin,
Rivoli, Italy
(Sacchetta) Cardiology Unit, Umberto I Hospital, ASP Siracusa, Siracusa,
Italy
(Moreno) Centro de Investigacion Biomedica en Red en Enfermedades
Cardiovasculares (CIBERCV), Madrid, Spain, Instituto de Investigacion
Hospital La Paz (IDIPAZ), University Hospital La Paz, Madrid, Spain
(Menozzi) S.C. Cardiologia, Ospedale Sant'Andrea, La Spezia, Italy
(Amat Santos) Centro de Investigacion Biomedica en Red en Enfermedades
Cardiovasculares (CIBERCV), Cardiology Department, Hospital Clinico
Universitario, Valladolid, Spain
(Diez Gil) Centro de Investigation Biomedica end Red en Enfermedades
Cardiovasculares, Cardiology Department, H. Universitario y Politecnico La
Fe, Valencia, Spain
(Scarsini) Azienda Ospedaliero Universitaria Integrata di Verona, Verona,
Italy
(Picchi) Cardiovascular Department, Azienda Unita Sanitaria Locale (USL)
Toscana Sud-Est, Misericordia Hospital, Grosseto, Italy
(Vadala) Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone,
Palermo, Italy
(Pilato) Department of Interventional Cardiology, San Giovanni Di Dio
Hospital, Agrigento, Italy
(Colaiori) Cardiology Unit, Ospedale Santa Maria Goretti, Latina, Italy
(Barbierato) Interventional Cardiology, Department of Cardio-Thoracic and
Vascular Sciences, Ospedale dell'Angelo, Mestre, Venice, Italy
(Arioti) Ospedale Santa Maria delle Croci, ASL Romagna, Ravenna, Italy
Publisher
Elsevier Inc.
Abstract
Background: The effectiveness of complete revascularization is well
established in patients with ST-segment elevation myocardial infarction
(STEMI), but it is less investigated in those with non-ST-segment
elevation myocardial infarction (NSTEMI). <br/>Objective(s): This study
aimed to assess whether complete revascularization, compared with
culprit-only revascularization, was associated with consistent outcomes in
older patients with STEMI and NSTEMI. <br/>Method(s): In the FIRE
(Functional Assessment in Elderly MI Patients with Multivessel Disease)
trial, 1,445 older patients with myocardial infarction (MI) were
randomized to culprit-only or physiology-guided complete
revascularization, stratified by STEMI (n = 256 culprit-only vs n = 253
complete) and NSTEMI (n = 469 culprit-only vs n = 467 complete). The
primary outcome comprised a composite of death, MI, stroke, or
revascularization at 1 year. The key secondary outcome included a
composite of cardiovascular death or MI at 1 year. <br/>Result(s): In the
overall study population, physiology-guided complete revascularization
reduced both primary and key secondary outcomes. The primary outcome
occurred in 54 (21.1%) STEMI patients randomized to culprit-only vs 41
(16.2%) STEMI patients of the complete group (HR: 0.75; 95% CI: 0.50-1.13)
and in 98 (20.9%) NSTEMI patients randomized to culprit-only vs 72 (15.4%)
NSTEMI patients of the complete group (HR: 0.71; 95% CI: 0.53-0.97), with
negative interaction testing (P for interaction, 0.846). Similarly, no
signal of heterogeneity with respect to the initial clinical presentation
was observed for the key secondary endpoint (P for interaction, 0.654).
<br/>Conclusion(s): Physiology-guided complete revascularization, compared
with culprit-only revascularization, provided consistent benefit across
the whole spectrum of patients with MI. (FIRE [Functional Assessment in
Elderly MI Patients With Multivessel Disease]; NCT03772743)<br/>Copyright
&#xa9; 2024 American College of Cardiology Foundation

<28>
Accession Number
2032016392
Title
Prophylactic corticosteroids for infants undergoing cardiac surgery with
cardiopulmonary bypass: a systematic review and meta-analysis of
randomized controlled trials.
Source
BMC Anesthesiology. 24(1) (no pagination), 2024. Article Number: 385. Date
of Publication: December 2024.
Author
Wang S.; Xu Y.; Yu H.
Institution
(Wang, Xu, Yu) Department of Anesthesiology, West China Hospital, Sichuan
University, Sichuan, Chengdu 610041, China
Publisher
BioMed Central Ltd
Abstract
Background: Prophylactic corticosteroids have been widely used to mitigate
the inflammatory response induced by cardiopulmonary bypass (CPB).
However, the impact of this treatment on clinically important outcomes in
infants remains uncertain. <br/>Method(s): We systematically searched
databases (Medline, Embase, and Cochrane Central Register of Controlled
Trials), Clinical Trials Registry, and Google Scholar from inception to
March 1, 2024. Randomized controlled trials (RCTs) in which infants
undergoing on-pump cardiac surgery received prophylactic corticosteroids
or placebo were selected. The risk of bias was assessed using the Cochrane
Collaboration risk-of-bias tool. Considering clinical heterogeneity
between studies, the random-effects model was used for analysis. Subgroup
analyses on the neonatal studies and sensitivity analyses by the
leave-one-out method were also conducted. <br/>Result(s): Eight RCTs
comprising 1,920 patients were included. Our analysis suggested no
significant difference in postoperative mortality (2.1% vs. 3.3%, risk
ratio (RR) = 0.71, 95% confidence interval (CI) [0.41, 1.21]).
Significantly increased insulin treatment in infants (19.0% vs. 6.5%, RR =
2.78, 95% CI [2.05, 3.77]) and significantly reduced duration of
mechanical ventilation in neonates (mean difference = -22.28 h, 95% CI
[-42.58, -1.97]) were observed in the corticosteroids group. There were no
differences between groups for postoperative acute kidney injury, cardiac
arrest, extracorporeal membrane oxygenation support, low cardiac output
syndrome, neurologic events, infection, or length of postoperative
intensive care unit stay. <br/>Conclusion(s): Current evidence does not
support the routine prophylactic use of corticosteroids in infants
undergoing cardiac surgery with CPB. Further large-scale research is
needed to investigate the optimal agent, dosing regimen, and specific
impact on various types of cardiac surgery. Trial registration: This
systematic review and meta-analysis was registered at the International
Prospective Register of Systematic Reviews (CRD42023400176).<br/>Copyright
&#xa9; The Author(s) 2024.

<29>
Accession Number
2031601509
Title
Proteomic Correlates and Prognostic Significance of Kidney Injury in Heart
Failure With Preserved Ejection Fraction.
Source
Journal of the American Heart Association. 13(20) (no pagination), 2024.
Article Number: e033660. Date of Publication: 15 Oct 2024.
Author
Salman O.; Zhao L.; Cohen J.B.; Dib M.J.; Azzo J.D.; Gan S.; Mark Richards
A.; Pourmussa B.; Doughty R.; Javaheri A.; Mann D.L.; Rietzschel E.; Zhao
M.; Wang Z.; Ebert C.; van Empel V.; Kammerhoff K.; Maranville J.; Gogain
J.; Dennis J.; Schafer P.H.; Seiffert D.; Gordon D.A.; Ramirez-Valle F.;
Cappola T.P.; Chirinos J.A.
Institution
(Salman, Cohen, Dib, Azzo, Gan, Zhao, Cappola, Chirinos) Hospital of the
University of Pennsylvania, Philadelphia, PA, United States
(Cohen, Pourmussa, Cappola, Chirinos) University of Pennsylvania Perelman
School of Medicine, Philadelphia, PA, United States
(Zhao, Wang, Ebert, Kammerhoff, Maranville, Schafer, Seiffert, Gordon,
Ramirez-Valle) Bristol Myers Squibb Company, Princeton, NJ, United States
(Mark Richards) Cardiovascular Research Institute, National University of
Singapore, Singapore
(Mark Richards) Christchurch Heart Institute, University of Otago, New
Zealand
(Doughty) University of Auckland, New Zealand
(van Empel) Department of Cardiology, Maastricht University Medical
Center, Maastricht, Netherlands
(Gogain, Dennis) SomaLogic, Inc, Boulder, CO, United States
(Javaheri, Mann) Washington University School of Medicine, St. Louis, MO,
United States
(Rietzschel) Department of Cardiovascular Diseases, Ghent University,
Ghent University Hospital, Ghent, Belgium
Publisher
American Heart Association Inc.
Abstract
BACKGROUND: Kidney disease is common in heart failure with preserved
ejection fraction (HFpEF). However, the biologic correlates and prognostic
significance of kidney injury (KI), in HFpEF, beyond the estimated
glomerular filtration rate (eGFR), are unclear. METHODS AND RESULTS: Using
baseline plasma samples from the TOPCAT (Treatment of Preserved Cardiac
Function Heart Failure With an Aldosterone Antagonist) trial, we measured
the following KI biomarkers: cystatin-C, fatty acid-binding protein-3,
Beta-2 microglobulin, neutrophil gelatinase-associated lipocalin, and
kidney-injury molecule-1. Factor analysis was used to extract the common
variability underlying these biomarkers. We assessed the relationship
between the KI-factor score and the risk of death or HF-related hospital
admission in models adjusted for the Meta-Analysis Global Group in Chronic
Heart Failure risk score and eGFR. We also assessed the relationship
between the KI factor score and ~5000 plasma proteins, followed by pathway
analysis. We validated our findings among HFpEF participants in the Penn
Heart Failure Study. KI was associated with the risk of death or
HF-related hospital admission independent of the Meta-Analysis Global
Group in Chronic Heart Failure risk score and eGFR. Both the risk score
and eGFR were no longer associated with death or HF-related hospital
admission after adjusting for the KI factor score. KI was predominantly
associated with proteins and biologic pathways related to complement
activation, inflammation, fibrosis, and cholesterol homeostasis. KI was
associated with 140 proteins, which reproduced across cohorts. Findings
regarding biologic associations and the prognostic significance of KI were
also reproduced in the validation cohort. <br/>CONCLUSION(S): KI is
associated with adverse outcomes in HFpEF independent of baseline eGFR.
Patients with HFpEF and KI exhibit a plasma proteomic signature indicative
of complement activation, inflammation, fibrosis, and impaired cholesterol
homeostasis.<br/>Copyright &#xa9; 2024 The Authors and Bristol Myers
Squibb.

<30>
Accession Number
2035284967
Title
Systematic Review of Case Manager Nurse in Heart Transplant and Heart
Failure Consultation.
Source
Transplantation Proceedings. (no pagination), 2024. Date of Publication:
2024.
Author
Villarreal-Granda P.; Recio-Platero A.; Martin-Bayo Y.; Durantez-Fernandez
C.; Cardaba-Garcia R.M.; Perez-Perez L.; Madrigal M.; Munoz-del Caz A.;
Bahillo Ruiz E.; Jimenez-Navascues L.; Prieto Zambrano P.;
Velasco-Gonzalez V.
Institution
(Villarreal-Granda, Martin-Bayo) Nursing Department (Graduate in
Nursing-Honorary collaborator), Faculty of Nursing, University of
Valladolid, Valladolid, Spain
(Recio-Platero) Unidad de Insuficiencia Cardiaca y Terapias Avanzadas,
Hospital Clinico Universitario de Valladolid, Valladolid, Spain
(Durantez-Fernandez, Cardaba-Garcia, Perez-Perez, Madrigal, Munoz-del Caz,
Bahillo Ruiz, Jimenez-Navascues, Velasco-Gonzalez) Nursing Department,
Faculty of Nursing, University of Valladolid, Valladolid, Spain
(Durantez-Fernandez, Cardaba-Garcia, Perez-Perez, Madrigal, Munoz-del Caz,
Velasco-Gonzalez) Nursing Care Research (GICE), Faculty of Nursing,
University of Valladolid, Valladolid, Spain
(Perez-Perez) Primary Care Management Valladolid West (SACYL), Valladolid,
Spain
(Munoz-del Caz) Hospital Clinico Universitario de Valladolid (HCUV),
Valladolid, Spain
(Bahillo Ruiz, Jimenez-Navascues) Nursing Department, Faculty of Health
Sciences, University of Valladolid, Soria, Spain
(Prieto Zambrano) Primary Care Management Valladolid East (SACYL),
Valladolid, Spain
Publisher
Elsevier Inc.
Abstract
Objective: To analyze the functions and activities of the case manager
nurse in the specialized practice of transplantation and heart failure.
<br/>Method(s): This systematic review is reported according to the PRISMA
guidelines. Selected articles were subjected to a detailed critical
reading and the evidence levels and recommendation grades of the Joanna
Briggs Institute were verified. The field of documentation search was
limited to the last 5 years. <br/>Result(s): Health education provided by
nursing is key in patients with heart failure and heart transplants. It
must be evidence-based and focuses primarily on promoting self-care and
adherence to therapy, although it includes other aspects such as
recognition of signs and symptoms by the patient. Both activities are
essential to prevent decompensations of heart failure, thus reducing
hospital readmissions and mortality rates. <br/>Conclusion(s): Nursing has
an essential role in multidisciplinary programs for the care of heart
failure and heart transplant patients. Case manager nurse role stands out
for being cost effective, as well as for improving treatment compliance
and reducing hospital stay and mortality rates. Nursing functions in this
practice ensure continuity and coordination of care between the different
health levels, increasing the patients' quality of life.<br/>Copyright
&#xa9; 2024 Elsevier Inc.

<31>
Accession Number
2032739633
Title
Direct Oral Anticoagulant Therapy With A Fully Magnetically Levitated LVAD
and Bridging to Heart Transplantation: A DOT-HM3 Study Analysis.
Source
Journal of Cardiac Failure. 30(11) (pp 1512-1515), 2024. Date of
Publication: November 2024.
Author
NETUKA I.V.A.N.; TUCANOVA Z.; MEHRA M.R.
Institution
(NETUKA, TUCANOVA) Institute for Clinical and Experimental Medicine,
Prague, Czechia
(MEHRA) Brigham and Women's Hospital and Harvard Medical School, Boston,
MA, United States
Publisher
Elsevier B.V.

<32>
Accession Number
2032037538
Title
Pooled comparative analysis of transcatheter aortic valve replacement
versus surgical aortic valve replacement in patients with left ventricular
assist device.
Source
General Thoracic and Cardiovascular Surgery. (no pagination), 2024. Date
of Publication: 2024.
Author
Magouliotis D.E.; Giamouzis G.; Athanasiou T.; Spiliopoulos K.; Briasoulis
A.; Skoularigis J.; Triposkiadis F.; Xanthopoulos A.
Institution
(Magouliotis) Department of Cardiac Surgery Research, Lankenau Institute
for Medical Research, Main Line Health, Wynnewood, PA 19096, United States
(Magouliotis, Spiliopoulos) Unit of Quality Improvement, Department of
Cardiothoracic Surgery, University of Thessaly, Larissa 41110, Greece
(Giamouzis, Skoularigis, Triposkiadis, Xanthopoulos) Department of
Cardiology, University Hospital of Larissa, Larissa 41110, Greece
(Athanasiou) Department of Surgery and Cancer, Imperial College London,
London W2 1NY, United Kingdom
(Briasoulis) Department of Clinical Therapeutics, Faculty of Medicine,
Alexandra Hospital, National and Kapodistrian University of Athens, Athens
11528, Greece
Publisher
Springer
Abstract
A thorough literature search was conducted on patients with Left
Ventricular Assist Device (LVAD) and aortic insufficiency undergoing
transcatheter aortic valve replacement (TAVR). We identified all original
research studies that compared the long-term outcomes of surgical
transcatheter aortic valve replacement (SAVR) versus TAVR for patients
with LVAD, published between 1990 and 2023. The primary endpoint was the
composite of in-hospital mortality, stroke, transient ischemic attack,
myocardial infarction (MI), pacemaker implantation, vascular complications
and cardiac tamponade. Secondary endpoints were the median overall
survival (OS), the incidence of acute kidney injury (AKI), any bleeding
needing transfusions or reintervention and cost. A total of fourteen
studies and 358 patients were included (TAVR: 242; SAVR: 116). The
composite outcome, the incidence of AKI, the bleeding needing transfusion,
along with cost were significantly higher in the SAVR group. In addition,
there was no significant difference between TAVR and SAVR in terms of
median OS. The median OS in the TAVR group was 18 months. Finally, the
most common causes of death were progression of heart failure and
pneumonia. The present meta-analysis indicates that TAVR is associated
with enhanced outcomes compared to SAVR for patients with LVAD presenting
aortic insufficiency. Further well-designed original studies with greater
sample sizes are necessary to validate our findings.<br/>Copyright &#xa9;
The Author(s), under exclusive licence to The Japanese Association for
Thoracic Surgery 2024.

<33>
Accession Number
2035209223
Title
Use of wearable devices to monitor post-operative activity following
cardiac surgery: a systematic scoping review.
Source
European Journal of Cardiovascular Nursing. 23(7) (pp 697-710), 2024. Date
of Publication: 01 Oct 2024.
Author
Edney J.; McDonall J.; Khaw D.; Hutchinson A.F.
Institution
(Edney) Cardiac Surgery Department, Epworth HealthCare, 189 Bridge Rd
Richmond, Melbourne, VIC 3004, Australia
(McDonall, Khaw, Hutchinson) School of Nursing & Midwifery, Institute of
Health Transformation, Centre for Quality and Patient Safety Research,
Epworth Health Care Partnership, Deakin University, Melbourne, VIC,
Australia
Publisher
Oxford University Press
Abstract
Aims: There is an emerging trend of using wearable digital technology to
monitor patient activity levels in acute care contexts. However, the
overall extent and quality of evidence for their use in acute cardiac
surgery care are unclear. The purpose of this systematic scoping review
was to evaluate current literature regarding the use of wearable activity
trackers/accelerometers to monitor patient activity levels in the first 30
days following cardiac surgery. Method and results: A systematic scoping
review was conducted. A search of CINAHL and MEDLINE Complete databases
identified all peer reviewed research evidence published in English
between 2010 and 2023. Studies evaluating the use of wearable technology
in adults who had undergone coronary artery bypass graft surgery and valve
replacement were included. Study data were summarized thematically. A
total of 853 citations were identified. Once duplicates were removed, 816
studies were screened by title and abstract, 54 full-text studies were
assessed for eligibility, and 11 studies were included. Accelerometers
were able to capture changing exercise and physical activity levels over
an acute care admission. Device use was acceptable to clinicians and
patients. Low activity levels in the early post-operative period were
associated with longer length of stay and higher 30-day readmissions.
<br/>Conclusion(s): Wearable devices are acceptable and feasible to use in
acute care. The use of wearable activity trackers by acute cardiac
patients may increase patient participation in exercise and identify more
sedentary patients who are a greater risk of increased length of stay and
hospital readmission. <br/>Copyright &#xa9; 2024 The Author(s).

<34>
Accession Number
2032105651
Title
Components of home-based palliative and supportive care for adults with
heart failure: A scoping review.
Source
Palliative Medicine. (no pagination), 2024. Date of Publication: 2024.
Author
Perera M.; Halahakone U.; Senanayake S.; Kularatna S.; Parsonage W.; Yates
P.; Singh G.K.
Institution
(Perera, Yates, Singh) Cancer and Palliative Care Outcomes Centre, School
of Nursing, Queensland University of Technology, Brisbane, QLD, Australia
(Perera, Halahakone, Senanayake, Kularatna, Parsonage, Yates, Singh)
Centre for Healthcare Transformation, Faculty of Health, Queensland
University of Technology, Brisbane, QLD, Australia
(Halahakone, Senanayake, Kularatna, Parsonage) Australian Centre for
Health Service Innovation, Queensland University of Technology, Brisbane,
QLD, Australia
(Senanayake, Kularatna) Health Services and Systems Research, Duke-NUS
Medical School, Singapore, Singapore
(Senanayake, Kularatna) National Heart Research Institute Singapore,
National Heart Centre Singapore, Singapore, Singapore
(Parsonage) Department of Cardiology, Royal Brisbane & Women's Hospital,
Brisbane, QLD, Australia
Publisher
SAGE Publications Ltd
Abstract
Background: Palliative care and supportive care provided in the home for
people with heart failure can improve quality of life, caregiver wellbeing
and reduce healthcare costs. Identifying components of home-based
palliative and supportive care in heart failure is useful to inform
tailored care to people with heart failure. <br/>Aim(s): To identify and
describe components of home-based palliative and supportive care in adults
with heart failure. <br/>Design(s): A scoping review was undertaken in
accordance with Joanna Briggs Institute guidelines. The protocol was
registered prospectively with the Open Science Framework
(https://doi.org/10.17605/OSF.IO/GHCME). Data sources: Embase, PubMed,
CINAHL and Cochrane databases were searched from inception in May 2023 and
re-run in January 2024. Original research focussed on palliative and
supportive care in the home setting that included adults diagnosed with
heart failure who have not undergone nor awaiting a heart transplant was
included. <br/>Result(s): Results were extracted from 13 papers based on
eight studies. The findings highlight that nurses supported by a
multidisciplinary team, providing symptom management, patient and carer
education and discussion of goals of care and advance care planning,
facilitates home-based palliative and supportive care for people with
heart failure. <br/>Conclusion(s): Ensuring patient and caregiver-centred
care supported by a multidisciplinary team is essential to delivering
home-based palliative and supportive care for people with heart failure.
Further research focussed on the role of digital interventions in
home-based palliative and supportive care, the composition of the
multidisciplinary team and research which includes individuals across all
stages of heart failure is needed.<br/>Copyright &#xa9; The Author(s)
2024.

<35>
Accession Number
2032095824
Title
The effect of spironolactone in reducing the risk of postoperative atrial
fibrillation in patients undergoing coronary artery bypass graft surgery:
randomized single-blind placebo-controlled study.
Source
General Thoracic and Cardiovascular Surgery. (no pagination), 2024. Date
of Publication: 2024.
Author
Farzaneh A.; Moradi M.; Safarpoor G.; Karamian A.
Institution
(Farzaneh, Moradi) Department of Cardiology, School of Medicine, Hamadan
University of Medical Sciences, Hamadan, Iran, Islamic Republic of
(Safarpoor) Department of Cardiac Surgery, Hamadan University of Medical
Sciences, Hamadan, Iran, Islamic Republic of
(Karamian) School of Medicine, Shahid Beheshti University of Medical
Sciences, Tehran, Iran, Islamic Republic of
Publisher
Springer
Abstract
Background: Postoperative atrial fibrillation (POAF), one of the most
common cardiac arrhythmias following coronary artery bypass graft (CABG)
surgery is associated with unfavorable outcomes. <br/>Objective(s): This
study investigated the effect of spironolactone administered two weeks
before surgery on the incidence of POAF in patients undergoing CABG.
<br/>Method(s): This randomized single-blind placebo-controlled study was
conducted on 130 CABG patients. All patients were randomly divided into
intervention and control groups including 65 cases for each group. In the
intervention group, patients received 50 mg of spironolactone orally daily
for 2 weeks before surgery, and in the control group patients received
placebo daily from 2 weeks before surgery. All patients were continuously
monitored for the occurrence of POAF for two weeks postoperatively.
<br/>Result(s): The mean age of the patients in the intervention and
control groups was 61.7 +/- 5.4 and 60 +/- 6.7 years, respectively. The
incidence of POAF in the intervention and control groups was 7.7% and 20%,
respectively (Odds Ratio = 0.33, P = 0.042). All demographic and clinical
variables were similar in patients with and without POAF (all P > 0.05).
<br/>Conclusion(s): Our findings revealed that in comparison to placebo,
the use of spironolactone is associated with reduced incidence of POAF in
CABG candidates.<br/>Copyright &#xa9; The Author(s), under exclusive
licence to The Japanese Association for Thoracic Surgery 2024.

<36>
Accession Number
2032095775
Title
Correction to: Superficial parasternal intercostal plane blocks in cardiac
surgery: a systematic review and meta-analysis (Canadian Journal of
Anesthesia/Journal canadien d'anesthesie, (2024), 71, 6, (883-895),
10.1007/s12630-024-02726-0).
Source
Canadian Journal of Anesthesia. (no pagination), 2024. Date of
Publication: 2024.
Author
Cameron M.J.; Long J.; Kardash K.; Yang S.S.
Institution
(Cameron, Long, Kardash, Yang) Faculty of Medicine, McGill University,
Montreal, QC, Canada
(Cameron) Department of Anesthesia, Jewish General Hospital, K1401-3755
Cote Sainte Catherine, Montreal, QC H3T 1E2, Canada
(Cameron, Yang) Lady Davis Research Institute, Montreal, QC, Canada
(Kardash, Yang) Department of Anesthesia, Jewish General Hospital,
Montreal, QC, Canada
Publisher
Springer
Abstract
The correct reference for reference 19 is Kumar et al., 2021.¹
Reference 32 should have been reference 21 of the manuscript, Zhang et
al., 2022.² References 33 to 38 have been renumbered to
correspond to the order in which they appear.<br/>Copyright &#xa9;
Canadian Anesthesiologists' Society 2024.

<37>
Accession Number
2032029123
Title
Prediction of Successful Liberation from Continuous Renal Replacement
Therapy Using a Novel Biomarker in Patients with Acute Kidney Injury after
Cardiac Surgery-An Observational Trial.
Source
International Journal of Molecular Sciences. 25(20) (no pagination), 2024.
Article Number: 10873. Date of Publication: October 2024.
Author
Tichy J.; Hausmann A.; Lanzerstorfer J.; Ryz S.; Wagner L.; Lassnigg A.;
Bernardi M.H.
Institution
(Tichy, Hausmann, Lanzerstorfer, Ryz, Lassnigg, Bernardi) Department of
Anesthesiology, Intensive Care Medicine and Pain Medicine, Division of
Cardiac Thoracic Vascular Anesthesia and Intensive Care Medicine, Medical
University of Vienna, Vienna 1090, Austria
(Wagner) Department of Internal Medicine III, Division of Nephrology and
Dialysis, Medical University of Vienna, Vienna 1090, Austria
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Abstract
An acute kidney injury (AKI) is the most common complication following
cardiac surgery, and can lead to the initiation of continuous renal
replacement therapy (CRRT). However, there is still insufficient evidence
for when patients should be liberated from CRRT. Proenkephalin A 119-159
(PENK) is a novel biomarker that reflects kidney function independently of
other factors. This study investigated whether PENK could guide successful
liberation from CRRT. Therefore, we performed a prospective,
observational, single-center study at the Medical University of Vienna
between July 2022 and May 2023, which included adult patients who
underwent cardiac surgery for a cardiopulmonary bypass; patients on
preoperative RRT were excluded. The PENK levels were measured at the time
of AKI diagnosis and at the initiation of and liberation from CRRT, and
were subsequently compared to determine whether the patients were
successfully liberated from CRRT. We screened 61 patients with
postoperative AKI; 20 patients experienced a progression of AKI requiring
CRRT. The patients who were successfully liberated from CRRT had mean PENK
levels of 113 +/- 95.4 pmol/L, while the patients who were unsuccessfully
liberated from CRRT had mean PENK levels of 290 +/- 175 pmol/L (p =
0.018). For the prediction of the successful liberation from CRRT, we
found an area under the curve of 0.798 (95% CI, 0.599-0.997) with an
optimal threshold value of 126.7 pmol/L for PENK (Youden Index = 0.53, 95%
CI, 0.10-0.76) at the time of CRRT liberation (sensitivity = 0.64,
specificity = 0.89). In conclusion, PENK is a novel biomarker that has the
potential to predict the successful liberation from CRRT for patients with
AKI after cardiac surgery.<br/>Copyright &#xa9; 2024 by the authors.

<38>
Accession Number
2035277497
Title
Secondary mitral regurgitation surgical management: a narrative review.
Source
Cardiovascular Diagnosis and Therapy. 14(5) (pp 958-973), 2024. Date of
Publication: 31 Oct 2024.
Author
Eapen S.R.; Zaky M.H.; Kostibas M.P.; Robich M.P.
Institution
(Eapen) Department of Thoracic and Cardiovascular Surgery, Cleveland
Clinic, Cleveland, OH, United States
(Zaky) Division of Cardiac Surgery, Department of Surgery, Yale School of
Medicine, New Haven, CT, United States
(Kostibas) Division of Adult Cardiothoracic Anesthesiology, Department of
Anesthesiology, Johns Hopkins School of Medicine, Baltimore, MD, United
States
(Robich) Division of Cardiac Surgery, Department of Surgery, Johns Hopkins
School of Medicine, Baltimore, MD, United States
Publisher
AME Publishing Company
Abstract
Background and Objective: The most common valvular heart disease in the US
is moderate to severe mitral regurgitation (MR). Function MR or secondary
MR comprises many of these cases. Moderate and severe secondary MR are
independently associated with increased all-cause mortality and
rehospitalization for heart failure. Both ischemic and nonischemic
cardiomyopathy can cause secondary MR via similar pathophysiology that
leads to inadequate valve leaflets coaptation. The management of secondary
MR is complex. The optimal treatment strategy for secondary MR remains
controversial, reflected in the vast array of treatment options and the
complexity of therapeutic decision-making. Several surgical mitral valve
repair techniques have been described in the literature. Many of these
aims to facilitate adequate valve leaflet coaptation. In this review, the
pathophysiology of MR is described with a focus on evaluating and managing
secondary MR. <br/>Method(s): A literature review was performed using
PubMed and Google Scholar. Clinical trials, meta-analyses, randomized
controlled trials, reviews, and systematic reviews were considered from
January 1, 1995 through December 31, 2022. Articles published in languages
other than English with limited text availability were excluded. Key
Content and Findings: Optimal therapeutic approach in severe secondary MR
is complex and several patient factor should be considered. We provide a
framework for the surgical management of secondary MR based on
echocardiographic parameters, the presence of ischemia, and myocardial
viability. <br/>Conclusion(s): Further study is needed to guide the
selection of patients most likely to benefit from mitral valve repair or
replacement in the setting of secondary MR.<br/>Copyright &#xa9; AME
Publishing Company.

<39>
Accession Number
2035191353
Title
Atrial tachyarrhythmia prevention by Shensong Yangxin after catheter
ablation for persistent atrial fibrillation: the SS-AFRF trial.
Source
European Heart Journal. 45(40) (pp 4305-4314), 2024. Date of Publication:
21 Oct 2024.
Author
Huang H.; Liu Y.; Shuai W.; Jiang C.; Zhang M.; Qu X.; Zheng W.; Yang H.;
Liu F.; Yu B.; Chen M.; Mu B.; Yao C.; Tang Y.; Huang C.; Ouyang F.; Jia
Z.
Institution
(Huang, Liu, Shuai, Tang, Huang) Department of Cardiology, Renmin Hospital
of Wuhan University, 238 Jiefang Road, Wuhan 430060, China
(Huang, Liu, Shuai, Tang, Huang) Cardiovascular Research Institute of
Wuhan University, 238 Jiefang Road, Wuhan 430060, China
(Huang, Tang, Huang) Hubei Key Laboratory of Cardiology, 238 Jiefang Road,
Wuhan 430060, China
(Jiang) Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang
University School of Medicine, Hangzhou, China
(Zhang) Department of Cardiology, The Second Affiliated Hospital, Shandong
University of Traditional Chinese Medicine, Jinan, China
(Qu) Department of Cardiology, The First Affiliated Hospital of Harbin
Medical University, Harbin, China
(Zheng) Department of Cardiology, Weihai Central Hospital, Weihai, China
(Yang) Department of Cardiology, The First Affiliated Hospital of Wannan
Medical College, Wuhu, China
(Liu) Department of Cardiology, The Second Hospital of Hebei Medical
University, Shijiazhuang, China
(Yu) Department of Cardiology, The First Hospital of China Medical
University, Shenyang, China
(Chen) Department of Cardiology, The Central Hospital of Wuhan, Tongji
Medical College, Huazhong University of Science and Technology, Wuhan,
China
(Mu) Department of Cardiology, General Hospital of Ningxia Medical
University, Yinchuan, China
(Yao) Peking University Clinical Research Institute, Peking University
First Hospital, Beijing, China
(Ouyang) Hongkong Asia Medical Group, University Medical Center
Hamburg-Eppendorf, University Heart and Vessel Center Hamburg,
Martinistrase 52, Hamburg 20246, Germany
(Jia) Department of Cardiology, Hebei Yiling Hospital, 385 Xinshibei Road,
Shijiazhuang 050091, China
(Jia) State Key Laboratory for Innovation and Transformation of Luobing
Theory, 238 Tianshan Street, Shijiazhuang 050035, China
Publisher
Oxford University Press
Abstract
Background and Despite advances in technology and techniques, the
recurrence rate of persistent atrial fibrillation (AF) following catheter
Aims ablation remains high. The Shensong Yangxin (SSYX) capsule, a
renowned traditional Chinese medicine formula, is used in the treatment of
cardiac arrhythmias. This trial aimed to investigate whether the SSYX can
improve clinical outcomes in patients who have undergone catheter ablation
for persistent AF. . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . Methods A multi-centre, randomized,
double-blind, placebo-controlled clinical trial was conducted at 66
centres in China among 920 patients with persistent AF undergoing first
ablation. Participants were randomized to oral SSYX, 1.6 g (.4 g/granule)
thrice daily (n = 460), or matched placebo (n = 460) for 12 months. The
primary endpoint was recurrent atrial tachyarrhythmias lasting for >=30 s
following a blanking period of 3 months. Secondary endpoints included time
to first documented atrial tachyarrhythmias, AF burden, cardioversion,
stroke/systemic embolism, changes in echocardiographic parameters, and
quality-of-life (QoL) score. Analyses were performed according to the
intention-to-treat principle. . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . Results A total of 920 patients
underwent randomization (460 assigned to SSYX group and 460 assigned to
placebo group). During the follow-up of 12 months, patients assigned to
SSYX had a higher event-free rate from recurrent atrial tachyarrhythmias
when compared with the placebo group (12-month Kaplan-Meier event-free
rate estimates, 85.5% and 77.7%, respectively; hazard ratio, .6; 95%
confidence interval .4-.8; P = .001). Patients assigned to receive SSYX
had a better QoL score at 12 months compared to those randomized to
placebo. There was no significant difference in the incidence of serious
adverse events between the two groups. . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . Conclusions Treatment with
SSYX following radiofrequency catheter ablation for persistent AF reduced
the incidence of recurrent atrial tachyarrhythmias and led to clinically
significant improvements in QoL during a 12-month follow-up in a Chinese
population.<br/>Copyright &#xa9; The Author(s) 2024. Published by Oxford
University Press on behalf of the European Society of Cardiology.

<40>
[Use Link to view the full text]
Accession Number
2035169071
Title
Introduction to the 2024 Cardiovascular Surgery-Themed Issue of
Circulation.
Source
Circulation. 150(17) (pp 1307), 2024. Date of Publication: 22 Oct 2024.
Author
Ruel M.; de Lemos J.; Fischbein M.; Hill J.A.
Publisher
Lippincott Williams and Wilkins

<41>
[Use Link to view the full text]
Accession Number
2035158350
Title
Bleeding After Cardiovascular Surgery: A Continuing Problem.
Source
Circulation. 150(17) (pp 1324-1326), 2024. Date of Publication: 22 Oct
2024.
Author
Sellke F.W.
Institution
(Sellke) Alpert Medical School of Brown University, Rhode Island Hospital,
Lifespan Cardiovascular Institute, Rhode Island Hospital, Providence,
United States
Publisher
Lippincott Williams and Wilkins

<42>
[Use Link to view the full text]
Accession Number
2035158349
Title
Topical Versus Intravenous Tranexamic Acid in Patients Undergoing Cardiac
Surgery: The DEPOSITION Randomized Controlled Trial.
Source
Circulation. 150(17) (pp 1315-1323), 2024. Date of Publication: 22 Oct
2024.
Author
Lamy A.; Sirota D.A.; Jacques F.; Poostizadeh A.; Noiseux N.; Efremov S.;
Demers P.; Akselrod B.; Wang C.Y.; Arora R.C.; Branny P.; McGuinness S.P.;
Brown C.D.; Jeanmart H.; Zhao Q.; Zhang H.; Belley-Cote E.P.; Whitlock
R.P.; Browne A.; Copland I.; Vincent J.; Khatun R.; Balasubramanian K.;
Bangdiwala S.I.; McGillion M.H.; Fox-Robichaud A.E.; Spence J.; Yusuf S.;
Devereaux P.J.
Institution
(Lamy, Belley-Cote, Whitlock, Copland, Vincent, Khatun, Balasubramanian,
Bangdiwala, McGillion, Spence, Yusuf, Devereaux) Population Health
Research Institute, Hamilton, ON, Canada
(Bangdiwala, Spence, Devereaux) Department of Health Research Methods,
Evidence, and Impact, McMaster University, Hamilton, ON, Canada
(Belley-Cote, Fox-Robichaud, Devereaux) Department of Medicine, McMaster
University, Hamilton, ON, Canada
(Lamy, Whitlock) Department of Surgery, McMaster University, Hamilton, ON,
Canada
(Spence) Department of Anesthesia, McMaster University, Hamilton, ON,
Canada
(McGillion) Department of School of Nursing, McMaster University,
Hamilton, ON, Canada
(Fox-Robichaud) Thrombosis and Atherosclerosis Research Institute,
McMaster University, Hamilton, ON, Canada
(Sirota) E. Meshalkin National Medical Research Center, Novosibirsk,
Russian Federation
(Wang) Department of Anesthesiology, Faculty of Medicine, University of
Malaya, Kuala Lumpur, Malaysia
(Efremov) Saint Petersburg State University Hospital, Russian Federation
(McGuinness) Auckland City Hospital, New Zealand
(Jacques) Institut Universitaire de Cardiologie et de Pneumologie de
Quebec, Universite Laval, Quebec, Canada
(Poostizadeh) Kelowna General Hospital, BC, Canada
(Noiseux) Centre de Recherche du Centre Hospitalier de l'Universite de
Montreal (CRCHUM), QC, Canada
(Demers) Montreal Heart Institute, University of Montreal, QC, Canada
(Akselrod) Petrovsky National Centre of Surgery, Moscow, Russian
Federation
(Arora) Division of Cardiac Surgery, University Hospitals Harrington Heart
and Vascular Institute, Cleveland, OH, United States
(Branny) Department of Cardiac Surgery, Hospital Agel Trinec-Podlesi,
Trinec, Czechia
(Brown) New Brunswick Heart Centre, Saint John, Canada
(Jeanmart) Centre Integre Universitaire de Sante et de Services Sociaux du
Nord-de-l'Ile-de-Montreal, Hopital du Sacre-Coeur de Montreal, QC, Canada
(Zhao) Rujin Hospital, Shanghai, China
(Zhang) Beijing Anzhen Hospital, China
(Browne) Hamilton Health Sciences, Hamilton General Hospital, ON, Canada
(Arora) Department of Surgery, Case Western Reserve University, Cleveland,
OH, United States
(Zhao) Shanghai Jiao Tong University School of Medicine, China
Publisher
Lippincott Williams and Wilkins
Abstract
BACKGROUND: Although intravenous tranexamic acid is used in cardiac
surgery to reduce bleeding and transfusion, topical tranexamic acid
results in lower plasma concentrations compared with intravenous
tranexamic acid, which may lower the risk of seizures. We aimed to
determine whether topical tranexamic acid reduces the risk of in-hospital
seizure without increasing the risk of transfusion among cardiac surgery
patients. <br/>METHOD(S): We conducted a multicenter, double dummy,
blinded, randomized controlled trial of patients recruited by convenience
sampling in academic hospitals undergoing cardiac surgery with
cardiopulmonary bypass. Between September 17, 2019, and November 28, 2023,
a total of 3242 patients from 16 hospitals in 6 countries were randomly
assigned (1:1 ratio) to receive either intravenous tranexamic acid
(control) through surgery or topical tranexamic acid (treatment) at the
end of surgery. The primary outcome was seizure, and the secondary outcome
was red blood cell transfusion. After the last planned interim analysis,
when 75% of anticipated participants had completed follow up, the data and
safety monitoring board recommended to terminate the trial, and upon
unblinding, the operations committee stopped the trial for safety.
<br/>RESULT(S): Among 3242 randomized patients (mean age, 66.0 years;
77.7% male), in-hospital seizure occurred in 4 of 1624 patients (0.2%) in
the topical group, and 11 of 1628 patients (0.7%) in the intravenous group
(absolute risk difference, -0.5% [95% CI, -0.9 to 0.03]; P=0.07). Red
blood cell transfusion occurred in 570 patients (35.1%) in the topical
group and in 433 (26.8%) in the intravenous group (absolute risk
difference, 8.3% [95% CI, 5.2-11.5]; P=0.007). The absolute risk
difference in transfusion of >=4 units of red blood cells in the topical
group compared with the intravenous group was 8.2% (95% CI, 3.4-12.9).
<br/>CONCLUSION(S): Among patients undergoing cardiac surgery, topical
administration of tranexamic acid resulted in an 8.3% absolute increase in
transfusion without reducing the incidence of seizure, compared with
intravenous tranexamic acid.<br/>Copyright &#xa9; 2024 American Heart
Association, Inc.

<43>
Accession Number
2031965555
Title
Post-operative delirium in different age groups and subtypes: a systematic
review of case reports.
Source
Frontiers in Neurology. 15 (no pagination), 2024. Article Number: 1465681.
Date of Publication: 2024.
Author
Guo J.; Guo X.; Liu W.; Zhou A.; Han J.; Yi R.; Dong L.; Zhou Y.
Institution
(Guo, Guo, Dong, Zhou) Department of Nursing, Zhongshan Hospital of
Traditional Chinese Medicine, Zhongshan, China
(Guo, Zhou, Han, Yi) The First School of Clinical Medicine, Xinxiang
Medical University, Xinxiang, China
(Liu) Department of Clinical Pharmacy, Zhongshan City People's Hospital,
Zhongshan, China
Publisher
Frontiers Media SA
Abstract
Aims: To explore the clinical presentations and outcomes among different
ages and subtypes of post-operative delirium patients. <br/>Design(s):
Systematic review of Published Cases. Methods and data sources: We
comprehensively searched PubMed, EMBASE, and MEDLINE for published case
reports of post-operative delirium up to April 2023. The systematic review
has been registered with PROSPERO. Two researchers independently conducted
unblinded reviews of the full-text articles. <br/>Result(s): This study
included 116 patients with post-operative delirium. Compared to
post-operative delirium patients aged 65 and above, those between 18 and
65 years old have lower rates of a history of hypertension, cardiovascular
disease and urinary system disorder comorbidities, as well as higher usage
rates of fentanyl analogs and lorazepam. Additionally, these patients
exhibit lower incidences of anemia and renal failure, along with a lower
mortality rate. Compared to post-operative delirium patients aged 65 and
above, those under 18 years old have a higher rate of fentanyl analog
usage and a higher incidence of post-operative delirium following
neurological surgeries. Among the hypoactive, hyperactive, and mixed
subtypes, the reasons for surgery, such as cardiovascular diseases,
reproductive system diseases, and neurological disorders, significantly
varied among these three subtypes. Furthermore, substance abuse history
and medication usage patterns also significantly varied among these three
subtypes. <br/>Conclusion(s): Our investigation has revealed noteworthy
insights into post-operative delirium in different patient populations.
Notably, age emerged as a pivotal factor. Compared to elderly patients
(>=65 years), those aged 18 to 65 demonstrate better prognosis.
Additionally, patients younger than 18 years with post-operative delirium
have a higher incidence of delirium following neurosurgical procedures
compared to those elderly patients. Additionally, a strong association was
found between a history of substance abuse and hyperactive delirium.
Variations in drug use patterns were observed across different subtypes.
Importantly, post-operative delirium patients younger than 18 years, as
well as those aged 18 to 65 with mixed-subtype delirium, exhibited similar
high mortality rates as elderly patients. This underscores the need for
increased attention to post-operative delirium patients under 65 and
highlights the necessity of rapid identification and early intervention
for these populations at risk of poor outcomes. Systematic review
registration:
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023473383,
Identifier [Registration ID: CRD 42023473383].<br/>Copyright &#xa9; 2024
Guo, Guo, Liu, Zhou, Han, Yi, Dong and Zhou.

<44>
Accession Number
2031601528
Title
Antiplatelet Strategy for Patients With Acute Coronary Syndrome Undergoing
Percutaneous Coronary Intervention: A Systematic Review and Network
Meta-Analysis.
Source
Journal of the American Heart Association. 13(20) (no pagination), 2024.
Article Number: e032490. Date of Publication: 15 Oct 2024.
Author
Ullah W.; Sandhyavenu H.; Taha A.; Gowda S.N.; Mukhtar M.; Polam A.R.;
Zahid S.; Fischman D.L.; Savage M.P.; Rao S.V.; Alkhouli M.
Institution
(Ullah, Fischman, Savage) Thomas Jefferson University Hospitals,
Philadelphia, PA, United States
(Taha, Polam) Weiss Memorial Hospital, Chicago, IL, United States
(Gowda) Houston Methodist DeBakey Heart and Vascular Center, Houston, TX,
United States
(Mukhtar) University Hospitals of Leicester National Health Service Trust,
Leicester, United Kingdom
(Zahid) Oregon Health and Science University, Portland, OR, United States
(Rao) New York University Langone Health, New York, NY, United States
(Alkhouli) Mayo Clinic, Rochester, MN, United States
(Sandhyavenu) UT Health San Antonio, San Antonio, TX, United States
Publisher
American Heart Association Inc.
Abstract
BACKGROUND: Optimal duration and choice of antiplatelet therapy in
patients with acute coronary syndrome undergoing percutaneous coronary
intervention remain controversial. METHODS AND RESULTS: Digital databases
(PubMed, Cochrane, and Embase) were queried to select all randomized
controlled trials on a post-percutaneous coronary intervention population
with acute coronary syndrome. Dual-antiplatelet therapy (DAPT) with
aspirin and clopidogrel for 12 months was compared with 4 major
strategies: high-potency, high-to low-potency, low-dose, and
short-duration DAPT. A network meta-analysis was performed to compare the
safety and efficacy of differ-ent antiplatelet strategies. This study was
the second updated manuscript under the International Prospective Register
of Systematic Review registration (CRD42021286552). Thirty-two randomized
controlled trials comprising 103 459 (51 750 ex-perimental, 51 709
control) patients were included. Compared with DAPT with aspirin and
clopidogrel for 12 months, high-to low-potency DAPT (risk ratio [RR], 0.69
[95% CI, 0.52-0.92]) and aspirin+prasugrel containing DAPT for 12 months
(RR, 0.84 [95% CI, 0.72-0.98]) had a significantly lower, whereas DAPT for
1 month followed by clopidogrel only (RR, 1.59 [95% CI, 1.06-2.39]) had a
higher, incidence of major adverse cardiovascular events at 1 year (median
follow-up). Prasugrel (RR, 1.35 [95% CI, 1.09-1.66]) and ticagrelor (RR,
1.38 [95% CI, 1.17-1.62]) containing DAPT for 12 months had significantly
higher rates, whereas high-to low-potency DAPT (RR, 0.85 [95% CI,
0.63-1.15]) had no significant risk of major bleeding. <br/>CONCLUSION(S):
Aspirin and ticagrelor for 3 months, followed by aspirin and clopidogrel
for the remaining duration, can be considered the optimal strategy for
treating post-percutaneous coronary intervention patients with acute
coronary syndrome because of a significantly reduced risk of major adverse
cardiovascular events without increasing the risk of
bleeding.<br/>Copyright &#xa9; 2024 The Author(s).

<45>
Accession Number
2031524238
Title
Comparison of systemic morphine, nalbuphine, and epidural analgesia on
acute and chronic postoperative pain in laparoscopic colorectal surgery: a
randomized controlled trial.
Source
Signa Vitae. 20(10) (pp 38-46), 2024. Date of Publication: October 2024.
Author
Jiang Y.; Liang X.-L.; Sun S.-F.; Chen Q.; Liu H.-L.
Institution
(Jiang, Liang, Sun, Chen, Liu) Department of anesthesiology, Chongqing
University Cancer Hospital, Chongqing 400030, China
Publisher
Pharmamed Mado Ltd
Abstract
This study aimed to assess the effectiveness of diverse postoperative
analgesic tech-niques in laparoscopic colorectal surgery and ascertain
whether systemic administration of nalbuphine is a suitable alternative
for this type of procedure. Sixty-nine patients suffering from colorectal
cancer and undergoing laparoscopic surgery were randomly divided into
three groups (n = 23, per group). Group R received patient-controlled
epidural analgesia (PCEA) with ropivacaine. Group M received
patient-controlled intravenous analgesia (PCIA) with morphine. Group N
received PCIA with nalbuphine. Pain at rest (PAR), movement-evoked pain
(MEP), stress hormone and any complications during the 72 hours after
surgery were recorded. Additionally, chronic post-surgical pain (CPSP) at
3 months and 6 months were also recorded. There was no significant
difference in PAR among the 3 groups. However, patients in Group N had a
higher intensity of MEP compared to those in Group R after surgery (p <
0.05). There was no significant difference in CPSP at 6 months among the 3
groups (p > 0.05), but the incidence of CPSP at 3 months was higher in
Group N (p = 0.01, as compared to Group R). The occurrences of pruritus
and postoperative nausea and vomiting (PONV) were observed to be
considerably greater in Group M as compared to the other two groups (p <
0.05). In conclusion, PCEA is more effective than PCIA with nalbuphine in
reducing postoperative MEP and CPSP at 3 months after laparoscopic
colorectal surgery. However, there was no significant difference between
PCEA and PCIA with nalbuphine in reducing CPSP at 6 months. Although
morphine and nalbuphine have the similar analgesic effects, morphine is
associated with more side effects. Therefore, PCIA with nalbuphine might
be a good option for patients who are not suitable for PCEA or have a high
risk for PONV or pruritus.<br/>Copyright &#xa9; 2024 The Author(s).

<46>
Accession Number
2030153074
Title
Clinical characteristics and outcomes in pseudomonas endocarditis: a
systematic review of individual cases: Systematic review of pseudomonas
endocarditis.
Source
Infection. 52(5) (pp 2061-2069), 2024. Date of Publication: October 2024.
Author
Meena D.S.; Kumar D.; Kumar B.; Bohra G.K.; Midha N.; Garg M.K.
Institution
(Meena, Kumar, Kumar, Bohra, Midha, Garg) Division of Infectious Diseases,
Department of Internal Medicine, All India Institute of Medical Sciences,
Jodhpur 342005, India
Publisher
Springer Science and Business Media Deutschland GmbH
Abstract
Background: The landscape of Pseudomonas infective endocarditis (IE) is
evolving with the widespread use of cardiac implantable devices and
hospital-acquired infections. This systematic review aimed to evaluate the
emerging risk factors and outcomes in Pseudomonas IE. <br/>Method(s): A
literature search was performed in major electronic databases (PubMed,
Scopus, and Google Scholar) with appropriate keywords and combinations
till November 2023. We recorded data for risk factors, diagnostic and
treatment modalities. This study is registered with PROSPERO,
CRD42023442807. <br/>Result(s): A total of 218 cases (131 articles) were
included. Intravenous drug use (IDUs) and prosthetic valve endocarditis
(PVE) were major risk factors for IE (37.6% and 22%). However, the
prosthetic valve was the predominant risk factor in the last two decades
(23.5%). Paravalvular complications (paravalvular leak, abscess, or
pseudoaneurysm) were described in 40 cases (18%), and the vast majority
belonged to the aortic valve (70%). The mean time from symptom onset to
presentation was 14 days. The incidence of difficult-to-treat resistant
(DTR) pseudomonas was 7.4%. Valve replacement was performed in 57.3% of
cases. Combination antibiotics were used in most cases (77%), with the
aminoglycosides-based combination being the most frequently used (66%).
The overall mortality rate was 26.1%. The recurrence rate was 11.2%.
Almost half of these patients were IDUs (47%), and most had aortic valve
endocarditis (76%). <br/>Conclusion(s): This review highlights the
changing epidemiology of Pseudomonas endocarditis with the emergence of
prosthetic valve infections. Acute presentation and associated high
mortality are characteristic of Pseudomonas IE and require aggressive
diagnostic and therapeutic approach.<br/>Copyright &#xa9; Springer-Verlag
GmbH Germany, part of Springer Nature 2024.

<47>
Accession Number
645638857
Title
Gradual Reperfusion in Cardioplegia-Induced Cardiac Arrest.
Source
Medicina (Kaunas, Lithuania). 60(10) (no pagination), 2024. Date of
Publication: 24 Sep 2024.
Author
von Zeppelin M.; Hecker F.; Keller H.; Hlavicka J.; Walther T.; Moritz A.;
Arsalan M.; Holubec T.
Institution
(von Zeppelin, Hecker, Hlavicka, Walther, Moritz, Arsalan, Holubec)
Department of Cardiovascular Surgery, University Hospital Frankfurt and
Johann Wolfgang Goethe University Frankfurt, Germany
(Keller) Department of Cardiovascular Surgery, Clinical Perfusion,
University Hospital Frankfurt and Johann Wolfgang Goethe University
Frankfurt, Germany
(Arsalan) Department of Cardiology and Angiology, Medical Clinic I,
University Hospital of the Justus Liebig University, Giessen 35392,
Germany
Abstract
Background and Objectives: The majority of cardiac surgical procedures are
performed using cardiopulmonary bypass and cardioplegia-induced cardiac
arrest. Cardiac arrest and reperfusion may lead to ischemia-reperfusion
injury of the myocardium. The aim of this study was to investigate whether
gradual reperfusion with a slow increase in oxygen partial pressure leads
to a reduction in reperfusion injury. <br/>Material(s) and Method(s):
Fifty patients undergoing elective cardiac surgery were included in this
prospective randomized study. Patients in the hyperoxemic (control) group
received conventional reoxygenation (paO2 250-300 mmHg). Patients in the
normoxemic (study) group received gradual reoxygenation (1st-minute venous
blood with paO2 30-40 mmHg, 2nd-minute arterial blood with paO2 100-150
mmHg). Periprocedural blood samples were taken serially, and markers of
myocardial injury were analyzed. In addition, the influence of gradual
reoxygenation on hemodynamics, inflammation, and the overall perioperative
course was evaluated. <br/>Result(s): There was a trend toward higher CK
levels in the hyperoxemia group without statistical significance; however,
CK-MB and troponin T levels did not show any statistical difference
between the two groups. Potassium concentrations in the coronary sinus
were significantly higher in the hyperoxemia group at 3 and 8 min after
opening of the aortic cross-clamp (6.88 +/- 0.87 mmol/L vs. 6.30 +/- 0.91
mmol/L and 5.87 +/- 0.73 mmol/L vs. 5.43 +/- 0.42 mmol/L, respectively; p
= 0.03 and p = 0.02). All other measurements did not show a statistical
difference between the two groups. <br/>Conclusion(s): The use of gradual
reperfusion in cardiac surgery with cardiopulmonary bypass and cardiac
arrest is safe. However, it does not reduce ischemia-reperfusion injury
compared to standard hyperoxemic reperfusion.

<48>
[Use Link to view the full text]
Accession Number
639543573
Title
Effect of Cytokine Adsorption on Mortality: A Meta-Analysis.
Source
Journal of the American Society of Nephrology. Conference: Kidney Week
2022. Orlando, FL United States. 33 (pp 729), 2022. Date of Publication:
2022.
Author
Schmidt B.M.; Lang H.; Barbosa C.V.; Tian Z.; Melk A.
Institution
(Schmidt, Lang, Barbosa, Tian) Department of Nephrology and Hypertension,
Hannover Medical School, Hannover, Germany
(Melk) Department of Pediatric Kidney,Liver and Metabolic Diseases,
Hannover Medical School, Hannover, Germany
Publisher
American Society of Nephrology
Abstract
Background: Cytokine adsorption using the CytoSorb device had been
proposed to be beneficial in various clinical settings including sepsis,
ARDS, hyperinflammatory syndromes, cardiac surgery or recovery after
cardiac arrest. The aim of this analysis was to provide evidence for the
efficacy of the CytoSorb device with regard to mortality in these
settings. <br/>Method(s): We searched Medline, Cochrane Library database
and used the database provided by CytosorbentsTM. Central Register of
Controlled Trials and clinicaltrials. gov for randomized, controlled
studies (01.1.2010-28.2.22). We considered randomized controlled trials
and observational studies with a control group. The longest reported
mortality (30 days-, hospital- or ICU-mortality) was defined as primary
endpoint. For analyzing the data we computed risk ratios and
95%-confidence intervals and used DerSimonian and Lairds random effects
model (R 4.1). We analysed all studies together and separated in the
subgroups sepsis, cardiac surgery, SARS-CoV-2 infection, recovery from
cardiac arrest, other severe illness. The meta-analysis was registered in
advance (PROSPERO: CRD42022290334). <br/>Result(s): Of initial 1249
publications, 37 trials were found eligible, in total including 1256
patients treated with CytoSorb and 1230 controls. Concerning the primary
endpoint mortality Cytosorb did not show a positive effect in all studies
together 1.10 [0.92; 1.33] RR [95%-CI], in sepsis 1.03 [0.81; 1.31], CPB
surgery 0.85 [0.51; 1.44], severe illness 1.05 [0.79; 1.39], SARS-CoV-2
1.58 [0.50; 4.94], and recovery from cardiac arrest 1.22 [1.02; 1.46]
(figure). Likewise we did not find significant difference in ICU length of
stay, lactate levels, or norepinephrine after treatment.
<br/>Conclusion(s): To date there is no evidence for a positive effect of
the CytoSorb adsorber on mortality across a bunch of indications that
justifies its widespread use in intensive care medicine. (Table
Presented).

<49>
Accession Number
2035096969
Title
Are Newer Drugs Better? An Analysis of Neonatal Pharmacological Treatments
across Generations.
Source
Medical Principles and Practice. 33(5) (pp 471-477), 2024. Date of
Publication: 10 Jun 2024.
Author
Lai N.M.; Veettil S.K.; Chaiyakunapruk N.; Glasziou P.
Institution
(Lai) School of Medicine, Faculty of Health and Medical Sciences, Taylor's
University, Subang Jaya, Malaysia
(Veettil) School of Pharmacy, Department of Pharmacy Practice,
International Medical University, Kuala Lumpur, Malaysia
(Chaiyakunapruk) Department of Pharmacotherapy, University of Utah College
of Pharmacy, Salt Lake City, UT, United States
(Glasziou) Institute for Evidence-Based Healthcare, Faculty of Health
Sciences & Medicine, Bond University, Gold Coast, QLD, Australia
Publisher
S. Karger AG
Abstract
Introduction: We evaluated the relative effects of newer versus older
medications for neonatal conditions and trends in margin of superiority
across generations. <br/>Material(s) and Method(s): We assessed network
meta-analyses (NMAs) on neonatal pharmacological interventions identified
from MEDLINE, Cochrane, and PROSPERO. Interventions were chronologically
arranged based on the earliest study and compared for their effects
against placebo or no treatment and their immediate predecessor. We
assessed the time trend in effect sizes using the Mann-Kendall test.
<br/>Result(s): From 8,048 retrieved records, 10 neonatal NMAs covering
352 trials and 102,653 participants were included. Compared to placebo,
56/61 (91.8%) interventions showed superiority with 23 (37.7%)
statistically significant. Compared to previous generation, 47/72 (65.3%)
showed superiority with 3 (4.2%) statistically significant. No significant
trends in effect sizes were observed across generations for most
conditions (p = 0.09 1). <br/>Conclusion(s): We found no evidence that
newer generation medications in neonatal care are consistently more
effective than older generation medications.<br/>Copyright &#xa9; 2024 The
Author(s).

<50>
Accession Number
2032939140
Title
Prognostic Value of CT-Derived Myocardial Biomarkers: Extracellular Volume
Fraction and Strain in Patients with Severe Aortic Stenosis Undergoing
Transcatheter Aortic Valve Replacement: A Systematic Review and
Meta-analysis.
Source
Academic Radiology. 31(11) (pp 4352-4364), 2024. Date of Publication:
November 2024.
Author
He X.; Li Y.; Wang Y.; Tian W.; Li Z.; Ge L.; Wang G.; Chen Z.
Institution
(He, Li, Wang, Tian, Li, Wang, Chen) Department of Radiology, The First
Hospital of Lanzhou University, The First Clinical Medical College of
Lanzhou University, Intelligent Imaging Medical Engineering Research
Center of Gansu Province, Accurate Image Collaborative Innovation
International Science and Technology Cooperation Base of Gansu Province,
Gansu Province Clinical Research Center for Radiology Imaging, Lanzhou
73000, China
(Ge) Evidence-Based Social Sciences Research Centre, School of Public
Health, Lanzhou University, Lanzhou 730030, China
Publisher
Elsevier Inc.
Abstract
Rationale and Objectives: This study aimed to investigate the prognostic
value of preoperative CT scan-derived myocardial biomarkers in patients
with severe aortic stenosis (AS) undergoing transcatheter aortic valve
replacement (TAVR). <br/>Material(s) and Method(s): In April 2024, three
databases (PubMed, Web of Science and Embase) were searched to identify
studies. A random-effects model for meta-analysis was conducted to
calculate pooled hazard ratios (HR) and 95% confidence intervals (CI) to
assess the prognostic value. The I² statistic was used to
assess heterogeneity. Meta-regression analysis was conducted to appraise
which variables yielded a significant impact on the HR of included
biomarkers. <br/>Result(s): 11 studies were identified, of which six
studies involved 678 patients reporting extracellular volume fraction
(ECV), one study involved 300 patients reporting ECV and left ventricular
global longitudinal strain (LVGLS), three studies involved 868 patients
reporting LVGLS and one study involved 376 patients reporting LVGLS and
peak left atrial longitudinal strain (PALS). The endpoints included
all-cause mortality, major adverse cardiovascular events (MACE) and a
composite outcome of the previous two. The meta-analysis revealed that
ECV, whether considered as a dichotomous variable (pooled HR: 3.87, 95%
CI: 2.63-5.70, I² = 0%), or as a continuous variable (pooled
HR: 1.12, 95% CI: 1.05-1.19, I² = 66%), and LVGLS, whether
considered as a dichotomous variable (pooled HR: 1.70, 95% CI: 1.30-2.22,
I² = 0%) or a continuous variable (pooled HR: 1.07, 95% CI:
1.04-1.10, I² = 0%) were all significant predictors for
outcomes in patients with severe AS after TAVR. Age, sex, follow-up time
and mean pressure gradient had a significant impact on the model of ECV
(continuous). <br/>Conclusion(s): The higher CT-derived ECV and impaired
LVGLS are able to predict worse outcomes in patients with severe AS who
have undergone TAVR.<br/>Copyright &#xa9; 2024 The Association of
University Radiologists

<51>
Accession Number
2032003493
Title
Comparing the Effectiveness of Open and Minimally Invasive Approaches in
Coronary Artery Bypass Grafting: A Systematic Review.
Source
Clinics and Practice. 14(5) (pp 1842-1868), 2024. Date of Publication:
October 2024.
Author
Alsharif A.; Alshamrani G.; Abu Alsoud A.; Abdullah R.; Aljohani S.;
Alahmadi H.; Fuadah S.; Mohammed A.; Hassan F.E.
Institution
(Alsharif, Alshamrani, Abu Alsoud, Abdullah, Aljohani, Fuadah, Mohammed)
Department of Medicine and Surgery, Batterjee Medical College, Jeddah
21442, Saudi Arabia
(Alsharif) Department of Medicine and Surgery, Vision College, Jeddah
23643, Saudi Arabia
(Alahmadi) Faculty of Medicine, Taibah University, Al-Madinah Almunawwarah
41477, Saudi Arabia
(Hassan) Medical Physiology Department, Kasr Alainy, Faculty of Medicine,
Cairo University, Giza 11562, Egypt
(Hassan) General Medicine Practice Program, Department of Physiology,
Batterjee Medical College, Jeddah 21442, Saudi Arabia
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Abstract
Coronary artery bypass grafting (CABG) is an essential operation for
patients who have severe coronary artery disease (CAD). Both open and
minimally invasive CABG methods are used to treat CAD. This in-depth
review looks at the latest research on the effectiveness of open versus
minimally invasive CABG. The goal is to develop evidence-based guidelines
that will improve surgical outcomes. This systematic review used databases
such as PubMed, MEDLINE, and Web of Science for a full electronic search.
We adhered to the PRISMA guidelines and registered the results in the
PROSPERO. The search method used MeSH phrases and many different study
types to find papers. After removing duplicate publications and conducting
a screening process, we collaboratively evaluated the full texts to
determine their inclusion. We then extracted data, including diagnosis,
the total number of patients in the study, clinical recommendations from
the studies, surgical complications, angina recurrence, hospital stay
duration, and mortality rates. Many studies that investigate open and
minimally invasive CABG methods have shown that the type of surgery can
have a large effect on how well the patient recovers and how well the
surgery works overall. While there are limited data on the possible
advantages of minimally invasive CABG, a conclusive comparison with open
CABG is still dubious. Additional clinical trials are required to examine
a wider spectrum of patient results.<br/>Copyright &#xa9; 2024 by the
authors.

<52>
Accession Number
2031994245
Title
Endoscopic Management of Post-Esophagectomy Delayed Gastric Conduit
Emptying (DGCE): Results from a Cohort Study in a Tertiary Referral Center
with Comparison between Procedures.
Source
Cancers. 16(20) (no pagination), 2024. Article Number: 3457. Date of
Publication: October 2024.
Author
Dell'Anna G.; Mandarino F.V.; Fanizza J.; Fasulo E.; Barchi A.; Bara R.;
Vespa E.; Viale E.; Azzolini F.; Fanti L.; Battaglia S.; Puccetti F.;
Cossu A.; Elmore U.; Fuccio L.; Annese V.; Malesci A.; Rosati R.; Danese
S.
Institution
(Dell'Anna, Mandarino, Fanizza, Fasulo, Barchi, Bara, Vespa, Viale,
Azzolini, Fanti, Malesci, Danese) Gastroenterology and Gastrointestinal
Endoscopy Unit, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan
20132, Italy
(Dell'Anna, Annese) Gastroenterology and Gastrointestinal Endoscopy Unit,
IRCCS Policlinico San Donato, Piazza Edmondo Malan 2, San Donato Milanese
20097, Italy
(Mandarino, Fanizza, Fasulo, Barchi, Bara, Elmore, Annese, Malesci,
Rosati, Danese) Faculty of Medicine and Surgery, Vita-Salute San Raffaele
University, Via Olgettina 56, Milan 20132, Italy
(Battaglia, Puccetti, Cossu, Elmore, Rosati) Gastrointestinal Surgery
Unit, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan 20132, Italy
(Fuccio) Unit of Gastroenterology, Department of Medical and Surgical
Sciences, S. Orsola-Malpighi University Hospital, University of Bologna,
Via Massarenti 9, Bologna 40138, Italy
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Abstract
Background/Objectives: Delayed gastric conduit emptying (DGCE) occurs in
15-39% of patients who undergo esophagectomy. Intra-Pyloric Injection of
Botulinum Toxin (IPBT), Pneumatic Balloon Dilation (PBD), and the same
session combination (BTPD) represent the main endoscopic procedures, but
comparative data are currently unavailable. <br/>Method(s): We
retrospectively analyzed prospectively collected data on all consecutive
patients with DGCE treated endoscopically with IPBT, PBD, or BTPD. ISDE
Diagnostic Criteria were used for DGCE diagnosis and classification. A
Gastric Outlet Obstruction Score was used for clinical staging. All
patients undergoing IPBT received 100 UI of toxin, while those undergoing
PBD were dilated up to 20 mm. Clinical success (CS) was defined as the
resolution of symptoms/resumption of feeding at discharge or expanding
dietary intake at any rate. Recurrence was defined as symptom relapse
after more than 15 days of well-being requiring endoscopic/surgical
intervention. <br/>Result(s): A total of 64 patients (81.2% male, 90.6%
Ivor-Lewis esophagectomy, 77.4% adenocarcinoma) with a median age of 62
years (IQR 55-70) were enrolled: 18 (28.1%) in the IPBT group, 24 (37.5%)
in the PBD group, and 22 (34.4%) in the BTPD group. No statistically
significant differences were found in the baseline characteristics,
surgical techniques, and median follow-up among the three groups. BTPD
showed a higher CS rate (100%) compared to the PD and BTPD groups (p =
0.02), and a Kaplan-Meier analysis with a log-rank test revealed that the
BTPD group was associated both with a significatively shorter mean time to
refeed of 1.16 days (95% CI 0.8-1.5; p = 0.001) and a shorter median time
to discharge of one day (95% CI 1-3; p = 0.0001). <br/>Conclusion(s):
Endoscopic management of DGCE remains challenging. Waiting for further
strong evidence, BTPD can offer patients a higher clinical efficacy rate
and a shorter time to refeed and be discharged.<br/>Copyright &#xa9; 2024
by the authors.

<53>
Accession Number
2031993828
Title
Evaluation of Red Blood Cell Biochemical Markers and Coagulation Profiles
Following Cell Salvage in Cardiac Surgery: A Systematic Review and
Meta-Analysis.
Source
Journal of Clinical Medicine. 13(20) (no pagination), 2024. Article
Number: 6073. Date of Publication: October 2024.
Author
Caceres-Matos R.; Luque-Oliveros M.; Pabon-Carrasco M.
Institution
(Caceres-Matos, Pabon-Carrasco) Research Group PAIDI-CTS-1050, "Complex
Care, Chronicity and Health Outcomes", Faculty of Nursing, Physiotherapy
and Podiatry, University of Seville, Seville 41009, Spain
(Luque-Oliveros) Cardiovascular and Thoracic Surgery Operating Theatre
Unit, Faculty of Nursing, Physiotherapy and Podiatry, Virgen Macarena
University Hospital, University of Seville, Seville 41009, Spain
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Abstract
Background: Individuals undergoing cardiac surgery face an increased risk
of bleeding, as well as alterations in biochemical and coagulation
patterns. Therefore, assessing the effectiveness of systems such as Cell
Salvage is necessary to prevent potential surgical complications.
<br/>Objective(s): To evaluate the efficacy of Cell Salvage in relation to
the biochemical parameters of the red blood series and coagulation, as
well as the risk of hemorrhage. <br/>Method(s): A systematic review,
accompanied by a meta-analysis, was executed via an extensive literature
exploration encompassing Medline, CINAHL, Scopus, Web of Science, and the
Cochrane Library. The inclusion criteria comprised studies in English or
Spanish, without year restrictions, conducted in adults and with a
randomized controlled trial design. <br/>Result(s): Twenty-six studies
were included in the systematic review, involving a total of 2850 patients
(experimental group = 1415; control group = 1435). Cell Salvage did not
demonstrate superior outcomes compared to allogeneic transfusions in the
management of post-surgical hemorrhage, as well as in total blood loss,
platelet count, fresh frozen plasma, and fibrinogen. However, Cell Salvage
showed a greater effectiveness for hemoglobin (moderate evidence),
hematocrit (low evidence), post intervention D-dimer (low evidence), and
some coagulation-related parameters (low evidence) compared to allogeneic
transfusions. Finally, better results were found in the control group for
INR parameters. <br/>Conclusion(s): The use of the Cell Salvage system
holds high potential to improve the postoperative levels of biochemical
and coagulation parameters. However, the results do not provide definitive
evidence regarding its effectiveness for hemorrhage control, platelet
count, fresh frozen plasma, and fibrinogen. Therefore, it is recommended
to increase the number of studies to assess the impact of the Cell Salvage
system on improvements in the red blood cell count and patient coagulation
patterns. In addition, protocols should be homogenized, and variables such
as the sex of the participants should be taken into account.<br/>Copyright
&#xa9; 2024 by the authors.

<54>
Accession Number
2031993823
Title
Diagnosis, Management and Outcome of Truncus Arteriosus Communis Diagnosed
during Fetal Life-Cohort Study and Systematic Literature Review.
Source
Journal of Clinical Medicine. 13(20) (no pagination), 2024. Article
Number: 6143. Date of Publication: October 2024.
Author
Wittek A.; Ploger R.; Walter A.; Strizek B.; Geipel A.; Gembruch U.;
Neubauer R.; Recker F.
Institution
(Wittek, Ploger, Walter, Strizek, Geipel, Gembruch, Neubauer, Recker)
Department of Obstetrics and Prenatal Medicine, University Hospital Bonn,
Venusberg Campus 1, Bonn 53127, Germany
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Abstract
Background/Objectives: Truncus arteriosus communis (TAC) is a rare
congenital heart defect characterized by a single arterial trunk that
supplies systemic, pulmonary, and coronary circulations. This defect,
constituting approximately 1-4% of congenital heart diseases, poses
significant challenges in prenatal diagnosis, management, and postnatal
outcomes. <br/>Method(s): A retrospective analysis was conducted at the
local tertiary referral center on cases of TAC diagnosed prenatally
between 2019 and 2024. Additionally, a systematic literature review was
performed to evaluate the accuracy of prenatal diagnostics and the
presence of associated anomalies in fetuses with TAC and compare already
published data with the local results. The review included studies that
especially described the use of fetal echocardiography, the course and
outcome of affected pregnancies, and subsequent management strategies.
<br/>Result(s): The analysis of local prenatal diagnoses revealed 14
cases. Of the 11 neonates who survived to birth, the TAC diagnosis was
confirmed in 7 instances. With all seven neonates undergoing surgery, the
intention-to-treat survival rate was 86%, and the overall survival rate
was 55%. By reviewing published case series, a total of 823 TAC cases were
included in the analysis, of which 576 were diagnosed prenatally and 247
postnatally. The presence of associated cardiac and extracardiac
manifestations as well as genetic anomalies was common, with a 22q11
microdeletion identified in 27% of tested cases. <br/>Conclusion(s):
Advances in prenatal imaging and early diagnosis have enhanced the
management of TAC, allowing for the detailed planning of delivery and
immediate postnatal care in specialized centers. The frequent association
with genetic syndromes underscores the importance of genetic counseling in
managing TAC. An early surgical intervention remains crucial for improving
long-term outcomes, although the condition is still associated with
significant risks. Long-term follow-up studies are essential to monitor
potential complications and guide future management strategies. Overall, a
coordinated multidisciplinary approach from prenatal diagnosis to
postnatal care is essential for improving outcomes for individuals with
TAC.<br/>Copyright &#xa9; 2024 by the authors.

<55>
Accession Number
2031956357
Title
Dexmedetomidine vs. propofol on arrhythmia in cardiac surgery: a
meta-analysis of randomized controlled trials.
Source
Frontiers in Cardiovascular Medicine. 11 (no pagination), 2024. Article
Number: 1433841. Date of Publication: 2024.
Author
Peng J.; Wu Y.; Li L.; Xia P.; Yu P.; Zhang J.; Liu X.
Institution
(Peng) Department of Anesthesiology, The Third Hospital of Nanchang,
Jiangxi, Nanchang, China
(Wu, Xia, Zhang) Department of Anesthesiology, The Second Affiliated
Hospital of Nanchang University, Jiangxi, Nanchang, China
(Li) Department of Traditional Chinese Medicine, Fujian University of
Traditional Chinese Medicine, Fuzhou, China
(Yu) Department of Endocrinology and Metabolism, The Second Affiliated
Hospital of Nanchang University, Nanchang, China
(Liu) Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun
Yat-sen University, Guangdong, Guangzhou, China
(Liu) Guangdong Provincial Key Laboratory of Arrhythmia and
Electrophysiology, Guangdong Provincial Key Laboratory of Malignant Tumor
Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for
RNA Medicine, Sun Yat-Sen University, Guangdong, Guangzhou, China
Publisher
Frontiers Media SA
Abstract
Background: Dexmedetomidine (DEX) and propofol are popular anesthetics,
but it remains unknown whether DEX reduces the incidence of arrhythmias
compared with propofol after cardiac surgery. <br/>Method(s): We performed
a comprehensive search for RCTs (Randomized Controlled Trials) that
compared the incidence of arrhythmias between DEX and propofol in adults
who had undergone cardiac surgery across three databases (PubMed, Embase,
the Cochrane Library), and ClinicalTrials.gov up to October 3, 2023. The
primary outcome was ventricular arrhythmias, the secondary outcomes were
bradycardia and atrial fibrillation (AF). <br/>Result(s): Our analysis
included 7 RCTs with 1,004 patients (mean age: 64.37, male: 71.11%)
undergoing cardiac surgery, and the incidence of in-hospital arrhythmia
was 22.01% (ventricular arrhythmias 2.75%, bradycardia 3.33%, AF 18.63%).
Perioperative or postoperative use of DEX reduced the incidence of
in-hospital ventricular arrhythmias [Odds Ratio (OR) 0.14, 95% Confidence
Interval (CI) 0.03-0.66], but increased the risk of in-hospital
bradycardia (OR 2.88, 95% CI 1.02-8.17) compared with propofol. The trial
sequence analysis verified the adequacy of sample size and robustness of
the ventricular arrhythmias and bradycardia. There was no significant
reduced incidence of the use of DEX in the incidence of AF (OR 0.69, 95%
CI 0.36-1.29). The GRADE assessment indicated a high certainty for
ventricular arrhythmias and bradycardia and a moderate certainty for AF.
<br/>Conclusion(s): Our findings suggested the use of DEX reduces
in-hospital ventricular arrhythmias but increases bradycardia incidence
compared to propofol in adult patients undergoing cardiac surgery. Further
studies are needed to assess the impact of dexmedetomidine on atrial
fibrillation compared to propofol. Systematic Review Registration:
http://www.crd.york.ac.uk/prospero/ PROSPERO, identifier
(CRD42023482193).<br/>Copyright 2024 Peng, Wu, Li, Xia, Yu, Zhang and Liu.

<56>
Accession Number
2031545922
Title
Comparison of Long-Term Results of Endovenous Ablation Techniques and
Classical Stripping Operations in the Treatment of Venous Insufficiency.
Source
Journal of Ankara University Faculty of Medicine. 77(3) (pp 272-278),
2024. Date of Publication: September 2024.
Author
Dikmen N.; Kaya B.
Institution
(Dikmen, Kaya) Ankara University Faculty of Medicine, Department of
Cardiovascular Surgery, Ankara, Turkey
Publisher
Galenos Publishing House
Abstract
Objectives: Chronic venous insufficiency affects approximately 25% of the
population and is primarily associated with reflux in the great saphenous
vein. Traditional treatments like high ligation and stripping have been
effective but are burdened with complications such as postoperative pain,
wound infections, and nerve damage, alongside high recurrence rates. In
contrast, minimally invasive endovenous techniques, including
radiofrequency ablation, endovenous laser ablation (EVLA), and
ultrasound-guided foam sclerotherapy, have gained popularity due to their
lower complication rates and efficacy demonstrated in short-and
medium-term studies. This study synthesizes existing literature comparing
these treatment modalities and aims to evaluate the effectiveness of
classical stripping and endovenous ablation techniques in the treatment of
venous insufficiency. <br/>Material(s) and Method(s): Between October 2011
and January 2016, 832 patients underwent different procedures at Ankara
University Faculty of Medicine, Department of Cardiovascular Surgery, with
a total of 1,390 lower extremities treated. The study assessed patient
demographics, procedural outcomes, complications, and quality of life
(QoL) improvements following each intervention. Statistical analyses,
including t-tests, Mann-Whitney U tests, and logistic regression, were
employed to compare outcomes and identify influencing factors.
<br/>Result(s): The findings underscored high procedural success across
all methods and significant QoL improvements post-treatment. However, no
statistically significant differences were observed in QoL outcomes
between treatment modalities. Complication rates varied, with EVLA showing
higher rates of postoperative ecchymosis and classical stripping
associated with increased wound infection incidence. Factors influencing
outcomes included body mass index, bilaterality of treatment, and use of
venoactive drugs. <br/>Conclusion(s): The study concluded with
recommendations for further randomized controlled trials to refine
treatment protocols and elucidate long-term efficacy.<br/>Copyright &#xa9;
2024 The Author.

<57>
Accession Number
2031545795
Title
The Effectiveness and Safety of Rhomboid Intercostal Block for
Postoperative Pain Management in Thoracic and Breast Surgical Procedures:
A Meta-analysis.
Source
Anesthesiology and Pain Medicine. 14(5) (no pagination), 2024. Article
Number: e150753. Date of Publication: 31 Oct 2024.
Author
Saputra T.; Sutiyono D.; Nurcahyo W.I.
Institution
(Saputra) Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia
(Sutiyono, Nurcahyo) Department of Anesthesiology and Intensive Care,
Faculty of Medicine, Universitas Diponegoro/Dr. Kariadi General Hospital,
Semarang, Indonesia
Publisher
Brieflands
Abstract
Background: The rhomboid intercostal block (RIB) is an emerging regional
anesthesia (RA) technique used for pain control following thoracic and
breast surgery. However, comprehensive documentation on its effectiveness
and safety profile remains limited. This study aims to assess the
effectiveness and safety of RIB in thoracic and breast surgical
procedures. <br/>Method(s): A study search was conducted following PRISMA
2020 guidelines in PubMed, Cochrane Library, Embase, Scopus, and ProQuest
from 2016 to 2023 to identify randomized controlled trials (RCTs)
evaluating the effectiveness and safety of RIB in thoracic and breast
surgeries. The primary outcome was patient pain scores at rest, recorded
at one, six, 12, and 24 hours post-surgery. Secondary outcomes included
24-hour opioid consumption and rates of postoperative nausea and vomiting
(PONV). <br/>Result(s): This meta-analysis included five RCTs with a total
of 368 patients. Rhomboid intercostal block led to a significant reduction
in NRS scores one hour post-surgery (SMD =-1.33; 95% CI =-1.74 to-0.91; P
< 0.00001, I2 = 18%, P = 0.27), 12 hours post-surgery (SMD =-0.74; 95% CI
=-0.99 to-0.48; P < 0.00001, I2 = 36%, P = 0.21), and 24 hours
post-surgery (SMD =-1.62; 95% CI =-2.56 to-0.69; P = 0.00006, I2 = 91%, P
< 0.00001). Regarding secondary outcomes, the RIB group showed a
significant reduction in 24-hour opioid consumption (SMD =-4.49; 95% CI
=-6.09 to-2.90; P < 0.00001, I2 = 95%, P < 0.00001) and PONV rates (RR
=-0.29; 95% CI = 0.18 to 0.47; P < 0.00001, I2 = 0%, P = 0.88).
<br/>Conclusion(s): Rhomboid intercostal block provides effective pain
reduction and lowers opioid consumption within 24 hours post-surgery,
while also minimizing PONV rates.<br/>Copyright &#xa9; 2024, Saputra et
al.

<58>
Accession Number
2034992848
Title
Postoperative delirium in 47 379 individuals undergoing transcatheter
aortic valve replacement: a systematic review and meta-analysis.
Source
Annals of Medicine and Surgery. 85(9) (pp 4476-4490), 2023. Date of
Publication: 26 Jul 2023.
Author
Ochani S.; Adnan A.; Siddiqui A.; Kalwar A.; Kukreja S.; Ahmad M.; Ashraf
M.H.; Ali Asghar M.
Institution
(Ochani) Department of Medicine, Khairpur Medical College, Khairpur Mir's,
Pakistan
(Adnan, Siddiqui) Department of Medicine, Karachi Medical and Dental
College, Karachi, Pakistan
(Kalwar, Kukreja, Ashraf, Ali Asghar) Department of Medicine, Dow
University of Health Sciences, Karachi, Pakistan
(Ahmad) Department of Medicine, Ziauddin Medical University, Karachi,
Pakistan
Publisher
Lippincott Williams and Wilkins
Abstract
Objective: The study aims to discuss the assessment methods used for the
incidence of in-hospital postoperative delirium (IHPOD) in transcatheter
aortic valve replacement (TAVR) patients and explore possible strategies
for preventing and reducing postoperative complications in the geriatric
population. Methodology: An electronic search of PubMed, Embase,
BioMedCentral, Google Scholar, and the Cochrane Central Register of
Controlled Trials was conducted up to August 2021, to identify studies on
the IHPOD following TAVR in patients above 70 years. The primary objective
of the study was to determine the incidence of delirium following TAVR and
procedures like transfemoral (TF) and non-TF approaches. The secondary
objectives were to determine the incidence of stroke and incidence
according to the confusion assessment method (CAM) diagnostic tool. The
authors only included studies published in English and excluded patients
with comorbidities and studies with inaccessible full-text.
<br/>Result(s): Among the selected 42 studies with 47 379 patients, the
incidence of IHPOD following TAVR was 10.5% (95% CI: 9.2-11.9%,
I² = 95.82%, P < 0.001). Incidence based on CAM was 15.6% (95%
CI: 10.5-20.7%, I² = 95.36%, P < 0.001). The incidence of IHPOD
after TF-TAVR was 9.3% (95% CI: 7.6-11.0%, I² = 94.52%, P <
0.001), and after non-TF TAVI was 25.3% (95% CI: 15.4-35.1%, I²
= 92.45%, P < 0.001). The incidence of stroke was 3.7% (95% CI: 2.9-4.5%,
I² = 89.76%, P < 0.001). Meta-regression analyses between mean
age (P = 0.146), logistic EuroSCORE (P = 0.099), or percentage of
participants treated using the TF approach (P = 0.276) were nonsignificant
while stroke (P = 0.010) was significant. When considering these
variables, the residual heterogeneity remained high indicating that other
variables influence the heterogeneity. <br/>Conclusion(s): IHPOD following
TAVR was observed in 10.5% of individuals and in 15.6% using CAM. Its
incidence was found to be three times higher after non-TF TAVR (25.3%)
compared to TF TAVR (9.3%). Stroke showed an incidence of 3.7% after TAVR
and was found to be significantly associated with the risk of developing
delirium following TAVR. Further studies are needed to evaluate possible
causes and risk factors responsible for delirium and to assess the role of
anesthesia and cerebral embolic protection in preventing delirium after
TAVR.<br/>Copyright &#xa9; 2023 The Author(s).

<59>
Accession Number
2035429854
Title
Decision-Making Approach to the Treatment of Young and Low-Risk Patients
With Aortic Stenosis.
Source
JACC: Cardiovascular Interventions. 17(21) (pp 2455-2471), 2024. Date of
Publication: 11 Nov 2024.
Author
Gupta T.; Malaisrie S.C.; Batchelor W.; Boudoulas K.D.; Davidson L.;
Ibebuogu U.N.; Kpodonu J.; Singh R.; Sultan I.; Theriot M.; Reardon M.J.;
Leon M.B.; Grubb K.J.
Institution
(Gupta) Division of Cardiology, University of Vermont Medical Center,
Burlington, VT, United States
(Malaisrie) Department of Cardiac Surgery, Northwestern University
Feinberg School of Medicine, Chicago, IL, United States
(Batchelor, Singh) Inova Schar Heart and Vascular Institute, Falls Church,
VA, United States
(Boudoulas) Division of Cardiovascular Medicine, The Ohio State
University, Columbus, OH, United States
(Davidson) Division of Cardiology, Northwestern University Feinberg School
of Medicine, Chicago, IL, United States
(Ibebuogu) Division of Cardiovascular Diseases, Department of Medicine,
University of Tennessee Health Science Center, Memphis, TN, United States
(Kpodonu) Division of Cardiac Surgery, Beth Israel Deaconess Medical
Center, Harvard Medical School, Boston, MA, United States
(Sultan) Division of Cardiac Surgery, Department of Cardiothoracic
Surgery, Center for Heart Valve Disease, University of Pittsburgh Medical
Center Heart and Vascular Institute, Pittsburgh, PA, United States
(Theriot) Lake Charles Memorial Hospital Heart & Vascular Center, Lake
Charles, LA, United States
(Reardon) Department of Cardiovascular Surgery, Houston Methodist DeBakey
Heart and Vascular Center, Houston, TX, United States
(Leon) Division of Cardiology, Columbia University Medical Center, New
York, NY, United States
(Leon) Cardiovascular Research Foundation, New York, NY, United States
(Grubb) Division of Cardiothoracic Surgery, Emory University School of
Medicine, Atlanta, GA, United States
Publisher
Elsevier Inc.
Abstract
Over a decade of randomized controlled trial data demonstrate excellent
outcomes with transcatheter aortic valve replacement or surgical aortic
valve replacement for patients with symptomatic severe aortic stenosis
regardless of surgical risk. The 2020 American College of
Cardiology/American Heart Association guidelines recommend both options
for low-risk AS patients aged 65 to 80 years. However, the fastest growing
population of patients receiving transcatheter aortic valve replacement in
the United States is <65 years old, with little data to support the
practice. The American College of Cardiology's Cardiac Surgery Team
Section Leadership and Interventional Cardiology Councils, a
multidisciplinary collaboration of cardiologists and cardiac surgeons,
sought to summarize the relevant data into a decision-making tool for
heart valve teams. A literature review was completed, and guidelines,
randomized controlled trials, and large observational studies were
summarized into a pragmatic decision-making approach to treating young and
low-risk patients with AS.<br/>Copyright &#xa9; 2024 American College of
Cardiology Foundation

<60>
Accession Number
2035218967
Title
Gender gap in cardiothoracic surgery randomized controlled trial and
post-hoc analysis of randomized controlled trial authorship from 2014 to
2020.
Source
European Journal of Cardio-thoracic Surgery. 66(4) (no pagination), 2024.
Article Number: ezae297. Date of Publication: 01 Oct 2024.
Author
Shariff M.; Kumar A.; Stulak J.; Naumann K.E.; Blackmon S.H.; Saddoughi
S.A.
Institution
(Shariff, Stulak, Blackmon, Saddoughi) Department of General Surgery, Mayo
Clinic, Rochester, MN, United States
(Kumar) Department of Cardiology, Mayo Clinic, Rochester, MN, United
States
(Stulak, Naumann, Saddoughi) Department of Cardiovascular Surgery, Mayo
Clinic, Rochester, MN, United States
(Blackmon, Saddoughi) Division of Thoracic Surgery, Department of Surgery,
Mayo Clinic, Rochester, MN, United States
Publisher
European Association for Cardio-Thoracic Surgery
Abstract
OBJECTIVES: To estimate gender disparities among first and last
authorships in cardiothoracic randomized controlled trials (RCTs) and
association of gender with publications in high-impact journals.
<br/>METHOD(S): PubMed/MEDLINE database was searched from 1 January 2014
to 31 December 2020 using R statistical software via the 'easyPubMed'
package to retrieve pertinent data. The 'gender' package was utilized to
determine gender using the United States Social Security Administration
Baby Name Data. The percentage of female first and last authors were
computed along with determining the uniqueness of the names. The
association of gender and publication in high-impact peer-reviewed
journals was delineated. Jonckheere's trend was computed. <br/>RESULT(S):
The database search retrieved a total of 4820 RCTs, of which gender was
encoded for the first author in 3247 (67%) RCTs, among which 911 (28%)
studies had women as first authors, with a similar trend across 7 years (P
= 0.23). Gender was encoded for the last author of 3204 (66%) RCTs, of
which 622 (19%) studies had women as last authors, with a similar trend
across 7 years (P = 0.45). A total of 627 studies were published in
high-impact-factor journals, among which 79 (16%) studies had female first
authors and 67 (13%) studies had female last authors. <br/>CONCLUSION(S):
There is an obvious gender disparity of first and last authors in
cardiothoracic surgery-related RCTs, with a similar trend across 7 years.
However, the post-hoc analysis did demonstrate a positive trend with an
increase in the number of female first authors, demonstrating
progress.<br/>Copyright &#xa9; 2024 The Author(s). Published by Oxford
University Press on behalf of the European Association for Cardio-Thoracic
Surgery. All rights reserved.

<61>
Accession Number
2035415921
Title
Anesthetic Management of Intracardiac Migration of Medical Devices.
Source
Journal of Cardiothoracic and Vascular Anesthesia. (no pagination), 2024.
Date of Publication: 2024.
Author
Holloway J.; Lee M.; Stephens B.; Byun W.Y.; Saklayen S.; Anam K.; Awad H.
Institution
(Holloway, Saklayen, Anam, Awad) Department of Anesthesiology, The Ohio
State University, Columbus, OH, United States
(Lee) College of Nursing, Nurse Anesthesia Program, Otterbein University,
Columbus, OH, United States
(Stephens) Department of Anesthesiology & Perioperative Medicine,
University of Pittsburgh Medical Center, Pittsburgh, PA, United States
(Byun) College of Medicine, The Ohio State University, Columbus, OH,
United States
Publisher
W.B. Saunders
Abstract
The use of endovascular, percutaneous interventions to treat cardiac,
arterial, and venous pathologies is becoming increasingly common in
medical practice. While endovascular device placement typically carries a
low risk, device migration remains a persistent problem with these
procedures for which anesthesia providers must have a high index of
suspicion. Anesthesia providers should be aware of the wide range of
indications for such devices, potential migration locations, and
hemodynamic consequences of both the inciting pathology and device
migration so they can safely care for patients in these settings. This
article aims to discuss a case series of five different device migration
events, review the literature surrounding the migration of each device,
and propose unique anesthetic considerations as well as a systematic
approach by which to approach these complications.<br/>Copyright &#xa9;
2024 Elsevier Inc.

<62>
Accession Number
2031981357
Title
The Impact of Frailty and Surgical Risk on Health-Related Quality of Life
After TAVI.
Source
Journal of Cardiovascular Development and Disease. 11(10) (no pagination),
2024. Article Number: 333. Date of Publication: October 2024.
Author
van der Velden K.E.H.M.; Spaetgens B.P.A.; Buhre W.F.F.A.; Maesen B.; de
Korte-de Boer D.J.D.; van Kuijk S.M.J.; van 't Hof A.W.J.; Schreiber J.U.
Institution
(van der Velden, de Korte-de Boer, Schreiber) Department of Anesthesiology
and Pain Medicine, Maastricht University Medical Center+ (MUMC+),
Maastricht 6229 HX, Netherlands
(van der Velden, van 't Hof) Cardiovascular Research Institute Maastricht
(CARIM), Maastricht University, Maastricht 6200 MD, Netherlands
(Spaetgens) Department of Internal Medicine, Division of General Internal
Medicine, Section Geriatric Medicine, Maastricht University Medical
Center+ (MUMC+), Maastricht 6229 HX, Netherlands
(Buhre) Department of Anesthesiology, Division of Vital Functions,
University Medical Center Utrecht (UMCU), Utrecht 3584 CX, Netherlands
(Maesen) Department of Cardiothoracic Surgery, Maastricht University
Medical Center+ (MUMC+), Maastricht 6229 HX, Netherlands
(van Kuijk) Department of Clinical Epidemiology and Medical Technology
Assessment, Maastricht University Medical Center+ (MUMC+), Maastricht 6229
HX, Netherlands
(van 't Hof) Department of Cardiology, Division of Interventional
Cardiology, Maastricht University Medical Center+ (MUMC+), Maastricht 6229
HX, Netherlands
(van 't Hof) Department of Cardiology, Division of Interventional
Cardiology, Zuyderland Medical Center, Heerlen 6419 PC, Netherlands
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Abstract
Symptomatic aortic stenosis and frailty reduce health-related quality of
life (HrQoL). Transcatheter aortic valve implantation (TAVI) in patients
at high to extreme risk has been proven to have a beneficial effect on
HrQoL. Currently, TAVI is also considered in patients at intermediate
risk. Our meta-analysis investigates whether benefits to HrQoL after TAVI
is more pronounced in frail patients and patients at high to extreme vs.
intermediate surgical risk. A systematic search of the literature was
performed in November 2021 and updated in November 2023 in PUBMED, EMBASE,
and the Cochrane Controlled Trials Register. Statistical analysis was
performed according to the inverse variance method and the random effects
model. A total of 951 studies were assessed, of which 19 studies were
included. Meta-analysis showed a mean increase in the Kansas City
Cardiomyopathy Questionnaire (KCCQ) score of 29.6 points (6.0, 33.1) in
high to extreme risk patients versus 21.0 (20.9, 21.1) in intermediate
risk patients (p < 0.00001) and 24.6 points (21.5, 27.8) in frail patients
versus 26.8 (20.2, 33.4) in the general TAVI population (p = 0.55).
However, qualitative analyses of non-randomized studies showed the
opposite results. In conclusion, TAVI improves HrQoL more in high to
extreme than intermediate risk patients. Frailty's impact on HrQoL
post-TAVI is inconclusive due to varying outcomes in RCTs vs.
non-RCTs.<br/>Copyright &#xa9; 2024 by the authors.

<63>
Accession Number
2031946122
Title
Outcomes of left atrial appendage closure versus oral anticoagulant
therapy in patients with atrial fibrillation: an updated meta-analysis of
randomized control trials.
Source
Egyptian Heart Journal. 76(1) (no pagination), 2024. Article Number: 144.
Date of Publication: December 2024.
Author
Pramana K.A.A.P.; Cahyani N.G.A.M.S.D.; Pintaningrum Y.; Rahmat B.
Institution
(Pramana, Cahyani) General Practitioner, Faculty of Medicine Mataram
University, Mataram, Indonesia
(Pintaningrum, Rahmat) Interventional Cardiology Division, Cardiology and
Vascular Department, Faculty of Medicine, Mataram University, Mataram,
Indonesia
Publisher
Springer Science and Business Media Deutschland GmbH
Abstract
Background: The purpose of this study is to compare the clinical results
of Left Atrial Appendage Closure (LAAC) and oral anticoagulation (OAC) in
individuals with AF. <br/>Method(s): For randomized controlled trials
(RCTs) comparing the clinical results of OAC to LAAC in patients with
atrial fibrillation (AF), we searched PubMed, ScienceDirect, and Cochrane.
The included publications were subjected to meta-analyses using Review
Manager v5.4. <br/>Result(s): In comparison to OAC, LAAC was linked with a
decreased incidence of all stroke (OR 0.68; 95% CI 0.55-0.84; p = 0.0004).
LAAC was also linked to a decreased risk of hemorrhagic stroke (OR 0.20,
95% CI 0.07-0.55; p = 0.002). There is no statistically significant
difference between the two groups in terms of ischemic stroke (OR 1.05;
95% CI 0.59-1.84; p = 0.88) or systemic embolization (OR 1.02; 95% CI
0.42-2.46; p = 0.97). <br/>Conclusion(s): According to our meta-analysis,
the LAAC was less likely than the OAC to have a complete or hemorrhagic
stroke. For the two groups, however, there was no difference in the risk
of ischemic stroke or systemic embolization.<br/>Copyright &#xa9; The
Author(s) 2024.

<64>
Accession Number
645624133
Title
Sleep-disordered breathing in pediatric patients with single ventricle
physiology: a systematic review.
Source
Cardiology in the Young. Conference: 8th World Congress of Pediatric
Cardiology and Cardiac Surgery, WCPCCS 2023. Washington, DC United States.
34(Supplement 1) (pp S938), 2024. Date of Publication: May 2024.
Author
Ligsay A.
Institution
(Ligsay) University of Michigan, Ann Arbor, MI, United States
Publisher
Cambridge University Press
Abstract
Background: The prevalence of sleep-disordered breathing (SDB) in the
general pediatric population is estimated to be between 2-11%. However,
patients with underlying comorbidities may be at greater risk for SDB. The
aim of this systematic review was to assess the prevalence, risk factors,
and outcomes associated with SDB in pediatric patients with single
ventricle (SV) congenital heart disease (CHD). <br/>Method(s): A
systematic search of online literature databases was performed to screen
for studies related to SDB, CHD, and SV physiology (last queried
03/31/2023). All peer-reviewed publications written in the English
language reporting SDB among pediatric subjects (ages 0-21 years) with SV
physiology were analyzed. Extracted data included year of publication,
sample size, subject ages, underlying cardiac lesion with stage of cardiac
palliative surgery, screening and testing measures for SDB, and patient
outcomes related to SDB. <br/>Result(s): Six publications were included in
the final analysis. The reported prevalence of SDB in pediatric SV
patients ranged from 15-47% in non-neonates. Four studies utilized either
polysomnography or at-home sleep tests to diagnose SDB. One study reported
cardiopulmonary concerns and showed improvements in overall respiratory
rates and work of breathing when SDB was treated with continuous positive
airway pressure (CPAP) therapy. Four studies reported neuropsychological
concerns potentially associated with SDB including lower overall
intellectual quotients, greater prevalence of mood disorders, and lower
scores on Quality-of-Life questionnaires. Zero current or upcoming
clinical trials focusing on SDB in pediatric patients with CHD were
identified. <br/>Conclusion(s): This is the first systematic review of the
published literature describing SDB in pediatric SV patients. These
studies suggest the prevalence of SDB in this cohort may be greater than
the prevalence in the general pediatric population. Moreover, they provide
insight into the hemodynamic and neuropsychological consequences SDB can
have in this unique population. While this review is limited by a small
number of studies with small sample sizes, these publications suggest a
need for prospective research on the consequences of SDB in pediatric
patients with SV physiology.

<65>
Accession Number
645623618
Title
The effect of high-calorie density formula versus standard formula in
calorie intake, nutritional status, and clinical outcomes among infants
who underwent congenital heart surgery: a randomized, double-blind
controlled trial.
Source
Cardiology in the Young. Conference: 8th World Congress of Pediatric
Cardiology and Cardiac Surgery, WCPCCS 2023. Washington, DC United States.
34(Supplement 1) (pp S933-S934), 2024. Date of Publication: May 2024.
Author
Fitriasari R.; Pohan F.Z.; Joe J.; Kesumarini D.; Fitria L.; Budiwardhana
N.; Nadobudskaya D.; Marwali E.M.
Institution
(Fitriasari, Pohan, Joe, Kesumarini, Fitria, Budiwardhana, Nadobudskaya,
Marwali) National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia
Publisher
Cambridge University Press
Abstract
Background: High-calorie density formula (HDF) may help the growth of
infants with congenital heart disease (CHD), who have a higher risk of
malnutrition and energy expenditure but a stricter limit of fluid intake.
However, the evidence of the efficacy and safety of HDF among infants with
postoperative CHD still needs to be clarified. <br/>Method(s): A parallel,
randomized, double-blind controlled trial was done at National
Cardiovascular Center Harapan Kita, Indonesia, from February 2018-October
2019. All postoperative CHD infants were eligible for inclusion. Infants
were recruited consecutively and randomly allocated to receive HDF (1
kcal/ml) or SF (0.67 kcal/ml) for 3 months. The primary outcome was the
nutritional status (weight-for-height [WHZ], height-for-age [HAZ), and
weightfor-age z-scores [WAZ]) at 3rd month. Furthermore, we explored
calorie intake, malnutrition risk, and clinical outcomes. <br/>Result(s):
A total of 158 infants (5.1+/-2.9 months) were randomized to HDF (n=77)
and SF (n=81) groups with comparable baseline characteristics. During
hospitalization, infants in the HDF group had greater calorie intake
(125(52-165) versus 90(42-125) kcal/kg/d, p<0.001). Among 123 infants
analyzed, there was no difference in WHZ, WAZ, and HAZ in the 3rd month.
There was also no difference in weight, height, z-scores, z-score
increment, or malnutrition risk between the intervention and control
groups at all time points. In both groups, a palliative procedure is
associated with a higher risk of malnutrition at 1st and 2nd month
(relative risk [RR]=3.26; 95% CI 1.30-9.56, p=0.013 and 3.56, 95%CI
1.42-8.96, p=0.007). Finally, we found no difference in the mortality,
duration of mechanical ventilation, length of stay, and side effect
between the two groups. <br/>Conclusion(s): HDF enabled higher calorie
intake in infants with CHD who underwent heart surgery compared to SF
without a higher risk of side effects. However, we found no difference in
nutritional status and clinical outcomes during three months of follow-up.
Further research is needed to elucidate the long-term impacts of HDF use
in children with postoperative CHD.

<66>
Accession Number
645623472
Title
Platelet reactivity in young children undergoing congenital heart disease
surgery: a NITRIC randomized clinical trial substudy.
Source
Cardiology in the Young. Conference: 8th World Congress of Pediatric
Cardiology and Cardiac Surgery, WCPCCS 2023. Washington, DC United States.
34(Supplement 1) (pp S332-S333), 2024. Date of Publication: May 2024.
Author
Van Loon K.; Koomen E.; Schlapbach L.; Van Belle-Van Haaren N.; Van Wijk
B.; Horton S.; Butt W.; Nijman J.; Korporaal S.
Institution
(Van Loon, Koomen, Schlapbach, Van Belle-Van Haaren, Van Wijk, Horton,
Butt, Nijman, Korporaal) UMC Utrecht, Wilhelmina Children's Hospital,
Utrecht, Netherlands
Publisher
Cambridge University Press
Abstract
Background: The international NITRIC trial studied the hypothesis that
nitric oxide (NO) applied into the cardiopulmonary bypass (CPB) oxygenator
in infants would improve recovery due to suppression of a widespread
inflammatory response. NO, like several endothelial cell-derived molecules
inhibits spontaneous activation of platelets. We hypothesized that NO
administration might temporarily inhibit platelet activation during CPB,
favoring the availability of functional platelets post CPB.
<br/>Method(s): Platelet (re)activity was studied in a substudy of the
NITRIC trial, a multicenter, randomized, double-blind trial that studied
administration of 20 parts per million (ppm) NO in the sweep gas of the
CPB oxygenator in children younger than 2 years. Blood was collected at 4
time points: (T=1) after the start of surgery before CPB, (T=2) after the
start of CPB, (T=3) before weaning from CPB, and (T=4) after weaning from
CPB. We analyzed platelet reactivity to five agonists: peptides PAR1-AP
and PAR4- AP to activate the thrombin/ protease activated receptors,
adenosine diphosphate (ADP) to activate its receptor P2Y12, crosslinked
collagen related peptide (CRP-xL) to activate GPVI, and U46619, a
thromboxane A2 mimetic. Activity of platelets (P-selectin expression and
fibrinogen binding) was measured as median fluorescence intensity (MFI)
with flow-cytometry testing and evaluated with mixed effect modelling
(MEM). <br/>Result(s): Blood samples for platelet (re)activity testing
were obtained in 22 NO-recipients and 20 controls. Platelet counts drop
after T1 due to the hemodilution of blood (p<0.001). Platelet activity was
modelled according to this MEMs formula: Platelet activity (MFI) ~ time
point + allocation + time: allocation + CPB duration + peak velocity +
(1<br/>subject). P-values for coefficients on fibrinogen binding and
P-selectin expression for NO allocation were p>0.08 and for CPB duration
were p>0.27 in all models. <br/>Conclusion(s): In this study we evaluated
platelet (re)activity in young children undergoing surgery on CPB as part
of the NITRIC study. 20 ppm NO administration in the sweep gas of the CPB
oxygenator did not affect platelet (re)activity. Interestingly, duration
of CPB exposure did not have a relevant nor significant effect on platelet
reactivity too.

<67>
Accession Number
645623039
Title
On-table extubation after congenital heart surgery: an updated systematic
review and meta-analysis.
Source
Cardiology in the Young. Conference: 8th World Congress of Pediatric
Cardiology and Cardiac Surgery, WCPCCS 2023. Washington, DC United States.
34(Supplement 1) (pp S330), 2024. Date of Publication: May 2024.
Author
Vizentin V.K.; Souza A.A.; Maia V.R.N.; Almeida A.X.; Swaminathan S.
Institution
(Vizentin, Souza, Maia, Almeida, Swaminathan) University of Vale do
Itajai, Itajai, Brazil
Publisher
Cambridge University Press
Abstract
Background: Fast tracking following cardiac surgery is commonly employed
to facilitate recovery and discharge. Its use, however, raised various
issues in terms of the type of surgery and the timing of extubation. The
aim of this study was to update the evidence on the safety and
effectiveness of on-table extubation in pediatric patients undergoing
congenital heart disease surgery. <br/>Method(s): We performed a
systematic review and meta-analysis comparing on-table extubation with the
standard protocol of extubation at the Pediatric Intensive Care Unit
(PICU). PubMed, Embase, and Cochrane databases were searched for trials
published up to April 2022. Data were extracted from published reports and
quality assessment was performed per Cochrane recommendations. Odds ratios
(OR) were computed using a random- effects model, with 95% CI. The primary
endpoints of interest were all-cause mortality and reintubation rate.
<br/>Result(s): Sixteen studies and 6549 patients were included. All-cause
mortality (OR 0.22; 95% CI 0.13-0.36; p<0.00001; I²=0%),
reintubation rate (OR 0.5; 95% CI 0.32-0.80; p=0.004; I²=51%)
and length of hospital stay (MD -5.28 days; 95% CI -7.41 to -3.14;
P<0,00001;I² = 99%) were significantly lower in on-table
extubation patients. <br/>Conclusion(s): Our meta-analysis suggests that
on-table extubation is associated with a decreased incidence of
reintubation rate, mortality and length of hospital stay when compared to
standard and delayed extubation protocol at the PICU.