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<1>
Accession Number
2037083732
Title
Protective effect of ulinastatin against negative inflammatory response
and organ dysfunction in acute aortic dissection surgery: The PANDA trial.
Source
Cell Reports Medicine. 6(1) (no pagination), 2025. Article Number: 101888.
Date of Publication: 21 Jan 2025.
Author
Liu H.; Qian S.-C.; Zhu K.; Diao Y.-F.; Xu X.-F.; Tang Z.-W.; Fan G.-L.;
Yue H.-H.; Chen J.-Q.; Yang J.-N.; Zhang Y.-Y.; Ma C.; Liu X.; Wu Y.; Wu
Z.; Liu N.; Li A.; Ni B.-Q.; Shao Y.-F.; Zhao S.; Li H.-Y.; Zhang H.-J.
Institution
(Liu, Diao, Xu, Tang, Li, Ni, Shao, Zhao) Department of Cardiovascular
Surgery, the First Affiliated Hospital of Nanjing Medical University,
Nanjing, China
(Qian, Zhu, Liu, Li, Zhang) Department of Cardiovascular Surgery, National
Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen
Hospital, Capital Medical University, Beijing, China
(Fan) Department of Critical Care Medicine, Shanghai East Hospital, Tongji
University, Shanghai, China
(Yue, Wu) Department of Cardiovascular Surgery, West China Hospital of
Sichuan University, Chengdu, China
(Chen) Department of Cardiovascular Surgery, Tianjin Chest Hospital,
Tianjin Medical University, Tianjin, China
(Yang) Department of Cardiovascular Surgery, The Affiliated Hospital of
Qingdao University, Qingdao, China
(Zhang) Department of Cardiovascular Surgery, The First Affiliated
Hospital of Guangzhou Medical University, Guangzhou, China
(Ma) Department of Cardiothoracic Surgery, The Third Affiliated Hospital
of Soochow University, Changzhou, China
(Liu) Department of Cardiothoracic Surgery, National Regional Medical
Center, Suqian Hospital of Nanjing Medical University, Suqian, China
(Wu) School of Public Health and Emergency Management, Southern University
of Science and Technology, Shenzhen, China
Publisher
Cell Press
Abstract
Ulinastatin is a protease-inhibiting drug with anti-inflammatory and other
pharmacological properties. Little is known regarding its role following
acute type A aortic dissection (ATAAD) surgery. We perform a randomized
controlled trial to investigate the protective effect of ulinastatin
against negative inflammatory response and organ dysfunction in ATAAD
surgery (PANDA). The primary outcome of mean daily Sequential Organ
Failure Assessment (SOFA) score from baseline to 7 days of surgery is 8.80
(SD, 4.11) in the ulinastatin group and 8.61 (SD, 4.47) in the control
group (mean difference between groups was 0.04; 95% confidence interval
[CI], -0.24 to 0.33; p = 0.765). Systemic inflammatory response syndrome
(SIRS) within 7 days of surgery is lower in the ulinastatin group than in
the control group (p < 0.001). Additional ulinastatin to standard
treatment is likely to reduce SIRS rates instead of preventing organ
dysfunction, highlighting the potential importance of the benefits of
anti-inflammatory pharmacotherapeutics. The trial is registered on
clinicaltrials.org (NCT04711889). Copyright © 2024 The Author(s)

<2>
Accession Number
2037256720
Title
Identifying potential predictors of the risk of surgical site infection
following cardiac surgery: a scoping review.
Source
Journal of Hospital Infection. 157 (pp 29-39), 2025. Date of Publication:
01 Mar 2025.
Author
Charlwood K.V.; Jackson J.; Vaja R.; Rogers L.J.; Dawson S.; Moawad K.R.;
Brown J.; Trevis J.; Vokshi I.; Layton G.R.; Magboo R.; Tanner J.; Rochon
M.; Murphy G.J.; Whiting P.
Institution
(Charlwood, Jackson, Dawson, Whiting) Population Health Sciences, Bristol
Medical School, University of Bristol, Bristol, United Kingdom
(Vaja) Royal Brompton Hospital, National Heart and Lung Institute,
Imperial College London, London, United Kingdom
(Rogers) Bristol Heart Institute, University Hospitals Bristol & Weston
NHS Foundation Trust, Bristol, United Kingdom
(Moawad) University Hospital Southampton Trust, Southampton, United
Kingdom
(Brown) Royal Victoria Hospital, Belfast, United Kingdom
(Trevis) Freeman Hospital, Newcastle-upon-Tyne, United Kingdom
(Vokshi) Heart and Lung Centre, New Cross Hospital, Wolverhampton, United
Kingdom
(Layton) University of Leicester, Leicester, United Kingdom
(Magboo) Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS
Trust, London, United Kingdom
(Tanner) School of Health Sciences, University of Nottingham, Nottingham,
United Kingdom
(Rochon) Guy's and St Thomas NHS Foundation Trust, London, United Kingdom
(Murphy) Leicester NIHR Biomedical Research Centre, University of
Leicester, Leicester, United Kingdom
Publisher
W.B. Saunders Ltd
Abstract
Objectives: This scoping review was undertaken to identify risk prediction
models and pre-operative predictors of surgical site infection (SSI) in
adult cardiac surgery. A particular focus was on the identification of
novel predictors that could underpin the future development of a risk
prediction model to identify individuals at high risk of SSI, and
therefore guide a national SSI prevention strategy. Method(s): A
scoping review to systematically identify and map out existing research
evidence on pre-operative predictors of SSI was conducted in two stages.
Stage 1 reviewed prediction modelling studies of SSI in cardiac surgery.
Stage 2 identified primary studies and systematic reviews of novel cardiac
SSI predictors. Result(s): The search identified 7887 unique reports;
7154 were excluded at abstract screening and 733 were selected for
full-text assessment. Twenty-nine studies (across 30 reports) were
included in Stage 1 and reported the development (N=14), validation
(N=13), or both development and validation (N=2) of 52 SSI risk prediction
models including 67 different pre-operative predictors. The remaining 703
reports were re-assessed in Stage 2; 49 studies met the inclusion
criteria, and 56 novel pre-operative predictors that have not been
assessed previously in models were identified. Conclusion(s): This
review identified 123 pre-operative predictors of the risk of SSI
following cardiac surgery, 56 of which have not been included previously
in the development of cardiac SSI risk prediction models. These candidate
predictors will be a valuable resource in the future development of risk
prediction scores, and may be relevant to prediction of the risk of SSI in
other surgical specialities. Copyright © 2024 The Author(s)

<3>
Accession Number
2032261248
Title
Effect of Ischemia Testing and Coronary Revascularization on Mortality and
Ventricular Tachycardia Recurrence in Patients With Monomorphic
Ventricular Tachycardia Without Acute Coronary Syndrome: A Meta-Analysis
and Systematic Review.
Source
Catheterization and Cardiovascular Interventions. 105(2) (pp 321-325),
2025. Date of Publication: 01 Feb 2025.
Author
Shah N.; Saraiya A.; Patel T.; Marchlinski F.E.; Pancholy S.
Institution
(Shah, Pancholy) The Wright Center for Graduate Medical Education,
Scranton, PA, United States
(Saraiya) Sidney Kimmel College of Medicine, Philadelphia, PA, United
States
(Patel) Apex Heart Institute, Ahmedabad, India
(Marchlinski) Perelman School of Medicine, University of Pennsylvania,
Philadelphia, PA, United States
Publisher
John Wiley and Sons Inc
Abstract
Background: Studies show mixed results regarding the effect of coronary
revascularization on mortality benefit and ventricular tachycardia (VT)
recurrence in patients with monomorphic VT without acute coronary syndrome
(ACS). This meta-analysis aimed to assess the effect of ischemia testing
and/or coronary revascularization on mortality and VT recurrence in a
pooled data set. Method(s): Databases including PubMed, Google
Scholar, and the Cochrane Library were searched from January 2000 to
December 2023 for studies reporting event data on mortality and VT
recurrence in patients without ACS who presented with monomorphic VT. Data
were pooled and analyzed using random effects meta-analysis.
 Result(s): The pooled sample consisted of a total of five studies,
with 1062 patients, of whom 433 underwent ischemia testing and/or coronary
revascularization and 629 did not. There was no statistically significant
difference in the mortality and VT recurrence in the patients who
underwent ischemia testing and/or revascularization versus those who did
not (mortality odds ratio [OR]: 0.98; [95% confidence interval (CI): 0.62
to 1.53]; p = 0.92; VT recurrence OR: 1.07; [95% CI: 0.51 to 2.26]; p =
0.86). No publication bias was detected by examination of the funnel plot,
Begg-Mazumdar's test (p = 0.80), and Egger's test (p = 0.91).
 Conclusion(s): In conclusion, in patients with sustained monomorphic
VT in the absence of ACS, ischemia testing and/or revascularization does
not lead to improved mortality or a decrease in the incidence of VT
recurrence. Copyright © 2024 Wiley Periodicals LLC.

<4>
Accession Number
2037130891
Title
Advances in Anesthesia Techniques for Postoperative Pain Management in
Minimally Invasive Cardiac Surgery: An Expert Opinion.
Source
Journal of Cardiothoracic and Vascular Anesthesia. (no pagination), 2025.
Date of Publication: 2025.
Author
Yuan K.; Cui B.; Lin D.; Sun H.; Ma J.
Institution
(Yuan, Cui, Lin, Sun, Ma) Department of Anesthesiology, Beijing Anzhen
Hospital, Capital Medical University, Beijing, China
Publisher
W.B. Saunders
Abstract
Minimally invasive cardiac surgery (MICS) often leads to severe
postoperative pain. At present, multimodal analgesia schemes for MICS have
attracted much attention, and the application of various chest wall
analgesia techniques is becoming increasingly widespread. However,
research on anesthesia techniques for postoperative pain management in
MICS remains relatively limited at present. We searched for relevant
literature and summarized recent related research in eight MICS
techniques, including thoracic epidural anesthesia, spinal anesthesia,
thoracic paravertebral plane block, erector spinae plane block, serratus
anterior plane block, pectoral nerve block, intercostal nerve block, and
parasternal block. This article provides an overview of the anatomy and
procedures involved in these analgesic techniques, their mechanisms of
action, and the latest clinical trial evidence. It also evaluates their
progress in MICS, compares their advantages and disadvantages, and
discusses practical challenges. Copyright © 2025 Elsevier Inc.

<5>
Accession Number
2037192063
Title
Clinical Outcomes with High- versus Low-Dose Tranexamic Acid Infusion in
Patients Undergoing Cardiac Surgery: A Systematic Review and
Meta-Analysis.
Source
Thoracic and Cardiovascular Surgeon. (no pagination), 2025. Date of
Publication: 2025.
Author
Rangwala H.S.; Rangwala B.S.; Alotaibi M.; Siddiq M.A.; Qamber A.; Zaidi
S.D.E.Z.; Naveed T.; Naveed H.; Azam S.T.; Hameed I.
Institution
(Rangwala, Rangwala, Siddiq, Qamber, Zaidi, Azam) Department of Medicine,
Jinnah Sindh Medical University, Sindh, Karachi, Pakistan
(Alotaibi) Department of Medicine, Imam Abdulrahman Bin Faisal University
College of Medicine, Eastern, Dammam, Saudi Arabia
(Naveed, Naveed) Department of Medicine, Ziauddin Medical College, Sindh,
Karachi, Pakistan
(Hameed) Department of Medicine, MedStar Health, Baltimore, MD, United
States
Publisher
Georg Thieme Verlag
Abstract
Objectives Antifibrinolytics, such as tranexamic acid (TXA), are widely
used in cardiac surgery to reduce bleeding risks; however, the optimal
dosage for TXA infusion remains a subject of debate. Hence, this study
aims to evaluate the safety and efficacy of high-dose compared with
low-dose TXA infusion in cardiac surgery patients. Methods PubMed, SCOPUS,
and Cochrane Central Register of Controlled Trials (CENTRAL) were searched
until June 10, 2023, for studies assessing efficacy outcomes (e.g., blood
loss, transfusions) and safety outcomes (e.g., mortality, complications).
Results Results were analyzed via random-effects model, using
Mantel-Haenszel risk ratio (RR) and standard mean difference (SMD). P
-value < 0.05 was considered significant. We analyzed 17 studies involving
93,206 participants (mean age 59.3 years, study duration 3 months to 10
years). Our analysis found significant reductions in total blood loss
(SMD, -0.17 g; CI, -0.34 to -0.01; p = 0.04), 24-hour blood loss (SMD,
-0.23 g; p = 0.005), and the need for fresh frozen plasma (FFP)
transfusions (RR: 0.94; CI, 0.89 to 1.00; p = 0.05) with high-dose TXA.
Chest tube output was also lower (SMD, -0.12 g; p = 0.0006), but
postoperative seizures increased (RR: 2.23; CI, 1.70 to 2.93; p < 0.00001)
with high-dose TXA. For other outcomes like blood transfusions,
hospital/ICU stay, mortality, stroke, myocardial infarction, pulmonary
embolism, renal dysfunction, and reoperation, no significant differences
were found between high-dose and low-dose TXA regimens. Conclusion Our
study showed that high TXA dose effectively reduce postoperative bleeding,
chest tube drainage, and the need for FFP transfusion, but it increases
the risk of seizures. Increasing TXA dose did not affect thromboembolic
events or mortality. This emphasizes the importance of weighing the
benefits and risks when selecting the appropriate TXA regimen for each
patient. Copyright © 2025. Thieme. All rights reserved.

<6>
Accession Number
645687837
Title
Foot Reflexology for Pain and Anxiety Associated with Chest Tube Removal
in Patients After Coronary Artery Bypass Graft: A Randomized Controlled
Trial.
Source
Alternative therapies in health and medicine. 31(1) (pp 15-21), 2025. Date
of Publication: 01 Jan 2025.
Author
Budak Erturk E.; Karadag M.
Abstract
Background: Reflexology is a method used to control the pain and anxiety
associated with chest tube removal in patients undergoing cardiovascular
surgery. Primary Study Objective: This study aimed to identify the effect
of foot reflexology applied before chest tube removal on pain and anxiety
levels in patients with coronary artery bypass graft surgery.
Methods/Design: This study was a randomized controlled clinical trial.
 Setting(s): This study was conducted in the cardiovascular surgery
intensive care unit of the Baskent University Ankara Hospital.
 Participant(s): Patients, who underwent coronary artery bypass graft
surgery, were randomly assigned either to the reflexology group or the
control group (n = 28 individuals/group). Intervention(s): The
reflexology group received foot reflexology for 30 minutes in two sessions
(first postoperative day and before chest tube removal). Primary Outcome
Measures: The primary outcomes of the surgery were pain, evaluated using a
Numeric Pain-Rating Scale; and anxiety, evaluated using the Profile of
Mood States Scale Tension-Anxiety Subscale. Pain and anxiety were
determined on the first (before and after the reflexology) and second
postoperative days (before and after the reflexology and immediately, 15
min, 1 hour (only pain level) after chest tube removal). Result(s):
The mean pain scores of the control and intervention groups were similar
during chest tube removal, 15 minutes after, and 1 hour after (P > .05).
Although mean anxiety scores were comparable after chest tube removal in
both groups (P > .05), a significant difference was found 15 minutes later
(P < .05). The increase in pain (P = .0001) and anxiety (P = .032) levels
before and after the removal was significantly less in the intervention
group compared to the control group, based on pain and anxiety scores.
 Conclusion(s): Foot reflexology significantly reduced the increase in
pain and anxiety during chest tube removal in patients with coronary
artery bypass graft surgery.

<7>
Accession Number
2037165564
Title
Rehabilitation at Home Using Mobile Health for Older Adults Hospitalized
for Ischemic Heart Disease: The RESILIENT Randomized Clinical Trial.
Source
JAMA Network Open. 8(1) (pp e2453499), 2025. Date of Publication: 08 Jan
2025.
Author
Dodson J.A.; Adhikari S.; Schoenthaler A.; Hochman J.S.; Sweeney G.;
George B.; Marzo K.; Jennings L.A.; Kovell L.C.; Vorsanger M.; Pena S.;
Meng Y.; Varghese A.; Johanek C.; Rojas M.; McConnell R.; Whiteson J.;
Troxel A.B.
Institution
(Dodson, Adhikari, Schoenthaler, Hochman, Sweeney, George, Marzo,
Vorsanger, Pena, Meng, Varghese, Johanek, Rojas, McConnell, Whiteson,
Troxel) New York University, Langone Medical Center, New York, United
States
(Jennings) College of Medicine, The University of Oklahoma Health Sciences
Center, Oklahoma City, United States
(Kovell) Division of Cardiology, Department of Medicine, University of
Massachusetts, Worcester, United States
Publisher
American Medical Association
Abstract
Importance: Among older adults with ischemic heart disease, participation
in traditional ambulatory cardiac rehabilitation (CR) remains low. While
mobile health CR (mHealth-CR) provides a novel opportunity to deliver
care, age-specific impairments to technology use may limit uptake, and
efficacy data are currently lacking. Objective(s): To test whether
mHealth-CR improves functional capacity in older adults. Design,
Setting, and Participant(s): The RESILIENT phase 2, multicenter,
randomized clinical trial recruited patients aged 65 years or older with
ischemic heart disease (defined as a hospital visit for myocardial
infarction or coronary revascularization) from 5 academic hospitals in New
York, Connecticut, and Massachusetts between January 9, 2020, and April
22, 2024. Intervention(s): Participants were randomized 3:1 to
mHealth-CR or usual care. mHealth-CR consisted of commercially available
software delivered on a tablet computer, coupled with remote monitoring
and weekly exercise therapist telephone calls, delivered over a 3-month
duration. As RESILIENT was a trial conducted in a routine care setting to
inform decision-making, participants in both arms were also allowed to
receive traditional CR at their cardiologist's discretion. Main
Outcomes and Measures: The primary outcome was change from baseline to 3
months in functional capacity, measured by 6-minute walk distance (6MWD).
Secondary outcomes were health status (12-Item Short Form Health Survey
[SF-12]), residual angina, and impairment in activities of daily living.
 Result(s): A total of 400 participants (median age, 71.0 years
[range, 65.0-91.0 years]; 291 [72.8%] male) were randomized to mHealth-CR
(n = 298) or usual care (n = 102) and included in the intention-to-treat
analysis. Of those, 356 participants (89.0%) returned in person for 6MWD
assessment at 3 months. For the primary outcome, there was no adjusted
difference in 6MWD between participants receiving mHealth-CR vs usual care
(15.6 m; 95% CI, -0.3 to 31.5 m; P =.06). Among subgroups, there was an
improvement in 6MWD among women (36.6 m; 95% CI, 8.7-64.4 m). There were
no differences in any secondary outcomes between groups (eg, adjusted
difference in SF-12 physical component scores at 3 months: -1.9 points;
95% CI, -3.9 to 0.2 points). Based on inverse propensity score weighting,
there was no effect of mHealth-CR on 6MWD among those who did not attend
traditional CR (25.7 m; 95% CI, -8.7 to 60.2 m). Conclusions and
Relevance: In this randomized clinical trial of mHealth-CR vs usual care,
mHealth-CR did not significantly increase 6MWD or result in improvements
in secondary outcomes. The findings suggest the older adult population may
require more age-tailored mHealth strategies to effectively improve
outcomes. Copyright © 2025 American Medical Association. All
rights reserved.

<8>
Accession Number
2037130822
Title
Entrapment of Pulmonary Artery Catheters in Cardiac Surgery: A Structured
Literature Review and Analysis of Published Case Reports.
Source
Journal of Cardiothoracic and Vascular Anesthesia. (no pagination), 2025.
Date of Publication: 2025.
Author
Kumar N.; Toda C.; Couture E.J.; Vlahakes G.J.; Fitzsimons M.G.
Institution
(Kumar, Fitzsimons) Department of Anesthesia, Critical Care, and Pain
Medicine, Massachusetts General Hospital, Harvard Medical School, Boston,
MA, United States
(Toda) Department of Anesthesia, TidalHealth Peninsula Regional,
Salisbury, MD, United States
(Couture) Department of Anesthesiology & Division of Intensive Care
Medicine, Institut Universitaire de Cardiologie et de Pneumologie de
Quebec, Quebec, QC, Canada
(Vlahakes) Cardiac Surgery Division, Department of Surgery, Massachusetts
General Hospital, Harvard Medical School, Boston, MA, United States
Publisher
W.B. Saunders
Abstract
Objectives: This systematic review aims to tabulate and analyze the
published literature regarding pulmonary artery catheter (PAC) entrapment
during cardiac surgery. Design(s): Systematic review.
 Setting(s): Case reports and series. Participant(s): Adults
undergoing cardiac surgery. Intervention(s): None. Measurements
and Main Results: 223 distinct incidents of PAC entrapment were published
across 77 case reports and 3 retrospective studies. The reported incidence
of an entrapped PAC was 137/200,831 (0.068%, 95% confidence interval:
0.067%, 0.069%). Reported PAC entrapment was most seen in the setting of
mitral valve surgery and was not discovered until the postoperative period
in 77% of cases. Inadvertent fixation to cardiac structures was the most
common mechanism of PAC entrapment. A total of 75% of patients with an
entrapped PAC required an immediate redo sternotomy for PAC retrieval.
After PAC retrieval, these patients still had longer hospital length of
stay compared with the Society of Thoracic Surgeons Adult Cardiac Surgery
Database averages. Conclusion(s): Although PAC entrapment during
cardiac surgery is rare, an entrapped PAC increases patient morbidity,
delays recovery, and increases hospital length of stay. Surgeons and
anesthesiologists are encouraged to be attentive to PAC entrapment before
chest closure. Copyright © 2025 Elsevier Inc.

<9>
Accession Number
643996451
Title
Significance Analysis of the Improvement in Postoperative Recovery of
Cardiac Surgery Patients Based on the Graded Management Established Using
the Delirium Prediction Model.
Source
Alternative therapies in health and medicine. 31(1) (pp 338-342), 2025.
Date of Publication: 01 Jan 2025.
Author
Zhang H.; Wang Q.; Feng P.
Abstract
Objective: To investigate the impact of graded management based on
delirium prediction modeling on the improvement of recovery of cardiac
surgery patients. Method(s): Three hundred and twenty patients
admitted to the Department of Critical Care Medicine of Nanjing Hospital
affiliated with Nanjing Medical University from June 2021 to December 2023
after Type A aortic coarctation were selected as study subjects. They were
grouped according to the randomized scale method and divided into 160
cases in each the control group and the observation group. In the control
group, conventional nursing measures were adopted, and in the observation
group, graded nursing interventions were carried out according to the
established delirium risk prediction model. Comparison between the two
groups in terms of the intensive care unit (ICU) monitoring time,
hospitalization time, duration of delirium, and delirium incidence, and
investigated nursing satisfaction, and quality of care scores.
 Result(s): Compared with the control group, the observation group's
ICU custody time, hospitalization time, and delirium duration, decreased,
and the quality of care, and satisfaction increased (P < .05). At the same
time, the incidence of delirium in the observation group was also lower
than that in the control group (P < .05). Conclusion(s): The graded
management based on the delirium prediction model can effectively reduce
the incidence of postoperative delirium in critically ill patients with
Type A aortic coarctation, and at the same time improve patient
satisfaction and quality of care.

<10>
Accession Number
2032322415
Title
Transcatheter Aortic Valve Replacement in Patients With Severe Rheumatic
Aortic Stenosis: A Proportional Meta-Analysis.
Source
Catheterization and Cardiovascular Interventions. 105(2) (pp 345-348),
2025. Date of Publication: 01 Feb 2025.
Author
Ahsan M.J.; Ahmad S.; Ghumman G.M.; Dvalishvili M.; Malik S.A.; Islam
A.M.; Goldsweig A.M.
Institution
(Ahsan) Department of Cardiology, Baylor University Medical Center,
Dallas, TX, United States
(Ahmad, Malik, Goldsweig) Department of Cardiology, University of Nebraska
Medical Center, Omaha, NE, United States
(Ghumman) Department of Cardiology, St. Vincent Mercy Medical Center,
Toledo, OH, United States
(Dvalishvili) Department of Cardiology, East Carolina University,
Greenville, NC, United States
(Islam, Goldsweig) Department of Cardiology, Baystate Medical Center/UMass
Chan Medical School, Springfield, MA, United States
Publisher
John Wiley and Sons Inc

<11>
Accession Number
2037153437
Title
Cytokine Hemoadsorption versus Standard Care in Cardiac Surgery Using the
Oxiris Membrane: the OXICARD single center randomized trial.
Source
Anesthesiology. (no pagination), 2025. Article Number: 5376. Date of
Publication: 2025.
Author
Abou-Arab O.; Huette P.; Ibrahima A.; Beyls C.; Bayart G.; Guilbart M.;
Coupez A.; Bennis Y.; Navarre A.; Lenglet G.; Beal R.; Touati G.; Caus T.;
Bar S.; Josse E.; Nguyen M.; Dupont H.; Gubler B.; Kamel S.; Diouf M.;
Mahjoub Y.
Institution
(Abou-Arab, Huette, Ibrahima, Beyls, Bayart, Guilbart, Coupez, Bar,
Dupont, Kamel, Mahjoub) Amiens Hospital University, Anesthesia and
critical care department, Amiens, France
(Abou-Arab, Lenglet) Jules Verne University of Picardie, EA7517,
Pathophysiological Mechanisms and Consequences of Cardiovascular
Calcifications (MP3CV), Amiens, France
(Bennis, Touati, Caus) Department of Clinical Pharmacology, Amiens
Hospital University, Amiens, France
(Navarre) Department of Immunology, Amiens Hospital University, Amiens,
France
(Beal) Department of Cardiac Surgery, Amiens Hospital University, Amiens,
France
(Josse) Division of Clinical Research, Amiens Hospital University, Amiens,
France
(Nguyen) Department of Anesthesiology and Critical Care Medicine, Dijon
University Medical Centre, Dijon, France
(Gubler) Department of Molecular Oncobiology, Amiens Hospital University,
Amiens, France
(Kamel) Department of Clinical Biochemistry, Amiens Hospital University,
Amiens, France
(Diouf) Department of Statistics, Amiens hospital university, Amiens,
France
Publisher
Lippincott Williams and Wilkins
Abstract
Background: Cardiac surgery can lead to dysregulation with a
pro-inflammatory state, resulting in adverse outcomes. Hemadsorption using
the AN69 membrane (Oxiris membrane) has the properties to chelate
inflammatory cytokines. We hypothesized that in patients at high risk of
inflammation, the use of the Oxiris membrane could decrease inflammation,
preserve endothelial function, and improve postoperative outcomes.
 Method(s): We conducted a randomized single-center study at Amiens
University Hospital. The study population consisted of adult patients
admitted for scheduled cardiac surgery with an expected cardiopulmonary
bypass (CPB) time over 90 minutes. The patients were allocated to either
the standard group or the Oxiris group. The intervention consisted of
using the Oxiris membrane on a Prismaflex device at a blood flow rate of
450 ml/min during CPB. The primary outcome was the assessment of
microcirculation on day 1 after surgery by measuring sublingual
microcirculation using the microvascular flow index (MFI). MFI reflects
the microcirculation flow type and is graded from 0 to 3 as follows: 0: no
flow; 1: intermittent flow; 2: sluggish flow; 3: continuous flow. The
secondary outcome was a composite adverse outcome within 30 days after
surgery. Cytokines and endothelial biomarkers were measured in all
patients at different time points. An intention-to-treat analysis was
performed. Result(s): From October 2019 to November 2022, we included
70 patients. Two patients were excluded from the Oxiris group: one patient
did not undergo surgery and one procedure was performed under deep
hypothermia. The MFI did not differ between groups on day 1 from baseline:
difference Oxiris-standard at -0.17 [-0.44; 0.10]; P=0.2. The occurrence
of a composite adverse outcome did not significantly differ between groups
(14 [42%] for the Oxiris group vs 12 [35%] for the standard group; P=0.7).
The overall variation in cytokines and angiopoietins did not significantly
differ between groups. Conclusion(s): In patients scheduled for a
cardiac surgery with prolonged CPB, we could not demonstrate the benefit
on microcirculation and major cardiovascular events. Copyright ©
2025 Lippincott Williams and Wilkins. All rights reserved.

<12>
Accession Number
2036477663
Title
Treating Older Patients in Cardiogenic Shock With a Microaxial Flow Pump:
Is it DANGERous?.
Source
Journal of the American College of Cardiology. 85(6) (pp 595-603), 2025.
Date of Publication: 18 Feb 2025.
Author
Klein A.; Schulze P.C.; Engstom T.; Moller J.E.; Jensen L.O.; Junker A.;
Veien K.T.; Udesen N.L.J.; Schmidt H.; Hassager C.; Engstrom T.; Holmvang
L.; Kjaergaard J.; Sorensen R.; Lonborg J.; Frydland M.; Beske R.P.;
Boesgaard S.; Eiskjaer H.; Christensen S.; Christiansen E.H.; Terkelsen
C.J.; Schafer A.; Linke A.; Woitek F.J.; Hommel J.; Mangner N.; Polzin A.;
Westenfeld R.; Schulze C.; Moebius-Winkler S.; Skurk C.; Nordbeck P.;
Clemmensen P.; Westermann D.; Panoulas V.; Zimmer S.; Werner N.
Institution
(Klein, Beske, Hassager, Engstom, Holmvang, Moller) Department of
Cardiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen,
Denmark
(Hassager) Department of Clinical Medicine, University of Copenhagen,
Copenhagen, Denmark
(Jensen, Junker, Moller) Department of Cardiology, Odense University
Hospital, Odense, Denmark
(Jensen, Schmidt, Moller) Department of Clinical Research, University of
Southern, Odense, Denmark
(Eiskjaer, Terkelsen) Department of Cardiology, Aarhus University
Hospital, Aarhus, Denmark
(Mangner, Linke) Department of Internal Medicine and Cardiology, Heart
Center Dresden University Hospital, Technische Universitat Dresden,
Dresden, Germany
(Polzin) Department of Cardiology, Pulmonology and Vascular Medicine,
University Hospital Dusseldorf, Medical Faculty of the Heinrich Heine
University Dusseldorf, Dusseldorf, Germany
(Schulze) Department of Internal Medicine I, Cardiology, Angiology and
Intensive Medical Care, University Hospital Jena, Jena, Germany
(Skurk) Department of Cardiology, Angiology and Intensive Care Medicine,
Deutsches Herzzentrum der Charite, Campus Benjamin Franklin, Berlin,
Germany
(Skurk) Deutsches Zentrum fur Herz-Kreislauf-Forschung e.V., Berlin,
Germany
(Nordbeck) Department of Internal Medicine I, University Hospital
Wurzburg, Wurzburg, Germany
(Clemmensen) Department of Cardiology, University Heart and Vascular
Center (UHZ), University Clinic Hamburg-Eppendorf (UKE), Hamburg, Germany
(Clemmensen) Department of Cardiology, Zealand University Hospital,
Roskilde and Nykobing Falster, Denmark
(Panoulas) Department of Cardiology, Royal Brompton and Harefield
Hospitals, Guy's and St Thomas' NHS Foundation Trust, Harefield Hospital,
Harefield, United Kingdom
(Zimmer) Department of Cardiology, University Hospital Bonn, Bonn, Germany
(Schafer) Department of Cardiology and Angiology, Hannover Medical School,
Hannover, Germany
(Werner) Department of Internal Medicine III, Heart Center Trier,
Krankenhaus der Barmherzigen Bruder, Trier, Germany
(Schmidt) Department of Anesthesiology and Intensive Care, Odense
University Hospital, Odense, Denmark
Publisher
Elsevier Inc.
Abstract
Background: Whether age impacts the recently demonstrated survival benefit
of microaxial flow pump (mAFP) treatment in patients with ST-segment
elevation myocardial infarction (STEMI) and cardiogenic shock (CS) is
unknown. Objective(s): The purpose of this study was to assess the
impact of age on mortality and complication rates in patients with
STEMI-related CS randomized to standard care or mAFP on top of standard
care. Method(s): This is a secondary analysis of the Danish-German
Cardiogenic Shock (DanGer Shock) trial, an international, multicenter,
open-label trial, in which 355 adult patients with STEMI-related CS were
randomized to receive an mAFP (Impella CP) plus standard care or standard
care alone. The primary outcome of 180-day all-cause mortality is analyzed
according to age and intervention. Result(s): From lowest to highest
age quartile, the median ages (range) were 54 years (Q1-Q3: 31-59 years),
65 years (Q1-Q3: 60-69 years), 73 years (Q1-Q3: 70-76 years), and 81 years
(Q1-Q3: 77-92 years). There were no differences in blood pressure, lactate
level, left ventricular ejection fraction, or shock severity at
randomization across age groups. Mortality increased from lowest to
highest quartile (31%, 47%, 61%, and 73%, respectively; log-rank P <
0.001), with an adjusted OR for death at 180 days of 7.85 (95% CI:
3.37-19.2; P < 0.001) in the highest quartile compared to the lowest. The
predicted risk of mortality was higher in the standard-care group until
approximately 77 years, after which the predicted risk became higher in
the mAFP group (P = 0.20). In patients <77 years, a reduced 180-day
mortality was observed in patients randomized to the mAFP (OR: 0.45; 95%
CI: 0.28-0.73; P = 0.001), opposed to patients aged >=77 years (OR: 1.52;
95% CI: 0.57-4.08; P = 0.40), P for interaction = 0.028. Complications
were more frequent in the mAFP group, but there were no apparent
differences in incidence of complications across all ages.
 Conclusion(s): This exploratory secondary analysis of the DanGer
Shock trial demonstrates that older patients with STEMI-related CS
experience high mortality and may not attain the same benefit from routine
treatment with an mAFP as younger patients. Incorporating age as a factor
in patient selection may enhance the overall benefit of this therapy.
(Danish Cardiogenic Shock Trial [DanShock]; NCT01633502) Copyright
© 2025 American College of Cardiology Foundation

<13>
Accession Number
2036903069
Title
Effect of different intraoperative blood pressure regulation levels on
postoperative myocardial injury in patients undergoing radical mastectomy
for breast cancer after receiving neoadjuvant chemotherapy: a study
protocol for a randomised controlled trial.
Source
BMJ Open. 15(1) (no pagination), 2025. Article Number: e088559. Date of
Publication: 06 Jan 2025.
Author
Zhou Z.; Liu H.; Wang X.; Sang X.; Zhang Y.; Liu Y.; Zhang X.
Institution
(Zhou, Wang, Sang, Zhang) Department of Anesthesiology, The Affiliated
Lianyungang Hospital of Xuzhou Medical University, Jiangsu, Lianyungang,
China
(Liu) Department of Anesthesiology, Guanyun Clinical College, Medical
School of Yangzhou University, Jiangsu, Lianyungang, China
(Zhang) Deapartment of Anesthesiology, The Affiliated Suzhou Hospital of
Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China
(Liu) Department of Anesthesiology, Lianyungang Clinical College of
Nanjing Medical University, Jiangsu, Lianyungang, China
(Zhang) Department of Anesthesiology, The First Affiliated Hospital of
Kangda College of Nanjing Medical University, Jiangsu, Lianyungang, China
Publisher
BMJ Publishing Group
Abstract
Introduction For patients with breast cancer receiving preoperative
neoadjuvant chemotherapy with anthracyclines, there is an increased risk
of postoperative myocardial injury due to the cardiotoxicity of the
chemotherapeutic agents. The optimal intraoperative blood pressure
regulation regimen for these patients is unclear. This study is being
conducted to determine whether targeting mean arterial pressure (MAP) to
100%-120% of the patient's baseline blood pressure reduces the incidence
of myocardial injury after non-cardiac surgery (MINS) compared with
targeting MAP to 80%-100%. MINS is defined as elevated cardiac troponin
levels within 30 days after non-cardiac surgery with or without clinical
and electrocardiographic signs of cardiac ischaemia. Methods and analysis
The study is a single-centre, single-blind, prospective randomised
controlled trial. It is expected to enrol 166 subjects receiving
neoadjuvant chemotherapy with anthracyclines, between the ages of 40 and
75 years, scheduled for radical mastectomy. Participants will be
randomised 1:1 to a lower-level group:intraoperative MAP control at
80%-100% of baseline values or a higher-level group:intraoperative MAP
control at 100%-120% of baseline values. The primary outcome is defined by
the incidence of MINS at 6-8 hours, 24 hours and 48 hours postoperatively.
The secondary outcomes are heart-type free fatty acid-binding protein
values at 1-2 hours, 6-8 hours and 24 hours postoperatively; the incidence
of acute kidney injury within 48 hours postoperatively; the Quality of
Recovery-15 score at 24 hours, 48 hours postoperatively; post-anaesthesia
care unit length of stay; other postoperative cardiovascular
complications; the number of times rescue analgesia and antiemetics are
required; the time to first ambulation and length of postoperative
hospitalisation. Ethics and dissemination This study involves the
participation of human subjects and has received approval from the
Clinical Trial Ethics Committee at The Affiliated Lianyungang Hospital of
Xuzhou Medical University (approval number: KY-20230915001). Study results
will be presented at scientific meetings and in scientific publications.
Trial registration number ChiCTR2300077675. Copyright © Author(s)
(or their employer(s)) 2025. Re-use permitted under CC BY-NC. No
commercial re-use. See rights and permissions. Published by BMJ Group.

<14>
Accession Number
2037120472
Title
Perioperative Use of GLP-1 Receptor Agonists in Patients Undergoing
Cardiac Procedures: A Scoping Review.
Source
Heart Lung and Circulation. 34(2) (pp 105-117), 2025. Date of Publication:
01 Feb 2025.
Author
Wookey O.; Galligan A.; Wilkie B.; MacIsaac A.; Paratz E.
Institution
(Wookey) St Vincent's Hospital Melbourne, Melbourne, VIC, Australia
(Galligan) Department of Endocrinology and Diabetes, St Vincent's Hospital
Melbourne, Melbourne, VIC, Australia
(Wilkie) Department of Surgery, Eastern Health, Melbourne, VIC, Australia
(MacIsaac, Paratz) Department of Cardiology, St Vincent's Hospital
Melbourne, Melbourne, VIC, Australia
(Paratz) Heart, Exercise and Research Trials (HEART) Laboratory, St
Vincent's Institute of Medical Research, Melbourne, VIC, Australia
(Paratz) Faculty of Medicine, Dentistry and Health Sciences, University of
Melbourne, Melbourne, VIC, Australia
Publisher
Elsevier Ltd
Abstract
Background: Glucagon-like peptide-1 receptor agonist (GLP-1RA) therapies
are increasingly used for the treatment of type 2 diabetes mellitus and
obesity. Despite growing awareness of potentially increased risk of
pulmonary aspiration due to delayed gastric emptying, the risks and
benefits of their perioperative use in patients undergoing cardiac
procedures remains unexplored. A scoping review was performed to
investigate the perioperative GLP-1RA use in patients undergoing cardiac
procedures and recommendations. Method(s): PubMed and Ovid MEDLINE
were searched up to April 2024 to identify English-language studies on the
perioperative use of weekly and daily dosed GLP-1RAs in adult patients
undergoing cardiac procedures (including cardiac surgery,
trans-oesophageal echocardiograms, and cardiac catheterisation
procedures). Result(s): Three studies were identified, which
investigated daily dosed GLP-1RAs in patients undergoing cardiac surgery.
No studies were found investigating GLP-1RA use in cardiac catheterisation
or trans-oesophageal echocardiograms procedures, and none which
specifically examined risk of pulmonary aspiration in patients using
GLP-1RAs undergoing cardiac procedures. Conclusion(s): GLP-1RAs are
beneficial for perioperative weight loss, glycaemic control, and
cardiovascular health. Existing guidelines and consensus recommendations
are highly contradictory on perioperative GLP-1RA management. Although no
known published case reports exist to date of pulmonary aspiration in
patients using GLP-1RAs undergoing cardiac procedures, non-cardiac
surgical literature strongly suggests that patients are at theoretical
risk and a cautious approach is advised in the absence of robust evidence
informing recommendations for optimal withholding periods. Copyright
© 2024 Australian and New Zealand Society of Cardiac and Thoracic
Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand
(CSANZ)

<15>
Accession Number
2033009615
Title
Maternal and neonatal outcomes in pregnant women undergoing cardiac
surgery: a systematic review and meta-analysis.
Source
Journal of Maternal-Fetal and Neonatal Medicine. 38(1) (no pagination),
2025. Article Number: 2451675. Date of Publication: 2025.
Author
Zhou C.; Zhou Y.; Xu Z.; Mei L.; Jin Y.
Institution
(Zhou, Zhou, Xu, Jin) Department of Gynaecology, Huzhou Maternity and
Child Health Care Hospital, Zhejiang Province, Huzhou City, China
(Mei) Department of Internal Medicine, Huzhou Maternity and Child Health
Care Hospital, Zhejiang Province, Huzhou City, China
Publisher
Taylor and Francis Ltd.
Abstract
Objective: Cardiac diseases that require surgical intervention present a
unique challenge during pregnancy and may affect both maternal and
neonatal outcomes. This systematic review and meta-analysis aimed to
evaluate maternal and neonatal outcomes in pregnant females undergoing
cardiac surgery. Method(s): A comprehensive manual and electronic
search was conducted in PubMed, EMBASE, Cochrane Library, and Web of
Sciences databases for studies published up to 31st May 2024.
Eligible studies were required to report maternal and neonatal outcomes of
women who underwent cardiac surgery during pregnancy. Random-effects
meta-analysis was conducted to estimate pooled maternal and neonatal
mortality proportions, and the results were presented as risk ratios (RR)
with 95% confidence intervals (CIs). Result(s): Seventeen studies met
the inclusion criteria, comprising a total sample size of 196 pregnant
women who underwent cardiac surgery. Cardiac surgery during pregnancy was
significantly (p < 0.001) linked to increased maternal and neonatal
mortality, with pooled RR of 4.9% (CI: 2.1%-7.6%) and 26.5% (CI:
19.7%-33.4%), respectively. Conclusion(s): This study highlights the
significant risks associated with cardiac surgery during pregnancy, such
as increased risk of maternal and neonatal mortality and higher incidence
of preterm labor. Our findings underscore the importance of specialized
care and multidisciplinary management for pregnant women with cardiac
conditions. Further research is warranted to identify strategies for risk
mitigation and improved outcomes in this vulnerable
population. Copyright © 2025 The Author(s). Published by Informa
UK Limited, trading as Taylor & Francis Group.

<16>
Accession Number
2037109444
Title
Long-term outcomes of second-generation drug-eluting stents versus
coronary artery bypass graft: A systematic review and meta-analysis of
randomized trials and multivariable adjusted data.
Source
Coronary Artery Disease. (no pagination), 2025. Article Number:
10.1097/MCA.0000000000001503. Date of Publication: 2025.
Author
Carvalho Ferreira A.L.; Benitez Gonzalez M.E.; Coelho Pessoa Lima A.E.;
Alamino Lacalle A.; Saad G.; Guida C.M.
Institution
(Carvalho Ferreira) Department of Medicine, Pontifical Catholic University
of Parana, Curitiba, Brazil
(Benitez Gonzalez) Department of Medicine, Advocate Illinois Masonic
Medical Center, Chicago, IL, United States
(Coelho Pessoa Lima) Department of Medicine, Bahiana School of Medicine
and Public Health, Salvador, Brazil
(Alamino Lacalle) Division of Cardiology, University of Sao Paulo,
Ribeirao Preto, Brazil
(Saad, Guida) Division of Cardiology, Dante Pazzanese Institute of
Cardiology, Sao Paulo, Brazil
Publisher
Lippincott Williams and Wilkins
Abstract
Long-term data are limited comparing percutaneous coronary intervention
(PCI) with second-generation drug-eluting stents (S-DES) vs coronary
artery bypass grafting (CABG) in patients with complex coronary artery
disease (CAD). We aimed to conduct a systematic review and meta-analysis
comparing these interventions in patients with left main or multivessel
CAD. We systematically reviewed PubMed, Embase, and Cochrane for studies
that compared PCI with S-DES and CABG in patients with left main or
multivessel CAD with a minimum mean follow-up period of 3 years. Outcomes
of interest were all-cause mortality, myocardial infarction (MI), stroke,
and major adverse cardiovascular events (MACE). We extracted data from
observational studies as multivariable-adjusted or propensity
score-matched hazard ratio to minimize confounding and pooled hazard
ratios with 95% confidence intervals (CIs) using a random effects model in
Review Manager 5.4.1. We included 10 studies, 3 of which were randomized
controlled trials, comprising a total of 26964 patients, of whom 14928
underwent PCI. As compared with CABG, S-DES had a significantly higher
risk of all-cause mortality (hazard ratio 1.35; 95% CI 1.22-1.49; P <
0.001; I2 = 0%), MACE (hazard ratio 1.27; 95% CI 1.08-1.50; P = 0.005; I2
= 67%), and MI (hazard ratio 2.43; 95% CI 1.80-3.28; P < 0.01; I2 = 0%).
There was no significant difference between groups in incidence of stroke.
In this meta-analysis of patients with complex CAD, PCI with S-DES was
associated with an increased risk of mortality, MI, and MACE compared with
CABG. Copyright © 2025 Wolters Kluwer Health, Inc. All rights
reserved.

<17>
Accession Number
2032949489
Title
Role of Video Assisted Thoracoscopic Surgery (VATS) in the Management of
Pulmonary Sequestration; A Meta-Analysis.
Source
Current Respiratory Medicine Reviews. 21(2) (pp 166-173), 2025. Date of
Publication: 2025.
Author
Kakamad F.H.; Amin B.J.H.; Ahmed H.K.; Najmadden Z.B.; Tahir S.H.;
Abdullah A.M.; Kareem P.M.; Ahmed H.S.; Mohammed S.H.; Mohammed K.K.;
Abdalla B.A.; Abdalla S.S.; Kakamad S.H.
Institution
(Kakamad, Amin, Ahmed, Tahir, Abdullah, Kareem, Ahmed, Abdalla, Abdalla)
Scientific Affairs Department, Smart Health Tower, Madam Mitterrand Str,
Kurdistan, Sulaimani, Iraq
(Kakamad, Tahir) Department of Surgery, College of Medicine, University of
Sulaimani, Madam Mitterrand Street, Kurdistan, Sulaimani, Iraq
(Kakamad, Mohammed, Mohammed, Abdalla, Kakamad) Kscien Organization, Hamid
Str, Azadi Mall, Sulaimani, Iraq
(Najmadden) Research Center, University of Halabja, Halabja, Kurdistan
Region, Iraq
(Abdullah) Sulaimani Teaching Hospital, Sulaimani, Kurdistan, Iraq
(Mohammed) Xzmat Polyclinic, Rzgary, Kalar, Sulaimani, Kurdistan, Iraq
(Mohammed) Smart Health Tower (Raparin Branch), Karux Str, Rania,
Sulaimani, Kurdistan, Iraq
Publisher
Bentham Science Publishers
Abstract
Background: Pulmonary sequestration is a rare birth defect. It is a
nonfunctioning dysplastic lung tissue without connection to the
tracheobronchial tree, and its blood supply is from one or more aberrant
systemic arteries. The aim of this study is to review the current
literature regarding the role of video-assisted thoracic surgery (VATS) in
the management of pulmonary sequestration. Objective(s): This review
aims to assess the safety, efficacy, and outcomes of Video-Assisted
Thoracoscopic Surgery (VATS) in managing pulmonary sequestration while
considering patient characteristics, symptoms, arterial sources, surgical
techniques, and postoperative advantages. Method(s): The Web of
Science, PubMed, MEDLINE, and Google Scholar were searched for articles
published in English. Article titles containing the words "Video-Assisted
Thoracoscopic Surgery for Pulmonary Sequestration and/or VATS" were
filtered out of the search to exclude a large portion of irrelevant
studies. The extracted data were analyzed. The data extracted were
presented as frequencies and percentages. Result(s): After excluding
the unrelated articles, 27 studies were identified for analysis; most of
the studies (18) were case reports, with nine being case series, and the
total number of patients who underwent pulmonary sequestration by VATS was
240. Both genders were equally affected (125, 52% were male and 115, 48%
were female), the most common presenting symptom was coughing,and the
descending thoracic aorta was the most common artery from which the
feeders originated. About 149 patients (62.08%) underwent a lobectomy.
 Conclusion(s): Pulmonary sequestration can safely be treated by VATS
at single or multiple ports with a shorter hospital stay, less
postoperative pain, and fewer analgesic requirements. Copyright ©
2025 Bentham Science Publishers.

<18>
Accession Number
2037118457
Title
Combined Short-Long Axis Versus Medial Oblique Axis for Internal Jugular
Vein Cannulation: A Prospective Single-Blinded Randomized Clinical Trial.
Source
Journal of Cardiothoracic and Vascular Anesthesia. (no pagination), 2025.
Date of Publication: 2025.
Author
Afifi S.; Soltan S.A.; Farag A.M.G.
Institution
(Afifi) Department of Anesthesia, Faculty of Medicine, Ain Shams
University, Cairo, Egypt
(Afifi, Soltan) Specialized Anesthesia Department, King Abdullah Medical
City in Holy Capital KAMC-HC, Makkah, Saudi Arabia
(Soltan) Department of Anesthesia, Faculty of Medicine, Al Azhar
University, Cairo, Egypt
(Farag) Department of Cardiac Anesthesia, King Abdullah Medical City in
Holy Capital KAMC-HC, Makkah, Saudi Arabia
Publisher
W.B. Saunders
Abstract
Objective(s): Previous literature suggested the advantage of combined
short-long axis (CSLA) technique to avoid posterior wall puncture during
internal jugular vein (IJV) cannulation. The purpose of this study is to
define the best ultrasound-guided IJV cannulation technique regarding the
success rate in the first trial of insertion, time to successful central
line placement, number of attempts, procedural complications, and operator
satisfaction. Design(s): Single-blinded, prospective randomized
clinical trial. Setting(s): Elective cardiac surgeries in a tertiary
care center. Participant(s): One hundred seventy-eight elective
cardiac surgery patients older than 18 years accepted to participate in
the study and signed the informed consent. Intervention(s): Patients
were randomized into two equal groups: medial oblique axis and CSLA.
During the technique, vein dimensions, patient characteristics, technique
duration, posterior wall puncture, number of attempts, complications, and
operator satisfaction were documented. Measurements and Main Results:
Apart from body weight, there were no significant differences in baseline
characteristics between both groups. Compared to the CSLA, the medial
oblique approach showed significantly higher first-trial success rate
(92.1% v 75.0%, p = 0.002), less time for successful insertion (mean +/-
SD, 60.9 +/- 54.9 seconds v 110.7 +/- 101.6 seconds, p < 0.001),
accomplishment with fewer attempts (mean +/- SD, 1.09 +/- 0.28 v 1.44 +/-
0.81, p < 0.001), and higher operator satisfaction (mean +/- SD, 4.45 +/-
0.92 v 3.46 +/- 1.32, p < 0.001). No significant difference in
complications, including posterior wall puncture (p = 0.469), was noted
between both groups. Conclusion(s): This study demonstrated the
medial oblique axis approach was superior to the CSLA approach regarding
first-trial success rate, time to successful line placement, number of
attempts, and operator satisfaction when used during elective cannulation
of the IJV. However, regarding the incidence of complications, there was
no advantage of one approach over the other. Further research is needed to
confirm these results among specific groups of operators, with awake
patients and in emergent situations. Copyright © 2025 Elsevier
Inc.

<19>
Accession Number
2037092865
Title
Emergency interventions for cardiogenic shock due to decompensated aortic
stenosis: A systematic review and meta-analysis.
Source
Open Heart. 12(1) (no pagination), 2025. Article Number: e003110. Date of
Publication: 19 Jan 2025.
Author
Kuhne S.G.; Patrignani A.; Elvinger S.; Wein B.; Harmel E.; Penev D.;
Owais T.; Girdauskas E.; Raake P.W.; Chiarito M.; Bongiovanni D.
Institution
(Kuhne, Elvinger, Wein, Harmel, Penev, Raake, Bongiovanni) Department of
Internal Medicine I, Cardiology, University Hospital Augsburg, Augsburg,
Germany
(Patrignani, Chiarito) Department of Biomedical Sciences, Humanitas
University, Milan, Italy
(Owais, Girdauskas) Department of Cardiovascular and Thoracic Surgery,
University Hospital Augsburg, Augsburg, Germany
Publisher
BMJ Publishing Group
Abstract
Background Cardiogenic shock (CS) induced by severe aortic stenosis (AS)
is a life-threatening condition with high mortality. Despite advancements
in emergency interventions, the optimal treatment approach remains
uncertain. Aim This study aimed to systematically review and analyse the
existing evidence on outcomes of emergency transcatheter aortic valve
implantation (eTAVI) and emergency balloon aortic valvuloplasty (eBAV) in
CS patients. Methods A systematic literature review and meta-analysis was
performed. The primary endpoint was mortality at 30 days. Secondary
endpoints were in-hospital mortality, 1-year mortality, bleeding, major
vascular complications, myocardial infarction, stroke, incidence of
pacemaker implantation, acute kidney injury and aortic regurgitation.
Results Seventeen studies were included, totalling 2811 patients. The
analysis revealed a 30-day mortality pooled estimated rate for eTAVI of
19% (CI 0.17 - 0.20) and for eBAV 39% (CI 0.32 - 0.46). In-hospital
mortality pooled estimated rates were 11% for eTAVI (CI 0.06 - 0.18) and
for eBAV 40% (CI 0.28 - 0.54). One-year mortality pooled estimated rates
for eTAVI were 29% (CI 0.20 - 0.40) and for eBAV 67% (CI 0.58 - 0.74).
Pooled estimated rates of any bleeding were 12% for eTAVI (CI 0.06 - 0.20)
and 15% for eBAV (CI 0.10 - 0.21). The rate of major vascular
complications for eTAVI was 8% (CI 0.07 - 0.10) and 3% for eBAV (CI 0.0 -
0.23). Conclusions This meta-analysis indicates that mortality in CS due
to AS remains high despite emergency interventional treatment. These
findings offer critical insights for clinical decision-making optimising
patient care in this critically ill population. Copyright ©
Author(s) (or their employer(s)) 2025.

<20>
Accession Number
2032850142
Title
Machine perfusion organ preservation: Highlights from the American
transplant congress 2024.
Source
Artificial Organs. 49(2) (pp 326-331), 2025. Date of Publication: 01 Feb
2025.
Author
Pitchaimuthu M.; Crochet C.; Battula N.R.; Faria I.; Martins P.N.
Institution
(Pitchaimuthu, Crochet, Battula, Martins) Department of Surgery, Division
of Transplantation, University of Oklahoma Health Sciences Center,
Oklahoma City, OK, United States
(Faria) Department of Surgery, University of Texas Medical Branch,
Galveston, TX, United States
Publisher
John Wiley and Sons Inc
Abstract
The American Transplant Congress (ATC) 2024, held in Philadelphia, serves
as a vital platform for unveiling new research and clinical experience in
organ machine perfusion-a key area in organ transplantation. This year's
congress gathered 4652 participants from 49 countries, including top
experts, to spotlight innovations in machine perfusion across various
organ types, such as the liver, kidney, heart, and lung. A total of 87
abstracts on organ machine perfusion were presented. We selected 39
abstracts that showed advances including new approaches to organ
preservation, promising treatments and biomarkers, cellular therapy, and
novel research areas. ATC 2024 underscored major advancements in machine
perfusion in both experimental and clinical studies and demonstrated its
role as a disruptive force in enhancing transplant outcomes and expanding
the donor pool, fostering a robust exchange of knowledge on a global
scale. Copyright © 2025 International Center for Artificial Organ
and Transplantation (ICAOT) and Wiley Periodicals LLC.

<21>
Accession Number
2032961919
Title
Comparative Efficacy of Antithrombotic Strategies in Bioprosthetic Aortic
Valve Replacement: A Network Meta-Analysis.
Source
Angiology. (no pagination), 2025. Date of Publication: 2025.
Author
Naito N.; Takagi H.
Institution
(Naito, Takagi) Department of Cardiovascular Surgery, Shizuoka Medical
Center, Shizuoka, Japan
Publisher
SAGE Publications Inc.
Abstract
This meta-analysis evaluates outcomes in patients undergoing bioprosthetic
aortic valve replacement (bAVR), comparing different antithrombotic
strategies. We conducted a systematic search through May 2024. A standard
meta-analysis compared outcomes between patients who received
anticoagulation therapy (AC) and those who did not. Therapeutic categories
were subdivided into four groups: AC alone, AC with antiplatelet therapy
(AP), AP alone, and no antithrombotic therapy. A network meta-analysis was
performed for these categories. The review included 16 studies, comprising
a total of 59,054 patients. There was no significant difference in
all-cause mortality rates (HR: hazard ratio [95% CI: confidence interval]
= 0.98 [0.77-1.25], P =.88) or thromboembolic events (HR [95% CI] = 0.91
[0.65-1.28], P =.60) between patients with and without AC. However,
bleeding events were significantly higher in patients receiving AC (HR
[95% CI] = 1.55 [1.20-2.00], P <.01). Network meta-analysis showed that AP
alone was associated with lower mortality rates compared with other
therapeutic categories. Additionally, AP alone was associated with fewer
bleeding events compared with AC alone and AC with AP. This meta-analysis
suggests that AP alone in patients undergoing bAVR is associated with
superior outcomes compared with other antithrombotic
strategies. Copyright © The Author(s) 2025.

<22>
Accession Number
2032956166
Title
Early and Late Outcomes of Transcatheter Aortic Valve Replacement in
Patients With Prior Chest Radiation: A Systematic Review and
Meta-Analysis.
Source
Catheterization and Cardiovascular Interventions. (no pagination), 2025.
Date of Publication: 2025.
Author
Tzoumas A.; Kyriakoulis I.; Ntoumaziou A.; Sagris M.; Kampaktsis P.N.
Institution
(Tzoumas) Division of Cardiovascular Health and Disease, University of
Cincinnati Medical Center, Cincinnati, OH, United States
(Kyriakoulis) Faculty of Medicine, School of Health Sciences, University
of Thessaly, Larissa, Greece
(Ntoumaziou) Cincinnati Children's Hospital, Cincinnati, OH, United States
(Sagris) School of Medicine, "Hippokration" General Hospital, National and
Kapodistrian University of Athens, Athens, Greece
(Kampaktsis) Hackensack University Medical Center, Hackensack, NJ, United
States
(Kampaktsis) Aristotle University of Thessaloniki, Thessaloniki, Greece
Publisher
John Wiley and Sons Inc
Abstract
Background: Patients with prior history of chest or mediastinal radiation
are deemed high risk for surgical AVR. Transcatheter aortic valve
replacement (TAVR) has emerged as a promising alternative for these
patients, however, this patient population was underrepresented in prior
TAVR trials. Aim(s): To compare the outcomes of TAVR in patients with
versus without a history of prior chest or mediastinal radiation.
 Method(s): This study was performed according to the Preferred
Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Systematic search of electronic databases was conducted up to September
2023. We compared early and late mortality as well as complications. A
meta-analysis was conducted with the use of a random effects model. The
I-square statistic was used to assess heterogeneity. Result(s): Seven
studies comprising 6358 patients were included in this meta-analysis.
Patients undergoing TAVR in the radiation group had a higher risk for
heart failure exacerbation (OR: 2.06; 95% CI: 1.18-3.59) and aortic valve
reintervention (OR: 5.68; 95% CI: 1.83-17.67) in the early postoperative
period compared to the nonradiation group. Analysis revealed similar
short-term (in-hospital or 30-day) all-cause-mortality (OR: 1.63; 95% CI:
0.89-2.98) between the two groups. Other perioperative complications
including myocardial infarction (MI), stroke, pacemaker insertion
requirement, major bleeding as well as access-related complications were
not significantly different between the two groups. TAVR in the radiation
group was not associated with increased all-cause mortality compared to
the nonradiation group (OR: 1.40; 95% CI: 0.93-2.11) after a mean
follow-up of 17.6 months. Other endpoints including MI, stroke, need for
pacemaker insertion, heart failure readmission rate, and need for aortic
valve reintervention were similar in the mid-term follow-up between the
two groups. Conclusion(s): TAVR in patients with a history of prior
chest or mediastinal radiation was associated with similar short-term and
mid-term mortality compared to patients without radiation. The history of
chest or mediastinal radiation was associated with more frequent heart
failure hospitalizations and aortic valve reintervention in the
postoperative period. No difference was found in mid-term complications.
Future studies are warranted to validate our findings. Copyright
© 2025 Wiley Periodicals LLC.

<23>
Accession Number
2037118155
Title
The Renal Effect of 20% Human Albumin Solution Fluid Bolus Therapy in
Patients After Cardiac Surgery. A Secondary Analysis of the HAS FLAIR II
Randomized Clinical Trial.
Source
Journal of Cardiothoracic and Vascular Anesthesia. (no pagination), 2025.
Date of Publication: 2025.
Author
Wigmore G.J.; Deane A.M.; Presneill J.J.; Serpa Neto A.; Eastwood G.;
Maiden M.J.; Bihari S.; Baker R.A.; Bennetts J.S.; Ghanpur R.; Anstey
J.R.; Raman J.; Bellomo R.
Institution
(Wigmore, Deane, Presneill, Serpa Neto, Maiden, Bellomo) Department of
Critical Care, Melbourne Medical School, University of Melbourne,
Parkville, VIC, Australia
(Wigmore) Department of Anaesthesia and Pain Medicine, Western Health,
Melbourne, VIC, Australia
(Deane, Presneill, Maiden, Anstey, Bellomo) Department of Intensive Care,
Royal Melbourne Hospital, Melbourne, VIC, Australia
(Presneill, Serpa Neto, Bellomo) Australian and New Zealand Intensive Care
Research Centre (ANZIC-RC), School of Public Health and Preventive
Medicine, Monash University, Melbourne, VIC, Australia
(Serpa Neto, Eastwood, Raman, Bellomo) Department of Intensive Care,
Austin Hospital, Melbourne, VIC, Australia
(Serpa Neto) Department of Critical Care Medicine, Hospital Israelita
Albert Einstein, Sao Paulo, Brazil
(Maiden) Intensive Care Unit, Barwon Health, Geelong, VIC, Australia
(Bihari) College of Medicine and Public Health, Flinders University,
Bedford Park, SA, Australia
(Bihari) Department of ICCU, Flinders Medical Centre, Bedford Park, SA,
Australia
(Baker, Bennetts) Cardiothoracic Quality and Outcomes, Flinders Medical
Centre and College of Medicine and Public Health Flinders University, SA,
Australia
(Ghanpur) Department of Intensive Care, Warringal Private Hospital,
Melbourne, Australia
(Raman) University of Melbourne, Parkville, VIC, Australia
(Raman) St Vincent's Hospital, Melbourne, VIC, Australia
(Raman) Department of Cardiothoracic Surgery, Townsville University
Hospital, Townsville, QLD, Australia
(Bellomo) Data Analytics Research and Evaluation Centre, Austin Hospital,
Melbourne, VIC, Australia
Publisher
W.B. Saunders
Abstract
Objective: To compare the effects of fluid bolus therapy (FBT) with 20%
albumin to crystalloid FBT on the incidence of cardiac surgery-associated
acute kidney injury (CSA-AKI) and its severity and duration.
 Design(s): Secondary analysis of the multicenter, parallel-group,
open-label, randomized HAS FLAIR-II trial. Setting(s): Six intensive
care units. Participant(s): Patients who required
clinician-determined FBT after cardiac surgery requiring cardiopulmonary
bypass. Intervention(s): Patients were randomized to receive FBT with
20% albumin (up to 400 mL/day) or crystalloid fluid for all FBTs in the
intensive care unit. Measurements and Main Results: A total of 452
patients were included in the modified intention-to-treat population (224
in the 20% albumin group and 228 in the crystalloid group). AKI occurred
in 54 (24%) patients in the 20% albumin group and 50 (22%) in the
crystalloid group (odds ratio: 1.13, 95% confidence interval [CI]: 0.73 to
1.76). However, in patients who developed stages 2 and 3 AKI, those
allocated to 20% albumin had a significantly lower median time-weighted
average (TWA) creatinine: 144 micromol/L (interquartile range [IQR]: 109
to 162) versus 254 micromol/L (IQR: 182 to 294) than the crystalloid group
(difference -105 micromol/L, [95% CI -170 to -41], p = 0.003) and a lower
peak serum creatinine (-110 micromol/L [-189 to -32], p = 0.01). The
reduced TWA creatinine in the 20% albumin group was seen in patients with
both a low (p = 0.04) and normal preoperative serum albumin concentration
(p < 0.001). Conclusion(s): FBT with 20% albumin compared with
crystalloid-based regimen did not reduce the occurrence of AKI in patients
after cardiac surgery. However, it reduced the severity and duration of
stages 2 and 3 AKI. Copyright © 2025 The Authors

<24>
Accession Number
645658527
Title
Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis
and Myocardial Fibrosis: The EVOLVED Randomized Clinical Trial.
Source
JAMA. 333(3) (pp 213-221), 2025. Date of Publication: 21 Jan 2025.
Author
Loganath K.; Craig N.J.; Everett R.J.; Bing R.; Tsampasian V.; Molek P.;
Botezatu S.; Aslam S.; Lewis S.; Graham C.; White A.C.; MacGillivray T.;
Tuck C.E.; Rayson P.; Cranley D.; Irvine S.; Armstrong R.; Milne L.; Chin
C.W.L.; Hillis G.S.; Fairbairn T.; Greenwood J.P.; Steeds R.; Leslie S.J.;
Lang C.C.; Bucciarelli-Ducci C.; Joshi N.V.; Kunadian V.; Vassiliou V.S.;
Dungu J.N.; Hothi S.S.; Boon N.; Prasad S.K.; Keenan N.G.; Dawson D.;
Treibel T.A.; Motwani M.; Miller C.A.; Mills N.L.; Rajani R.; Ripley D.P.;
McCann G.P.; Prendergast B.; Singh A.; Newby D.E.; Dweck M.R.
Institution
(Loganath, Craig, White, Tuck, Mills, Newby, Dweck) British Heart
Foundation Centre of Research Excellence, University of Edinburgh,
Edinburgh, United Kingdom
(Craig, Everett, Bing, White, Mills, Newby, Dweck) Edinburgh Heart Centre,
Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
(Tsampasian, Vassiliou) Norwich Medical School, University of East Anglia,
Norwich, United Kingdom
(Tsampasian, Vassiliou) Department of Cardiology, Norfolk and Norwich
University Hospital, Norwich, United Kingdom
(Molek) Department of Coronary Disease and Heart Failure, Jagiellonian
University Medical College, Krakow, Poland
(Botezatu) University of Medicine and Pharmacy Carol Davila, Cardiology
Department, Bucharest, Romania
(Aslam, McCann, Singh) Department of Cardiovascular Sciences, University
of Leicester and the NIHR Leicester Biomedical Research Centre, Glenfield
Hospital, Leicester, United Kingdom
(Lewis, Rayson, Cranley, Irvine, Armstrong, Milne) Edinburgh Clinical
Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, United
Kingdom
(Graham) Edinburgh Clinical Research Facility, University of Edinburgh,
Edinburgh, United Kingdom
(MacGillivray) University of Edinburgh, Edinburgh, United Kingdom
(Chin) Department of Cardiology, National Heart Centre Singapore,
Singapore
(Chin) Cardiovascular Medicine ACP Duke NUS Medical School, Singapore
(Hillis) Medical School, University of Western Australia, Perth, WA,
Australia
(Hillis) Department of Cardiology, Royal Perth Hospital, Perth, WA,
Australia
(Fairbairn) Department of Cardiology, Liverpool Centre for Cardiovascular
Science, Liverpool Heart and Chest Hospital, Liverpool, United Kingdom
(Greenwood) Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
(Greenwood) Baker Heart and Diabetes Institute, Melbourne, VIC, Australia
(Steeds) Department of Cardiology, Queen Elizabeth Hospital Birmingham,
University Hospitals of Birmingham NHS Foundation Trust, Birmingham,
United Kingdom
(Leslie) Cardiac Unit, Raigmore Hospital, Inverness, United Kingdom
(Lang) Division of Molecular and Clinical Medicine, School of Medicine,
University of Dundee, Dundee, United Kingdom
(Lang) National University of Malaysia, Malaysia
(Bucciarelli-Ducci, Joshi) Bristol Heart Institute, University Hospitals
Bristol NHS Foundation Trust, Bristol, United Kingdom
(Bucciarelli-Ducci, Prasad) Royal Brompton and Harefield Hospitals, Guys'
and St Thomas NHS Foundation Trust, London, United Kingdom
(Kunadian) Translational and Clinical Research Institute, Faculty of
Medical Sciences, Newcastle, United Kingdom
(Kunadian) University and Cardiothoracic Centre, Freeman Hospital,
Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne,
United Kingdom
(Dungu) Essex Cardiothoracic Centre, Nethermayne, Basildon, Essex, United
Kingdom
(Dungu) Anglia Ruskin University, Chelmsford, Essex, United Kingdom
(Hothi) Department of Cardiology, Royal Wolverhampton NHS Trust, Institute
of Cardiovascular Sciences, University of Birmingham, Wolverhampton,
United Kingdom
(Boon) Retired, Hertfordshire, United Kingdom
(Keenan) Department of Cardiology, West Hertfordshire Hospitals NHS Trust,
Watford, United Kingdom
(Keenan) Imperial College, London, United Kingdom
(Dawson) Aberdeen Cardiovascular and Diabetes Centre, University of
Aberdeen, Aberdeen, United Kingdom
(Treibel) Institute of Cardiovascular Sciences, University College London,
and St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield,
London, United Kingdom
(Motwani) Department of Cardiology, Manchester Royal Infirmary, Manchester
University NHS Foundation Trust, Manchester, United Kingdom
(Miller) Division of Cardiovascular Sciences, School of Medical Sciences,
Faculty of Biology, Medicine and Health, Manchester Academic Health
Science Centre, University of Manchester, Manchester, United Kingdom
(Mills) Usher Institute, University of Edinburgh, Edinburgh, United
Kingdom
(Rajani) Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
(Ripley) Cardiology, Northumbria Healthcare NHS Foundation Trust,
Newcastle upon Tyne, United Kingdom
(Prendergast) Cleveland Clinic London and St Thomas' Hospital, London,
United Kingdom
Abstract
Importance: Development of myocardial fibrosis in patients with aortic
stenosis precedes left ventricular decompensation and is associated with
an adverse long-term prognosis. Objective(s): To investigate whether
early valve intervention reduced the incidence of all-cause death or
unplanned aortic stenosis-related hospitalization in asymptomatic patients
with severe aortic stenosis and myocardial fibrosis. Design, Setting,
and Participant(s): This prospective, randomized, open-label, masked end
point trial was conducted between August 2017 and October 2022 at 24
cardiac centers across the UK and Australia. Asymptomatic patients with
severe aortic stenosis and myocardial fibrosis were included. The final
date of follow-up was July 26, 2024. Intervention(s): Early valve
intervention with transcatheter or surgical aortic valve replacement or
guideline-directed conservative management. Main Outcomes and
Measures: The primary outcome was a composite of all-cause death or
unplanned aortic stenosis-related hospitalization in a time-to-first-event
intention-to-treat analysis. There were 9 secondary outcomes, including
the components of the primary outcome and symptom status at 12 months.
 Result(s): The trial enrolled 224 eligible patients (mean [SD] age,
73 [9] years; 63 women [28%]; mean [SD] aortic valve peak velocity of 4.3
[0.5] m/s) of the originally planned sample size of 356 patients. The
primary end point occurred in 20 of 113 patients (18%) in the early
intervention group and 25 of 111 patients (23%) in the guideline-directed
conservative management group (hazard ratio, 0.79 [95% CI, 0.44-1.43]; P =
.44; between-group difference, -4.82% [95% CI, -15.31% to 5.66%]). Of 9
prespecified secondary end points, 7 showed no significant difference.
All-cause death occurred in 16 of 113 patients (14%) in the early
intervention group and 14 of 111 (13%) in the guideline-directed group
(hazard ratio, 1.22 [95% CI, 0.59-2.51]) and unplanned aortic stenosis
hospitalization occurred in 7 of 113 patients (6%) and 19 of 111 patients
(17%), respectively (hazard ratio, 0.37 [95% CI, 0.16-0.88]). Early
intervention was associated with a lower 12-month rate of New York Heart
Association class II-IV symptoms than guideline-directed conservative
management (21 [19.7%] vs 39 [37.9%]; odds ratio, 0.37 [95% CI,
0.20-0.70]). Conclusions and Relevance: In asymptomatic patients with
severe aortic stenosis and myocardial fibrosis, early aortic valve
intervention had no demonstrable effect on all-cause death or unplanned
aortic stenosis-related hospitalization. The trial had a wide 95% CI
around the primary end point, with further research needed to confirm
these findings. Trial Registration: ClinicalTrials.gov Identifier:
NCT03094143.

<25>
Accession Number
2037195667
Title
Partial Cardiac Denervation to Prevent Postoperative Atrial Fibrillation
After Coronary Artery Bypass Grafting: The pCAD-POAF Randomized Clinical
Trial.
Source
JAMA Cardiology. 10(1) (pp 71-77), 2025. Date of Publication: 08 Jan 2025.
Author
Yang Z.; Tiemuerniyazi X.; Xu F.; Wang Y.; Sun Y.; Yan P.; Tian L.; Han
C.; Zhang Y.; Pan S.; Hu Z.; Li X.; Zhao W.; Feng W.
Institution
(Yang, Tiemuerniyazi, Xu, Yan, Tian, Han, Zhang, Pan, Hu, Zhao, Feng)
Department of Cardiovascular Surgery, Fuwai Hospital, National Center for
Cardiovascular Diseases, National Clinical Research Center for
Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union
Medical College, Beijing, China
(Wang) Department of Medical Research and Biometrics Center, State Key
Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for
Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union
Medical College, Beijing, China
(Sun) Department of Pathology Diagnostic Laboratory Service, Fuwai
Hospital, National Center for Cardiovascular Diseases, Chinese Academy of
Medical Sciences, Peking Union Medical College, Beijing, China
(Li) State Key Laboratory of Cardiovascular Disease, Fuwai Hospital,
National Center for Cardiovascular Diseases, National Clinical Research
Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences,
Peking Union Medical College, Beijing, China
Publisher
American Medical Association
Abstract
Importance: Efficient approaches to prevent postoperative atrial
fibrillation (POAF) after coronary artery bypass grafting (CABG) are still
needed. Objective(s): To investigate whether partial cardiac
denervation, achieved by cutting off the ligament of Marshall (LOM) and
resecting the fat pad along the Waterston groove, can reduce the risk of
POAF following CABG. Design, Setting and Participants: This single-center,
randomized clinical trial enrolled adult patients scheduled for isolated
CABG in China. Enrollment was from August 15, 2022, to December 13, 2023;
follow-up visits were 30 days after discharge. Intervention(s):
Participants were randomized into the intervention group (CABG plus
partial cardiac denervation) and the control group (CABG only) in a 1:1
pattern. All participants were continuously monitored for the incidence of
POAF until day 6 after the operation. Main outcome and Measures: The
primary end point was the incidence of POAF in 6 days, defined as a
supraventricular arrhythmia lasting for more than 30 seconds.
 Result(s): The trial enrolled 430 patients (79 [18.4%] female; mean
[SD] age, 61.9 [7.8] years). Compared with the control group, the 6-day
incidence of POAF was significantly lower in the intervention group (18.1%
vs 31.6%; P =.001; risk ratio, 0.57 [95% CI, 0.41-0.81]). To further
support these results, a sensitivity analysis performed with Kaplan-Meier
survival curves also showed a significant reduction in the occurrence of
POAF in the intervention group (hazard ratio, 0.53 [95% CI, 0.36-0.79]; P
=.002). Safety assessments showed no difference between the 2 groups,
while postoperative medical cost was reduced in the intervention group.
 Conclusions and Relevance: This randomized clinical trial found that
partial cardiac denervation was an effective procedure to reduce the
occurrence of POAF after isolated CABG without additional postoperative
complications. These results suggest that partial cardiac denervation may
be a good option for cardiac surgeons to consider for preventing POAF
after CABG. Copyright © 2024 Yang Z et al.

<26>
Accession Number
2036751433
Title
Postoperative delirium under general anaesthesia by remimazolam versus
propofol: A systematic review and meta-analysis of randomised controlled
trials.
Source
Journal of Clinical Anesthesia. 101 (no pagination), 2025. Article Number:
111735. Date of Publication: 01 Feb 2025.
Author
Suga M.; Yasuhara J.; Watanabe A.; Takagi H.; Kuno T.; Nishimura T.; Ijuin
S.; Taira T.; Inoue A.; Ishihara S.; Pakavakis A.; Glassford N.; Shehabi
Y.
Institution
(Suga, Pakavakis, Glassford) Department of Intensive Care, Monash Medical
Centre, Melbourne, Australia
(Suga, Nishimura, Ijuin, Taira, Inoue, Ishihara) Department of Emergency
and Critical Care Medicine, Hyogo Emergency Medical Centre, Hyogo, Japan
(Yasuhara) Department of Pediatric Cardiology, Monash Heart and Monash
Children's Hospital, Monash Health, Melbourne, Australia
(Watanabe) Department of Medicine Icahn School of Medicine at Mount Sinai,
Mount Sinai Beth Israel, NY, United States
(Takagi) Department of Cardiovascular Surgery Shizuoka Medical Centre,
Shizuoka, Japan
(Kuno) Cardiology Division, Massachusetts General Hospital, Harvard
Medical School, Boston, MA, United States
(Kuno) Division of Cardiology, Montefiore Medical Centre, Albert Einstein
College of Medicine, NY, United States
(Shehabi) Monash Health School of Clinical Sciences, Monash University,
Melbourne, Australia
Publisher
Elsevier Inc.
Abstract
Background: Remimazolam, an ultra-short-acting benzodiazepine, has similar
clinical effects to propofol for sedation in general anaesthesia. However,
it remains uncertain whether remimazolam could increase postoperative
delirium (POD) compared with propofol. Objective(s): The purpose of
our study was to compare the incidence of POD between remimazolam and
propofol as sedative agents in general anaesthesia. Study design:
Systematic review and meta-analysis of randomised controlled trials
(RCTs). Method(s): PubMed, Embase, Cochrane Library, and Web of
Science databases were searched for prospective RCTs published through
September 16, 2024. RCTs reporting the incidence of POD and comparing
remimazolam with propofol for general anaesthesia were included. Odds
ratio (ORs) were calculated using a random-effects model. The primary
outcome was the incidence of POD. The secondary outcomes included time to
extubation, awakening time, and adverse events such as intraoperative
hypotension. Result(s): A total of six RCTs involving 1107 patients
were included in this meta-analysis. For the primary outcome, the
incidence of POD did not differ between the remimazolam and propofol
groups (OR, 0.92; 95 % confidence interval [CI], 0.58-1.44). Regarding the
secondary outcomes, remimazolam was associated with a lower incidence of
intraoperative hypotension compared with propofol (OR, 0.31; 95 % CI,
0.21-0.46). There were no significant differences in other secondary
outcomes. In the sensitivity analysis on three RCTs including only older
patients (>=60 years old), there was no significant difference in the
incidence of POD (OR, 1.00; 95 % CI, 0.52-1.93). Conclusion(s):
Perioperative remimazolam administration did not increase POD and reduced
the risk of intraoperative hypotension compared to propofol. Further
large-scale RCTs are warranted to explore the association of remimazolam
and POD. Systematic review protocol: PROSPERO
CRD42024544122. Copyright © 2024

<27>
Accession Number
2037197260
Title
30-Day Transcatheter Aortic Valve Replacement Outcomes in Severe
Symptomatic Aortic Stenosis Chinese Patients.
Source
JACC: Asia. 5(2) (pp 318-321), 2025. Date of Publication: 01 Feb 2025.
Author
Chen M.; Liu X.; Zhou Y.; Chen Y.; Feng Y.; Boatman S.V.; Wang J.
Institution
(Chen, Feng) Department of Cardiology, West China Hospital of Sichuan
University, Sichuan, Chengdu, China
(Liu, Wang) Department of Cardiology, The Second Affiliated Hospital
Zhejiang University School of Medicine, Zhejiang, Hangzhou, China
(Zhou) Department of Cardiology, Anzhen Hospital of the Capital University
of Medical Science, Beijing, China
(Chen) Department of Cardiology, Chinese PLA General Hospital, Beijing,
China
(Boatman) Medtronic, Minneapolis, MN, United States
Publisher
Elsevier Inc.

<28>
Accession Number
2037208703
Title
The current state of the multidisciplinary heart team approach: a
systematic review.
Source
European Journal of Cardio-thoracic Surgery. 67(1) (no pagination), 2025.
Article Number: ezae461. Date of Publication: 01 Jan 2025.
Author
Arjomandi Rad A.; Streukens S.; Vainer J.; Athanasiou T.; Maessen J.; Nia
P.S.
Institution
(Arjomandi Rad, Maessen, Nia) Department of Cardiothoracic Surgery,
Maastricht University Medical Center, Maastricht, Netherlands
(Arjomandi Rad) Department of Cardiothoracic Surgery, Bristol Heart
Institute, University of Bristol, Bristol, United Kingdom
(Streukens, Vainer) Department of Cardiology, Maastricht University
Medical Center, Maastricht, Netherlands
(Athanasiou) Department of Surgery and Cancer, Imperial College London,
London, United Kingdom
Publisher
European Association for Cardio-Thoracic Surgery
Abstract
The heart team (HT) approach, recommended for managing cardiovascular
diseases, emphasizes multidisciplinary collaboration. Despite its
potential benefits, evidence on its effectiveness and implementation is
varied and sparse. This review assesses the HT approach's impact on
patient outcomes and care delivery in cardiovascular care. A systematic
review was conducted across MEDLINE, EMBASE, PubMed, Cochrane and Google
Scholar up to July 2023, focusing on studies that implemented an HT
approach in coronary and heart valve disease management. Exclusion
criteria included non-human studies, case reports and studies not focusing
on HT outcomes. From 6270 identified articles, 20 met the inclusion
criteria. These studies demonstrated significant variability in HT
composition and organization, coupled with a lack of standardized metrics
for evaluating clinical outcomes and the impact of the HT. Significant
variability was observed in HT composition, with 13 of the 20 studies did
not utilize structured templates, those that did demonstrated more
consistent decision-making. In mitral valve interventions, HTs were linked
to reduced in-hospital mortality and improved long-term survival (5-year
survival probability of 0.74 vs 0.70, P = 0.04). In aortic valve
interventions, 80% of patients underwent tailored valve procedures
following HT evaluation. The HT approach in cardiovascular care
demonstrates improved patient outcomes, particularly in specialized
interventions for mitral and aortic valve diseases and coronary artery
disease management. Despite these positive findings, the variability in HT
implementation and the need for standardized outcome metrics call for
further advances to optimize this collaborative care model. Copyright
© 2024 The Author(s).

<29>
Accession Number
2035464972
Title
Rivaroxaban, in combination with low-dose aspirin, is associated with a
reduction in proinflammatory and prothrombotic circulating vesicle
signatures in patients with cardiovascular disease.
Source
Journal of Thrombosis and Haemostasis. 23(2) (pp 531-545), 2025. Date of
Publication: 01 Feb 2025.
Author
Weiss L.; O'Doherty A.; Uhrig W.; Szklanna P.B.; Hong-Minh M.; Wynne K.;
Blanco A.; Zivny J.; Lima Passos V.; Kevane B.; Murphy S.; Ni Ainle F.;
O'Donnell M.; Maguire P.B.
Institution
(Weiss, Uhrig, Szklanna, Hong-Minh, Kevane, Ni Ainle, Maguire) UCD Conway
SPHERE Research Group, Conway Institute, University College Dublin,
Dublin, Ireland
(Weiss, Szklanna, Hong-Minh, Maguire) School of Biomolecular and
Biomedical Science, University College Dublin, Dublin, Ireland
(Weiss, Maguire) AI for Healthcare Hub, Institute for Discovery, O'Brien
Centre for Science, University College Dublin, Dublin, Ireland
(O'Doherty, O'Donnell) Health Research Board Clinical Research Facility
Galway, School of Medicine, University of Galway, Galway, Ireland
(Wynne) Mass Spectrometry Core, Systems Biology Ireland, University
College Dublin, Dublin, Ireland
(Blanco) Flow Cytometry Core, Conway Institute, University College Dublin,
Dublin, Ireland
(Zivny) Institute of Pathological Physiology, First Faculty of Medicine,
Charles University, Prague, Czechia
(Lima Passos) School of Pharmacy and Biomolecular Science, Royal College
of Surgeons in Ireland, Dublin, Ireland
(Kevane, Ni Ainle) Department of Haematology, Mater Misericordiae
University Hospital, Dublin, Ireland
(Kevane, Murphy, Ni Ainle) School of Medicine, University College Dublin,
Dublin, Ireland
(Murphy) Department for Stroke Medicine, Mater Misericordiae University
Hospital, Dublin, Ireland
(Murphy) School of Medicine, Royal College of Surgeons in Ireland, Dublin,
Ireland
(Ni Ainle) Department of Haematology, Rotunda Hospital, Dublin, Ireland
Publisher
Elsevier B.V.
Abstract
Background: Despite secondary prevention with aspirin, patients with
stable cardiovascular disease (CVD) remain at elevated long-term risk of
major adverse cardiovascular events. The Cardiovascular Outcomes in People
Using Anticoagulant Strategies (COMPASS) double-blind, randomized clinical
trial demonstrated that aspirin plus low-dose rivaroxaban (COMPASS regime)
significantly decreased the incidence of major adverse cardiovascular
events by 24% compared with aspirin alone. However, the mechanisms
underlying these potential synergistic/nonantithrombotic effects remain
elusive. Extracellular vesicles (EVs) are crucial messengers regulating a
myriad of biological/pathological processes and are highly implicated in
CVD. Objective(s): We hypothesized that circulating EV profiles
reflect the cardioprotective properties of the COMPASS regime.
 Method(s): A cohort of stable CVD patients (N = 40) who participated
in the COMPASS trial and were previously randomized to receive aspirin
were prospectively recruited and assigned a revised regimen of open-label
aspirin plus rivaroxaban. Blood samples were obtained at baseline (aspirin
only) and 6-month follow-up. Plasma EV concentration, size, and origin
were analyzed by nanoparticle tracking analysis and flow cytometry. EVs
were enriched by ultracentrifugation for proteomic analysis.
 Result(s): The COMPASS regime fundamentally altered small (<200 nm)
and large (200-1000 nm) EV concentration and size compared with aspirin
alone. Crucially, levels of platelet-derived and myeloperoxidase-positive
EVs became significantly decreased at follow-up. Comparative proteomic
characterization further revealed a significant decrease in highly
proinflammatory protein expression at follow-up. Conclusion(s): The
observed changes in EV subpopulations, together with the differential
protein expression profiles, suggest amelioration of an underlying
proinflammatory and prothrombotic state upon dual therapy, which may be of
clinical relevance toward understanding the fundamental mechanism
underlying the reported superior cardiovascular outcomes associated with
this antithrombotic regimen. Copyright © 2024 The Author(s)

<30>
Accession Number
2033003465
Title
A Review of Needle Navigation Technologies in Minimally Invasive
Cardiovascular Surgeries-Toward a More Effective and Easy-to-Apply
Process.
Source
Diagnostics. 15(2) (no pagination), 2025. Article Number: 197. Date of
Publication: 01 Jan 2025.
Author
Steeg K.; Krombach G.A.; Friebe M.H.
Institution
(Steeg, Krombach) Department of Diagnostic and Interventional Radiology,
University Hospital Giessen, Justus-Liebig-University Giessen,
Klinikstrase 33, Giessen, Germany
(Friebe) Faculty of Computer Science, AGH University Krakow, Krakow,
Poland
(Friebe) INKA Innovation Lab, Faculty of Medicine,
Otto-von-Guericke-University, Magdeburg, Germany
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Abstract
Background: This review evaluates needle navigation technologies in
minimally invasive cardiovascular surgery (MICS), identifying their
strengths and limitations and the requirements for an ideal needle
navigation system that features optimal guidance and easy adoption in
clinical practice. Method(s): A systematic search of PubMed, Web of
Science, and IEEE databases up until June 2024 identified original studies
on needle navigation in MICS. Eligible studies were those published within
the past decade and that performed MICS requiring needle navigation
technologies in adult patients. Animal studies, case reports, clinical
trials, or laboratory experiments were excluded to focus on actively
deployed techniques in clinical practice. Extracted data included the
study year, modalities used, procedures performed, and the reported
strengths and limitations, from which the requirements for an optimal
needle navigation system were derived. Result(s): Of 36 eligible
articles, 21 used ultrasound (US) for real-time imaging despite depth and
needle visibility challenges. Computer tomography (CT)-guided fluoroscopy,
cited in 19 articles, enhanced deep structure visualization but involved
radiation risks. Magnetic resonance imaging (MRI), though excellent for
soft-tissue contrast, was not used due to metallic tool incompatibility.
Multimodal techniques, like US-fluoroscopy fusion, improved accuracy but
added cost and workflow complexity. No single technology meets all the
criteria for an ideal needle navigation system, which should combine
real-time imaging, 3D spatial awareness, and tissue integrity feedback
while being cost-effective and easily integrated into existing workflows.
 Conclusion(s): This review derived the criteria and obstacles an
ideal needle navigation system must address before its clinical adoption,
along with novel technological approaches that show potential to overcome
those challenges. For instance, fusion technologies overlay information
from multiple visual approaches within a single interface to overcome
individual limitations. Additionally, emerging diagnostic methods like
vibroacoustic sensing or optical fiber needles offer information from
complementary sensory channels, augmenting visual approaches with insights
into tissue integrity and structure, thereby paving the way for enhanced
needle navigation systems in MICS. Copyright © 2025 by the
authors.

<31>
Accession Number
2037107387
Title
Efficacy and safety of dapagliflozin in patients with CKD: real-world
experience in 93 Italian renal clinics.
Source
Clinical Kidney Journal. 18(1) (no pagination), 2025. Article Number:
sfae396. Date of Publication: 01 Jan 2025.
Author
Minutolo R.; Borrelli S.; Ambrosini A.; Amoroso L.; Aucella F.; Batini V.;
Battaglia Y.; Bregoli L.; Cantaluppi V.; Cianciolo G.; Conti P.; Fabbrini
P.; Giammarresi C.; Imbalzano E.; La Rosa S.; Marengo M.; Montinaro V.;
Musone D.; Napoli M.; Nappi F.; Pluvio C.; Santoro D.; Scarpioni R.;
Sopranzi F.; Tullio T.; De Nicola L.
Institution
(Minutolo, Borrelli, De Nicola) Nephrology and Dialysis Unit, Department
of Advanced Medical and Surgical Sciences, University of Campania, Naples,
Italy
(Ambrosini) Nephrology and Dialysis Unit, ASST dei Sette Laghi, Varese,
Italy
(Amoroso) Nephrology and Dialysis Unit, "G. Mazzini" Hospital, Teramo,
Italy
(Aucella) Nephrology and Dialysis Unit, Casa Sollievo della Sofferenza
Foundation, San Giovanni Rotondo, Italy
(Batini) Nephrology Unit ASL Toscana NordOvest, Livorno, Italy
(Battaglia) Department of Medicine, University of Verona, Verona, Italy
(Battaglia) Nephrology and Dialysis Unit, Pederzoli Hospital, Peschiera
del Garda, Italy
(Bregoli) Nephrology Unit, ASST Spedali Civili Brescia, Italy
(Cantaluppi) Nephrology and Kidney Transplantation Unit, Department of
Translational Medicine (DIMET), University of Piemonte Orientale (UPO),
"Maggiore della Carita" University Hospital, Novara, Italy
(Cianciolo) Nephrology, Dialysis and Kidney Transplant Unit, IRCCS Azienda
Ospedaliero-Universitaria di Bologna, Bologna, Italy
(Conti) Nephro-Urological Department, AUSL "Toscana Sud Est", Italy
(Fabbrini) Nephrology Unit, ASST Nord Milano, Ospedale Bassini, Cinisello
Balsamo, Italy
(Giammarresi) Unit of Nephrology, Dialysis and Kidney Transplant. Civico
Hospital of Palermo, Palermo, Italy
(Imbalzano) Internal Medicine, Department of Clinical and Experimental
Medicine, University of Messina, Messina, Italy
(La Rosa) Nephrology and Dialysis Unit, "Giovanni Paolo II" Hospital,
Sciacca, Italy
(Marengo) Nephrology and Dialysis Unit, Department of Medical Specialties,
ASLCN1, Cuneo, Italy
(Montinaro) Division of Nephrology and Dialysis, "Miulli" General
Hospital, Acquaviva delle Fonti, Italy
(Musone) Division of Nephrology and Dialysis, Department of Medicine,
Santa Maria Goretti Hospital, Latina, Italy
(Napoli) Nephrology Unit, Hospital V. Fazzi, Lecce, Italy
(Nappi) Nephrology and Dialysis Unit, Hospital Santa Maria della Pieta,
Nola, Italy
(Pluvio) Nephrology Unit, AORN dei Colli, Naples, Italy
(Santoro) Nephrology and Dialysis Unit, Department of Clinic and
Experimental Medicine, University of Messina, Messina, Italy
(Scarpioni) Nephrology and Dialysis Unit, "Guglielmo da Saliceto"
Hospital, Piacenza, Italy
(Sopranzi) Nephrology and Dialysis Unit, County Hospital of Macerata,
Macerata, Italy
(Tullio) Nephrology Unit, Hospital A. Fiorini, Terracina, Italy
Publisher
Oxford University Press
Abstract
Background. Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are
recommended for reducing the renal and cardiovascular risk in patients
with chronic kidney disease (CKD) based on the positive results reported
by clinical trials. However, real-world data on the efficacy and the
safety of these drugs in CKD population followed in nephrology setting are
lacking. Methods. We report the effects of dapagliflozin in CKD patients
by using data collected during a learning program in which 105
nephrologists added dapagliflozin (10 mg/day) to consecutive patients
referred to their renal clinics. Efficacy endpoints were the albuminuria
change and the determinants of an albuminuria decline >=30%. Adverse
events were also collected. Results. A total of 1724 patients with CKD
(age 67.4 +/- 13.2 years, 72.8% males, diabetes 59.9%, eGFR 43.5 +/- 17.4
ml/min/1.73 m2, severe albuminuria 70.1%) received
dapagliflozin for 4 +/- 1 months. Dapagliflozin significantly reduced body
weight (-1.3 kg), eGFR (-0.27 ml/min/month), and blood pressure (-3.6/-1.7
mmHg). Albuminuria declined by 25.1% (95%CI 23.0-27.2) from 500 mg/day
[IQR 225-1425] to 320 mg/day [IQR 100-900]. Albuminuria reduction was
>=30% in 48.3% of patients, 0-29% in 37.6% while it increased in 14.1% of
patients. At logistic regression analysis, older age, female sex, use of
mineralocorticoid receptor antagonist, higher eGFR, and higher albuminuria
were all significant predictors of albuminuria decline >=30%. We collected
46 side effects leading to drug discontinuation in 36 patients (2%), with
acute kidney injury and urinary tract infection being the most frequent
adverse events. Conclusions. We provide evidence of the anti-proteinuric
efficacy of short-term dapagliflozin in the presence of good safety
profile in patients with CKD followed in nephrology. Copyright ©
The Author(s) 2024. Published by Oxford University Press on behalf of the
ERA.

<32>
Accession Number
2037126033
Title
Prognostic role of con-/discordant coronary flow reserve and microvascular
resistance in coronary microvascular disease: a systematic review and
network meta-analysis.
Source
Open Heart. 12(1) (no pagination), 2025. Article Number: e003055. Date of
Publication: 21 Jan 2025.
Author
Al-Gully J.; Oliveri F.; Forouzanfar J.P.; Montero-Cabezas J.M.; Jukema
J.W.; Den Haan M.C.; Al Amri I.; Bingen B.O.
Institution
(Al-Gully, Oliveri, Forouzanfar, Montero-Cabezas, Jukema, Den Haan, Al
Amri, Bingen) Department of Cardiology, Leiden University Medical Center,
Zuid-Holland, Leiden, Netherlands
(Al-Gully, Forouzanfar, Den Haan, Al Amri, Bingen) Women's Heart Health
Clinic, Leiden University Medical Center, Leiden, Netherlands
(Jukema) Netherlands Heart Institute, Utrecht, Netherlands
Publisher
BMJ Publishing Group
Abstract
Background Coronary microvascular disease (CMD) is defined as impaired
coronary flow reserve (CFR) and/or increased microvascular resistance (MR)
without significant epicardial coronary stenosis. This definition allows
for discordant CFR and MR values within patients with CMD. The aim of this
meta-analysis is to characterise the prognostic value and
pathophysiological backgrounds of CFR and MR con-/discordance. Methods A
systematic search (PROSPERO CRD42024573004) identified studies determining
CFR and MR in patients without significant epicardial coronary artery
disease. Patients were divided into four groups: (1) normal CFR and MR,
(2) abnormal CFR and MR, (3) abnormal CFR with normal MR and (4) normal
CFR with abnormal MR and analysed for all-cause mortality and major
adverse cardiovascular events (MACE). Results We identified four studies
representing 2310 total participants. Group B had the highest MACE (OR:
3.23; 95% CI 1.95 to 5.36) and mortality rate (OR: 2.27; 95% CI 1.12 to
4.58) compared with group A. Group C, associated with female sex, showed
significantly higher MACE (OR: 2.07; 95% CI 1.25 to 3.45) but not
mortality (OR: 1.89; 95% CI 0.92 to 3.88) compared with group A. In group
D, associated with high body mass index, MACE and mortality rates did not
differ significantly from group A (OR: 1.19; 95% CI 0.67 to 2.11 and OR:
0.55; 95% CI 0.16 to 1.90, respectively). Conclusions Abnormal CFR and MR
are associated with a high risk of MACE and death. Abnormal CFR and normal
MR are associated with an increased MACE - but not death. MACE and
mortality risk in discordantly normal CFR and abnormal MR are low. Our
findings show the need for tailoring CFR and MR diagnostic thresholds to
patient characteristics and raise questions about the presence of CMD in
patients with abnormal MR with normal CFR. Copyright © 2025 BMJ
Publishing Group. All rights reserved.

<33>
Accession Number
2033005317
Title
Artificial Intelligence in Cardiac Surgery: Transforming Outcomes and
Shaping the Future.
Source
Clinics and Practice. 15(1) (no pagination), 2025. Article Number: 17.
Date of Publication: 01 Jan 2025.
Author
Leivaditis V.; Beltsios E.; Papatriantafyllou A.; Grapatsas K.; Mulita F.;
Kontodimopoulos N.; Baikoussis N.G.; Tchabashvili L.; Tasios K.; Maroulis
I.; Dahm M.; Koletsis E.
Institution
(Leivaditis, Papatriantafyllou, Dahm) Department of Cardiothoracic and
Vascular Surgery, WestpfalzKlinikum, Kaiserslautern, Germany
(Beltsios) Department of Anesthesiology and Intensive Care, Hannover
Medical School, Hannover, Germany
(Grapatsas) Department of Thoracic Surgery and Thoracic Endoscopy,
Ruhrlandklinik, West German Lung Center, University Hospital Essen,
University Duisburg-Essen, Essen, Germany
(Mulita, Tchabashvili, Tasios, Maroulis) Department of General Surgery,
General University Hospital of Patras, Patras, Greece
(Kontodimopoulos) Department of Economics and Sustainable Development,
Harokopio University, Athens, Greece
(Baikoussis) Department of Cardiac Surgery, Ippokrateio General Hospital
of Athens, Athens, Greece
(Koletsis) Department of Cardiothoracic Surgery, General University
Hospital of Patras, Patras, Greece
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Abstract
Background: Artificial intelligence (AI) has emerged as a transformative
technology in healthcare, with its integration into cardiac surgery
offering significant advancements in precision, efficiency, and patient
outcomes. However, a comprehensive understanding of AI's applications,
benefits, challenges, and future directions in cardiac surgery is needed
to inform its safe and effective implementation. Method(s): A
systematic review was conducted following PRISMA guidelines. Literature
searches were performed in PubMed, Scopus, Cochrane Library, Google
Scholar, and Web of Science, covering publications from January 2000 to
November 2024. Studies focusing on AI applications in cardiac surgery,
including risk stratification, surgical planning, intraoperative guidance,
and postoperative management, were included. Data extraction and quality
assessment were conducted using standardized tools, and findings were
synthesized narratively. Result(s): A total of 121 studies were
included in this review. AI demonstrated superior predictive capabilities
in risk stratification, with machine learning models outperforming
traditional scoring systems in mortality and complication prediction.
Robotic-assisted systems enhanced surgical precision and minimized trauma,
while computer vision and augmented cognition improved intraoperative
guidance. Postoperative AI applications showed potential in predicting
complications, supporting patient monitoring, and reducing healthcare
costs. However, challenges such as data quality, validation, ethical
considerations, and integration into clinical workflows remain significant
barriers to widespread adoption. Conclusion(s): AI has the potential
to revolutionize cardiac surgery by enhancing decision making, surgical
accuracy, and patient outcomes. Addressing limitations related to data
quality, bias, validation, and regulatory frameworks is essential for its
safe and effective implementation. Future research should focus on
interdisciplinary collaboration, robust testing, and the development of
ethical and transparent AI systems to ensure equitable and sustainable
advancements in cardiac surgery. Copyright © 2025 by the authors.

<34>
Accession Number
2037187549
Title
The Italian version of the Surgical Fear Questionnaire: validation of its
measurement properties.
Source
Minerva Anestesiologica. 90(12) (pp 1065-1073), 2024. Date of Publication:
01 Dec 2024.
Author
Theunissen M.; Scarone P.; Van Kuijk S.M.; Smeets A.Y.; Maino P.; Peters
M.L.; Koetsier E.
Institution
(Theunissen, Peters) Department of Clinical Psychological Science,
Maastricht University, Maastricht, Netherlands
(Theunissen) Department of Anesthesiology, Maastricht UMC+, Maastricht,
Netherlands
(Scarone) Neurosurgical Center, Clinica Santa Chiara, Locarno, Switzerland
(Van Kuijk) Department of Clinical Epidemiology and Medical Technology
Assessment, Maastricht UMC+, Maastricht, Netherlands
(Smeets) Department of Neurosurgery, Maastricht UMC+, Maastricht,
Netherlands
(Maino, Koetsier) Pain Management Center, Neurocenter of Southern
Switzerland, EOC, Lugano, Switzerland
(Maino, Koetsier) Faculty of Biomedical Sciences, Universita della
Svizzera Italiana, Lugano, Switzerland
Publisher
Edizioni Minerva Medica
Abstract
BACKGROUND: Surgical fear is present in many patients awaiting surgery.
However, a validated Italian version of the Surgical Fear Questionnaire
(SFQ) was not available yet. Therefore, the aim of this study was to
translate the SFQ into Italian and to test its reliability and validity.
 METHOD(S): Design: prospective cohort study on Italian-speaking Swiss
patients scheduled for a minimally invasive spinal procedure or spinal
surgery. After forward and back translation and a pilot test, reliability
and validity of the 8-item SFQ was assessed using the intraclass
correlation coefficient, (ICC), Cronbach's alpha, confirmatory factor
analysis (CFA), and Spearman's correlation coefficient. RESULT(S):
Results on 63 patients revealed median SFQ-total scores of 22
(minimum-maximum: 0-68) at inclusion and 22.5 (0-70) one week before
surgery. Test-retest reliability between first and second SFQ-total score
was high, ICC=0.947 (95% CI: 0.912-0.968). Internal consistency of the
SFQ-total score at both assessment times were high, Cronbach's alphas
0.916 and 0.931 respectively. This was also the case for the subscale
short-term fear, item 1-4 and long-term fear, item 5-8 (range
0.853-0.909). CFA-results for a one-factor and a two-factor model favored
the two-factor model. Correlations with pain catastrophizing, other
anxiety measures, and health status were weak and only state anxiety
assessed by PROMIS reached statistical significance. CONCLUSION(S):
We conclude that the Italian version of the SFQ is suitable for use in
practice and has a high reliability. Validity and sensitivity need
additional testing on a larger population. Copyright © 2024
Edizioni Minerva Medica. All rights reserved.

<35>
Accession Number
2033028861
Title
Enhancing heart and circulatory well-being through optimized radial artery
techniques: a meta-analysis of hemostasis and patient comfort.
Source
Frontiers in Cardiovascular Medicine. 11 (no pagination), 2024. Article
Number: 1412479. Date of Publication: 2024.
Author
Yang Y.; Zhu H.; Zai G.
Institution
(Yang, Zhu, Zai) Department of Cardiovascular Medicine, Capital Medical
University, Beijing LuHe Hospital, Beijing, China
Publisher
Frontiers Media SA
Abstract
Objective: This meta-analysis elucidates the efficacy of the Transradial
Band Device (TR Band) in minimizing complications like radial artery
occlusion and hematoma, preserving heart health, and enhancing blood flow
post-transradial catheterization. Method(s): A comprehensive
literature search across databases including PubMed, Cochrane, and Embase
examined the impact of radial artery compression techniques and
decompression times on complications. Data from 13 studies were analyzed
using R 4.1.2 with fixed-effects and random-effects models. The
Newcastle-Ottawa Scale assessed the risk of bias in observational cohort
studies. Result(s): In our meta-analysis, we evaluated data from
various studies encompassing different air volumes in transradial band
devices across several outcomes including bleeding, hematoma, radial
artery occlusion (RAO), Visual Analog Scale (VAS) scores, and compression
time. The collective analysis integrated findings from 11 studies,
totaling 4,679 patients. No significant difference in bleeding risk (OR
1.04, 95% CI 0.60-1.82, p > 0.05, I2 = 78%), hematoma incidence
(OR 0.96, 95% CI 0.78-1.19, p > 0.05, I2 = 0%), or RAO
incidence (OR 0.96, 95% CI 0.78-1.19, p > 0.05, I2 = 0%) was
observed between the "Less air" and "15 ml air" groups. However, the "Less
air" group reported significantly higher VAS scores indicating increased
pain or discomfort (Mean Difference 0.25, 95% CI 0.09-0.41, p < 0.05,
I2 = 0%). Compression time analyses showed no significant
difference between groups (Mean Difference -17.73, 95% CI -54.65-19.20, p
> 0.05, I2 = 99%). Sensitivity analyses confirmed the stability
of these findings, and Egger's test indicated no significant publication
bias across the outcomes. This synthesis highlights the nuanced impact of
air volume adjustments in transradial bands on patient outcomes,
emphasizing the necessity for further research and standardized protocols
to optimize patient safety and comfort post-intervention.
 Conclusion(s): The TR Band, when utilized with optimized air
volume/pressure, maintains an essential balance between ensuring
hemostasis and enhancing patient comfort without elevating the risk of
radial artery complications. These findings support the careful selection
of TR Band settings to optimize clinical outcomes in patients undergoing
transradial cardiac procedures. Further research is warranted to establish
standardized guidelines for the most effective use of TR Band in various
clinical scenarios. Copyright 2025 Yang, Zhu and Zai.

<36>
Accession Number
2033020185
Title
Silent cerebral lesions after catheter ablation for atrial fibrillation
using cryoballoon, hotballoon, laserballoon and radiofrequency catheters:
a Bayesian network meta-analysis.
Source
Frontiers in Cardiovascular Medicine. 11 (no pagination), 2024. Article
Number: 1510468. Date of Publication: 2024.
Author
Zheng T.; Kong Y.; Wu L.; Wu C.; Mao W.; Zhou X.
Institution
(Zheng, Kong, Wu, Zhou) Department of Cardiology, The First Affiliated
Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial
Hospital of Chinese Medicine), Zhejiang, Hangzhou, China
(Wu, Mao) Department of Cardiology, Affiliated Zhejiang Hospital, Zhejiang
University School of Medicine, Hangzhou, China
(Wu, Mao, Zhou) Zhejiang Key Laboratory of Integrative Chinese and Western
Medicine for Diagnosis and Treatment of Circulatory Diseases, Hangzhou,
China
Publisher
Frontiers Media SA
Abstract
Background: Catheter ablation (CA) is an effective therapeutic option for
patients with symptomatic atrial fibrillation (AF). Previous studies have
reported silent cerebral lesions (SCLs) detected by magnetic resonance
imaging (MRI) after different CA techniques; however, the results were
controversial. Therefore, we performed this network meta-analysis (NMA) to
assess the incidence of SCLs after cryoballoon, hotballoon, laserballoon,
and radiofrequency ablation (RFA). Method(s): Databases such as
PubMed, Embase, and the Cochrane Library were searched systematically.
Both pairwise meta-analysis (PMA) and NMA were conducted. The primary
outcome was the incidence of new SCLs on MRI after CA procedures.
 Result(s): Nine studies were analyzed and 1,057 patients were
enrolled. Laserballoon ablation (LBA) had a higher incidence of SCLs than
cryoballoon ablation (CBA) [odds ratio [OR] = 1.86, 95% confidence
interval [CI] 1.06-3.27, p = 0.032] in the PMA, while no significant
difference was detected between the CA techniques according to the NMA.
The surface under the cumulative ranking curve (SUCRA) values indicated
that CBA may be the best therapeutic option (SUCRA = 81.1%). The NMA
results demonstrated similar procedure-related complication rates and mean
activated clotting time between CBA (SUCRA = 53.7%, 66.3%), hotballoon
ablation (HBA) (SUCRA = 81.5%, 43.6%), LBA (SUCRA = 3.39%, 42.8%) and RFA
(SUCRA = 61.3%, 47.3%). LBA therapy required significantly more procedure
time than CBA [weighted mean difference (WMD) = 24.36 min, 95% CI
12.51-36.21 min, p = 0.00]. Conclusion(s): CBA treatment had lower
incidence of post-procedural SCLs and took less procedure time compared
with LBA for patients with AF. The procedure-related complications were
comparable between CBA, LBA, HBA and RFA. Systematic Review Registration:
PROSPERO, identifier (CRD42024511110). Copyright 2025 Zheng, Kong, Wu,
Wu, Mao and Zhou.

<37>
Accession Number
2037116093
Title
Efficacy and safety of different revascularization strategies in patients
with non-ST-segment elevation myocardial infarction with multivessel
disease: a systematic review and network meta-analysis.
Source
Postepy w Kardiologii Interwencyjnej. 20(4) (pp 382-392), 2024. Date of
Publication: 2024.
Author
Chen T.; Lu C.; Mo J.; Wang T.; Li X.; Yang Y.
Institution
(Chen, Lu, Mo, Wang, Li) Department of Cardiology, School of Clinical
Medicine, Dali University, Yunnan Province, China
(Yang) Department of Cardiology, The First Affiliated Hospital, Dali
University, Yunnan Province, China
Publisher
Termedia Publishing House Ltd.
Abstract
Introduction: The optimal timing of revascularization in non-ST-segment
elevation myocardial infarction (NSTEMI) with multivessel disease (MVD)
remains controversial. Aim(s): We investigated the impact of
different revascularization strategies on clinical outcomes to assess the
optimal revascularization strategy for these patients. Method(s): We
performed a network meta-analysis of cohort studies comparing
revascularization strategies in NSTEMI with MVD. Effect sizes were
calculated as odds ratios (ORs) using a random-effects model. The primary
efficacy outcome was all-cause mortality and the primary safety outcome
was recurrent myocardial infarction. Result(s): Eight eligible
studies involving 34,151 patients receiving four revascularization
strategies were analyzed. Compared to conventional culprit-only
revascularization (COR), planned complete multi-vessel percutaneous
coronary intervention during a second hospitalization (MV-PCI) reduced the
risk of major adverse cardiovascular events (MACEs) (MV-PCI vs. COR: OR =
0.53; 95% CI: 0.38-0.74) and decreased all-cause mortality (MV-PCI vs.
COR: OR = 0.53; 95% CI: 0.30-0.93) and the likelihood of repeat
revascularization (MV-PCI vs. COR: OR = 0.55; 95% CI: 0.37-0.82). However,
compared to COR, immediate complete revascularization (ICR) but not MV-PCI
was associated with reduced risk of recurrent MI (COR vs. ICR: OR = 1.39;
95% CI: 1.07-1.81; MV-PCI vs. COR: OR = 0.64; 95% CI: 0.40-1.01). Compared
to MV-PCI: COR and staged complete revascularization during index PCI
(SCR) increased the risk of cardiovascular mortality (MV-PCI vs. COR: OR =
0.48; 95% CI: 0.34-0.70; MV-PCI vs. SCR: OR = 0.62; 95% CI: 0.40-0.96).
COR also had significantly higher cardiovascular mortality compared to ICR
(COR vs. ICR: OR = 1.38; 95% CI: 1.02-1.85). Conclusion(s): Complete
revascularization is more effective compared to culprit-only
revascularization for most follow-ups. Copyright © 2024 Termedia
Publishing House Ltd.. All rights reserved.

<38>
Accession Number
2029634829
Title
Evaluating the Efficacy of the Erector Spinae Plane Block as a
Supplementary Approach to Cardiac Anesthesia during Off-Pump Coronary
Bypass Graft Surgery via Median Sternotomy: A Randomized Clinical Trial.
Source
Journal of Clinical Medicine. 13(8) (no pagination), 2024. Article Number:
2208. Date of Publication: 01 Apr 2024.
Author
Kim S.; Song S.W.; Jeon Y.-G.; Song S.A.; Hong S.; Park J.-H.
Institution
(Kim, Song, Jeon, Song, Park) Department of Anesthesiology and Pain
Medicine, Wonju College of Medicine, Yonsei University, Wonju, South Korea
(Hong) Department of Cardiovascular Surgery, Wonju College of Medicine,
Yonsei University, Wonju, South Korea
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Abstract
Background: Pain control after off-pump coronary artery bypass graft
(OPCAB) facilitates mobilization and improves outcomes. The efficacy of
the erector spinae plane block (ESPB) after cardiac surgery remains
controversial. Method(s): We aimed to investigate the analgesic
effects of ESPB after OPCAB. Precisely 56 patients receiving OPCAB were
randomly divided into ESPB and control groups. The primary outcome was
visual analog scale (VAS) pain scores at 6, 12, 24, and 48 h
postoperatively. Secondary outcomes were the dose of rescue analgesics in
terms of oral morphine milligram equivalents, the dose of antiemetics, the
length of intubation time, and the length of stay in the intensive care
unit (ICU). Result(s): The VAS scores were similar at all time points
in both groups. The incidence of severe pain (VAS score > 7) was
significantly lower in the ESPB group (50% vs. 15.4%; p = 0.008). The dose
of rescue analgesics was also lower in the ESPB group (19.04 +/- 18.76,
9.83 +/- 12.84, p = 0.044) compared with the control group. The other
secondary outcomes did not differ significantly between the two groups.
 Conclusion(s): ESPB provides analgesic efficacy by reducing the
incidence of severe pain and opioid use after OPCAB. Copyright ©
2024 by the authors.

<39>
Accession Number
2032215781
Title
Identifying the association between serum urate levels and gout flares in
patients taking urate-lowering therapy: a post hoc cohort analysis of the
CARES trial with consideration of dropout.
Source
Annals of the Rheumatic Diseases. 83(10) (pp 1375-1380), 2024. Date of
Publication: 30 Sep 2024.
Author
Tedeschi S.K.; Hayashi K.; Zhang Y.; Choi H.; Solomon D.H.
Institution
(Tedeschi, Hayashi, Solomon) Brigham and Women's Hospital, Boston, MA,
United States
(Zhang, Choi) Massachusetts General Hospital, Boston, MA, United States
Publisher
BMJ Publishing Group
Abstract
Objective To investigate gout flare rates based on repeated serum urate
(SU) measurements in a randomised controlled trial of urate-lowering
therapy (ULT), accounting for dropout and death. Methods We performed a
secondary analysis using data from Cardiovascular Safety of Febuxostat or
Allopurinol in Patients with Gout, which randomised participants to
febuxostat or allopurinol, titrated to target SU <6 mg/dL with flare
prophylaxis for 6 months. SU was categorised as <=3.9, 4.0-5.9, 6.0-7.9,
8.0-9.9 or >= 10 mg/dL at each 3-6 month follow-up. The primary outcome
was gout flare. Poisson regression models, adjusted for covariates and
factors related to participant retention versus dropout, estimated gout
flare incidence rate ratios by time-varying SU category. Results Among
6183 participants, the median age was 65 years and 84% were male. Peak
gout flare rates for all SU categories were observed in months 0-6,
coinciding with the initiation of ULT and months 6-12 after stopping
prophylaxis. Flare rates were similar across SU groups in the initial year
of ULT. During months 36-72, a dose-response relationship was observed
between the SU category and flare rate. Lower flare rates were observed
when SU <=3.9 mg/dL and greater rates when SU >=10 mg/dL, compared with SU
4.0-5.9 mg/dL (p for trend <0.01). Conclusion Gout flare rates were
persistently higher when SU >=6 mg/dL after the first year of ULT after
accounting for censoring. The spike in flares in all categories after
stopping prophylaxis suggests a longer duration of prophylaxis may be
warranted. Copyright © Author(s) (or their employer(s)) 2024. No
commercial re-use. See rights and permissions. Published by BMJ on behalf
of EULAR.

<40>
Accession Number
2030011614
Title
Cardiac comorbidities in McArdle disease: case report and systematic
review.
Source
Neurological Sciences. 45(10) (pp 4757-4765), 2024. Date of Publication:
01 Oct 2024.
Author
Hoxhaj D.; Vadi G.; Bianchi L.; Fontanelli L.; Torri F.; Siciliano G.;
Ricci G.
Institution
(Hoxhaj, Vadi, Fontanelli, Torri, Siciliano, Ricci) Department of Clinical
and Experimental Medicine, Neurological Institute, University of Pisa, Via
Roma 67, Pisa, Italy
(Bianchi) Department of Internal Medicine, University of Genova, Genoa,
Italy
Publisher
Springer-Verlag Italia s.r.l.
Abstract
Introduction and methods: Myophosphorylase deficiency, also known as
McArdle disease or Glycogen Storage Disease type V (GSD-V), is an
autosomal recessive metabolic myopathy that results in impaired glycogen
breakdown in skeletal muscle. Despite being labelled as a "pure myopathy,"
cardiac involvement has been reported in some cases, including various
cardiac abnormalities such as electrocardiographic changes, coronary
artery disease, and cardiomyopathy. Here, we present a unique case of a
72-year-old man with GSD-V and both mitral valvulopathy and coronary
artery disease, prompting a systematic review to explore the existing
literature on cardiac comorbidities in McArdle disease. Result(s):
Our systematic literature revision identified 7 case reports and 1
retrospective cohort study. The case reports described 7 GSD-V patients,
averaging 54.3 years in age, mostly male (85.7%). Coronary artery disease
was noted in 57.1% of cases, hypertrophic cardiomyopathy in 28.5%, severe
aortic stenosis in 14.3%, and genetic dilated cardiomyopathy in one. In
the retrospective cohort study, five out of 14 subjects (36%) had coronary
artery disease. Discussion and conclusion: Despite McArdle disease
primarily affecting skeletal muscle, cardiac involvement has been
observed, especially coronary artery disease, the frequency of which was
moreover found to be higher in McArdle patients than in the background
population in a previous study from a European registry. Exaggerated
cardiovascular responses during exercise and impaired glycolytic
metabolism have been speculated as potential contributors. A comprehensive
cardiological screening might be recommended for McArdle disease patients
to detect and manage cardiac comorbidities. A multidisciplinary approach
is crucial to effectively manage both neurological and cardiac aspects of
the disease and improve patient outcomes. Further research is required to
establish clearer pathophysiological links between McArdle disease and
cardiac manifestations in order to clarify the existing
findings. Copyright © The Author(s) 2024.

<41>
Accession Number
2036876019
Title
A Randomized, Controlled Trial of In-Hospital Use of Virtual Reality to
Reduce Preoperative Anxiety Prior to Cardiac Surgery.
Source
Mayo Clinic Proceedings. 100(2) (pp 220-234), 2025. Date of Publication:
01 Feb 2025.
Author
Subramaniam T.; Dearani J.A.; Stulak J.M.; Lahr B.; Lee A.; Miller J.D.
Institution
(Subramaniam, Dearani, Stulak, Miller) Departments of Cardiovascular
Surgery, Mayo Clinic, Rochester, MN, United States
(Lahr, Lee) Quantitative Health Sciences, Mayo Clinic, Rochester, MN,
United States
(Miller) Physiology and Biomedical Engineering, Mayo Clinic, Rochester,
MN, United States
(Miller) Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester,
MN, United States
Publisher
Elsevier Ltd
Abstract
Objective: To study the effectiveness of virtual reality (VR) in reducing
anxiety levels in patients undergoing first-time sternotomy for cardiac
surgery. Patients and Methods: A total of 100 adult patients
scheduled for cardiac surgery at Mayo Clinic in Rochester, Minnesota, USA,
was recruited from April 19, 2022, to October 12, 2022. Before surgery,
patients wore a physiological monitor to record vital signs. On the day of
surgery, patients completed the State-Trait Anxiety Inventory (STAI) and
were randomized into two groups: one receiving a tablet-based intervention
(control) and the other an immersive VR experience in the preoperative
holding area. After the interventions, patients repeated the state anxiety
component of the STAI. Result(s): The results showed that overall
state anxiety scores decreased an average of 2.0 points with tablet
treatment, but this change failed to reach statistical significance.
However, 6 of 20 specific state anxiety features significantly improved
with tablet treatment whereas 1 feature significantly worsened. With the
VR experience, overall state anxiety scores were significantly reduced by
an average of 2.9 points, with improvement in seven state anxiety features
(three of which did not overlap with the tablet intervention). Despite a
greater reduction in the STAI score with the VR experience, there were no
significant differences in the anxiolytic responses between groups.
Physiologically, both tablet and VR treatments slightly but significantly
reduced pulse rate, with no difference between the groups.
 Conclusion(s): Overall, the findings suggest that treatment of older
adults with an immersive VR experience before cardiac surgery can
significantly reduce overall anxiety. Further investigation determining
how such interventions can be optimally implemented in surgical practices
and whether such interventions reduce the need for anxiolytic medications
and improve the overall patient experience is needed. Copyright ©
2024

<42>
Accession Number
2032553550
Title
Prevalence of extracardiac vascular complications in Abiotrophia spp. and
Granulicatella spp. infective endocarditis: Two case reports and a
systematic review.
Source
Clinical Infection in Practice. 23 (no pagination), 2024. Article Number:
100367. Date of Publication: 01 Jul 2024.
Author
Pozza G.; Mariani C.; Passerini M.; Colaneri M.; Giacomelli A.; Prokop
L.J.; Murad M.H.; Schiavini M.; Gori A.; Antinori S.
Institution
(Pozza, Mariani, Giacomelli, Antinori) III Infectious Diseases Unit, Luigi
Sacco Hospital, ASST Fatebenefratelli Sacco, via GB Grassi 74, Milan,
Italy
(Pozza, Mariani, Gori, Antinori) Department of Biomedical and Clinical
Sciences, Universita degli Studi di Milano, via GB Grassi 74, Milan, Italy
(Passerini, Colaneri, Schiavini, Gori) II Infectious Diseases Unit, Luigi
Sacco Hospital, ASST Fatebenefratelli Sacco, via GB Grassi 74, Milan,
Italy
(Passerini) Department of Pathophysiology and Transplantation, Universita
degli Studi di Milano, via GB Grassi 74, Milan, Italy
(Prokop) Mayo Medical Libraries, Mayo Clinic, 200 1st St SW, Rochester,
MN, United States
(Murad) Division of Public Health, Infectious Diseases and Occupational
Medicine, Department of Medicine, Mayo Clinic, 200 1st St SW, Rochester,
MN, United States
Publisher
Elsevier B.V.
Abstract
Objectives: Infective endocarditis (IE) caused by Abiotrophia spp. and
Granulicatella spp. share an increased risk of extracardiac vascular
complications (EVC). The current work aims to assess the prevalence of EVC
in IE due to these microorganisms. Method(s): This was a study with
mixed design, consisting in a single center experience combined with a
systematic review of multiple databases. We included studies enrolling
adults >18 years old with a diagnosis of Abiotrophia spp. and
Granulicatella spp. IE. We collected data regarding the presence and the
description of EVC in IE along with clinical and microbiological details.
Risk of bias assessment was performed using the Newcastle-Ottawa Scale for
comparative observational studies, and a dedicated tool for single-arm
non-comparative studies. The review was registered in PROSPERO
(CRD42023433130). Result(s): The cohort study identified 2 patients.
The systematic review included 83 studies, involving 228 cases of
Abiotrophia spp. (n = 103), Granulicatella spp. (n = 94), and unspecified
nutritionally variant streptococci (n = 31) IE. EVC occurred in 101/230
(44 %) patients, central nervous system involvement occurred in 66/101 (66
% of total embolisms), and pseudoaneurysm or peripheral vascular
embolization occurred in 11/101 (11 %). Conclusion(s): Considering
the observed prevalence of EVC a proactive approach in the diagnosis of
such a complication is warranted. Copyright © 2024 The Authors

<43>
Accession Number
2033003097
Title
Osteopontin as a Biomarker for Coronary Artery Disease.
Source
Cells. 14(2) (no pagination), 2025. Article Number: 106. Date of
Publication: 01 Jan 2025.
Author
Layton G.R.; Antoun I.; Copperwheat A.; Khan Z.L.; Bhandari S.S.; Somani
R.; Ng A.; Zakkar M.
Institution
(Layton, Antoun, Bhandari, Somani, Ng, Zakkar) Department of
Cardiovascular Sciences, University of Leicester, Leicester, United
Kingdom
(Layton, Copperwheat, Zakkar) Department of Cardiac Surgery, University
Hospitals of Leicester NHS Trust, Leicester, United Kingdom
(Layton, Ng, Zakkar) Leicester British Heart Foundation Centre of Research
Excellence, Glenfield Hospital, Groby Road, Leicester, United Kingdom
(Antoun, Bhandari, Somani, Ng) Department of Cardiology, University
Hospitals of Leicester NHS Trust, Leicester, United Kingdom
(Khan) University of Lancaster, Lancaster, Bailrigg, United Kingdom
(Ng) National Institute of Health Research, Leicester, United Kingdom
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Abstract
Osteopontin (OPN) is a sialylated phosphoprotein highly expressed in
atherosclerosis and upregulated in settings of both acute and chronic
inflammation. It is hypothesised that plasma levels of OPN may correlate
with the presence of coronary artery disease, "CAD". This offers potential
as a point-of-care testing biomarker for early diagnosis, disease
monitoring, and prognosis. This review evaluates the current literature on
the association between plasma OPN levels and coronary artery disease and
what is currently known to support its potential as a biomarker for future
practice. Electronic searches of MEDLINE and EMBASE databases were
undertaken from inception until July 2024. Thirty-three studies met the
inclusion criteria. All studies were observational, with gross
heterogeneity in methods used to analyse the association of plasma OPN
with clinical characteristics. They included case series, case-control,
cross-sectional, and cohort study designs. OPN has been linked to higher
cardiovascular risk and unfavourable cardiovascular outcomes. However, the
evidence regarding the direct assessment of CAD severity using tools like
the SYNTAX or TIMI scores, which focus on anatomical complexity and risk
factors, is less definitive. This suggests that OPN may be a more precise
reflection of the inflammatory processes and atherosclerotic activity
contributing to unfavourable outcomes rather than a direct indicator of
the anatomical severity of CAD itself. Consequently, OPN is increasingly
perceived as a marker of a poor prognosis rather than a tool for assessing
the severity of coronary artery lesions. Copyright © 2025 by the
authors.

<44>
Accession Number
2035527052
Title
A Systematic Review of the Potential of Cold Compresses Therapy: Strategy
for Preventing Hematoma and Alleviating Pain in Post Cardiac
Catheterization Patients.
Source
Journal of Pain Research. 18 (pp 161-175), 2025. Date of Publication:
2025.
Author
Sugiharto F.; Yusanti I.; Sari W.P.; Yuliandani E.; Kosasih C.E.; Trisyani
Y.; Priambodo A.P.; Nuraeni A.; Anna A.; Emaliyawati E.; Mirwanti R.
Institution
(Sugiharto, Yusanti, Sari, Yuliandani) Master Study Program, Faculty of
Nursing, Universitas Padjadjaran, West Java, Sumedang, Indonesia
(Kosasih, Trisyani, Priambodo, Nuraeni, Anna, Emaliyawati, Mirwanti)
Department of Critical Care and Emergency Nursing, Faculty of Nursing,
Universitas Padjadjaran, West Java, Bandung, Indonesia
Publisher
Dove Medical Press Ltd
Abstract
Background: Patients still frequently report complications after cardiac
catheterization procedures, such as hematoma and pain. These complications
increase the length of stay and hospital costs. Several studies have
determined cold compress therapy's effectiveness in preventing hematomas
and reducing pain in patients after cardiac catheterization. However, to
date, no review study has synthesized this comprehensively.
 Purpose(s): This review aimed to explores the potential of cold
compress therapy as a strategy for preventing hematoma and alleviating
pain in post-cardiac catheterization patients. Method(s): Systematic
review was reported based on the PRISMA Extension. A literature search
used relevant keywords from six primary databases, such as CINAH Medline
Plus, PubMed, ScienceDirect, Scopus, Taylor and Francis, and one search
engine, Google Scholar. The quality of evidence was assessed using the
Joanna Briggs Institute critical appraisal checklist and Risk of Bias.
Data synthesis was used thematically with an explorative, descriptive
approach. Result(s): This review found and analyzed twelve articles.
Based on the results of the analysis, cold compress therapy for 15 to 20
minutes can potentially prevent hematomas and reduce pain in patients
after cardiac catheterization. Conclusion(s): This review concludes
that cold compress therapy can potentially prevent hematomas and reduce
pain in this population. Health workers, especially nurses, can consider
cold compress therapy as a strategy in the nursing care program for
patients after cardiac catheterization. Copyright © 2025
Sugiharto et al.

<45>
Accession Number
2031910494
Title
A Bayesian meta-analysis of double kissing (DK) crush or provisional
stenting for coronary artery bifurcation lesions.
Source
Indian Heart Journal. 76(2) (pp 113-117), 2024. Date of Publication: 01
Mar 2024.
Author
Kumar A.; Shariff M.; Singal A.; Bhat V.; Stulak J.; Reed G.; Kalra A.
Institution
(Kumar) Department of Internal Medicine, Cleveland Clinic Akron General,
Akron, OH, United States
(Kumar, Reed) Department of Cardiovascular Medicine, Heart, Vascular and
Thoracic Institute, Cleveland Clinic, Cleveland, OH, United States
(Shariff, Stulak) Department of General Surgery, Mayo Clinic, Rochester,
MN, United States
(Shariff, Stulak) Department of Cardiovascular Surgery, Mayo Clinic,
Rochester, MN, United States
(Singal) Department of Cardiology, Aakash Healthcare, New Delhi, India
(Bhat) Department of Medicine, St. John's Medical College, Bangalore,
India
(Kalra) Franciscan Health, Lafayette, IN, United States
(Kalra) Krannert Cardiovascular Research Center, Indianapolis, IN, United
States
Publisher
Elsevier B.V.
Abstract
Objective: Despite the development of dedicated, two-stent strategies,
including the double kissing (DK) crush technique, the ideal technique for
coronary artery bifurcation stenting has not been identified. We aimed to
compare and determine the absolute risk difference (ARD) of the DK crush
technique alone versus provisional stenting approaches for coronary
bifurcation lesions, using the Bayesian technique. Method(s): We
queried PubMed/MEDLINE to identify randomized controlled trials (RCTs)
that compared DK crush technique with provisional stenting for bifurcation
lesions, published till January 2023. We used Bayesian methods to
calculate the ARD and 95% credible interval (CrI). Result(s): We
included three RCTs, with 916 patients, in the final analysis. The ARD of
cardiac death was centered at -0.01 (95% CrI: -0.04 to 0.02; Tau: 0.02,
85% probability of ARD of DK crush vs. provisional stenting <0). ARD for
myocardial infarction was centered at -0.03 (95%CrI: -0.9 to 0.03; Tau:
0.05, 87% probability of ARD of DK crush vs. provisional stenting <0). ARD
for stent thrombosis was centered at 0.00 (95% CrI: -0.04 to 0.03, Tau:
0.03, 51% probability of ARD for DK crush vs. provisional stenting <0).
Finally, ARD for target lesion revascularization was centered at -0.05
(95% CrI: -0.08 to -0.03, Tau: 0.02, 99.97% probability of ARD for DK
crush vs. provisional stenting <0). Conclusion(s): Bayesian analysis
demonstrated a lower probability of cardiac death, myocardial infarction
and target lesion revascularization, with DK crush compared with
provisional stenting techniques, and a minimal probability of difference
in stent thrombosis. Copyright © 2024 Cardiological Society of
India

<46>
Accession Number
2032965717
Title
The impact of pulmonary hypertension on prognosis in moderate-to-severe
mitral regurgitation patients treated with transcatheter edge-to-edge
mitral valve repair: a comprehensive meta-analysis.
Source
Frontiers in Cardiovascular Medicine. 11 (no pagination), 2024. Article
Number: 1489674. Date of Publication: 2024.
Author
Wei Z.; Shao X.; An Z.; Chang Y.; Liu S.; Luo Z.; Chen Y.; Song B.
Institution
(Wei, Shao, An, Chang, Liu, Luo, Chen) The First Clinical Medical College
of Lanzhou University, Lanzhou University, Lanzhou, China
(Wei, An, Chang, Liu, Luo, Chen, Song) Department of Cardiovascular
Surgery, First Hospital of Lanzhou University, Lanzhou, China
Publisher
Frontiers Media SA
Abstract
Objective: This meta-analysis aims to assess the impact of pulmonary
hypertension (PH) on the clinical prognosis of patients with moderate to
severe mitral valve regurgitation (MR) undergoing transcatheter
edge-to-edge mitral valve repair (TEER). Method(s): As of August
2024, relevant studies were identified through searches of the PubMed,
Cochrane Library, Web of Science, and Embase databases. A comprehensive
screening process was conducted, with quality assessment performed
utilizing the Newcastle Ottawa Scale (NOS). Data analysis was carried out
using Stata17.0 software, generating forest plots, funnel plots, Egger's
test, and sensitivity analysis plots to analyze heterogeneity and
publication bias. Odds ratios (OR) and standardized mean differences (SMD)
were calculated for dichotomous and continuous variables, respectively,
each presented with a 95% confidence interval (CI). Result(s): A
total of 10 studies involving 28,404 patients were included, with all
articles achieving a NOS score of >=7. The outcome indicators were as
follows: 2-year all-cause mortality [OR = 2.06, 95%CI(1.49, 2.84), p <
0.01, I2 = 79.9%]; heart failure rehospitalization rate [OR =
1.56, 95%CI(1.29,1.76), p < 0.01, I2 = 41.7%]; 30-day all-cause
mortality [OR = 2.10, 95%CI(1.78,2.47), p < 0.01, I2 = 0%];
cardiogenic mortality [OR = 2.00, 95%CI (1.61,2.49), p < 0.01,
I2 = 0%]; and length of hospital stay [OR = 0.17,
95%CI(0.14,0.20), p < 0.01, I2 = 0%]. All outcome indicators
demonstrated that the PH group had significantly worse outcomes compared
to the non-PH group. Subgroup analyses were performed on outcome
indicators with notable heterogeneity, focusing on PH measurement methods,
PH diagnostic criteria, and the severity of PH. The results indicated that
most combined subgroup outcomes were consistent with the overall findings
and showed significantly reduced heterogeneity. The sources of
heterogeneity are likely attributed to the methods of PH measurement,
diagnostic criteria for PH, and the severity of PH. Conclusion(s):
Within two years after undergoing transcatheter edge-to-edge repair
(TEER), patients with MR and PH experiecne significantly higher rates of
all-cause mortality, 30-day all-cause mortality, heart failure
readmissions, cardiogenic mortality, and longer hospital stays compared to
those without PH. Systematic Review Registration: https://inplasy.com/,
identifier (INPLASY202480068). Copyright 2025 Wei, Shao, An, Chang,
Liu, Luo, Chen and Song.

<47>
Accession Number
2035529408
Title
Clonidine (30microg) and Midazolam (2mg) as Intrathecal Adjuvants to
Bupivacaine: Hemodynamic Changes.
Source
Research Journal of Medical Sciences. 18(12) (pp 271-274), 2024. Date of
Publication: 2024.
Author
Thanuja R.; Shalini C.; Harshitha M.G.; Geethashree B.
Institution
(Thanuja, Shalini, Harshitha, Geethashree) Department of Anaesthesiology,
ESIC Medical College and PGIMSR, Karnataka, Bangalore, India
Publisher
MAK Hill Publications
Abstract
Clonidine affects the blood pressure in a complex fashion after neuraxial
or systemic administration because of opposing action at multiple sites.
In the nucleus tractus solitarius and locus coeruleus of the brain stem,
activation of post-synaptic a2 adrenoreceptors reduces sympathetic drive.
It also activates noradrenergic imidazoline preferring binding sites in
the lateral reticular nucleus producing hypotension and anti-arrythmogenic
action. Patients fulfilling the required essential criteria were selected
and 90 patients were randomly allocated to following 2 groups: Group BC
(45 No.)-Spinal Bupivacaine with Clonidine. Group BM (45 No.)-Spinal
Bupivacaine with Midazolam. Patient allocation was made based on computer
generated numbers and sealed envelope method. The study solution for
spinal anaesthesia was prepared separately by a person not involved in the
patient care. Patients and Anaesthesiologists were blinded to both the
study groups. The mean intra-operative fall of heart rate in BC group was
14bpm (range-10-40bpm) with a mean maximum fall of 21.4+/-7.2bpm. On the
other hand, these figures in BM group were 3 bpm (range-2-25 bpm) and
12.5+/-4.4 bpm only. Copyright © MAK HILL Publications.

<48>
Accession Number
2037231157
Title
Neurologic Complications Rate Following Aortic Manipulation after Off-Pump
Coronary Artery Bypass Grafting: A Meta-Analysis.
Source
Heart Surgery Forum. 28(1) (pp E096-E106), 2025. Date of Publication:
2025.
Author
Li L.; Yang J.; Li R.; Li G.; Wang X.; Feng S.; Guo H.
Institution
(Li, Yang, Li, Li, Wang, Feng, Guo) Cardiovascular Surgery, HanDan First
Hospital, Hebei, Handan, China
Publisher
Forum Multimedia Publishing LLC
Abstract
Background: Neurologic complications after coronary artery bypass grafting
continue to be among the most devastating complications. The goal of
coronary artery bypass grafting, which is performed utilizing off-pump
techniques on a beating heart, was to reduce this risk. The purpose of the
study was to assess the neurologic complications rate following aortic
manipulation after off-pump coronary artery bypass grafting.
 Method(s): Dichotomous random or fixed effect models generated the
odds ratio (OR) and mean difference (MD) with 95% confidence intervals
(CIs) based on the study of the meta-analysis data. 28 papers, with a
total of 823,972 patients, were available between 2002 and 2021 and were
comprised in this meta-analysis. Result(s): Aortic manipulation was
much less likely to cause a stroke in people with off-pump coronary artery
bypass grafting (OR, 0.58; 95% CI, 0.44-0.77; p < 0.001) than non-aortic
manipulation. However, no significant difference was found between aortic
manipulation and non-aortic manipulation in all-cause mortality (OR, 0.84;
95% CI, 0.69-1.02, p = 0.08), acute renal failure (OR, 0.86; 95% CI,
0.69-1.08, p = 0.20), atrial fibrillation (OR, 0.67; 95% CI, 0.21-2.15, p
= 0.50), myocardial infarction (OR, 0.75; 95% CI, 0.56-1.01, p = 0.06),
respiratory complications (OR, 0.64; 95% CI, 0.40-1.03, p = 0.07),
reoperation for bleeding (OR, 0.89; 95% CI, 0.57-1.38, p = 0.59), and
mediastinitis (OR, 0.77; 95% CI, 0.46-1.28, p = 0.31) in subjects with
off-pump coronary artery bypass grafting. Conclusion(s): The present
evaluation showed that using aortic manipulation resulted in a
significantly lower rate of stroke occurence; however, no significant
difference was found in all-cause mortality, acute renal failure, atrial
fibrillation, myocardial infarction, respiratory complications,
reoperation for bleeding, and mediastinitis compared to non-aortic
manipulation in subjects with off-pump coronary artery bypass grafting.
However, given that some comparisons comprised a small number of studies,
attention ought to be given to their values. Copyright: © 2025
The Author(s).

<49>
Accession Number
646384046
Title
The Effect of Music Combined With Preoperative Education on Perioperative
Anxiety in Patients Undergoing Open Cardiac Surgery: A Randomized
Controlled Trial.
Source
Journal of perianesthesia nursing : official journal of the American
Society of PeriAnesthesia Nurses. (no pagination), 2025. Date of
Publication: 21 Jan 2025.
Author
Zhou B.; Hu Z.
Institution
(Zhou) Department of Anesthesiology, First Affiliated Hospital, Jiangxi
Medical College, Nanchang University, Nanchang, Jiangxi, China
(Hu) Department of Anesthesiology, First Affiliated Hospital, Jiangxi
Medical College, Nanchang University, Nanchang, Jiangxi, China
Abstract
PURPOSE: The aim of this study is to observe the effect of music combined
with preoperative education on perioperative anxiety in patients
undergoing open cardiac surgery. DESIGN: This was a randomized controlled
study. METHOD(S): A group of 322 patients undergoing elective open
cardiac surgery were randomly allocated to receive either music combined
with preoperative education (the experimental group) or routine
preoperative preparation (the control group). The primary endpoint was
perioperative anxiety scores. The secondary outcome measures included
length of stay in the intensive care unit, length of hospital stay,
perioperative mean blood pressure, heart rate, respiratory rate, and
quality of life score measured with the SF-36 subscale scores. This study
collected data at the following 6 time points: T0 (preoperative baseline
value), T1 (10 minutes after preoperative combined intervention), T2
(after patient extubation), T3 (10 minutes after intensive care unit
intervention), T4 (the first day after patient admission), and T5 (1 month
after patient discharge). FINDINGS: The experimental group reported
significantly lower anxiety scores than the control group at both T1 and
T4 time points. The experimental group had a significantly shorter length
of stay in the intensive care unit and length of hospital stay than the
control group. Heart rate, mean blood pressure, and respiratory rate were
significantly lower in the experimental group at T1, T3, and T4 time
points. The mean blood pressure and heart rate were significantly lower in
the experimental group at the T2 time point. The SF-36 subscale scores
were significantly higher in the experimental group at the T5 time point.
 CONCLUSION(S): The combination of music and preoperative education
provides effective antianxiety and accelerates recovery in patients
undergoing open cardiac surgery. Copyright © 2025 The American
Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights
reserved.

<50>
Accession Number
646383149
Title
Cardiovascular Disease-Specific Responses to Autonomic Denervation.
Source
JACC. Clinical electrophysiology. (no pagination), 2025. Date of
Publication: 08 Jan 2025.
Author
Zhang Y.; Po S.S.; Xin F.; Zhao J.; Zhao K.; Tao D.; Chakraborty P.; Yin
Z.; Liu G.; Wang H.
Institution
(Zhang, Xin, Zhao, Zhao, Tao, Yin, Liu, Wang) Department of Cardiovascular
Surgery, General Hospital of Northern Theater Command, Shenyang, Liaoning,
China
(Po, Chakraborty) Section of Cardiovascular Diseases and Heart Rhythm
Institute, University of Oklahoma Health Sciences Center, Oklahoma City,
OK, United States
Abstract
BACKGROUND: Calcium-mediated autonomic denervation has been shown to
suppress postoperative atrial fibrillation (POAF) after coronary artery
bypass grafting. OBJECTIVE(S): This study sought to evaluate whether
similar autonomic denervation can prevent POAF after mitral or aortic
valve surgeries. METHOD(S): This research consisted of 2
single-center, randomized, double-blind, sham-controlled trials: CAP-AF2
(Calcium Autonomic Denervation Prevents Postoperative Atrial Fibrillation
in Patients Undergoing Isolated Mitral Valve Surgery for Mitral
Regurgitation) for mitral valve (MV) surgery and CAP-AF3 (Calcium
Autonomic Denervation Prevents Postoperative Atrial Fibrillation in
Patients Undergoing Isolated Aortic Valve Surgery) for aortic valve
surgery. Patients were randomized to receive injections of either 5% CaCl2
or 0.9% NaCl (control) into the atrial ganglionated plexi during surgery.
The primary outcome was the incidence of POAF >=30 seconds within 7 days
after surgery. Secondary outcomes included hospital stay, AF burden,
actionable antiarrhythmic therapy for POAF, and inflammatory marker.
 RESULT(S): After 160 patients were enrolled into the CAP-AF2 trial,
mid-term analysis revealed a significant increase in POAF incidence in the
CaCl2 group (55.13%, CaCl2 vs 37.80%, NaCl; P = 0.028). The CAP-AF2 trial
was terminated by the safety committee. In the CAP-AF3 trial, 239 patients
were randomized; final analysis showed no significant difference in the
POAF incidence between the CaCl2 and NaCl groups (35.59% vs 39.67%, P =
0.516). Postoperative hospital stay, AF burden, antiarrhythmic therapy for
POAF, and plasma levels of inflammatory markers were not different between
the 2 groups in both trials. Immunohistochemical analyses showed
parasympathetic predominance at the tissue level in patients receiving MV
surgery. CONCLUSION(S): Calcium-mediated autonomic denervation did
not uniformly prevent POAF across all cardiac surgeries, with an increased
incidence observed in the MV surgery group, highlighting the need for
disease-specific strategies to prevent POAF. (Calcium Autonomic
Denervation Prevents Postoperative Atrial Fibrillation in Patients
Undergoing Isolated Mitral Valve Surgery for Mitral Regurgitation
[CAP-AF2]; ChiCTR2000029314; Calcium Autonomic Denervation Prevents
Postoperative Atrial Fibrillation in Patients Undergoing Isolated Aortic
Valve Surgery [CAP-AF3]; ChiCTR2000029313). Copyright © 2025
American College of Cardiology Foundation. Published by Elsevier Inc. All
rights reserved.

<51>
Accession Number
2037281963
Title
Impact of neuromuscular block monitoring and reversal on postoperative
pulmonary complications in thoracic surgery: a Bayesian analysis of the
iPROVE-OLV trial.
Source
British Journal of Anaesthesia. (no pagination), 2025. Date of
Publication: 2025.
Author
Mazzinari G.; Diaz-Cambronero O.; Garutti I.; Errando C.L.; Ferrando C.
Institution
(Mazzinari, Diaz-Cambronero) Department of Anesthesiology and Pain
Medicine, Hospital Universitario y Politecnico la Fe, Valencia, Spain
(Mazzinari, Diaz-Cambronero) Perioperative Medicine Research Group,
Instituto de Investigacion Sanitaria la Fe, Valencia, Spain
(Mazzinari) Department of Statistics and Operational Research, Universidad
de Valencia, Valencia, Spain
(Garutti) Department of Anesthesiology, Hospital General Universitario
Gregorio Maranon, Madrid, Spain
(Errando) Department of Anesthesiology, Consorcio Hospital General
Universitario, Valencia, Spain
(Ferrando) Department of Anesthesia and Critical Care, Hospital Clinic i
Provincial, Barcelona, Spain
(Ferrando) CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos
III, Madrid, Spain
Publisher
Elsevier Ltd
Abstract
Background: Postoperative pulmonary complications (PPCs) are a significant
concern in thoracic surgery. A modifiable factor influencing PPCs is
postoperative residual neuromuscular block (NMB), which impairs
respiratory muscle function. Method(s): We performed a post hoc
Bayesian analysis of data from the iPROVE-OLV study, a multicentre
randomised controlled trial involving patients undergoing thoracic surgery
with one-lung ventilation. We compared participants managed with any
neuromuscular monitoring and any reversal vs those managed without either.
The primary outcome was the occurrence of a composite of PPCs within the
first 7 postoperative days. Result(s): Of the 698 patients included,
657 received any neuromuscular monitoring and any reversal, while 41 did
not. Patients managed with any neuromuscular monitoring and any reversal
had a lower incidence of PPCs (20%) compared with those without either
(34%). Bayesian random effect logistic regression indicated that the use
of any neuromuscular monitoring and any reversal reduced PPCs with an odds
ratio (OR) ranging from 0.67 (95% credibility interval, CrI, 0.39-1.11) to
0.84 (95% CrI 0.48-1.37), depending on the prior model used. The
probability of benefit (OR <1) was between 77% and 94%. Subgroup analysis
indicated that sugammadex was more effective than neostigmine in reducing
PPCs, with a high probability of benefit (97%), and both neuromuscular
monitoring and reversal reduced PCCs when evaluated separately with a high
probability of benefit. Conclusion(s): Utilising neuromuscular
monitoring and reversal agents significantly reduced the risk of PPCs in
thoracic surgery. Sugammadex was more efficacious in reducing PPCs
compared with neostigmine. These findings support the combined use of
neuromuscular monitoring and reversal drugs. Clinical trial registration:
NCT03182062. Copyright © 2024 British Journal of Anaesthesia

<52>
Accession Number
646382999
Title
Bempedoic Acid: A Review in Cardiovascular Risk Reduction in
Statin-Intolerant Patients.
Source
American journal of cardiovascular drugs : drugs, devices, and other
interventions. (no pagination), 2025. Date of Publication: 23 Jan 2025.
Author
McGuigan A.; Blair H.A.
Institution
(McGuigan) Springer Nature, Private Bag 65901 ,Mairangi Bay, Auckland, New
Zealand
(Blair) Springer Nature, Private Bag 65901 ,Mairangi Bay, Auckland, New
Zealand
Abstract
Oral bempedoic acid (NEXLETOL in the USA; Nilemdo in the EU) and the fixed
dose combination (FDC) of bempedoic acid/ezetimibe (NEXLIZET in the USA;
Nustendi in the EU) are approved to reduce cardiovascular (CV) risk in
statin-intolerant patients who are at high risk for, or have, CV disease.
A first-in-class therapy, bempedoic acid inhibits the adenosine
triphosphate-citrate lyase enzyme in the cholesterol biosynthesis pathway.
In the multinational phase III CLEAR Outcomes trial in statin-intolerant
patients, once-daily bempedoic acid 180 mg significantly reduced the risk
of the primary endpoint (a four-component major adverse CV event composite
of CV death, nonfatal myocardial infarction, nonfatal stroke, or coronary
revascularization) compared with placebo. Bempedoic acid was generally
well tolerated and, unlike statins, was associated with a low incidence of
musculoskeletal adverse events (AEs). In conclusion, bempedoic acid as a
monotherapy or adjunctive to other lipid-lowering therapies expands the
treatment options available for the pharmacological reduction of CV risk
in statin-intolerant patients, supporting achievement of low-density
lipoprotein cholesterol (LDL-C) targets required for CV risk
reduction. Copyright © 2025. Springer Nature Switzerland AG.

<53>
Accession Number
2037218646
Title
Coronary artery bypass grafting vs. percutaneous coronary intervention in
severe ischaemic cardiomyopathy: long-term survival.
Source
European Heart Journal. 46(1) (pp 72-80), 2025. Date of Publication: 01
Jan 2025.
Author
Bloom J.E.; Vogrin S.; Reid C.M.; Ajani A.E.; Clark D.J.; Freeman M.; Hiew
C.; Brennan A.; Dinh D.; Williams-Spence J.; Dawson L.P.; Noaman S.; Chew
D.P.; Oqueli E.; Cox N.; McGiffin D.; Marasco S.; Skillington P.; Royse
A.; Stub D.; Kaye D.M.; Chan W.
Institution
(Bloom) Cardiology Division, Columbia University Medical Center, 161 Fort
Washington Ave, Herbert Irving Pavilion, 6th Floor, New York, NY, United
States
(Bloom, Dawson, Stub, Kaye, Chan) Department of Cardiology, Alfred Health,
55 Commercial Road, Melbourne, VIC, Australia
(Bloom, Dinh, Kaye, Chan) Heart Failure Research Group, Baker Heart and
Diabetes Institute, 75 Commercial Road, Melbourne, VIC, Australia
(Bloom, Reid, Brennan, Williams-Spence, Dawson, Stub) School of Public
Health and Preventive Medicine, Monash University, 553 St. Kilda Road,
Melbourne, VIC, Australia
(Vogrin, Royse, Chan) Melbourne Medical School, University of Melbourne,
Grattan Street, Melbourne, VIC, Australia
(Reid) School of Population Health, Curtin University, Kent Street, Perth,
WA, Australia
(Ajani) Department of Cardiology, The Royal Melbourne Hospital, Grattan
Street, Melbourne, VIC, Australia
(Clark) Department of Cardiology, Austin Hospital, 145 Studley Road,
Heidelberg, VIC, Australia
(Freeman) Department of Cardiology, Eastern Health, 8 Arnold Street, Box
Hill, VIC, Australia
(Hiew) Department of Cardiology, University Hospital Geelong, Bellarine
Street, Geelong, VIC, Australia
(Noaman, Cox, Chan) Department of Cardiology, Western Health, Furlong
Road, St Albans, VIC, Australia
(Chew) Victorian Heart Institute, Monash University, Melbourne, Australia
(Oqueli) Department of Cardiology, Grampians Health Ballarat, 1 Drummond
Street N, Ballarat, VIC, Australia
(Oqueli) Faculty of Health, School of Medicine, Deakin University,
Geelong, VIC, Australia
(McGiffin, Marasco) Department of Cardiothoracic Surgery, Alfred Health,
55 Commercial Road, Melbourne, VIC, Australia
(Skillington, Royse) Department of Cardiothoracic Surgery, The Royal
Melbourne Hospital, Grattan Street, Melbourne, VIC, Australia
Publisher
Oxford University Press
Abstract
Background and Aims. The optimal revascularization strategy in patients
with ischaemic cardiomyopathy remains unclear with no contemporary
randomized trial data to guide clinical practice. This study aims to
assess long-term survival in patients with severe ischaemic cardiomyopathy
revascularized by either coronary artery bypass grafting (CABG) or
percutaneous coronary intervention (PCI). Methods. Using the Australian
and New Zealand Society of Cardiac and Thoracic Surgeons and Melbourne
Interventional Group registries (from January 2005 to 2018), patients with
severe ischaemic cardiomyopathy [left ventricular ejection fraction (LVEF)
<35%] undergoing PCI or isolated CABG were included in the analysis. Those
with ST-elevation myocardial infarction and cardiogenic shock were
excluded. The primary outcome was long-term National Death Index-linked
mortality up to 10 years following revascularization. Risk adjustment was
performed to estimate the average treatment effect using propensity score
analysis with inverse probability of treatment weighting (IPTW). Results.
A total of 2042 patients were included, of whom 1451 patients were treated
by CABG and 591 by PCI. Inverse probability of treatment
weighting-adjusted demographics, procedural indication, coronary artery
disease extent, and LVEF were well balanced between the two patient
groups. After risk adjustment, patients treated by CABG compared with
those treated by PCI experienced reduced long-term mortality [adjusted
hazard ratio 0.59, 95% confidence interval (CI) 0.45-0.79, P = .001] over
a median follow-up period of 4.0 (inter-quartile range 2.2-6.8) years.
There was no difference between the groups in terms of in-hospital
mortality [adjusted odds ratio (aOR) 1.42, 95% CI 0.41-4.96, P = .58], but
there was an increased risk of peri-procedural stroke (aOR 19.6, 95% CI
4.21-91.6, P < .001) and increased length of hospital stay (exponentiated
coefficient 3.58, 95% CI 3.00-4.28, P < .001) in patients treated with
CABG. Conclusions. In this multi-centre IPTW analysis, patients with
severe ischaemic cardiomyopathy undergoing revascularization by CABG
rather than PCI showed improved long-term survival. However, future
randomized controlled trials are needed to confirm the effect of any such
benefits. Copyright © The Author(s) 2024. Published by Oxford
University Press on behalf of the European Society of Cardiology. All
rights reserved.

<54>
Accession Number
2037281968
Title
The Society of Thoracic Surgeons Expert Consensus Statements on a
Framework for a Standardized National Robotic Curriculum for Thoracic
Surgery Trainees.
Source
Annals of Thoracic Surgery. (no pagination), 2025. Date of Publication:
2025.
Author
Kim S.S.; Schumacher L.; Cooke D.T.; Servais E.; Rice D.; Sarkaria I.;
Yang S.; Abbas A.; Sanchetti M.; Long J.; Kotova S.; Park B.J.; D'Souza
D.; Shah-Jadeja M.; Ajouz H.; Godoy L.; Bahatyrevich N.; Hayanga J.; Lazar
J.
Institution
(Kim) Canning Thoracic Institute, Northwestern Memorial Hospital,
Northwestern University Feinberg School of Medicine, Chicago, Illinois,
United States
(Schumacher) Division of General Thoracic Surgery, Tufts University School
of Medicine, Boston, Massachusetts, United States
(Cooke, Godoy, Bahatyrevich) Division of General Thoracic Surgery,
University of California, Davis Health, Sacramento, California, United
States
(Servais) Division of Thoracic Surgery, Lahey Hospital and Medical Center,
UMass Chan Medical School, Burlington, Massachusetts, United States
(Rice) Division of Thoracic Surgery, MD Anderson Cancer Center, University
of Texas, Houston, Texas, United States
(Sarkaria) Division of Thoracic Surgery, University of Texas Southwestern
Medical Center, Dallas, Texas, United States
(Yang) Division of Thoracic Surgery, The Johns Hopkins University School
of Medicine, Baltimore, Maryland, United States
(Abbas, Ajouz) Division of Thoracic Surgery, Brown University School of
Medicine, Providence, Rhode Island, United States
(Sanchetti) Division of Thoracic Surgery, Emory School of Medicine,
Atlanta, GA, United States
(Long) Division of Cardiothoracic Surgery, University of North Carolina at
Chapel Hill School of Medicine, Chapel Hill, NC, United States
(Kotova) Division of Thoracic Surgery, Oregon Health and Science
University School of Medicine, Portland, Oregon, United States
(Park) Thoracic Service, Department of Surgery, Memorial Sloan Kettering
Cancer Center, New York, New York, United States
(D'Souza) Division of Thoracic Surgery, Ohio State University, Columbus,
Ohio, United States
(Shah-Jadeja) Division of Thoracic Surgery, University of Kentucky,
Lexington, Kentucky, United States
(Hayanga) Department of Cardiothoracic and Vascular Surgery, West Virginia
University Medicine, Morgantown, WV, United States
(Lazar) Division of Thoracic Surgery, Ascension Saint Thomas Hospital,
University of Tennessee Health Science Center, Nashville, TN, United
States
Publisher
Elsevier Inc.
Abstract
Objective: With robotic technology's rapid growth and integration, an
urgent need to bridge the educational gap in thoracic surgical training
has emerged. This document, a result of consensus among a group of experts
in the practice and training of robotic surgery from The Society of
Thoracic Surgeons, aims to provide a framework for a standardized national
robotic curriculum for thoracic surgery trainees. Method(s): The
Society of Thoracic Surgeons Task Force on Robotic Thoracic Surgery and
Workforce on E-learning and Educational Innovation assembled an expert
group with the input of the Thoracic Surgery Director's Association. A
focused literature review was performed, and expert consensus statements
were developed using a modified Delphi process to address 3 major themes:
(1) program expectations, (2) components of training, and (3) assessment
and feedback. Result(s): A consensus was reached on 12
recommendations. These consensus statements reflect updated insights on
developing a standardized robotics curriculum based on the latest
literature and current educational experience, focusing on program
expectations and educational guidelines to develop an optimal training
curriculum. Conclusion(s): The expert panel provides several key
recommendations to provide a framework for developing a standardized
national robotic thoracic curriculum, which would improve resident
education and abridge any educational disparity that may exist among
programs. Copyright © 2025 The Authors

<55>
Accession Number
646384437
Title
Off-pump versus on-pump coronary artery bypass grafting in patients with
chronic obstructive pulmonary disease: a systematic review and
meta-analysis.
Source
General thoracic and cardiovascular surgery. (no pagination), 2025. Date
of Publication: 23 Jan 2025.
Author
Cappellaro A.P.; de Almeida L.F.C.; Pinto M.L.; Martins M.A.B.; Sousa
A.G.E.; Gadelha J.G.; Vieira A.C.P.; Rocha L.F.R.; Thet M.S.
Institution
(Cappellaro) Centro Universitario Mauricio de Nassau de Barreiras,
Barreiras, Brazil
(de Almeida, Rocha) Department of Surgery, Federal Fluminense University,
Niteroi, Brazil
(Pinto) Universidade Federal de Ciencias da Saude de Porto Alegre, Porto
Alegre, Brazil
(Martins) Universidade Federal de Ouro Preto, Ouro Preto, Brazil
(Sousa) Centro Universitario de Anapolis, Anapolis, Brazil
(Gadelha) Afya Faculdade de Ciencias Medicas da Paraiba, Joao Pessoa,
Brazil
(Vieira) Universidade Santo Amaro, Sao Paulo, Brazil
(Thet) Department of Surgery & Cancer, Imperial College London, South
Kensington, United Kingdom
Abstract
INTRODUCTION: Off-pump coronary artery bypass graft surgery (OPCAB) has
been suggested as superior to on-pump coronary artery bypass graft surgery
(ONCAB) in certain high-risk subgroups, but its benefit in patients with
chronic obstructive pulmonary disease (COPD) remains controversial. This
meta-analysis aimed to evaluate OPCAB versus ONCAB outcomes in COPD
patients. METHOD(S): We followed PRISMA guidelines and searched
PubMed, Embase, and the Cochrane Library in August 2024 for studies
comparing OPCAB and ONCAB in COPD patients. Statistical analysis was
conducted using Review Manager 5.4.1 and Rstudio with a fixed or random
effects model. RESULT(S): Six studies with a total of 1,687 patients
were included, of which 1,062 (62.95%) underwent OPCAB. The mean patient
age was 63.6 years. OPCAB did not significantly affect all-cause mortality
compared to ONCAB (OR 1.14; 95% CI 0.65-1.99). There were no significant
differences in reintubation (OR 0.81; 95% CI 0.53-1.23), prolonged
ventilation (OR 0.54; 95% CI 0.24-1.22), post-operative atrial
fibrillation (OR 0.90; 95% CI 0.70-1.15), or ARDS (OR 0.43; 95% CI
0.14-1.33). However, ventilation time was significantly shorter in the
OPCAB group (MD - 5.30 h; 95% CI - 7.22 to - 3.38). CONCLUSION(S):
OPCAB is associated with reduced ventilation time in COPD patients though
it shows no significant difference in all-cause mortality or other
post-operative complications compared to ONCAB. Copyright © 2025.
The Author(s).

<56>
Accession Number
2037282988
Title
Prognostic impact of intravascular imaging in percutaneous coronary
intervention according to atherothrombotic risk: a post hoc analysis of a
randomized clinical trial.
Source
Revista Espanola de Cardiologia. (no pagination), 2025. Date of
Publication: 2025.
Author
Hong D.; Ha J.; Choi K.H.; Lee S.H.; Shin D.; Lee J.-Y.; Lee S.-J.; Lee
S.Y.; Kim S.M.; Yun K.H.; Cho J.Y.; Kim C.J.; Ahn H.-S.; Nam C.-W.; Yoon
H.-J.; Park Y.H.; Lee W.S.; Yang J.H.; Choi S.-H.; Gwon H.-C.; Song Y.B.;
Hahn J.-Y.; Park T.K.; Lee J.M.
Institution
(Hong, Ha, Choi, Yang, Choi, Gwon, Song, Hahn, Park, Lee) Division of
Cardiology, Department of Medicine, Heart Vascular Stroke Institute,
Samsung Medical Center, Sungkyunkwan University School of Medicine, Seul,
South Korea
(Lee) Department of Internal Medicine and Cardiovascular Center, Chonnam
National University Hospital, Gwangju, South Korea
(Shin) Department of Cardiology, St Francis Hospital and Heart Center,
Roslyn, Nueva York, United States
(Lee, Lee) Division of Cardiology, Department of Internal Medicine,
Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine,
Seul, South Korea
(Lee, Kim) Division of Cardiology, Department of Internal Medicine,
Chungbuk National University Hospital, Chungbuk National University
College of Medicine, Cheongju, South Korea
(Lee) Division of Cardiology, Department of Internal Medicine, Chung-Ang
University College of Medicine, Chung-Ang University Gwangmyeong Hospital,
Gwangmyeong, South Korea
(Yun, Cho) Division of Cardiology, Department of Internal Medicine,
Wonkwang University Hospital, Iksan, South Korea
(Kim, Ahn) Division of Cardiology, Department of Internal Medicine, The
Catholic University of Korea, Uijeongbu St. Mary's Hospital, Seul, South
Korea
(Nam, Yoon) Division of Cardiology, Department of Internal Medicine,
Keimyung University Dongsan Hospital, Daegu, South Korea
(Park) Department of Cardiology, Samsung Changwon Hospital, Sungkyunkwan
University School of Medicine, Changwon, South Korea
(Lee) Division of Cardiology, Department of Internal Medicine, Chung-Ang
University College of Medicine, Chung-Ang University Hospital, Seul, South
Korea
Publisher
Ediciones Doyma, S.L.
Abstract
Introduction and objectives: Recent randomized controlled trials support
the use of intravascular imaging-guided percutaneous coronary intervention
(PCI) to improve patient prognosis. However, the subsequent risk of
clinical events in patients with coronary artery disease is not determined
solely by lesion characteristics or how these lesions are treated. The
current study investigated whether the effects of intravascular imaging in
complex PCI vary according to atherothrombotic risks. Method(s): This
study was a post hoc analysis of the RENOVATE-COMPLEX-PCI trial, which
compared intravascular imaging-guided PCI with angiography-guided PCI in
patients with complex coronary artery lesions. The study population was
stratified by atherothrombotic risk, assessed using the Thrombolysis in
Myocardial Infarction risk score for secondary prevention (TRS-2P). TRS-2P
is calculated based on the presence of the following factors: age >= 75
years, diabetes mellitus, hypertension, smoking, peripheral arterial
disease, stroke, coronary artery bypass grafting, heart failure, and renal
dysfunction. Patients were categorized into low-risk (TRS-2P < 3) or
high-risk (TRS-2P >= 3) groups. The primary endpoint was target vessel
failure, a composite of cardiac death, target vessel-related myocardial
infarction, or clinically driven target vessel revascularization.
 Result(s): Among the total study population, 1247 patients were
categorized as low-risk, and 392 as high-risk. The risk of target vessel
failure was significantly higher in the high-risk group than in the
low-risk group (15.5% vs 7.2%; HR, 2.13; 95%CI, 1.51-3.00; P < .001). The
benefits of intravascular imaging-guided PCI over angiography-guided PCI
did not differ between the low-risk group (5.6% vs 10.4%; HR, 0.56; 95%CI,
0.36-0.86) and the high-risk group (14.1% vs 18.5%; HR, 0.71; 95%CI,
0.41-1.24), with no significant interaction (interaction P = .496).
 Conclusion(s): In this hypothesis-generating post hoc analysis of the
RENOVATE-COMPLEX-PCI trial, patients with high atherothrombotic risk had
significantly worse clinical outcomes than those with low atherothrombotic
risk. Nevertheless, the prognostic impact of intravascular imaging-guided
PCI compared with angiography-guided PCI was similarly observed in both
low- and high-risk groups. RENOVATE-COMPLEX-PCI clinical trial register
number: NCT03381872. Copyright © 2024 Sociedad Espanola de
Cardiologia

<57>
Accession Number
646384931
Title
Intracardiac or transesophageal echocardiography for left atrial appendage
occlusion: an updated systematic review and meta-analysis.
Source
The international journal of cardiovascular imaging. (no pagination),
2025. Date of Publication: 22 Jan 2025.
Author
Beneki E.; Dimitriadis K.; Theofilis P.; Pyrpyris N.; Iliakis P.;
Kalompatsou A.; Kostakis P.; Koukos M.; Soulaidopoulos S.; Tzimas G.;
Tsioufis K.; Lancellotti P.; Aggeli C.
Institution
(Beneki, Dimitriadis, Theofilis, Pyrpyris, Iliakis, Kalompatsou, Kostakis,
Koukos, Soulaidopoulos, Tsioufis, Aggeli) First Cardiology Department,
School of Medicine, Hippokration General Hospital, National and
Kapodistrian University of Athens, Athens, Greece
(Beneki, Tzimas) Department of Cardiology, Lausanne University Hospital
and University of Lausanne, Lausanne, Switzerland
(Lancellotti) Department of Cardiology, University Hospital Center, Liege,
Belgium
Abstract
BACKGROUND: Intracardiac echocardiography (ICE) appears to be a potential
alternative for percutaneous left atrial appendage occlusion (LAAO) to
transesophageal echocardiography (TEE). Thus, a meta-analysis was
performed comparing ICE vs. TEE for LAAO guidance. METHOD(S): A
comprehensive literature search was performed using MEDLINE, Scopus and
Web of Science electronic databases from their inception to November 2023.
 RESULT(S): 18 studies (124,230 patients) were included. Technical
success was higher in ICE- compared to TEE-guidance (OR: 1.36, 95% CI 1.14
to 1.63, p = 0.006) and fewer devices employed (SMD: -0.22, 95% CI -0.43
to -0.01, p = 0.04, I2 = 62%). ICE guidance related with more pericardial
effusion/tamponade and iatrogenic residual shunts (logRR: 0.62, 95% CI
0.36 to 0.89, p < 0.001 and RR: 1.53, 95% CI 1.12 to 2.09, p = 0.02, I2 =
1%, respectively). More vascular complications were noted in ICE group
(logRR: 0.45, 95% CI 0.11 to 0.78, p = 0.009). CONCLUSION(S):
ICE-guided imaging is an effective alternative to TEE in LAAO, as it shows
better efficacy than TEE, considering technical success. However, the
higher rates of adverse events should be carefully
considered. Copyright © 2025. The Author(s).

<58>
Accession Number
2033036350
Title
Biomarkers predicting postoperative adverse outcomes in children with
congenital heart disease: a systematic review and meta-analysis.
Source
Frontiers in Pediatrics. 13 (no pagination), 2025. Article Number:
1508329. Date of Publication: 2025.
Author
Zhou S.; Liu L.; Jin X.; Dorikun D.; Ma S.
Institution
(Zhou, Jin, Dorikun, Ma) Pediatric Cardiothoracic Surgery, First
Affiliated Hospital of Xinjiang Medical University, Urumqi, China
(Zhou) College of Pediatrics, Xinjiang Medical University, Urumqi, China
(Liu) Hematology Department, First Affiliated Hospital of Xinjiang Medical
University, Urumqi, China
Publisher
Frontiers Media SA
Abstract
Objective: To statistically analyze biomarkers predicting postoperative
outcomes in children with congenital heart disease (CHD). Method(s):
PubMed, Embase, Cochrane Library, and Web of Science were performed to
search up to February 2024. The measured outcomes were biomarkers,
mortality, length of hospital stay, complication rates, and infection
rates. Adults with CHD were excluded. Standard deviation or odds ratio
(OR) with 95% confidence interval (95% CI) were extracted. A
random-effects model synthesized SMDs or ORs with 95% CIs. Sensitivity
analysis investigated heterogeneity, and Egger's test assessed publication
bias. Result(s): Seventeen eligible articles were included, the
biomarkers involved include serum lactate, NT-Pro BNP, PaO2, serum
creatinine, C1-INH activity, ST2, serum chloride concentration, GH,
glycemia, cTOI, NLR, serum albumin, and glucose levels, with 2,888
patients who underwent surgery(modified Norwood procedure, arterial switch
procedure, biventricular repair etc.). Serum lactate was higher in the
postoperative death group (SMD: 1.18, 95% CI: 0.59-1.77). Lower
postoperative N-terminal pro-B-type natriuretic peptide (NT-pro BNP)
levels were associated with lower mortality (OR: 0.23, 95% CI: 0.08-0.68)
and shorter mechanical ventilation time (OR: 0.40, 95% CI: 0.18-0.90).
Higher serum albumin levels were associated with longer hospital stays
(OR: 3.12, 95% CI: 1.66-5.84). Significant heterogeneity was found in
serum creatinine, B-type natriuretic peptide (BNP), serum lactate, and
NT-Pro BNP. Publication bias was detected in some studies.
 Conclusion(s): Serum lactate, NT-Pro BNP, and serum albumin are
reliable biomarkers for predicting adverse outcomes in children with CHD
after surgery. Systematic Review Registration: PROSPERO
[CRD42024512753]. Copyright 2025 Zhou, Liu, Jin, Dorikun and Ma.

<59>
Accession Number
2032572757
Title
Fibrinogen and Prothrombin Complex Concentrate: The Importance of the
Temporal Sequence-A Post-Hoc Analysis of Two Randomized Controlled Trials.
Source
Journal of Clinical Medicine. 13(23) (no pagination), 2024. Article
Number: 7137. Date of Publication: 01 Dec 2024.
Author
Ranucci M.; Aloisio T.; Di Dedda U.; Anguissola M.; Barbaria A.;
Baryshnikova E.
Institution
(Ranucci, Aloisio, Di Dedda, Anguissola, Barbaria, Baryshnikova)
Department of Cardiothoracic and Vascular Anesthesia and Intensive Care,
Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San
Donato, San Donato Milanese, Milan, Italy
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Abstract
Background/Objectives: A low level of soluble coagulation factors after
cardiac surgery may cause excessive bleeding and trigger clinical
correction using prothrombin complex concentrate (PCC). According to the
current guidelines, the trigger values for PCC administration are not
defined. In the published algorithms, when driven by ROTEM, the
triggers vary from 80 s to >100 s of coagulation time (CT) during an EXTEM
test. Two randomized controlled trials on fibrinogen (FC) supplementation
after cardiac surgery previously pointed out that the patients receiving
FC supplementation had a significant decrease in their EXTEM CT. This
study investigates the hypothesis that after increasing the availability
of a substrate (fibrinogen), thrombin generation induces fibrin network
formation faster, and that, before considering PCC administration, the
normalization of fibrinogen levels should be sought. Method(s): A
retrospective study based on a post-hoc analysis of the data collected in
two previous RCTs involving 85 patients, all of whom received FC
supplementation. Result(s): The results of this post-hoc analysis
demonstrate that there is a significant negative association between
FIBTEM maximum clot firmness (MCF) and the EXTEM CTs before and after FC
supplementation; FC supplementation decreases the EXTEM CTs both in
patients with a low FIBTEM MCF and a normal FIBTEM MCF. After FC
supplementation, 45 (53%) of the patients had an EXTEM CT of >80 s, 22
(26%) had an EXTEM CT of >90 s, and 8 (9%) had an EXTEM CT of >100 s.
 Conclusion(s): Our study confirms and quantifies the effects of
reducing EXTEM CTs through FC supplementation. A stepwise strategy of
factors correction with FC supplementation should be used before
considering PCC administration as it might reduce the need for
PCC. Copyright © 2024 by the authors.

<60>
Accession Number
646375125
Title
Transcatheter management of residual mitral regurgitation after
transcatheter edge-to-edge repair: a systematic review.
Source
Cardiovascular intervention and therapeutics. (no pagination), 2025. Date
of Publication: 21 Jan 2025.
Author
Baudo M.; Cuko B.; Ternacle J.; Sicouri S.; Busuttil O.; Denti P.; Godino
C.; De Vincentiis C.; Ramlawi B.; Leroux L.; Modine T.; Palloshi A.;
Maisano F.
Institution
(Baudo, Sicouri, Ramlawi) Department of Cardiac Surgery Research, Lankenau
Institute for Medical Research, Main Line Health, 100 E Lancaster Avenue,
Wynnewood, PA, United States
(Cuko, Ternacle, Busuttil, Leroux, Modine) Department of Cardiology and
Cardio-Vascular Surgery, Hopital Cardiologique du Haut-Leveque, Bordeaux
University Hospital, Pessac, France
(Denti, Godino, Palloshi, Maisano) Heart Valve Center, IRCCS San Raffaele,
Milan, Italy
(De Vincentiis) Department of Cardiac Surgery, IRCCS San Donato, Milan,
Italy
(Ramlawi) Department of Cardiac Surgery, Lankenau Heart Institute, Main
Line Health, Wynnewood, PA, United States
(Palloshi) Department of Interventional Cardiology, Istituto Clinico Citta
Studi, Milan, Italy
Abstract
BACKGROUND: Treatment of residual mitral regurgitation (MR) with different
percutaneous devices after transcatheter edge-to-edge repair (TEER) has
been reported as an alternative option to reclipping or surgery. This
review aims at describing the different transcatheter strategies available
and their results when managing residual MR after TEER. METHOD(S): A
literature search was undertaken across Pubmed, ScienceDirect, SciELO,
DOAJ, and Cochrane library databases, to identify article reporting
patients with post-TEER residual MR managed by a transcatheter approach
that did not involve only the implantation of new clips. RESULT(S):
From 439 deduplicated studies, 24 articles ultimately met the inclusion
criteria. Fifteen described an occluder device implantation, 12 with an
Amplatzer and 3 with a Cardioform. The most feared complications were
hemolysis and device embolization. Three cases of transcatheter
annuloplasty were reported in patients with residual functional MR. An
electrosurgical detachment of the TEER device from the anterior mitral
leaflet (ELASTA-Clip) before mitral valve replacement was reported in 6
articles. CONCLUSION(S): Transcatheter procedures addressing residual
MR after TEER in carefully selected patients are feasible in experienced
centers. Outcomes are promising despite some technical issues.
Percutaneous strategies and related complications should be anticipated
using multimodality imaging. Copyright © 2025. The Author(s)
under exclusive licence to Japanese Association of Cardiovascular
Intervention and Therapeutics.

<61>
Accession Number
646369166
Title
Computed tomography coronary angiography as an alternative to invasive
coronary angiography in preoperative evaluation for mitral surgery.
Source
The Journal of thoracic and cardiovascular surgery. (no pagination),
2025. Date of Publication: 19 Jan 2025.
Author
Patil A.R.; Zheng A.; Israel Y.; Shah A.; El-Eshmawi A.; Pandis D.;
Anyanwu A.C.; Adams D.H.; Boateng P.
Institution
(Patil, Zheng, El-Eshmawi, Pandis, Anyanwu, Adams, Boateng) Mount Sinai
Health System, New York, NY
(Israel) Icahn School of Medicine, New York, NY
(Shah) Quality Operations and Clinical Data Registries, Icahn School of
Medicine at Mount Sinai, New York, NY
Abstract
OBJECTIVE: The aim of this study was to assess the effectiveness of
non-invasive coronary computed tomography angiography (CTA) as an
alternative to traditional invasive coronary angiography (ICA) for
preoperative evaluation of low risk patients with an indication for
non-emergent mitral surgery and to assess any difference in adverse
outcomes from this strategy. METHOD(S): This was a retrospective
cohort study from a single center with data collected from July 2014 -
June 2020 for 1576 patients undergoing mitral valve surgery of all
etiologies - excluding patients requiring coronary artery bypass surgery.
We performed a 1:2 propensity score matching for patients evaluated with
CT (n=345) to those evaluated with ICA (n=602). The primary outcome was a
composite of major adverse events in the immediate postoperative period,
including death, stroke, new onset renal failure, post-operative cardiac
arrest, need for unplanned coronary artery bypass grafting or percutaneous
coronary re-vascularization. The odds ratio was calculated for occurrence
of major adverse events in the CT angiography group compared to the
catheterization group. RESULT(S): The mean age (standard deviation)
was 55.62 years (11.54) for the CTA group and 58.22 years (10.11) for the
ICA group. In the CTA group 334 (96.8%) and from the ICA group 582 (96.7%)
patients underwent mitral valve repair. 13 (3.8%) patients in the CTA
group experienced a major adverse event compared to 25 (4.2%) patients in
the ICA group. Of these, there were no mortalities in the CTA group but
one (0.2%) operative mortality in the ICA group. Four (1.2%) patients in
the CTA group had a post-operative stroke compared to three (0.5%)
patients in the ICA group. One (0.3%) patient in the CTA group required
renal replacement therapy postoperatively compared to 11 (1.8%) in the ICA
group. Percutaneous coronary intervention was required in one (0.3%)
patient in CTA group and 2 (0.3%) patients in ICA group for a coronary
complication of valve surgery despite non-obstructive coronary anatomy
being confirmed in both groups pre-operatively. The odds ratio for having
a major adverse event when worked up by CTA compared to ICA was 0.904
(0.443, 1.761). CONCLUSION(S): There were no increased odds of
experiencing a major adverse event for low risk mitral valve patients
undergoing preoperative coronary evaluation with CTA compared to ICA. This
data has modified our practice pattern where we now offer coronary CTA to
all elective patients who are low risk for coronary artery
disease. Copyright © 2025. Published by Elsevier Inc.

<62>
Accession Number
2037234264
Title
Age-related outcomes in CMR versus CT-guided TAVR: a secondary analysis of
a randomized clinical trial.
Source
Journal of Cardiovascular Magnetic Resonance. Conference: CMR 2025 Global
CMR Conference. Omni Shoreham Hotel, Washington United States.
27(Supplement 1) (no pagination), 2025. Article Number: 101352. Date of
Publication: 01 Mar 2025.
Author
Lechner I.; Reindl M.; Tiller C.; Holzknecht M.; Oberhollenzer F.; Kaser
A.; Binder R.; Klug G.; Mayr A.; Bauer A.; Metzler B.; Reinstadler S.
Institution
(Lechner, Reindl, Tiller, Holzknecht, Oberhollenzer, Kaser, Bauer,
Metzler, Reinstadler) University Clinic of Internal Medicine III,
Cardiology, Innsbruck, Tirol, Austria
(Binder) Clinic for Internal Medicine II, Cardiology, Wels,
Niederosterreich, Austria
(Klug) Deparment of Internal Medicine, Bruck an der Mur, Steiermark,
Austria
(Mayr) University Clinic of Radiology, Innsbruck, Tirol, Austria
Publisher
Elsevier B.V.
Abstract
Background: Transcatheter aortic valve replacement (TAVR) is the treatment
of choice for older patients with severe aortic stenosis and is expanding
into younger age groups. Computed tomography (CT) is the gold standard for
TAVR planning. Cardiac magnetic resonance (CMR) is an alternative imaging
modality for TAVR guidance. The aim of this study was to evaluate the
impact of age on implantation success in patients undergoing CT- or
CMR-guided TAVR. Method(s): This was a secondary analysis of the
randomized TAVR-CMR clinical trial comparing TAVR planning by CT or CMR
(NCT03831087). For this analysis, patients were categorized according to
the median age (82 years). Implantation success, defined according to the
Valve Academic Research Consortium-2 definition (absence of procedural
mortality, correct positioning of a single prosthetic valve, and proper
prosthetic valve performance), was compared at hospital discharge between
age groups for each imaging strategy. Result(s): A total of 267
patients (median age 82 [IQR 80-85] years, 50% female) underwent TAVR at
two hospitals in Austria between September 2017 and December 2022.
Implantation success was not significantly different between imaging
strategies for patients <=82 years (92% (CT group) vs. 95% (CMR group),
p=0.524) and patients >82 years (89.4% (CT group) vs. 91.9% (CMR group),
p=0.622). All-cause mortality at 6 months was not significantly different
between imaging strategies for patients <=82 years (4.8% (CT group) vs.
5.3% (CMR group), p=0.839) and >82 years (9.1% (CT group) vs. 12.9% (CMR
group), p=0.490). Conclusion(s): CMR-guided TAVR was associated with
similar TAVR outcomes compared with CT-guided TAVR irrespective of age.
Implantation Success [Formula presented] Mortality at 6 Months [Formula
presented] Copyright © 2024

<63>
Accession Number
646348835
Title
Syndrome of a truly broken heart: left ventricular rupture in a patient
with recurrent takotsubo syndrome.
Source
Polish Archives of Internal Medicine. Conference: 9th McMaster
International Review Course in Internal Medicine. Krakow Poland.
134(Supplement 1) (pp 17), 2024. Date of Publication: 2024.
Author
Stepien K.; Eliasz K.; Zalewski J.
Institution
(Stepien, Eliasz, Zalewski) Department of Coronary Artery Disease and
Heart Failure, St. John Paul II Hospital, Krakow, Poland
(Stepien) Department of Thromboembolic Disorders, Institute of Cardiology,
Jagiellonian University Medical College, Krakow, Poland
(Zalewski) Department of Coronary Artery Disease and Heart Failure,
Institute of Cardiology, Jagiellonian University Medical College, Krakow,
Poland
Publisher
Medycyna Praktyczna Cholerzyn
Abstract
INTRODUCTION Takotsubo syndrome (TTS) is an acute, potentially reversible
clinical syndrome characterized by transient left ventricular (LV)
dysfunction. It has been considered to be relatively benign and associated
with favorable prognosis. However, recent studies have shown that the
mortality rate in TTS patients is comparable to that observed in
individuals with coronary syndrome. Moreover, it has been recognized that
complications occur in half of the TTS patients. CASE DESCRIPTION An
83-year-old woman was admitted to a hospital with ST-segment elevation
myocardial infarction (STEMI). Coronary angiography was immediately
performed and showed no significant narrowing in the coronary arteries.
However, a slow-flow phenomenon was observed, mainly in the left coronary
artery. Simultaneously, ventriculography presented a pattern of segmental
contractility abnormalities typical of apical TTS. Echocardiography showed
akinetic apex and periapical segments of the LV with hyperkinesis of the
basal segments and LV ejection fraction (LVEF) of 35%. The patient denied
the occurrence of emotional or physical triggers. The InterTAK Diagnostic
Score was 37, with a 2.3% probability of TTS. The course of the
hospitalization was uncomplicated. Follow-up echocardiography showed a
gradual improvement in LV contractility with LVEF of 45%. The patient was
discharged after a few days. Four years later, she was readmitted due to
similar stenocardial acute chest pain with STEMI. As before, coronary
angiography showed no significant narrowing in the coronary arteries, with
a clearly marked slow-flow phenomenon. Transthoracic echocardiography
(TTE) demonstrated akinetic and ballooning apex and periapical segments of
the LV with LVEF of 35%. No emotional or physical triggers were identified
again during in-depth history-taking, and the same result was obtained in
the InterTAK Diagnostic Score. TTS recurrence was diagnosed and
conservative treatment was applied. At night-time, the patient's condition
deteriorated, as she developed hypotension and sudden cardiac arrest in
pulseless electrical activity. Point-of-care TTE showed cardiac tamponade
with features of LV free-wall rupture. Cardiopulmonary resuscitation was
immediately initiated. Pericardiocentesis involving drainage of 500 ml of
blood was performed by a cardiac surgeon but it was not completely
effective due to active bleeding. Despite intensive treatment, the patient
died due to a lack of hemodynamic response. DISCUSSION Patients with TTS
are at a risk of recurrence. As shown in the GEIST registry, the
recurrence rate is 4%, and the individuals who suffer from recurrence more
frequently develop pulmonary edema (13.3% vs 4.9%; P = 0.04). Moreover,
most recurrences occur in the first 5 years after the index TTS episode.
LV rupture is a rare and most serious complication of TTS, associated with
an extremely high risk of death. In a recent systematic review, 35 such
cases have been reported. To our best knowledge, this is the first
description of LV rupture in a patient with recurrent TTS. CONCLUSIONS
Patients with recurrent TTS are at a risk of LV rupture, which is a rare
complication with an extremely high risk of death.

<64>
[Use Link to view the full text]
Accession Number
646373715
Title
TIME-TO-EVENT ANALYSIS OF MORTALITY AND STROKE IN TRIALS COMPARING
TRANS-CATHETER AND SURGICAL AORTIC VALVE IMPLANTATION WITH DIFFERENT RISK
PROFILES.
Source
Journal of Cardiovascular Medicine. Conference: 32nd National Congress of
the SICCH Societa Italiana di Chirurgia Cardiaca (Italian Society of
Cardiac Surgery). Rome Italy. 25(Supplement 1) (pp e20), 2024. Date of
Publication: 01 Dec 2024.
Author
Gastino E.; Scarpanti M.; Anselmi A.; Brophy J.; Boden W.; De Caterina R.;
Sousa Uva M.; Almeida R.M.S.; Verhoye J.; Mandrola J.; Kaul S.; Barili F.;
Parolari A.
Institution
(Gastino, Scarpanti, Parolari) University Cardiac Surgery Unit, IRCCS
Policlinico San Donato, San Donato, Italy
(Anselmi, Verhoye) Department of Thoracic and Cardiovascular Surgery,
University Hospital of Rennes, France
(Brophy) Department of Medicine, Mc- Gill University Health Center,
Montreal, Canada
(Boden) Boston University, School of Medicine and Lecture in Medicine,
Harvard Medical School, Boston, MA, United States
(De Caterina) Department of Cardiology, University of Pisa, Pisa, Italy
(Sousa Uva) Department of Cardiac Surgery and Physiology, Porto University
Medical School, Porto, Portugal
(Almeida) University Center Assis Gurgacz Foundation, Cascavel, Parana,
Brazil
(Mandrola) Baptist Health Louisville, Louisville, KY, United States
(Kaul) Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles,
CA, United States
(Barili) University Cardiac Surgery Unit, IRCCS Ospedale Galeazzi
Sant'Ambrogio, Milan, Italy
Publisher
Lippincott Williams and Wilkins
Abstract
Background: We compared the effectiveness of TAVI versus SAVR on a
composite of death or stroke at 5-year follow-up within high, intermediate
and low-risk profiles. Method(s): From January 2007 to January 2024,
we performed a systematic review of literature including randomized
control trials (RCTs) comparing TAVI or SAVR with a minimum 1-year
follow-up and reporting Kaplan-Meier analysis. The primary endpoint was
the composite of all-cause mortality or stroke. Hazard ratios (HRs) and
restricted mean survival time (RMST) differences within high, intermediate
and low-risk profiles were estimated by reconstructing time-to-event data.
 Result(s): Seven trials were included (8418 participants). The
incidence of composite endpoints increased with higher baseline risk
profiles for both treatments. A time-variant effect was present with an
early superiority of TAVI, as supported by a cumulative additional
time-to-event of 0.73 months at 4 years driven by the high-risk group. The
benefit of TAVI increased over time up to 5 years in high-risk patients
(RMST difference 2.495. 95%CI: -0.019; 5.01. P-value 0.05). In
intermediate and low-risk patients it showed a quadratic association with
a smaller increase and attenuation of the observed benefit after 60 months
(Low risk 0.813, 95%CI -0.177 1.802; p-value 0.107. Intermediate risk
0.076, 95%CI -1.131 1.282, p-value 0.902). Conclusion(s): In RCTs
comparing TAVI vs SAVR, the benefits of TAVI differ according to the
patient's risk category. The advantage of TAVI over surgery progressively
increases up to 5 years in high-risk patients. At 5 years in low and
intermediate-risk there are no significant observed benefits.

<65>
Accession Number
646349497
Title
35th Annual ELSO Conference.
Source
ASAIO Journal. Conference: 35th Annual Conference of Extracorporeal Life
Support Organization, ELSO 2024. Detroit, MI United States. 70(Supplement
4) (no pagination), 2024. Date of Publication: 01 Sep 2024.
Author
Anonymous
Publisher
Lippincott Williams and Wilkins
Abstract
The proceedings contain 227 papers. The topics discussed include: awake
insertion of transplant-bridging veno-arterial extracorporeal membrane
oxygenation in a shocked patient with severe thrombocytopenia: a case
report; extracorporeal membrane oxygenation support in adult patients with
calcium channel blocker toxicity - an ELSO Registry analysis; systemic
inflammatory responses in ECMO-treated patients: a systematic reviews and
meta-analysis; CIRBP aggravation of cardiac fibrosis after myocardial
infarction during ECMO assistance; a case of thyroid storm with incessant
ventricular tachycardia complicated by left atrial thrombus supported by
ECPELLA; hemodynamic effect of hydroxocobalamin during extracorporeal
membrane oxygenation; outcomes of ECMO as a bridge to cardiac surgery; the
impact of cannulation sites on post-cardiotomy ECMO outcomes; and the role
of veno-arterial extracorporeal membrane oxygenation in amniotic fluid
embolism: a case report.

<66>
[Use Link to view the full text]
Accession Number
646373711
Title
COMPARATIVE EFFICACY OF SUBVALVULAR PROCEDURE VERSUS ISOLATED ANNULOPLASTY
IN MITRAL VALVE REPAIR: A META- ANALYSIS ON MORTALITY AND MITRAL
REGURGITATION RECURRENCE.
Source
Journal of Cardiovascular Medicine. Conference: 32nd National Congress of
the SICCH Societa Italiana di Chirurgia Cardiaca (Italian Society of
Cardiac Surgery). Rome Italy. 25(Supplement 1) (pp e4), 2024. Date of
Publication: 01 Dec 2024.
Author
Giambuzzi I.; Messi P.; Maccarana A.; Di Mauro M.; Bonalumi G.
Institution
(Giambuzzi) Policlinico di Monza Monza, Italy
(Messi) IRCCS Ospedale Galeazzi - Sant'Ambrogio Milano, Italy
(Maccarana) Papa Giovanni XXIII Bergamo, Italy
(Di Mauro) Cardiovascular Research Institute Maastricht (CARIM)
Maastricth, Netherlands
(Bonalumi) IRCCS Centro Cardiologico Monzino Milano, Italy
Publisher
Lippincott Williams and Wilkins
Abstract
Introduction: The aim of this meta-analysis is to identify if adding
subvalvular procedure (SVP) in mitral valve repair in functional mitral
regurgitation (MR) improves the result in contrast to isolated
annuloplasty (AN). Method(s): A literature search in PubMed, Cochrane
Library, and ClinicalTrials. gov covered January 2010 to August 2024,
focusing on ischemic and functional mitral disease, mitral valve repair,
and surgical techniques. Inclusion criteria followed PRISMA guidelines
with the primary objective to compare early and late mortality and MR
recurrence. Screening involved independent assessments with a PRISMA
flowchart. Bias was evaluated with ROBINS-E, quality with the modified
Newcastle-Ottawa scale, and heterogeneity with I 2 statistics, controlling
for high-quality studies only as sensitivity analysis. Result(s): A
total of 1904 papers were found with a traditional research and 164 with
the Umbrella research. After screening, 14 studies were included, for a
total of 999 patients, of which 519 (51.95%) underwent AN and 480 (48.05%)
underwent adjunctive SVP. There was no difference in early mortality (OR
0.91, CI95% 0.46-1.8, p=0.87, I2=0), in late mortality (OR 1.24, CI95%
-0.17-0.60, p=0.28, I2=0) nor post operative complications (OR 0.7, CI95%
0.35- 1.39, p=0.3035, I2= 70.63) but in the SVP group there was a
significant reduction in MR recurrence with OR 0.48, CI95% 0.33-0.71, p =
0.0002, I2=0. No publication bias was found, even if 9 studies (64.29%)
showed high risk of bias with ROBINS-E tool. Conclusion(s): SVP are
associated with lower rates of MR recurrence, without modifying mortality
nor immediate post-operative complications.

<67>
[Use Link to view the full text]
Accession Number
646373712
Title
COMPARISON OF SAVR VERSUS TAVR 5-YEAR MORTALITY IN REAL- WORLD SCENARIOS.
Source
Journal of Cardiovascular Medicine. Conference: 32nd National Congress of
the SICCH Societa Italiana di Chirurgia Cardiaca (Italian Society of
Cardiac Surgery). Rome Italy. 25(Supplement 1) (pp e20), 2024. Date of
Publication: 01 Dec 2024.
Author
Scarpanti M.; Gastino E.; Dalbesio B.; Marin-Cuartas M.; Anselmi A.; Sousa
Uva M.; Verhoye J.; Barili F.; Parolari A.
Institution
(Scarpanti, Gastino, Parolari) University Cardiac Surgery Unit, IRCCS
Policlinico San Donato, San Donato, Italy
(Dalbesio) Department of Cardiac Surgery, S. Croce Hospital, Cuneo, Italy
(Marin-Cuartas) University Department of Cardiac Surgery, Leipzig Heart
Center, Leipzig, Germany
(Anselmi, Verhoye) Department of Thoracic and Cardiovascular Surgery,
University Hospital of Rennes, France
(Sousa Uva) Department of Cardiac Surgery, Hospital Santa Cruz, Carnaxide,
Portugal
(Barili) University Cardiac Surgery Unit, IRCCS Ospedale Galeazzi
Sant'Ambrogio, Milan, Italy
Publisher
Lippincott Williams and Wilkins
Abstract
Purpose: While Randomized clinical trials (RCTs) are designed to provide
evidence of efficacy, real world data (RWD) shows actual effectiveness. We
designed a systematic review and meta-analysis of reconstructed
time-to-event data (RTE) from propensity score matching studies comparing
the effectiveness of TAVR vs SAVR to assess differences in 5-year
mortality. Method(s): Using MEDLINE, Embase and CENTRAL databases
from 2007 to 2023, we performed a systematic review of the literature
including propensity score matching studies comparing TAVR and SAVR. The
primary endpoint was the composite of all-cause mortality at follow- up.
The Hazard Ratio (HR) was considered as the effect size. Result(s):
Twenty-one studies were included (39538 participants). TAVR showed a
higher incidence of all-cause mortality (HR 1.39; 95% CI 1.33 - 1.46,
p-value < 0.001), with a significant heterogeneity (random parameter theta
= 0.85, p-value < 0.001). The analysis of HR trend over time showed that
TAVR superiority to surgery is limited to the first month with a steep
reversal afterwards. All-cause mortality in low-risk was significantly
higher in TAVR (HR 1.33; 95% CI 1.06 - 1.67, p-value < 0.001). The HR
trend in the low-risk group differed from the whole population as there
was no advantage of TAVR. Conclusion(s): In real-word settings TAVR
is associated with a significantly higher incidence of all-cause of death
while maintaining a survival benefit only in the first month after
implantation. These results indicate that TAVR effectiveness may not
reflect the efficacy demonstrated by RCTs and pose a serious threat to
their external validity.

<68>
Accession Number
646373764
Title
32nd National Congress of the SICCH Societa Italiana di Chirurgia Cardiaca
(Italian Society of Cardiac Surgery).
Source
Journal of Cardiovascular Medicine. Conference: 32nd National Congress of
the SICCH Societa Italiana di Chirurgia Cardiaca (Italian Society of
Cardiac Surgery). Rome Italy. 25(Supplement 1) (no pagination), 2024. Date
of Publication: 01 Dec 2024.
Author
Anonymous
Publisher
Lippincott Williams and Wilkins
Abstract
The proceedings contain 127 papers. The topics discussed include:
comparison of surgical techniques in Barlow's disease; re-intervention
after failed mitral valve repair with ring: trans-ventricular beating
heart neochord implantation vs standard surgery; risk stratification in
re-operative mitral valve surgery; pulmonary hypertension severity is not
a limit for minimally invasive mitral valve surgery: results of a
multicentric observational study; survival and recurrence of endocarditis
following mechanical vs. biological mitral valve replacement for
endocarditis in patients aged 40 to 70 years: data from the
infect-registry; body mass index impact on minimally invasive mitral valve
surgery: report from a multicenter registry; and comparative efficacy of
subvalvular procedure versus isolated annuloplasty in mitral valve repair:
a meta- analysis on mortality and mitral regurgitation recurrence.

<69>
Accession Number
646355648
Title
Effect of listening to music on anxiety, pain, and cardiorespiratory
parameters in cardiac surgery: A randomized clinical trial.
Source
Intensive & critical care nursing. 87 (pp 103939), 2025. Date of
Publication: 17 Jan 2025.
Author
de Andrade EV.; Haas V.J.; de Faria M.F.; Dos Santos Felix M.M.; Guimaraes
Raponi M.B.; Barichello E.; da Silva Pires P.; Gomez-Cantarino S.; Barbosa
M.H.
Institution
(de Andrade) Stricto sensu Graduate Program in Health Care, Federal
University of Triangulo Mineiro, 38025-440 Uberaba Minas Gerais Brazil.
(Haas, de Faria, Dos Santos Felix) Stricto sensu Graduate Program in
Health Care, Federal University of Triangulo Mineiro, 38025-440 Uberaba
Minas Gerais Brazil
(Guimaraes Raponi) Faculty of Medicine. College of Nursing. Federal
University of Uberlandia Av. Para, 2U, 38400-902 Uberlandia Minas Gerais
Brazil
(Barichello, Barbosa) Didactic-Scientific Department of Nursing in
Hospital Care, Institute of Health Sciences, Federal University of
Triangulo Mineiro, 38025-440 Uberaba Minas Gerais Brazil
(da Silva Pires) Multidisciplinary Health Institute, 45.029-094, Federal
University of Bahia. Rua Hormindo Barros, Quadra, Brazil
(Gomez-Cantarino) Faculty of Physiotherapy and Nursing. Castilla-La Mancha
University, Arms Factory Technological Campus. Avda. Carlos III s/n 45071
Toledo Castilla-La Mancha Spain
Abstract
PURPOSE: To evaluate the effect of listening to music on preoperative
anxiety, postoperative pain (at rest and during coughing), and
cardiorespiratory parameters in patients undergoing cardiac surgery.
DESIGN: Single-centered, randomized, parallel, superiority clinical trial.
 METHOD(S): This study was carried out with 50 adult patients
undergoing elective cardiac surgery randomly allocated at a 1:1 ratio to
one of the groups, experimental (n = 25) or control (n = 25). The
experimental group listened to music during the immediate preoperative
period and on the first postoperative day. The control group received
standard care. State-Trait Anxiety Inventory and Numeric Pain Rating Scale
were used to collect data. FINDINGS: The classical music significantly
reduced preoperative state anxiety scores (p < 0.001; dCohen = 2.1),
postoperative pain intensity at rest (p < 0.001; dCohen = 1.4) and during
coughing (p < 0.001; dCohen = 1.3). There was also a statistically
significant reduction in systolic (p = 0.001; dCohen = 0.9) and diastolic
blood pressure (p = 0.01; dCohen = 0.6), heart rate (p < 0.001; dCohen =
2.5), respiratory rate (p < 0.001; dCohen = 1.4), and a significant
increase in oxygen saturation (p < 0.001; dCohen = 1.2).
 CONCLUSION(S): Listening to music had a significant impact on the
evaluated outcomes, demonstrating its potential as a complementary
intervention to pharmacological treatment for patients undergoing cardiac
surgery. IMPLICATIONS FOR CLINICAL PRACTICE: The findings reinforce the
evidence that listening to music is a promising nursing intervention to be
used in the perioperative period of cardiac surgeries, with the potential
to promote well-being to patients and improve the quality of care
provided. Copyright © 2024 Elsevier Ltd. All rights reserved.

<70>
Accession Number
646359511
Title
Effects of a Preoperative Psychological Expectation-focused Intervention
in Patients Undergoing Valvular Surgery - the Randomized Controlled ValvEx
(valve patients' expectations) Study.
Source
American heart journal. (no pagination), 2025. Date of Publication: 17
Jan 2025.
Author
Horn N.; Gartner L.; Rastan A.J.; Andrasi T.B.; Lenz J.; Boning A.;
Salzmann-Djufri M.; Puvogel U.; Niemann B.; Genovese M.; Habash S.;
Euteneuer F.; Rief W.; Salzmann S.
Institution
(Horn) Division of Clinical Psychology and Psychotherapy, Philipps
University of Marburg, Marburg, Germany
(Gartner, Genovese, Habash, Rief) Division of Clinical Psychology and
Psychotherapy, Philipps University of Marburg, Marburg, Germany
(Rastan, Andrasi, Lenz) Department of Cardiovascular Surgery, Heart
Center, Philipps University of Marburg, Marburg, Germany
(Boning, Salzmann-Djufri, Puvogel, Niemann) Department of Cardiovascular
Surgery, Justus Liebig University, Giessen, Germany
(Euteneuer) Department of Psychology, Clinical Psychology and
Psychotherapy, Medical School Berlin, Berlin, Germany
(Salzmann) Division of Clinical Psychology and Psychotherapy, Philipps
University of Marburg, Marburg, Germany,; Medical Psychology, Department
of Medicine, Health and Medical University, Erfurt, Germany
Abstract
BACKGROUND: Many patients experience a reduced quality of life for months
after heart surgery. Besides medical factors, psychological factors such
as preoperative expectations influence the recovery process. The ValvEx
study investigated whether an expectation-focused preoperative
intervention before heart valve surgery would i) increase positive
realistic expectations, ii) reduce preoperative anxiety and iii) improve
the postoperative recovery process. METHOD(S): N = 89 patients
undergoing heart valve surgery were randomized into one of two groups
after a baseline assessment: Standard medical care (SOC) vs. SOC plus
psychological expectation-focused intervention (EXPECT) on the day of
hospital admission. Further assessments were conducted on the evening
before surgery, four to six days and three months after surgery. The
primary outcome was illness-related disability. Constrained longitudinal
data analyses were conducted to analyze the intervention effects, while
the need for information was considered as a potential moderator.
 RESULT(S): No general effects were observed for the EXPECT
intervention over time regarding the primary outcome illness-related
disability (Pain Disability Index, PDI) and the secondary outcomes (p >=
.167). The intervention effects were moderated by the individual need for
information: Patients with a higher need for information who received the
EXPECT intervention were less anxious on the evening before surgery (p =
.020, d = 0.314) and less restricted in their quality of life four to six
days after surgery compared to patients who received SOC (p = .005, d =
0.464). CONCLUSION(S): The ValvEx study is the first multicentre
study investigating the expectation-optimizing preoperative intervention
in heart valve patients. The implementation of the EXPECT intervention
seemed to optimize outcomes after heart valve surgery for certain
patients, such as patients with a high need for information. It is
possible that there were no direct effects of the EXPECT intervention
because the intervention dose was too low. These preliminary findings need
to be corroborated by larger multi-center trials. Trial registration The
study was preregistered at ClinicalTrials (identifier: NCT04502121,
https://clinicaltrials.gov/study/NCT04502121). Copyright © 2025.
Published by Elsevier Inc.

<71>
Accession Number
2037218551
Title
Safety Interventions in Cardiac Anesthesia: A Systematic Review.
Source
Joint Commission Journal on Quality and Patient Safety. (no pagination),
2025. Date of Publication: 2025.
Author
O'Callaghan L.; Ahern S.; Doyle A.
Publisher
Joint Commission Resources, Inc.
Abstract
Background: The cardiac operating room is a complex, high-risk,
sociotechnical system. Risks in cardiac surgery and anesthesiology have
been extensively categorized, but less is known about effective risk
reduction strategies. A comprehensive understanding of effective,
evidence-based risk reduction strategies is necessary to improve patient
safety in cardiac anesthesia. Method(s): An advanced literature
search of MEDLINE, CINAHL, Embase, and Web of Science databases was
conducted to identify studies involving the introduction of a tool or
intervention to improve patient safety and human factors in cardiac
anesthesia. Studies were screened independently by two authors applying
prespecified inclusion and exclusion criteria. Risk reduction strategies
and safety initiatives identified were classified according to the Systems
Engineering Initiative for Patient Safety model. Data were extracted using
a standardized form and were narratively synthesized. Result(s): A
total of 18 studies were identified for inclusion using preoperative
briefing tools, intraoperative checklists, and postoperative handover
tools. Preoperative briefing tools were associated with a significant
reduction in patient mortality and length of hospital stay and also led to
adaptations to planned operation. Intraoperative checklists demonstrated
decreased bleeding, mortality, and blood transfusion requirements.
Postoperative handover tools were associated with improved information
transfer and teamwork. Conclusion(s): This review identified three
categories of tools that may be used to improve patient and organizational
outcomes. Many of these tools are simple to introduce and sustainable in
the long term and can be readily adapted to different
centers. Copyright © 2024 The Joint Commission

<72>
Accession Number
2037231062
Title
Regional Analgesia in Pediatric Cardiothoracic Surgery: A Bayesian Network
Meta-Analysis.
Source
Journal of Cardiothoracic and Vascular Anesthesia. (no pagination), 2025.
Date of Publication: 2025.
Author
Ren Y.; Li L.; Gao J.; Hua L.; Zheng T.; Wang F.; Zhang J.
Institution
(Ren, Li, Hua, Zheng, Wang, Zhang) Department of Anesthesiology, Beijing
Children's Hospital, Capital Medical University, National Center for
Children's Health, China
(Gao) Department of Orthopedics, Beijing Children's Hospital, Capital
Medical University, National Center for Children's Health, China
Publisher
W.B. Saunders
Abstract
Various regional analgesia techniques are used to reduce postoperative
pain in pediatric patients undergoing cardiothoracic surgeries. This study
aimed to determine the relative efficacy of regional analgesic
interventions. PubMed, EMBASE, Web of Science, and Cochrane databases were
searched to identify all randomized controlled studies evaluating the
effects of regional block after cardiothoracic surgery. The primary
endpoint was opioid consumption within 24 hours postoperatively, Pain
scores, the time to first rescue analgesic, and the incidence of
postoperative nausea and vomiting were also collected. A Bayesian NMA was
performed to compare the outcomes of interest. A total of 24 studies
involving 1602 patients and 13 regional blocks were included. All
techniques reduced opioid consumption within 24 hours postoperatively. The
largest decrease was in the thoracic retrolaminar block group, with a WMD
of -0.97 (95% CrI -1.1, -0.84) mg/kg morphine equivalent. In terms of pain
scores, there was no significant difference between any block and the
control at any time point except for the thoracic retrolaminar block group
at 0 hours postoperatively. In addition, all regional blocks prolonged the
time to first rescue analgesic, which was the longest in the pectoral
nerve block group. The incidence of postoperative nausea and vomiting was
the lowest in the epidural anesthesia group, followed by the transversus
thoracis muscle plane block group. Regional anesthesia revealed
significant opioid-sparing effects following pediatric cardiothoracic
surgery. However, indirect comparisons are limited because of the
heterogeneity of previous studies, and direct comparisons are needed to
establish the relative efficacies of different blocks. Copyright
© 2024

<73>
Accession Number
2037167260
Title
Pharmacological preventions and treatments for pericardial complications
after open heart surgeries.
Source
Heart. (no pagination), 2025. Article Number: heartjnl-2024-324805. Date
of Publication: 2025.
Author
Malektojari A.; Tahmasebipour R.; Fadaeihosein M.; Ghazizadeh S.; Ardali
F.; Haghighat B.; Keshavarz F.; Azari Y.Y.; Javdan F.; Shahsavari E.; Ersi
M.H.; Abbaszadeh S.; Al-Jafar R.; Dehghan A.; Pitre T.
Institution
(Malektojari, Ghazizadeh, Ardali, Shahsavari) Evidence Based Medicine
Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran,
Islamic Republic of
(Malektojari, Tahmasebipour, Ghazizadeh, Azari, Abbaszadeh) Cardiovascular
Research Center, Hormozgan University of Medical Sciences, Bandar Abbas,
Iran, Islamic Republic of
(Tahmasebipour, Fadaeihosein, Haghighat, Keshavarz, Azari, Javdan, Ersi)
Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar
Abbas, Iran, Islamic Republic of
(Al-Jafar, Dehghan) Department of Epidemiology and Biostatistics, School
of Public Health, Imperial College London, London, United Kingdom
(Al-Jafar) Data Services Sector, Lean Business Services, Riyadh, Saudi
Arabia
(Dehghan) MRC-PHE Centre for Environment and Health, School of Public
Health, Imperial College London, London, United Kingdom
(Pitre) Division of Respirology, Department of Medicine, University of
Toronto, Toronto, ON, Canada
Publisher
BMJ Publishing Group
Abstract
Background: Pericardial complications following cardiac surgery are common
and debilitating, significantly impacting patients' survival. We performed
this network meta-analysis to identify the most effective and safest
preventions and treatments for pericardial complications following cardiac
surgery. Method(s): We systematically searched PubMed/MEDLINE, EMBASE
and Cochrane CENTRAL from inception to 22 January 2024. Pairs of reviewers
screened eligible studies. They included randomised controlled trials that
enrolled adults undergoing major cardiac surgeries and reported
postpericardiotomy syndrome, pericardial effusion and pericarditis as
primary or secondary outcomes. We summarised the effects of interventions
using relative risks and corresponding 95% CIs. We performed a frequentist
random-effects network meta-analysis using the restricted maximum
likelihood estimator. Result(s): We included 39 trials that enrolled
a total of 6419 participants. Our network meta-analysis demonstrates
colchicine reduces the risk of postpericardiotomy syndrome (RR 0.53, 95%
CI 0.38 to 0.73). Beta-blockers probably prevent atrial fibrillation with
a large magnitude of effect (RR 0.4, 95% CI 0.20 to 0.81) and may prevent
postoperative pericarditis (RR 0.66, 95% CI 0.45 to 0.97) compared with
control. Fish oil (RR 0.28, 95% CI 0.09 to 0.90), non-steroidal
anti-inflammatory drugs (RR 0.37, 95% CI 0.23 to 0.59) and colchicine (RR
0.37, 95% CI 0.23 to 0.59) may reduce the risk of postoperative atrial
fibrillation. We found no evidence of a difference in the risk of pleural
effusion, all-cause mortality, serious adverse events or postoperative ICU
stay. Conclusion(s): The results of our study highly recommend
colchicine use to reduce the risk of the postpericardiotomy syndrome and
beta-blocker use to reduce postoperative atrial fibrillation.
Additionally, our study suggests that further research is needed to
investigate other interventions and to evaluate newly proposed
interventions in large, high-quality trials, as the current evidence for
some interventions is relatively weak. Copyright © Author(s) (or
their employer(s)) 2025. No commercial re-use. See rights and permissions.
Published by BMJ Group.

<74>
[Use Link to view the full text]
Accession Number
646342493
Title
Safety and Efficacy of Perioperative Intravenous Tranexamic Acid
Administration in Oncologic Surgery: A Systematic Review and
Meta-Analysis.
Source
Journal of the American College of Surgeons. Conference: Owen H.
Wangensteen Scientific Forum at 2024 ACS Clinical Congress. San Francisco,
CA United States. 239(5 Supplement 1) (pp S455-S456), 2024. Date of
Publication: 01 Nov 2024.
Author
Park L.J.; Wang C.; Archer V.A.; McKechnie T.; Bogach J.; Simunovic M.;
Serrano P.E.; Breau R.H.; Karanicolas P.J.; Devereaux P.J.
Institution
(Park, Wang, Archer, McKechnie, Bogach, Simunovic, Serrano, Breau,
Karanicolas, Devereaux) McMaster University, Hamilton, ON, Canada; London
Health Sciences Centre, London, ON, Canada; University of Ottawa, Ottawa,
ON, Canada; Sunnybrook Health Sciences Centre, Toronto, ON, Canada;
Population Health Research Institute, Hamilton, ON, Canada
Publisher
Lippincott Williams and Wilkins
Abstract
Introduction: Surgical oncology patients are considered high-risk for both
perioperative bleeding and thromboembolic disease. The objective of this
review was to investigate the safety and efficacy of prophylactic
tranexamic acid (TXA) use in non-cardiac surgical oncology.
 Method(s): Medline, Embase, and CENTRAL were searched from inception
to June 2023. Randomized controlled trials (RCT) that compared
perioperative TXA versus placebo among surgical oncology patients were
included. Outcomes included perioperative transfusion rate, estimated
blood loss (EBL), and thromboembolic complications. Pairwise meta-analyses
were performed using the Mantel-Haenszel method for dichotomous outcomes
and inverse variance model for continuous outcomes. Fixed effects models
were used to account for large discrepancies in trial sizes.
 Result(s): We included 21 RCTs involving 6200 patients (3116 TXA vs.
3804 placebo) undergoing uncategorized non-cardiac (N = 2771),
hepatobiliary (N = 1677), genitourinary (N = 1107), head and neck (N =
449), and other intra-abdominal (N = 196) oncologic surgeries.
Meta-analysis demonstrated reduction in transfusion rates with TXA
(448/2770 vs. 541/2781, relative risk [RR] 0.79, 95% CI 0.68-0.90, p <
0.001, I2 = 67%) and a risk difference (RD) of 41 fewer transfusion events
per 1000 (from 62 fewer to 19 fewer). TXA use was associated with reduced
EBL by 120.3 mL (95% CI -189.6 to -51.0, p < 0.001, I2 = 95%) and no
difference in thromboembolic complications (57/2705 vs. 44/2691, RR 1.29,
95% CI 0.87-1.92, p = 0.21, I2 = 0%; RD 0.00, 95% CI -0.008-0.01) compared
to placebo. Conclusion(s): Evidence demonstrates TXA use reduces
perioperative transfusion rates and blood loss, although high
heterogeneity suggests efficacy may have differed in some trials. Clinical
interpretation of thromboemboli is limited by low event rates.

<75>
[Use Link to view the full text]
Accession Number
646342847
Title
Variations in Patterns of Perioperative Thromboprophylaxis Practices after
Esophagectomy: Do the Guidelines Need a Closer Look?.
Source
Journal of the American College of Surgeons. Conference: Owen H.
Wangensteen Scientific Forum at 2024 ACS Clinical Congress. San Francisco,
CA United States. 239(5 Supplement 1) (pp S482-S483), 2024. Date of
Publication: 01 Nov 2024.
Author
Christophel E.; Martins R.S.; Poulikidis K.P.; Jawad Latif M.; Razi S.S.;
Luo J.; Bhora F.
Institution
(Christophel, Martins, Poulikidis, Jawad Latif, Razi, Luo, Bhora)
Hackensack Meridian Health, Nutley, NJ; JFK University Medical Center,
Edison, NJ
Publisher
Lippincott Williams and Wilkins
Abstract
Introduction: Current AATS (American Association for Thoracic
Surgery)/ESTS (European Society for Thoracic Surgery) guidelines on the
use of thromboprophylaxis for esophageal cancer surgery are based on low
levels of evidence. We aimed to explore thoracic surgeons' current
practices regarding use of perioperative thromboprophylaxis after
esophagectomy for esophageal cancer. Method(s): An anonymous survey
was disseminated to boardcertified thoracic surgeons in the United States
between March- November 2023. Result(s): A total of 103 thoracic
surgeons, most (71%) with over 10 years experience, responded to our
survey. Approximately two-thirds (67%) of surgeons routinely administer
preoperative chemical thromboprophylaxis, while 18.4% never do so
preoperatively. Postoperatively, over 95% of surgeons use inpatient
chemoprophylaxis, with half (58%) initiating prophylaxis on postoperative
day (POD) 0 and the remainder on POD1. The most common agent used was
low-molecular-weight heparin (LMWH: 74%), while 24% used unfractionated
heparin and 2% used direct-oral anticoagulants (DOACs). Contrary to the
AATS/ESTS guidelines, most surgeons did not routinely use chemical
thromboprophylaxis post-discharge (67%). Amongst those that did, 78.8%
used LMWH and 15.2% used DOACs. Approximately 40% of these surgeons
discontinued chemoprophylaxis before the guideline-recommended duration of
4 weeks post-surgery (Figure 1). Conclusion(s): Despite guidelines
from two major thoracic societies, there are wide variations in the
real-world use of perioperative chemical thromboprophylaxis after
esophagectomy. These variations may stem from the lack of high-quality
evidence informing the existing guidelines. Our preliminary results
highlight the need for future randomized control trials exploring the
benefit, choice of agent, and optimal duration for thromboprophylaxis
after esophageal cancer surgery.

<76>
[Use Link to view the full text]
Accession Number
646345620
Title
MAPPING CONSUMER INVOLVEMENT IN A FOLLOW UP STUDY.
Source
Pediatric Critical Care Medicine. Conference: 12th Congress of the World
Federation of Pediatric Intensive and Critical Care Societies, WFPICCS
2024. Cancun Mexico. 25(11 Supplement) (pp e101), 2024. Date of
Publication: 01 Nov 2024.
Author
Masterson K.; Long D.; Rose B.; Macdonald A.; Gibbons K.
Institution
(Masterson) Murdoch Children's Research Institute, Paediatric Intensive
Care Unit, Parkville, Australia
(Masterson) Royal Children's Hospital, Paediatric Intensive Care Unit,
Parkville, Australia
(Long) Queensland University of Technology, Centre For Healthcare
Transformation, Brisbane, Australia
(Long) Queensland Children's Hospital, Brisbane, Australia
(Rose) Australian and New Zealand Fontan Advocacy Committee, Heartkids
Australia Inc, Sydney, Australia
(Rose, Macdonald, Gibbons) University of Queensland, Children's Intensive
Care Research Program, Brisbane, Australia
Publisher
Lippincott Williams and Wilkins
Abstract
Aims & Objectives: The escalating requirement for paediatric cardiac
surgery has prompted a surge in research exploring interventions and
outcomes of this population. Recognising the importance of engaging
patient and families in study design to increase engagement with research,
we aimed to involve families in the design of a follow up study
investigating neurodevelopmental and socioemotional outcomes in children
after open heart surgery in Australia and New Zealand. Method(s):
Focus groups were conducted with representatives from a support
organisation for families with congenital heart disease and families who
participated in the Nitric Oxide During Cardiopulmonary Bypass to Improve
Recovery in Infants with Congenital Heart Defects (NITRIC) multicentre,
multinational randomised controlled trial. The focus groups were conducted
online, transcribed, and analysed using thematic analysis. Result(s):
Three focus groups were conducted with a total of 14 participants. Key
themes included meaningful engagement with families with a broad
representation, informed participation, and dissemination. Broad
representation of families reflected both traditional understanding
including education but also focused on variance in cardiac journeys and
distance to hospitals as key variants in parental experience. Informed
participation defined plain language consent, clear expectations of their
involvement and access to support throughout the study.
 Conclusion(s): These areas were addressed in protocol design through
inclusion of open-ended questions for all participants and through ongoing
engagement with consumers. We acknowledge that while inclusion was
emphasised, we were limited by the original NITRIC sample. These themes
will be explored further throughout the longitudinal study with a focus on
accessible dissemination of study findings to all participants.

<77>
[Use Link to view the full text]
Accession Number
646344411
Title
NEURODEVELOPMENT AND QUALITY OF LIFE IN INFANTS ONE YEAR AFTER OPEN HEART
SURGERY FOR CONGENITAL HEART DEFECT: A RCT OF NITRIC OXIDE VIA
CARDIOPULMONARY BYPASS.
Source
Pediatric Critical Care Medicine. Conference: 12th Congress of the World
Federation of Pediatric Intensive and Critical Care Societies, WFPICCS
2024. Cancun Mexico. 25(11 Supplement) (pp e4-e5), 2024. Date of
Publication: 01 Nov 2024.
Author
Long D.; Gibbons K.; Horton S.; Johnson K.; Buckley D.; Erickson S.; Festa
M.; D'Udekem Y.; Alphonso N.; Lemarsney R.; Winlaw D.; Masterson K.; Van
Loon K.; Young P.; Schibler A.; Schlapbach L.; Butt W.
Institution
(Long) Queensland Children's Hospital, Brisbane, Australia
(Gibbons, Lemarsney) University of Queensland, Children's Intensive Care
Research Program, Brisbane, Australia
(Horton, Festa) Royal Children's Hospital, Cardiac Surgical Unit,
Melbourne, Australia
(Johnson) Queensland Children's Hospital, PICU, Brisbane, Australia
(Buckley) Starship Children's Hospital, PICU, Auckland, New Zealand
(Erickson) Perth Children's Hospital, PICU, Perth, Australia
(D'Udekem) Children's National Hospital, Cardiac Surgery, Washington,
United States
(Alphonso) Queensland Children's Hospital, Cardiac Surgery, Brisbane,
Australia
(Winlaw) Children's Hospital at Westmead, Heart Centre For Children,
Sydney, Australia
(Masterson, Butt) Royal Children's Hospital, PICU, Melbourne, Australia
(Van Loon) Wilhelmina Children's Hospital, Utrecht, Netherlands
(Young) Monash University, Australian and New Zealand Intensive Care
Research Centre, Melbourne, Australia
(Schibler) James Cook University, Townsville, Australia
(Schlapbach) University Children's Hospital Zurich, Intensive Care and
Neonatology, Zurich, Switzerland
Publisher
Lippincott Williams and Wilkins
Abstract
Aims & Objectives: Children born with congenital heart defects, who
undergo cardiopulmonary bypass (CPB) surgery, are at risk for impaired
neurodevelopment. Nitric oxide (NO) added during CPB has been proposed as
a candidate to reduce systemic inflammation to CPB and improve recovery.
We investigated neurodevelopment, HRQoL and factors associated with
impaired neurodevelopment 12 months post-surgery in infants who received
CPB with NO versus standard care in the NITRIC randomised controlled trial
(RCT). Method(s): Secondary analysis from a double-blind,
multicentre, international RCT of 1332 infants <2 years of age who
underwent CPB and were alive 12 months post-randomisation.
Neurodevelopment and HRQoL were assessed by parent-reported Ages and
Stages Questionnaire (ASQ) and Pediatric Quality of Life Inventory
(PedsQL), respectively. Result(s): Follow-up was performed in 462
(69.8%) and 464 (69.5%) patients in the NO versus standard care group,
respectively. There were no differences between groups in mean (SD) ASQ
Total Score (NO 196.6 [75.4]; standard care 198.6 [73.9]; adjusted mean
difference [aMD] -2.19 [95% CI -11.78, 7.42]); and PedsQL Total Score (NO
74.2 [15.3]; standard care 74.9 [14.6]; aMD -0.77 [95% CI -2.70, 1.16]).
Prematurity, univentricular lesions, congenital syndromes, RACHS-6 surgery
and ICU length of stay were associated with lower total ASQ scores in
multivariate analyses. Conclusion(s): In infants with congenital
heart disease, the use of NO into the CPB oxygenator did not alter
neurodevelopment or HRQoL 12 months following surgery. Further
longitudinal research should be undertaken to determine if
neurodevelopmental outcomes become evident at school entry age.

<78>
[Use Link to view the full text]
Accession Number
646343264
Title
Safety and Efficacy of Magnetic-Anchoring Video-Assisted Thoracic Surgery
(VATS) Versus Conventional Vats Pulmonary Resection: A Randomized,
Open-Label, Non- Inferiority Clinical Trial.
Source
Journal of the American College of Surgeons. Conference: Owen H.
Wangensteen Scientific Forum at 2024 ACS Clinical Congress. San Francisco,
CA United States. 239(5 Supplement 1) (pp S485-S486), 2024. Date of
Publication: 01 Nov 2024.
Author
Zhang Y.; Li X.; Chen N.; Yu C.; Wang T.; Xu H.; Liang R.; Jin L.; Bai X.;
She X.
Institution
(Zhang, Li, Chen, Yu, Wang, Xu, Liang, Jin, Bai, She) Department of
Thoracic Surgery, First Affiliated Hospital of Xi'an Jiaotong University,
Xi'an, China
Publisher
Lippincott Williams and Wilkins
Abstract
Introduction: Video-assisted thoracic surgery (VATS) for pulmonary
resection is a widely performed procedure. Magnetic anchoring technology
uses magnetic force for organ traction and enhances intraoperative
exposure, potentially reducing incisions and easing the assisting
surgeon's workload. The current study evaluated the safety and efficacy of
the use of magnetic anchoring technology in the context of VATS pulmonary
resection. Method(s): This randomized, controlled, open clinical
trial included 40 participants assigned to either a magnetic anchoring
technology-assisted VATS group (group A, n = 20) or a conventional VATS
group (group B, n = 20). Patients underwent VATS pulmonary resection and
were discharged 3-5 days post-surgery, with a 1-month follow-up. The
primary endpoints included the intraoperative exposure effect, grade III
or greater intraoperative secondary injury incidence, and accidental
injuries to medical staff. Patients were categorized into intraoperative
exposure levels I-IV, corresponding to excellent, good, fair, and poor,
respectively. Result(s): In group A, 15 patients were categorized as
I, 4 as II, 1 as III, and 0 as IV. There were no significant differences
between groups A and B (p = 0.056). Group A exhibited significant
improvements in intraoperative blood loss (p = 0.006) and postoperative
drainage tube removal time (p = 0.022) compared to group B. There were no
statistically significant differences in the incidence rates of grade III
or greater intraoperative secondary injuries (p = 0.292) or accidental
injuries to medical staff (p = 1.000) between two groups.
 Conclusion(s): Magnetic anchoring technology-assisted VATS pulmonary
resection was more effective and safe than conventional VATS.

<79>
[Use Link to view the full text]
Accession Number
646344317
Title
SYSTEMATIC REVIEW AND META-ANALYSIS OF PREVALENCE AND POPULATION-LEVEL
FACTORS CONTRIBUTING TO POSTTRAUMATIC STRESS DISORDER IN PEDIATRIC
INTENSIVE CARE SURVIVORS.
Source
Pediatric Critical Care Medicine. Conference: 12th Congress of the World
Federation of Pediatric Intensive and Critical Care Societies, WFPICCS
2024. Cancun Mexico. 25(11 Supplement) (pp e75), 2024. Date of
Publication: 01 Nov 2024.
Author
Hay R.; O'Hearn K.; Zorko D.; Lee L.A.; Mooney S.; Mcquaid C.; Albrecht
L.; Henshall D.; Campes Dannenburg V.; Fiamenghi V.I.; Thibault C.; Lee
W.K.; Shi Min Ko M.; Cree M.; St Louis J.; Heneghan J.; Leung K.K.Y.; Wood
A.; Lopez-Baron E.; Temsah M.-H.; Almazyad M.; Retallack J.; Reddy M.;
Aldairi N.; Eduardo Lasso Palomino R.; Choong K.; Du Pont-Thibodeau G.;
Ducharme-Crevier L.; Mcnally D.; Garcia Guerra G.
Institution
(Hay, O'Hearn, Mcquaid, Albrecht, Mcnally) University of Ottawa, Pediatric
Critical Care, Ottawa, Canada
(Zorko) McMaster University, Pediatric Critical Care, Hamilton, Canada
(Lee, Garcia Guerra) University of Calgary, Pediatric Critical Care,
Calgary, Canada
(Mooney, Campes Dannenburg) University of Alberta, Pediatric Critical
Care, Edmonton, Canada
(Henshall) University of Edinburgh, Edinburgh, United Kingdom
(Fiamenghi, Retallack) University of British Columbia, Vancouver, Canada
(Thibault, Du Pont-Thibodeau, Ducharme-Crevier) CHU Sainte-Justine,
Montreal, Canada
(Lee, Shi Min Ko) Singapore Health Services (Singhealth), Singapore,
Singapore
(Cree) Queensland Children's Hospital, Pharmacy Department, Brisbane,
Australia
(St Louis) University of Toronto, Toronto, Canada
(Heneghan) University of Minnesota, Minnesota, United States
(Leung) Hong Kong Children's Hospital, Hong Kong, Hong Kong
(Wood) RHCYP NHS Lothian, Edinburgh, United Kingdom
(Lopez-Baron) Universidad de Antioquia, Pediatric Critical Care, Medellin,
Colombia
(Temsah, Almazyad) King Saud University, Riyadh, Saudi Arabia
(Reddy) All India Institute of Medical Sciences Bibinagar, Bibinagar,
India
(Aldairi) Dr. Sulaiman Al Habib Medical Group, Riyadh, Saudi Arabia
(Eduardo Lasso Palomino) ICESI University, Cali, Colombia
(Choong) McMaster University, Pediatrics and Critical Care, Hamilton,
Canada
Publisher
Lippincott Williams and Wilkins
Abstract
Aims = Objectives: Pediatric intensive care unit (PICU) admission is a
life-threatening event placing survivors at risk for posttraumatic stress
disorder (PTSD). This systematic review sought to describe the prevalence
of PTSD in PICU survivors and analyze potential risk-factors driving
variation in prevalence estimates. Method(s): MEDLINE, Embase,
CINAHL, and CENTRAL databases were searched from 2000 to August 2022, no
language restrictions. Stage one screening of abstract and full text
sought to identify studies evaluating PICU survivors postdischarge. Stage
two screening identified specific studies reporting on incidence or
prevalence of PTSD and/or risk factors. Given the large number of
citations, we utilized a validated hybrid model of machine learning and
crowdsourcing, recruiting a global community at the WFPICCS 2022 meeting.
Random effects metaanalysis calculated pooled PTSD prevalence and
evaluated subgroup differences. Result(s): From the original 15950
citations, 22 met criteria with a median cohort size 59 (IQR 49-76). PTSD
prevalence ranged from 3% to 37%, with 529 of the total 1898 survivors
reported as having PTSD (I2 = 72%). Study factors impacting PTSD
variability included months assessed post-PICU (p<0.01) and instrument
utilized (n=9, range 4-27%; p=0.03). Patient diagnosis mattered, with
lower PTSD (8%) in post-operative cardiac patients (p<0.01).
Interestingly, PICU length of stay did not impact PTSD, although
heterogeneity was high. Conclusion(s): 1 in 4 PICU survivors (29%)
developed PTSD six months post- PICU. We identified numerous population
and study design factors that influence prevalence and heterogeneity. This
review demonstrates the need for more standardization in post-PICU PTSD
clinical application and research. Trial registration: PROSPERO,
CRD42022348997.

<80>
Accession Number
2035561032
Title
Type B Aortic Dissection Management: A Narrative Review of Guidelines and
Systematic Reviews.
Source
Galen Medical Journal. 12 (no pagination), 2023. Article Number: e2967.
Date of Publication: 20 Jan 2023.
Author
Ghimire S.; Arghami A.; Shah A.M.; Billoo M.; Billoo R.; Zarenezhad M.;
Iqbal A.; Ahmadnezhad S.; Maleki F.; Kakhki B.R.; Sadrzadeh S.M.; Mehrpour
S.; Farzaneh R.; Yaqoob U.
Institution
(Ghimire) Carribean Medical University, Willemstad, Curacao
(Arghami) Cardiovascular Surgery Department, Mayo Clinic, Rochester, MN,
United States
(Shah, Billoo, Billoo, Iqbal) Jinnah Postgraduate Medical Centre, Karachi,
Pakistan
(Zarenezhad) Legal Medicine Research Center, Legal Medicine Organization,
Tehran, Iran, Islamic Republic of
(Ahmadnezhad) Mazandaran University of Medical Sciences, Ramsar Campus,
Ramsar, Iran, Islamic Republic of
(Maleki) Department of Emergency Medicine, Faculty of Medicine, Birjand
University of Medical Sciences, Birjand, Iran, Islamic Republic of
(Kakhki, Sadrzadeh, Farzaneh) Department of Emergency Medicine, Faculty of
Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Islamic
Republic of
(Mehrpour) Department of Anesthesiology and Critical Care, Qom University
of Medical Sciences, Iran, Islamic Republic of
(Yaqoob) Department of Neurosurgery, Civil Hospital, SMBBIT, Karachi,
Pakistan
Publisher
Salviapub
Abstract
Background: Surgical or medical treatment for type B or descending aortic
dissections with difficult presentation or stable hemodynamics is
debatable. This study aimed to review the type B aortic dissection therapy
to assess safety and effectiveness. Material(s) and Method(s): Online
databases of PubMed, Science Direct, Web of Science, Cochrane, and Scopus
were searched for relevant systematic reviews, guidelines, and
meta-analysis studies on the management of type B aortic dissection, up to
July 2023. The conclusions were qualitatively synthesized. Result(s):
Best medical therapy (BMT], thoracic aortic endovascular repair (TEVAR),
and open surgeries (OS) were management approaches. Hemodynamics classify
type B aortic dissection as complex or simple. Both examples reveal
decreased in-hospital all-cause mortality with TAVR than OS. Guidelines
recommend TEVAR for difficult situations and OS if it fails. Complication
analyses favour TEVAR, however left subclavian artery coverage without
revascularization increases stroke risk. Studies show Type B aortic
dissection is simpler than TEVAR and BMT. Acute or subacute presentation
did not affect reintervention rates between treatments. TEVAR had a
greater early stroke risk than BMT but a decreased long-term
aortic-related and all-cause mortality. The best data showed no
differences in in-hospital mortality or early re-intervention between
regimens. BMT reduced early stroke but increased late all-cause death.
 Conclusion(s): In conclusion, addressing Type B aortic dissection is
complicated, depending on presentation and hemodynamics. TEVAR is best for
difficult patients, however BMT and OS also work. TEVAR may reduce
in-hospital mortality but increase early stroke risk. Copyright ©
2023, Galen Medical Journal.

<81>
Accession Number
646339709
Title
Outcome and complications in postcardiotomy cardiogenic shock treated with
extracorporeal life support - a systematic review and meta-analysis.
Source
BMC anesthesiology. 25(1) (pp 29), 2025. Date of Publication: 17 Jan 2025.
Author
Kienlein R.M.; Trauzeddel R.F.; Akbari N.; Avalli L.; Biancari F.; Dini
C.S.; Guenther S.; Hagl C.; Heringlake M.; Kruppa J.; Makikallio T.;
Martins R.; de Chambrun M.P.; Rastan A.J.; Rubino A.; van den Brink F.;
Nordine M.; Treskatsch S.
Institution
(Kienlein, Trauzeddel, Treskatsch) Charite - Universitatsmedizin Berlin,
corporate member of Freie Universitat Berlin and Humboldt-Universitat zu
Berlin, Department of Anesthesiology and Intensive Care Medicine, Campus
Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany
(Akbari) Charite - Universitatsmedizin Berlin, corporate member of Freie
Universitat Berlin and Humboldt-Universitat zu Berlin, Institute of
Biometry and Clinical Epidemiology, Chariteplatz 1, Berlin, Germany
(Avalli) Department of Cardiovascular Surgery, Centro Cardiologico
Monzino, Milan, Italy
(Biancari) Department of Cardiovascular Surgery, Centro Cardiologico
Monzino IRCCS, Milan, Italy
(Dini) Intensive Cardiac Care Unit, Azienda Ospedaliero-Universitaria
Careggi, Florence, Italy
(Dini) Intensive Cardiac Care Unit, Azienda Ospedaliera-Universitaria
Senese, Siena, Italy
(Guenther, Hagl) Department of Cardiac Surgery, University Hospital
Munich, Ludwig-Maximilian-University, Munich, Germany
(Guenther, Hagl) DZHK (German Centre for Cardiovascular Research), Partner
Site Munich Heart Alliance, Munich, Germany
(Heringlake) Department of Anesthesiology and Intensive Care Medicine,
Karlsburg Hospital, Heart- and Diabetes Center Mecklenburg - Western
Pomerania, Karlsburg, Germany
(Kruppa) University of Applied Sciences, Hochschule Osnabruck, Germany
(Makikallio) Department of Medicine, South Karelia Central Hospital,
University of Helsinki, Lappeenranta, Finland
(Martins) Service de Cardiologie Et Maladies Vasculaires, Rennes, France
(de Chambrun) Sorbonne Universite, Assistance Publique-Hopitaux de Paris
(AP-HP), Hopital La Pitie-Salpetriere, Service de Medecine Intensive
Reanimation, Paris, France
(de Chambrun) Sorbonne Universite, Inserm, Institut de Cardiometabolisme
Et Nutrition (ICAN), Paris, France
(Rastan) Department of Cardiac and Thoracic Vascular Surgery, Marburg
University Hospital, Marburg, Germany
(Rubino) Department of Anaesthesia and Intensive Care, Royal Papworth
Hospital, Cambridge, United Kingdom
(van den Brink) Department of Intensive Care, Leids Universitair Medisch
Centrum, Albinusdreef 2, Leiden, Netherlands
(Nordine) Department of Anesthesiology, Intensive Care Medicine, Pain
Therapy, University Hospital Frankfurt, Goethe University, Frankfurt,
Germany
Abstract
BACKGROUND: Postcardiotomy cardiogenic shock (PCCS) in cardiac surgery is
associated with a high rate of morbidity and mortality. Beside other
therapeutic measures (e.g. intraaortic balloon pump (IABP)),
extracorporeal life support is being increasingly used in this particular
form of shock. Objectives of this meta-analysis were to determine
mortality and complications of extracorporeal life support treatment
(ECLS) in cardiac surgery patients, and if outcomes were influenced by a
preexisting cardiovascular risk profile. METHOD(S): MEDLINE and
EMBASE were searched for studies in English, published between January 1st
2000 and January 16th 2023, reporting mortality and morbidity in patients
aged >= 18 treated with ECLS for PCCS. Supplementary data were requested
from the respective corresponding authors. Outcomes were weaning from
extracorporeal life support, hospital survival and complications.
 RESULT(S): Two thousand, seven hundred seventy-four papers were
screened, of which 132 full text articles were assessed for suitability.
70 remaining studies were included for further evaluation and data
analysis. Five studies could be included in the final analysis since the
corresponding authors provided additional necessary information.
Successful weaning from extracorporeal life support was accomplished in
52.8% (30.8%-57.4%) and 31.1% were discharged alive (mortality of 25.0 -
56.2% after weaning). 95.1% of all treated patients suffered from at least
one complication. Diabetes mellitus and obesity seem to be independent
risk factors for poor outcome. CONCLUSION(S): Extracorporeal life
support for PCCS is associated with a substantial mortality and
complication rate. Diabetes mellitus and obesity seem to be independent
risk factors. Therefore, until future work has elucidated which patients
benefit at all, the risks of ECLS-treatment must be critically weighed up
against a possible benefit. Copyright © 2025. The Author(s).

<82>
Accession Number
2037180228
Title
Comparative Evaluation of Regain of Consciousness in
Dexmedetomidine-Propofol versus Ketamine-Propofol in the Pediatric Cardiac
Catheterization Procedure under Sedation using BIS Monitoring: A
Randomized Prospective Study.
Source
Annals of Cardiac Anaesthesia. 28(1) (pp 33-38), 2025. Date of
Publication: 2025.
Author
Banga P.; Negi S.L.; Mandal B.; Barwad P.; Saini K.; Gourav K.P.
Institution
(Banga, Negi, Mandal, Saini, Gourav) Department of Anaesthesia and
Intensive Care, Postgraduate Institute of Medical Education and Research,
Chandigarh, India
(Barwad) Department of Cardiology, Postgraduate Institute of Medical
Education and Research, Chandigarh, India
Publisher
Wolters Kluwer Medknow Publications
Abstract
Background: Congenital heart diseases (CHDs) are not rare and often
require an intervention at some point of time. Pediatric cardiac
catheterization, a minimally invasive procedure, is performed to diagnose
and to correct many cardiac abnormalities. Deep sedation with
spontaneously breathing patients is the preferred technique for pediatric
catheterization in the pediatric population. Therefore, the author aimed
to find the best combination of drugs for pediatric cardiac
catheterization procedures using dexmedetomidine-propofol (DP) and
ketamine-propofol (KP). Material(s) and Method(s): Cyanotic and
acyanotic CHD children, weighing 5-20 kg and undergoing sedation for
cardiac catheterization, were randomly assigned into two groups. DP group
children received a bolus intravenous (IV) propofol at 1 mg/kg body weight
followed by 1 mcg/kg dexmedetomidine over 10 minutes. KP group children
received a bolus IV propofol 1 mg/kg followed by ketamine 1 mg/kg over 10
minutes. For maintenance in the DP group, propofol infusion at 1.5 to 2
mg/kg/h and dexmedetomidine at 0.5 mcg/kg/h was started. In the KP group,
propofol infusion at 1.5 to 2 mg/kg/h and ketamine at 1 mg/kg/h was
started as maintenance. The bispectral index (BIS) was monitored
throughout the procedure, and the BIS value was maintained between 60 and
80. Propofol top of 1 mg/kg was administered when the BIS value became
more than 80 or when the child moved during the femoral vessel puncture or
when the child moved during the procedure. Result(s): The mean time
for regain of consciousness was faster (P < 0.005) in the KP group (11.02
+/- 11.98) compared to the DP group (21.62 +/- 18.68). BIS was monitored
throughout the procedure; BIS values were lower (P < 0.001) in the DP
group (60.0 +/- 11.1) as compared to the KP group (73.7 +/- 5.6). The
cumulative doses of propofol in the KP group and DP group were comparable.
Total fentanyl consumptions in the intraoperative period in the KP group
and DP group were comparable (P > 0.001). There was no difference in drug
side effects between the groups. Conclusion(s): The KP combination
had fast and early recovery compared to the DP combination in children who
underwent the cardiac catheterization procedure under sedation in children
undergoing cardiac catheterization procedures requiring
sedation. Copyright © 2025 Annals of Cardiac Anaesthesia.

<83>
Accession Number
646338878
Title
Effects of a home-based multicomponent exercise programme on frailty in
postcardiac surgery patients: A randomized controlled trial.
Source
European journal of cardiovascular nursing. (no pagination), 2025. Date
of Publication: 18 Jan 2025.
Author
Huang W.-T.; Liu C.-Y.; Shih C.-C.; Chen Y.-S.; Chou C.-L.; Lee J.-T.;
Chiou A.-F.
Institution
(Huang) Assistant Professor, Department of Post-Baccalaureate in Nursing,
Da-Yeh University, Changhua, Taiwan; Department of Nursing, Da-Yeh
University, Changhua, Taiwan
(Liu) Biostatistical Consultant Laboratory, Department of Health Care
Management, National Taipei University of Nursing and Health Sciences,
Taipei, Taiwan (Republic of China)
(Shih) Professor, Taipei Heart Institute, Taipei Medical University;
Division of Cardiovascular Surgery, Department of Surgery, Wan Fang
Hospital, Taipei Medical University; Department of Surgery, School of
Medicine, College of Medicine, Taipei Medical University; Cardiovascular
Research Center, Taipei Medical University Hospital; and Cardiovascular
Research Center, Wan Fang Hospital, Managed by Taipei Medical University,
Taipei, Taiwan
(Chen) Department of Surgery, National Taiwan University Hospital, College
of Medicine, National Taiwan University, Taipei, Taiwan (Republic of
China)
(Chou) Department of Physical Medicine and Rehabilitation, Taipei Veterans
General Hospital, School of Medicine, National Yang Ming Chiao Tung
University, Taipei, Taiwan (Republic of China)
(Lee) Physical therapist, Department of Physical Medicine and
Rehabilitation, Taipei Veterans General Hospital, Taipei, Taiwan (Republic
of China)
(Chiou) College of Nursing, National Yang Ming Chiao Tung University,
Taipei, Taiwan (Republic of China)
Abstract
AIMS: A randomized controlled trial was conducted to examine the effects
of a home-based multicomponent exercise programme on frailty in patients
who underwent cardiac surgery. METHODS AND RESULTS: A convenience sample
of 92 patients who underwent cardiac surgery at two medical centres in
Taiwan were recruited and randomly allocated to the intervention (n = 46)
and control (n = 46) groups. The intervention group underwent a 12-week
home-based multicomponent exercise programme, including individual nursing
consultation, home-based exercise intervention, nutritional assessment and
guidance, and continuous support. The control group did not receive any
interventions. Frailty was assessed with the Fried Frailty Phenotype at
baseline, 6 weeks, and 12 weeks. The prevalence rates of prefrailty and
frailty at baseline were 67% and 33%, respectively, and no statistically
significant differences in frailty status were noted between the two
groups at baseline. However, patients in the intervention group
demonstrated significantly greater improvements in their frailty scores,
handgrip strength, and physical activity than the control group at 6 weeks
and 12 weeks postintervention, with no adverse events reported.
 CONCLUSION(S): A home-based multicomponent exercise programme is safe
and effective in improving frailty outcomes among postcardiac surgery
patients and is suitable for application in clinical practice. Future
studies with larger sample sizes and long-term follow-up are needed to
verify the long-term effects of this home-based multicomponent exercise
programme. REGISTRATION: Clinicaltrial.gov: NCT04332887. Copyright
© The Author(s) 2025. Published by Oxford University Press on behalf
of the European Society of Cardiology. All rights reserved. For commercial
re-use, please contact reprints@oup.com for reprints and translation
rights for reprints. All other permissions can be obtained through our
RightsLink service via the Permissions link on the article page on our
site-for further information please contact

<84>
[Use Link to view the full text]
Accession Number
646341262
Title
RBT-1 Reduces the Number of Postoperative Complications Associated with
Cardiac Surgery.
Source
Journal of the American College of Surgeons. Conference: Owen H.
Wangensteen Scientific Forum at 2024 ACS Clinical Congress. San Francisco,
CA United States. 239(5 Supplement 1) (pp S18-S19), 2024. Date of
Publication: 01 Nov 2024.
Author
Jessen M.E.; Khanna A.K.; Shaw A.; Van Wagenberg F.; Singh B.; Rodriguez
J.; Wang C.; Ramdas A.; Ruiz S.
Institution
(Jessen, Khanna, Shaw, Van Wagenberg, Singh, Rodriguez, Wang, Ramdas,
Ruiz) University of Texas Southwestern Medical Center, Dallas, TX; Wake
Forest University School of Medicine, Winston Salem, NC; Cleveland Clinic,
Cleveland, OH; Huntsville Heart Center, Huntsville, AL; Renibus
Therapeutics, Southlake, TX; Pharma Data Associates, Piscataway, NJ
Publisher
Lippincott Williams and Wilkins
Abstract
Introduction: Postoperative complication in cardiac surgery is common and
results in poor outcomes, especially as the number of complications
increases. RBT-1, a novel anti-inflammatory and antioxidant
preconditioning drug, is being developed to improve outcomes in patients
undergoing cardiac surgery. We hypothesized that RBT-1 would reduce the
aggregate number of postoperative complications, potentially contributing
to better outcomes in this patient population. Method(s): In this
Phase 2, randomized, double-blind, placebocontrolled study, 121 patients
scheduled to undergo cardiac surgery on cardiopulmonary bypass received
RBT-1 or placebo 24-48 hours before operation. Incidence of death, acute
kidney injury requiring dialysis, prolonged ICU time (>3 days), prolonged
ventilator time (>24 hours), 30-day cardiopulmonary readmission, new-onset
atrial fibrillation, and blood transfusion were evaluated. Result(s):
The number of postoperative complications was significantly reduced in
response to RBT-1 compared with placebo, with a mean of 1.76 and 1.05
complications in the placebo and RBT-1 treatment groups, respectively (p =
0.0011). Each postoperative complication was lower in the RBT-1 group vs
placebo group. More patients in the RBT-1 group (31%) were free of
postoperative complication compared with the placebo group (15%).
Accordingly, multiple complications (>=2) occurred in only 23% of patients
in the RBT-1 group vs 54% in the placebo group. The number of
complications per patient, as well as the distribution of complications
across treatment groups, are shown in Table 1. Conclusion(s): RBT-1
significantly reduces the number of postoperative complications in
patients undergoing cardiac surgery. A confirmatory Phase 3 study has
commenced. RBT-1 has received Breakthrough Therapy designation by the FDA.
(Table Presented).

<85>
[Use Link to view the full text]
Accession Number
646341274
Title
Effects of Postoperative Music Therapy on Patient Outcomes: A Systematic
Review and Meta-Analysis.
Source
Journal of the American College of Surgeons. Conference: Owen H.
Wangensteen Scientific Forum at 2024 ACS Clinical Congress. San Francisco,
CA United States. 239(5 Supplement 1) (pp S154-S155), 2024. Date of
Publication: 01 Nov 2024.
Author
Raees S.; Chang H.; Ku K.; Tehrani N.S.; Howard J.C.; Akhtar M.; Frezza
E.E.
Institution
(Raees, Chang, Ku, Tehrani, Howard, Akhtar, Frezza) California Northstate
University, College of Medicine, Elk Grove, CA, United States
Publisher
Lippincott Williams and Wilkins
Abstract
Introduction: This review endeavors to systematically review the effect of
postoperative music therapy on patient outcomes after different types of
operation. Method(s): We conducted a systematic review of 3 databases
according to guidelines established by PRISMA using the terms music,
noise, postoperative, surgery, outcome, and recovery. Collected data
included study characteristics, patient outcomes (pain, anxiety,
physiologic markers, etc), measurement methods, type of operation, and
statistical data. Result(s): Our search yielded 3736 studies, of
which 35 met the inclusion criteria for data analysis. The included
studies largely consisted of therapeutic evidence levels I. A total of 19
of 27 studies reporting pain showed a significant reduction, 4 of 7 showed
a reduction in anxiety scores, 6 of 10 showed a reduction in heart rate,
and 2 of 5 showed a reduction in opioid use. An exploratory software for
confidence intervals (ESCI) random effects model analysis showed a mean
reduction of 0.775 (p < 0.0001) for Visual Analogue Scale pain scores,
1.896 (p < 0.0001) for Numerical Rating Scale pain scores, 2.508 (p =
0.0436) for State-Trait Anxiety Inventory scores, 4.565 (p < 0.0001) for
heart rate, and 0.961 (p = 0.0409) for opioid use. For this analysis,
operation types (orthopaedic, cardiac, ENT, etc) were grouped and reported
values were standardized to the first day postoperation whenever
applicable. Conclusion(s): Postoperative music therapy appears to
significantly improve postoperative patient outcomes, including subjective
markers (pain and anxiety) and physiologic markers (heart rate and opioid
consumption), after a variety of operation types.

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