EMBASE Cardiac Update AutoAlert: EPICORE Cardiac Surgery Blogger2

Total documents retrieved: 42

Results Generated From:
Embase <1980 to 2014 Week 46>
Embase (updates since 2014-11-07)

<1>
Accession Number
2014737798
Authors
Lavi S. Bainbridge D. D'Alfonso S. Diamantouros P. Syed J. Jablonsky G.
Lavi R.
Institution
(Lavi, Bainbridge, Diamantouros, Syed, Jablonsky, Lavi) Division of
Cardiology, University of Western Ontario, 339 Windermere Road, London, ON
N6A 5A5, Canada
(Lavi, Bainbridge, D'Alfonso, Diamantouros, Syed, Jablonsky, Lavi) London
Health Sciences Centre, London, ON, Canada
Title
Sevoflurane in acute myocardial infarction: A pilot randomized study.
Source
American Heart Journal. 168 (5) (pp 776-783), 2014. Date of Publication:
01 Nov 2014.
Publisher
Mosby Inc.
Abstract
Background: Experimental evidence suggests that the inhalational
anesthetic sevoflurane has a cardioprotective effect. Our objective was to
determine if sedation with sevoflurane will reduce infarct size in
patients with acute myocardial infarction (MI) who are treated with
primary percutaneous coronary intervention (PCI).

<2>
Accession Number
23564447
Authors
Liu C. Xiu C.H. Xiao X.G. Ni L.X. Liu Z.H. Wang B.C. Shen J.X. Zhu K.
Zhang G.W. Xu L. Liu H.Y.
Institution
(Liu) Department of Cardiovascular Surgery, The First Affiliated Hospital
of Harbin Medical University, Harbin, Heilongjiang, 150001, The People's
Republic of China.
Title
Effect of graft patency on the prediction of myocardial viability by
dobutamine stress and myocardial contrast echocardiography before coronary
artery bypass surgery.
Source
Journal of clinical ultrasound : JCU. 42 (1) (pp 9-15), 2014. Date of
Publication: Jan 2014.
Abstract
Myocardial functional recovery after revascularization is considered the
"gold standard" for myocardial viability (MV) assessment. However, the
patency of the revascularized coronary artery affects myocardial
functional recovery in patients subjected to coronary artery bypass
grafting (CABG). The influence of graft patency on viability results has
not been widely studied. We evaluated the effect of graft patency on the
prediction of MV after CABG by myocardial contrast echocardiography (MCE)
and low-dose dobutamine stress echocardiography (LD-DSE). Fifty-three
subjects with chronic ischemic heart disease scheduled for CABG were
divided randomly into groups A (n = 26) and B (n = 27). They underwent MCE
and LD-DSE preoperatively. Patients were followed up 12 months after CABG.
Group B patients underwent multislice computed tomography angiography to
assess CABG patency, and patients with obstructed grafts were excluded.
Group A patients were not subjected to multislice CT angiography. The
accuracy of MCE and LD-DSE for assessing MV between the two groups was
compared. The accuracy and positive predictive values of MCE and LD-DSE
for predicting MV were higher in group B than in group A (p < 0.05).
Preoperative LD-DSE and MCE ability to predict MV depends on the patency
of CABG. Copyright 2013 Wiley Periodicals, Inc.

<3>
Accession Number
2014826327
Authors
Conrotto F. D'ascenzo F. Francesca G. Colaci C. Sacciatella P.
Biondi-Zoccai G. Moretti C. D'amico M. Gaita F. Marra S.
Institution
(Conrotto, D'ascenzo, Francesca, Colaci, Sacciatella, Moretti, D'amico,
Gaita, Marra) Department of Cardiology, Citta della Salute e della Scienza
Hospital, Turin, Italy
(Biondi-Zoccai) Department of Medico-Surgical Sciences and
Biotechnologies, Sapienza University of Rome, Latina, Italy
Title
Impact of access on TAVI procedural and midterm follow-up: A meta-analysis
of 13 studies and 10,468 patients.
Source
Journal of Interventional Cardiology. 27 (5) (pp 500-508), 2014. Date of
Publication: 01 Oct 2014.
Publisher
Blackwell Publishing Inc.
Abstract
Conclusions The TF approach reduces mortality in TAVI patients, due to
lower rates of periprocedural bleedings and strokes. (J Interven Cardiol
2014;27:500-508)

<4>
Accession Number
2014871581
Authors
Hsu H.-T. Chou S.-H. Chou C.-Y. Tseng K.-Y. Kuo Y.-W. Chen M.-C. Cheng
K.-I.
Institution
(Hsu, Chou, Tseng, Kuo, Chen, Cheng) Department of Anesthesiology,
Kaohsiung Medical University Hospital, No.100 Ziyou 1st Rd., Sanmin
District, Kaohsiung, Taiwan 807, China
(Hsu, Tseng) Graduate Institute of Medicine, College of Medicine,
Kaohsiung Medical University, Kaohsiung, Taiwan 807, China
(Cheng) Faculty of Anesthesiology, College of Medicine, Kaohsiung Medical
University, Kaohsiung, Taiwan 807, China
(Chou) Department of Chest Surgery, Kaohsiung Medical University Hospital,
Kaohsiung, Taiwan 807, China
(Chou) School of Medicine, College of Medicine, Kaohsiung Medical
University, Kaohsiung, Taiwan 807, China
Title
A modified technique to improve the outcome of intubation with a
left-sided double-lumen endobronchial tube.
Source
BMC Anesthesiology. 14 (1) , 2014. Article Number: 72. Date of
Publication: August 18, 2014.
Publisher
BioMed Central Ltd.
Abstract
Background: The use of a video-assisted laryngoscope (VL) has been shown
to reduce the time to achieve intubation with a double-lumen endobronchial
tube (DLT). As the blade of the VL is curved differently to a standard
laryngoscope, the DLT must be angled into a hockey stick shape to fit
properly. We conducted a study to establish which direction of angulation
was best to facilitate correct positioning of the DLT when using a
VL.Methods: We enrolled patients scheduled for thoracic surgery who
required intubation with a DLT. They were prospectively randomized into
one of two groups: those intubated with a DLT angled to conceal the
tracheal orifice (the tracheal orifice-covered, TOC) group or the tracheal
orifice-exposed (TOE) group. The composite primary outcome measures were
time taken to intubate and the frequency of first-time success. The time
taken to intubate was divided into: T1, the time from mouth opening to
visualization of the vocal cords with the VL; and T2, the time taken to
advance the DLT through the cords until its tip lay within the trachea and
three carbon dioxide waveforms had been detected by capnography. The
hemodynamic responses to intubation and intubation-related adverse events
were also recorded.Results: Sixty-six patients completed the study, with
33 in each group. Total intubation time was significantly shorter in the
TOC group (mean 30.6 + standard deviation 2.7 seconds versus 38.7 + 3.3
seconds, p <0.0001). T2 was also significantly shorter in the TOC group
than the TOE group (27.2 + 2.5 seconds versus 34.9 + 3.0 seconds, p
<0.0001). The severity of hoarseness on the first postoperative day and
sore throat on the fourth postoperative day were significantly lower in
the TOC group than the TOE group (p = 0.02 and <0.0001, respectively). The
hemodynamic responses to intubation were broadly similar between the
groups.Conclusion: When placing a left-sided DLT using a VL, angling the
bronchial lumen to a hockey stick shape that conceals the tracheal lumen
saves time and ameliorates the severity of post-intubation
complications.Trial registration: ClinicalTrials.gov Identifier:
NCT01605591.

<5>
Accession Number
2014875233
Authors
Mayosi B.M. Ntsekhe M. Bosch J. Pandie S. Jung H. Gumedze F. Pogue J.
Thabane L. Smieja M. Francis V. Joldersma L. Thomas K.M. Thomas B. Awotedu
A.A. Magula N.P. Naidoo D.P. Damasceno A. Banda A.C. Brown B. Manga P.
Kirenga B. Mondo C. Mntla P. Tsitsi J.M. Peters F. Essop M.R. Russell
J.B.W. Hakim J. Matenga J. Barasa A.F. Sani M.U. Olunuga T. Ogah O. Ansa
V. Aje A. Danbauchi S. Ojji D. Yusuf S.
Institution
(Mayosi, Ntsekhe, Pandie, Francis) Department of Medicine, University of
Cape Town, Groote Schuur Hospital, J Fl., Groote Schuur Dr., Observatory,
Cape Town 7925, South Africa
(Gumedze) Department of Statistical Sciences, University of Cape Town,
Cape Town, South Africa
(Thomas, Thomas, Awotedu) Department of Internal Medicine, Nelson Mandela
Academic Hospital, Walter Sisulu University, Mthatha, South Africa
(Magula) Division of Medicine, King Edward VIII Hospital, University of
KwaZulu Natal, Durban, South Africa
(Naidoo) Department of Cardiology, Inkosi Albert Luthuli Central Hospital,
University of KwaZulu Natal, Durham, South Africa
(Brown) Department of Cardiology, Provincial and Livingstone Hospitals,
Walter Sisulu University, Port Elizabeth, South Africa
(Manga) Division of Cardiology, Charlotte Maxeke Johannesburg Academic
Hospital, University of the Witwatersrand, Johannesburg, South Africa
(Mntla) Division of Cardiology, Dr. George Mukhari Hospital, University of
Limpopo, Pretoria, South Africa
(Tsitsi, Peters, Essop) Division of Cardiology, Chris Hani Baragwanath
Hospital, University of Witwatersrand, Soweto, South Africa
(Bosch, Jung, Pogue, Thabane, Smieja, Joldersma, Yusuf) McMaster
University and the Population Health Research Institute, Hamilton Health
Sciences, Hamilton, ON, Canada
(Damasceno) Hospital Central de Maputo, Maputo, Mozambique
(Banda) Malawi Military Health Services, Lilongwe, Malawi
(Kirenga, Mondo) New Mulago Hospital, Kampala, Uganda
(Russell) Connaught Hospital, Freetown, Sierra Leone
(Hakim, Matenga) Parirenyatwa Hospital, Harare, Zimbabwe
(Barasa) Moi Hospital, Eldoret, Kenya
(Sani) Aminu Kano Teaching Hospital, Kano, Nigeria
(Olunuga, Ogah) Federal Medical Center, Abeokuta, Ogun State, Nigeria
(Ansa) University of Calabar Teaching Hospital, Calabar, Nigeria
(Aje) University College Hospital, Ibadan, Oyo State, Nigeria
(Danbauchi) Ahmadu Bello Teaching Hospital, Zaria, Kaduna State, Nigeria
(Ojji) Abuja Teaching Hospital, Abuja, Nigeria
Title
Prednisolone and Mycobacterium indicus pranii in tuberculous pericarditis.
Source
New England Journal of Medicine. 371 (12) (pp 1121-1130), 2014. Date of
Publication: 18 Sep 2014.
Publisher
Massachussetts Medical Society
Abstract
Conclusions In patients with tuberculous pericarditis, neither
prednisolone nor M. indicus pranii had a significant effect on the
composite of death, cardiac tamponade requiring pericardiocentesis, or
constrictive pericarditis.

<6>
Accession Number
2014867399
Authors
Spaziano M. Francese D.P. Leon M.B. Genereux P.
Institution
(Spaziano, Genereux) Hopital du Sacre-Coeur de Montreal, Universite de
Montreal, 5400 Boulevard Gouin Ouest, Montreal, QC H4J 1C5, Canada
(Francese, Leon, Genereux) Cardiovascular Research Foundation, New York,
NY, United States
(Leon, Genereux) Columbia University Medical Center, New York-Presbyterian
Hospital, New York, NY, United States
Title
Imaging and functional testing to assess clinical and subclinical
neurological events after transcatheter or surgical aortic valve
replacement: A comprehensive review.
Source
Journal of the American College of Cardiology. 64 (18) (pp 1950-1963),
2014. Date of Publication: 04 Nov 2014.
Publisher
Elsevier USA
Abstract
Neurological events after transcatheter (TAVR) or surgical aortic valve
replacement (SAVR) are potentially devastating and associated with a poor
prognosis. With technological improvements and increased operator
experience, their incidence is markedly declining, justifying the need for
surrogate endpoints to be used in future comparative trials. Moreover,
imaging studies after TAVR and SAVR suggest that neurological events are
mainly embolic in nature; however, there is significant discrepancy
between imaging findings and clinically overt symptoms, raising the
possibility of more subtle subclinical cognitive decline. Different
modalities have been used to assess both overt and subclinical
neurological events after SAVR and TAVR. The purpose of this report is to
systematically review and describe currently used imaging, functional, and
neurocognitive testing modalities and to better understand how they could
be integrated in future prospective studies.

<7>
Accession Number
2014864332
Authors
Beohar N. Zajarias A. Thourani V.H. Herrmann H.C. Mack M. Kapadia S. Green
P. Arnold S.V. Cohen D.J. Genereux P. Xu K. Leon M.B. Kirtane A.J.
Institution
(Beohar) Columbia University, Division of Cardiology, Mount Sinai Medical
Center, Miami Beach, FL, United States
(Zajarias) Washington University School of Medicine, St. Louis, MO, United
States
(Thourani) Emory University, Atlanta, GA, United States
(Herrmann) Hospital of the University of Pennsylvania, Philadelphia, PA,
United States
(Mack) Baylor Healthcare System, Dallas, TX, United States
(Kapadia) Cleveland Clinic Foundation, Cleveland, OH, United States
(Green, Genereux, Leon, Kirtane) Columbia University Medical Center/New
York Presbyterian Hospital, New York, NY, United States
(Arnold, Cohen) Saint Luke's Mid-America Heart Institute, Kansas City, MO,
United States
(Genereux, Xu, Leon, Kirtane) Cardiovascular Research Foundation, New
York, NY, United States
Title
Analysis of early out-of hospital mortality after transcatheter aortic
valve implantation among patients with aortic stenosis successfully
discharged from the hospital and alive at 30 days (from the Placement of
Aortic Transcatheter Valves Trial).
Source
American Journal of Cardiology. 114 (10) (pp 1550-1555), 2014. Date of
Publication: 15 Nov 2014.
Publisher
Elsevier Inc.
Abstract
In high-risk or inoperable patients with severe symptomatic aortic
stenosis, transcatheter aortic valve implantation (TAVI) is a proven
alternative to standard (i.e., medical) therapy or surgical aortic valve
replacement. Concerns have been raised, however, about patients who
survive the procedure but have short subsequent survival. The aim of this
study was therefore to identify correlates of early out-of-hospital
mortality (EOHM) in patients who underwent successful TAVI, rendering TAVI
potentially "futile." Patients who were discharged from the hospital and
survived >30 days but <12 months after TAVI were identified (the EOHM
group). Independent predictors of EOHM were explored, including
patient-level factors and procedural nonfatal major complications (NFMCs).
A sensitivity analysis was also performed, excluding patients with NFMCs.
Among 485 patients who were discharged from the hospital and survived 30
days after TAVI, 101 (21%) were dead within 1 year. Independent predictors
of EOHM included serum creatinine, liver disease, coagulopathy, mental
status, body mass index, male gender, and Society of Thoracic Surgeons
score. Although NFMCs were strongly associated with EOHM, patient-level
risk factors for EOHM were similar between patients who did and those who
did not experience NFMCs. Compared with standard therapy, TAVI patients
with EOHM had similar 6-month 6-minute walk distances and functional
classes, with higher rates of repeat hospitalization. In conclusion, in
high-risk or inoperable patients who underwent TAVI and were discharged
and alive at 30 days, EOHM was not infrequent and was determined largely
by presenting characteristics and the occurrence of periprocedural NFMCs.
Careful screening and minimization of NFMCs may maximize the benefit of
TAVI.

<8>
Accession Number
2014863762
Authors
Bagai A. Tan M. Di Mario C. Halvorsen S. Cantor W.J. Le May M.R.
Fernandez-Aviles F. Scheller B. Armstrong P.W. Borgia F. Piscione F.
Sanchez P.L. Westerhout C.M. Goodman S.G. Yan A.T.
Institution
(Bagai, Goodman, Yan) Terrance Donnelly Heart Centre, St Michael's
Hospital, Toronto, ON M5B1W8, Canada
(Bagai, Cantor, Goodman, Yan) University of Toronto, Toronto, ON, Canada
(Tan, Goodman) Canadian Heart Research Centre, Toronto, ON, Canada
(Di Mario) Royal Brompton Hospital and Imperial College, London, United
Kingdom
(Halvorsen) Oslo University Hospital Ulleval, Oslo, Norway
(Cantor) Southlake Regional Health Centre, Newmarket, ON, Canada
(Le May) University of Ottawa Heart Institute, Ottawa, ON, Canada
(Fernandez-Aviles, Sanchez) Hospital General Universitario Gregorio
Maranon, Madrid, Spain
(Scheller) Innere Medizin III, Universitat des Saarlandes, Homburg,
Germany
(Armstrong, Westerhout) Canadian VIGOUR Centre, University of Alberta,
Edmonton, AB, Canada
(Borgia) Federico II University, Italy
(Piscione) University Hospital San Giovanni di Dio e Ruggi d'Aragona,
Salerno, Italy
Title
Routine invasive management early after fibrinolysis: Relationship between
baseline risk and treatment effects in a pooled patient-level analysis of
7 randomized controlled trials.
Source
American Heart Journal. 168 (5) (pp 757-765.e3), 2014. Date of
Publication: 01 Nov 2014.
Publisher
Mosby Inc.
Abstract
Conclusions: Although clearly beneficial among the larger subgroup of
patients at low/intermediate risk, the benefit of a routine early invasive
strategy was not evident in the smaller subgroup of higher-risk patients
in the context of an increased requirement for urgent PCI in the
comparative standard treatment arm.

<9>
Accession Number
2014709937
Authors
Myles P.S. Leslie K. Chan M.T.V. Forbes A. Peyton P.J. Paech M.J. Beattie
W.S. Sessler D.I. Devereaux P.J. Silbert B. Schricker T. Wallace S.
Institution
(Myles, Wallace) Department of Anaesthesia and Perioperative Medicine,
Alfred Hospital, Melbourne, VIC 3004, Australia
(Myles, Leslie, Forbes) Monash University, Melbourne, VIC, Australia
(Leslie) Royal Melbourne Hospital, Parkville, Melbourne, VIC, Australia
(Chan) Chinese University of Hong Kong, Hong Kong Special Administrative
Region, Hong Kong, Hong Kong
(Peyton) Austin Hospital, Heidelberg, Melbourne, VIC, Australia
(Paech) University of Western Australia, Perth, WA, Australia
(Beattie) Toronto General Hospital, Toronto, ON, Canada
(Sessler) Cleveland Clinic, Cleveland, OH, United States
(Devereaux) Hamilton Health Sciences, Hamilton, ON, Canada
(Silbert) St Vincent's Hospital, Fitzroy, Melbourne, VIC, Australia
(Schricker) Royal Victoria Hospital, Montreal, QC, Canada
Title
The safety of addition of nitrous oxide to general anaesthesia in at-risk
patients having major non-cardiac surgery (ENIGMA-II): A randomised,
single-blind trial.
Source
The Lancet. 384 (9952) (pp 1446-1454), 2014. Date of Publication: 18 Oct
2014.
Publisher
Lancet Publishing Group
Abstract
Funding Australian National Health and Medical Research Council;
Australian and New Zealand College of Anaesthetists; Heart and Stroke
Foundation of Quebec, Heart and Stroke Foundation of Ontario, Canada;
General Research Fund of the Research Grant Council, Hong Kong Special
Administrative Region, China.

<10>
Accession Number
2014861914
Authors
Kim H.-J. Kim W.H. Kim G. Kim E. Park M.-H. Shin B.S. Sim W.S. Kim C.S.
Lee Y.T. Cho H.S.
Institution
(Kim, Kim) Department of Anesthesiology and Pain Medicine, Samsung
Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon,
South Korea
(Kim, Kim, Kim, Park, Shin, Sim, Kim, Cho) Department of Anesthesiology
and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School
of Medicine, Seoul, South Korea
(Lee) Department of Thoracic and Cardiovascular Surgery, Samsung Medical
Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Title
A comparison among infusion of lidocaine and dexmedetomidine alone and in
combination in subjects undergoing coronary artery bypass graft: A
randomized trial.
Source
Contemporary Clinical Trials. 39 (2) (pp 303-309), 2014. Date of
Publication: November 01, 2014.
Publisher
Elsevier Inc.
Abstract
Background: Previous studies have reported the cardioprotective effect of
dexmedetomidine and lidocaine. We compared the effect of lidocaine and
dexmedetomidine infusion during off-pump coronary artery bypass graft
(OPCAB). Methods: 153 patients undergoing OPCAB were enrolled. The
lidocaine group (n. =. 36, Group LIDO) received an infusion of lidocaine
2. mg/kg/h after bolus 1.5. mg/kg; the dexmedetomidine group (n. =. 40,
Group DEX) received dexmedetomidine 0.3-0.7. mug/kg/h; the combined group
(n. =. 39, Group Combined) received infusion of both drugs; and the
control group (n. =. 38) received nothing. We measured serum creatinine
kinase-myocardial band (CK-MB) and cardiac troponin I (cTnI) concentration
before and immediately after the surgery, postoperative day (POD)#1 and
#2. The complication rate and clinical outcomes were compared. Results:
The concentration of cTnI was significantly lower in the Group LIDO and
Group Combined than the control group on POD#2. The concentration of CK-MB
was significantly lower in the Group LIDO and Group Combined compared to
the control group on POD#1 and #2 [CK-MB on POD#1: 7.67 (5.78-11.92) vs.
7.18 (5.01-11.72) vs. 13.19 (6.85-23.87) in the Group LIDO, combined and
control, respectively, Group LIDO vs. control: p. =. 0.003, Group Combined
vs. control: p. =. 0.015]. The AUC of CK-MB was significantly lower in the
Group LIDO and Group Combined than the control group. However, clinical
variables including complication rate, ICU stay and one-year mortality
were not different. Conclusions: Lidocaine infused at 2. mg/kg/h, but not
dexmedetomidine infused at 0.3-0.7. mug/kg/h reduced postoperative
myocardial injury marker levels compared with the control group. However,
no other clinical benefits were observed.

<11>
Accession Number
2014860719
Authors
Carrie D. Delarche N. Piot C. Berland J. Menneveau N. Bonello L. Py A.
Teiger E. Leborgne L. Bayet G. Wittenberg O. Schiele F.
Institution
(Carrie) Cardiology B, Cardiovascular and Metabolic Pole, Rangueil
Hospital, Toulouse, France
(Delarche) Cardiology Department, Hospital Centre, Pau, France
(Piot) Cardiology Department, Arnaud de Villeneuve Hospital, Montpellier,
France
(Berland) Cardiology Department, St. Hilaire Clinic, Rouen, France
(Menneveau, Schiele) Cardiology Department, Jean Minjoz Hospital,
Besancon, France
(Bonello) Cardiology Department, North Hospital, Marseille, France
(Py) Cardiology Department, Alexandre Dumas Medical Centre, Amiens, France
(Teiger) Cardiology Department, Henri Mondor Hospital, Creteil, France
(Leborgne) Cardiology Department, North Hospital, Amiens, France
(Bayet) Cardiology Department, Rhone Durance Clinic, Avignon, France
(Wittenberg) Cardiology Department, Beauregard Polyclinic, Marseille,
France
Title
Everolimus-eluting stent for the treatment of bare metal in-stent
restenosis: Clinical and angiographic outcomes at nine-month follow-up of
XERES (Xience Evaluation in bare metal stent REStenosis) trial.
Source
EuroIntervention. 10 (6) , 2014. Date of Publication: 01 Oct 2014.
Publisher
EuroPCR
Abstract
Conclusions: EES for the treatment of bare metal in-stent restenosis
seemed safe and efficacious.

<12>
Accession Number
2014856696
Authors
Martinez-Atienza J. Rosso-Fernandez C. Roca C. Aydillo T.A. Gavalda J.
Moreno A. Montejo J.M. Torre-Cisneros J. Farinas M.C. Fortun J. Sabe N.
Munoz P. Blanes-Julia M. Suarez-Benjumea A. Lopez-Medrano F. Perez-Romero
P. Cordero E. Pilar P.R. Cristina R.O. Teresa A.A. angel B.R. Juliana M.A.
Clara R.F. Ortega F.J.M. Miguel A.G. Jose M.A. Jose M.S. Ernesto L.C.
Antonia G.I. Magdalena S.A. Hernandez M.J.R. Bravo M.A.G. Gabriel B.B.
Laureano G.C. Rosario L.C. Barranco J.L. Vega A.P. Morales J.M. Delgado
J.F. Minero M.V. Martinez I.C. Magdalena S. Casasnovas Y.S. Rodriguez
Ferrero M.L. Roa P.L. Catalan P. Cruz C.P. Davila P.M. Jimenez M.A.
Marugan R.B. Letosa R.M. Elena N.M. Revilla A. Abad O.L. Peguin M. Berga
A.P. Lidia G. Broto A.R. Nuria S. Marimont B. Bosch J.N. Navarro A.F.
Garriga L.L. Comellas C.B. Costello J.G. Sorroche B.B. Ferrer A. Gonzalez
E. Fornieles L.M. Gil R.F. Elias J.R. Margalef M.N. Bayas J.M. alvarez
C.C. Villa F.P. Ulloa I.H. Arroyo J.C. Frederic C. Marcos M.A.
Juarros.G.S. Hernandez J.M. Urcelay Lopez M.I. Herran N.D. Rienda M.I.M.
Rodriguez J.C. Guerrero R.C. Busselo M.S. Txertudi A.B. Tovar S.C.
Aldeguer J.L. Lleti M.S. Zazo N.B. Maria.T. Torder Raquel P Belen G.
Acebal J.G. Ruiz A.L. Castilla C.G. Barroso I.M. Santander M. Duran Calvo
M.R. Goni F.Z. Belaustegui M.C. Morencos F.C. Garcia E.F. Castillo C.A.
Luis M. Rico C.G. Rozas S.F.
Institution
(Martinez-Atienza, Roca, Aydillo, Perez-Romero, Cordero) Hospital
Universitario Virgen del Rocio and Biomedicine Research Institute (IBIS),
Infectious Diseases Research Group, Avda. Manuel Siurot, s/n, Seville
41013, Spain
(Martinez-Atienza, Rosso-Fernandez) Hospital Universitario Virgen del
Rocio, Clinical Trial Unit, Avda. Manuel Siurot s/n, Seville 41013, Spain
(Gavalda) Hospital Vall d'Hebron, Infectious Diseases Research Group,
Passeig de la Vall d'Hebron, 119-129, Barcelona 08035, Spain
(Moreno) Hospital Clinic, Infectious Diseases Research Group, Carrer
Villarroel,170, Barcelona 08036, Spain
(Montejo) Hospital Universitario de Cruces, Infectious Diseases Research
Group, Plaza de Cruces, 12, San Vicente de Barakaldo, Vizcaya 48903, Spain
(Torre-Cisneros) Hospital Universitario Reina Sofia, Infectious Diseases
Research Group, Avda. Menendez Pidal, s/n, Cordoba 14004, Spain
(Farinas) Hospital Universitario Marques de Valdecilla, Infectious
Diseases Research Group, Av Valdecilla, s/n, Santander, Cantabria 39008,
Spain
(Fortun) Hospital Universitario Ramon y Cajal, Ctra. de Colmenar Viejo,
km. 9, 100, Madrid 28034, Spain
(Sabe) Hospital Universitario de Bellvitge, Infectious Diseases Research
Group, Feixa Llarga, s/n, 08907 L'Hospitalet de Llobregat, Barcelona,
Spain
(Munoz) Hospital General Universitario Gregorio Maranon, Infectious
Diseases Research Group, Calle Doctor Esquerdo, 46, Madrid 28007, Spain
(Blanes-Julia) Hospital Universitario La Fe, Infectious Diseases Research
Group, Avenida Campanar, 21, Valencia 46026, Spain
(Suarez-Benjumea) Hospital Universitario Virgen Macarena, Infectious
Diseases Research Group, Avd. Dr. Fedriani, Sevilla 341007, Spain
(Lopez-Medrano) Hospital Universitario 12 de Octubre, Infectious Diseases
Research Group, Avda de Cordoba, s/n, Madrid 28041, Spain
(Pilar, Cristina, Teresa, angel, Juliana, Clara, Ortega, Miguel, Jose,
Jose, Ernesto, Antonia, Magdalena, Hernandez, Bravo, Gabriel, Laureano)
Virgen del Rocio University Hospital, Elisa Cordero Matia PI Seville,
Spain
(Rosario, Barranco, Vega) Reina Sofia University Hospital-IMIBIC-UCO
Cordoba, Julian de la Torre Cisneros PI, Spain
(Morales, Delgado) 12 de Octubre University Hospital, Francisco
Lopez-Medrano PI, Madrid, Spain
(Morales, Delgado) Gregorio Maranon General University Hospital, Patricia
Munoz Garcia (PI), Madrid, Spain
(Minero, Martinez, Magdalena, Casasnovas, Rodriguez Ferrero, Roa, Catalan,
Cruz) Ramon y Cajal University Hospital, Jesus Fortun Abete (PI), Madrid,
Spain
(Davila, Jimenez, Marugan, Letosa, Elena, Revilla) Vall d'Hebron Hospital,
Joan Gavalda Sant Pau PI, Barcelona, Spain
(Abad, Peguin, Berga, Lidia, Broto) Bellvitge University Hospital, Jordi
Carratala (PI), Barcelona, Spain
(Nuria, Marimont, Bosch, Navarro, Garriga, Comellas, Costello, Sorroche,
Ferrer, Gonzalez, Fornieles, Gil, Elias, Margalef) Barcelona Clinic
Hospital, Asuncion Moreno Camacho PI, Barcelona, Spain
(Bayas, alvarez, Villa, Ulloa, Arroyo, Frederic, Marcos, Juarros.G.S.)
Cruces University Hospital, San Vicente de Barakaldo, Jose Miguel Montejo
PI, Spain
(Hernandez, Urcelay Lopez, Herran, Rienda, Rodriguez, Guerrero, Busselo,
Txertudi) La Fe University Hospital, Marino Blanes Julia PI, Valencia,
Spain
(Tovar, Aldeguer, Lleti, Zazo, Maria.T., Raquel) Virgen Macarena
University Hospital, Alejandro Suarez Benjumea PI, Seville, Spain
(Belen, Acebal, Ruiz, Castilla, Barroso) Marques de Valdecilla University
Hospital, Carmen Farinas PI, Spain
Title
Efficacy and safety of a booster dose of influenza vaccination in solid
organ transplant recipients, TRANSGRIPE 1-2: Study protocol for a
multicenter, randomized, controlled clinical trial.
Source
Trials. 15 (1) , 2014. Article Number: 338. Date of Publication: August
28, 2014.
Publisher
BioMed Central Ltd.
Abstract
Background: Despite administration of annual influenza vaccination,
influenza-associated complications in transplant recipients continue to be
an important cause of hospitalization and death. Although influenza
vaccination has been proven to be the most effective measure to reduce
influenza infection after transplantation, transplant recipients are still
vulnerable to influenza infections, with lower serological responses to
vaccination compared to the general population. In order to assess the
efficacy and safety of an alternative immunization scheme for solid organ
transplant recipients, the TRANSGRIPE1-2 Study Group aimed to test a
booster dose administration 5 weeks after the standard vaccination. The
primary objective of this trial was to compare short-term and long-term
neutralizing antibody immunogenicity of a booster dose of influenza
vaccination to the standard single-dose immunization scheme. Secondary
objectives included the evaluation of the efficacy and/or safety, cellular
immune response, incidence of influenza infection, graft rejection,
retransplant and mortality rates.Methods/Design: This phase III,
randomized, controlled, open-label clinical trial was conducted between
October 2012 and December 2013 in 12 Spanish public referral hospitals.
Solid organ transplant recipients (liver, kidney, heart or lung), older
than 16 years of age more than 30 days after transplantation were eligible
to participate. Patients (N = 514) were stratified 1:1 by center, type of
organ and time after transplantation and who either received the standard
single dose (n = 257) or were treated according to a novel influenza
vaccination schedule comprising the administration of a booster dose 5
weeks after standard vaccination (n = 254). Seroconversion rates were
measured as a determinant of protection against influenza (main outcome).
Efficacy and safety outcomes were followed until 1 year after influenza
vaccination with assessment of short-term (0, 5, 10 and 15 weeks) and
long-term (12 months) results. Intention-to-treat, per-protocol and safety
analyses will be performed.Discussion: This trial will increase knowledge
about the safety and efficacy of a booster dose of influenza vaccine in
solid organ transplant recipients. At the time the manuscript was
submitted for publication, trial recruitment was closed with a total of
499 participants included during a 2-month period (within the seasonal
influenza vaccination campaign).Trial registration: ClinicalTrials.gov
Identifier: NCT01761435 (registered 13 December 2012).EudraCT Identifier:
2011-003243-21 (registered 4 July 2011).

<13>
Accession Number
2014817606
Authors
Engels G.E. Dodonov M. Rakhorst G. van Oeveren W. Milano A.D. Gu Y.J.
Faggian G.
Institution
(Engels, van Oeveren) HaemoScan BV, Groningen, Netherlands
(Dodonov, Milano, Faggian) Department of Cardiothoracic Surgery,
University of Verona Medical School, Verona, Italy
(Rakhorst, van Oeveren, Gu) Department of Cardiothoracic Surgery,
University of Groningen, University Medical Center Groningen, Groningen,
Netherlands
Title
The effect of pulsatile cardiopulmonary bypass on lung function in elderly
patients.
Source
International Journal of Artificial Organs. 37 (9) (pp 679-687), 2014.
Date of Publication: 01 Sep 2014.
Publisher
Wichtig Publishing Srl
Abstract
Conclusions: Pulsatile flow does not seem beneficial to postoperative lung
function in elderly patients. Moreover, pulsatile flow does not affect
lung function on a subclinical level as assessed by lung biomarkers.

<14>
Accession Number
2014864637
Authors
Chekan E. Whelan R.L.
Institution
(Chekan) Ethicon Inc, Cincinnati, OH, United States
(Whelan) St Luke's Roosevelt Hospital, New York, NY, United States
Title
Surgical stapling device-tissue interactions: What surgeons need to know
to improve patient outcomes.
Source
Medical Devices: Evidence and Research. 7 (pp 305-318), 2014. Date of
Publication: 12 Sep 2014.
Publisher
Dove Medical Press Ltd (PO Box 300-008, Albany, 44 Corinthian Drive,
Albany,Auckland 0752, New Zealand. E-mail: angela@dovepress.com)
Abstract
The introduction of both new surgical devices and reengineered existing
devices leads to modifications in the way traditional tasks are carried
out and allows for the development of new surgical techniques. Each new
device has benefits and limitations in regards to tissue interactions
that, if known, allow for optimal use. However, most surgeons are unaware
of these attributes and, therefore, new device introduction creates a
"knowledge gap" that is potentially dangerous. The goal of this review is
to present a framework for the study of device- tissue interactions and to
initiate the process of "filling in" the knowledge gap via the available
literature. Surgical staplers, which are continually being developed, are
the focus of this piece. The integrity of the staple line, which depends
on adequate tissue compression, is the primary factor in creating a stable
anastomosis. This review focuses on published studies that evaluated the
creation of stable anastomoses in bariatric, thoracic, and colorectal
procedures. Understanding how staplers interact with target tissues is key
to improving patient outcomes. It is clear from this review that each
tissue type presents unique challenges. The thickness of each tissue
varies as do the intrinsic biomechanical properties that determine the
ideal compressive force and prefiring compression time for each tissue
type. The correct staple height will vary depending on these
tissue-specific properties and the tissue pathology. These studies
reinforce the universal theme that compression, staple height, tissue
thickness, tissue compressibility, and tissue type must all be considered
by the surgeon prior to choosing a stapler and cartridge. The surgeon's
experience, therefore, is a critical factor. Educational programs need to
be established to inform and update surgeons on the characteristics of
each stapler. It is hoped that the framework presented in this review will
facilitate this process.

<15>
Accession Number
2014847697
Authors
Espinosa A. Stenseth R. Videm V. Pleym H.
Institution
(Espinosa, Videm) Department of Immunology and Transfusion Medicine, St.
Olav University Hospital, Trondheim, Norway
(Stenseth) Department of Cardiothoracic Anesthesia and Intensive Care
Medicine, St. Olav University Hospital, Trondheim, Norway
(Stenseth, Pleym) Department of Circulation and Medical Imaging, Norwegian
University of Science and Technology, Trondheim, Norway
(Videm) Department of Laboratory Medicine, Children's and Women's Health,
Norwegian University of Science and Technology, Trondheim, Norway
(Pleym) Clinic of Anaesthesia and Intensive Care, St. Olav University
Hospital, Trondheim, Norway
Title
Comparison of three point-of-care testing devices to detect hemostatic
changes in adult elective cardiac surgery: A prospective observational
study.
Source
BMC Anesthesiology. 14 (1) , 2014. Article Number: 80. Date of
Publication: September 22, 2014.
Publisher
BioMed Central Ltd.
Abstract
Background: Bleeding complications in cardiac surgery may lead to
increased morbidity and mortality. Traditional blood coagulation tests are
not always suitable to detect rapid changes in the patient's coagulation
status. Point-of-care instruments such as the TEG (thromboelastograph) and
RoTEM (thromboelastometer) have been shown to be useful as a guide for the
clinician in the choice of blood products and they may lead to a reduction
in the need for blood transfusion, contributing to better patient blood
management.Methods: The purpose of this study was to evaluate the ability
of the TEG, RoTEM and Sonoclot instruments to detect changes in hemostasis
in elective cardiac surgery with cardiopulmonary bypass and to investigate
possible correlations between variables from these three instruments and
routine hematological coagulation tests. Blood samples from thirty-five
adult patients were drawn before and after surgery and analyzed in TEG,
RoTEM, Sonoclot and routine coagulation tests. Data were compared using
repeated measures analysis of variance and Pearson's test for linear
correlation.Results: We found significant changes for all TEG variables
after surgery, for three of the RoTEM variables, and for one variable from
the Sonoclot. There were significant correlations postoperatively between
plasma fibrinogen levels and variables from the three
instruments.Conclusions: TEG and RoTEM may be used to detect changes in
hemostasis following cardiac surgery with CPB. Sonoclot seems to be less
suitable to detect such changes. Variables from the three instruments
correlated with plasma fibrinogen and could be used to monitor treatment
with fibrinogen concentrate.

<16>
Accession Number
2014759662
Authors
Dall C.H. Snoer M. Christensen S. Monk-Hansen T. Frederiksen M. Gustafsson
F. Langberg H. Prescott E.
Institution
(Dall, Snoer, Monk-Hansen, Frederiksen, Prescott) Department of
Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen,
Denmark
(Dall) Institute of Sports Medicine Copenhagen, Bispebjerg Hospital,
University of Copenhagen, Copenhagen, Denmark
(Christensen) Department of Cardiology, Gentofte Hospital, University of
Copenhagen, Copenhagen, Denmark
(Gustafsson) Department of Cardiology, Rigshospitalet, University of
Copenhagen, Copenhagen, Denmark
(Langberg) CopenRehab, Department of Public Health, University of
Copenhagen, Copenhagen, Denmark
Title
Effect of high-intensity training versus moderate training on peak oxygen
uptake and chronotropic response in heart transplant recipients: A
randomized crossover trial.
Source
American Journal of Transplantation. 14 (10) (pp 2391-2399), 2014. Date of
Publication: 01 Oct 2014.
Publisher
Blackwell Publishing Ltd
Abstract
In heart transplant (HTx) recipients, there has been reluctance to
recommend high-intensity interval training (HIIT) due to denervation and
chronotropic impairment of the heart. We compared the effects of 12 weeks'
HIIT versus continued moderate exercise (CON) on exercise capacity and
chronotropic response in stable HTx recipients >12 months after
transplantation in a randomized crossover trial. The study was completed
by 16 HTx recipients (mean age 52 years, 75% males). Baseline peak oxygen
uptake (VO_2peak) was 22.9mL/kg/min. HIIT increased
VO_2peak by 4.9+2.7mL/min/kg (17%) and CON by 2.6+2.2mL/kg/min
(10%) (significantly higher in HIIT; p<0.001). During HIIT, systolic blood
pressure decreased significantly (p=0.037) with no significant change in
CON (p=0.241; between group difference p=0.027). Peak heart rate
(HR_peak) increased significantly by 4.3beats per minute
(p=0.014) after HIIT with no significant change in CON (p=0.34; between
group difference p=0.027). Heart rate recovery (HR_recovery)
improved in both groups with a trend toward greater improvement after
HIIT. The 5-month washout showed a significant loss of improvement. HIIT
was well tolerated, had a superior effect on oxygen uptake, and led to an
unexpected increase in HR_peak accompanied by a faster
HR_recovery. This indicates that the benefits of HIIT are partly
a result of improved chronotropic response.

<17>
Accession Number
2014720866
Authors
Shea J. Sodhi G. Najam F. Solomon A.J.
Institution
(Shea, Sodhi, Solomon) Division of Cardiology, Department of Medicine,
George Washington University Hospital, 2150 Pennsylvania Ave, NW,
Washington, DC 20037, United States
(Najam) Division of Cardiac Surgery, Department of Surgery, George
Washington University Hospital, Washington, DC, United States
Title
Does the addition of atrial pacing to amiodarone reduce the incidence of
postoperative atrial fibrillation: A pilot study.
Source
Journal of Thoracic and Cardiovascular Surgery. 148 (4) (pp 1752-1753),
2014. Date of Publication: 01 Oct 2014.
Publisher
Mosby Inc.

<18>
Accession Number
2014720838
Authors
Galas F.R.B.G. De Almeida J.P. Fukushima J.T. Vincent J.L. Osawa E.A.
Zeferino S. Camara L. Guimaraes V.A. Jatene M.B. Hajjar L.A.
Institution
(Galas, De Almeida, Fukushima, Vincent, Osawa, Zeferino, Camara,
Guimaraes, Jatene, Hajjar) Surgical Intensive Care Unit, InCor Heart
Institute, University of Sao Paulo, Sao Paulo, Brazil
Title
Hemostatic effects of fibrinogen concentrate compared with cryoprecipitate
in children after cardiac surgery: A randomized pilot trial.
Source
Journal of Thoracic and Cardiovascular Surgery. 148 (4) (pp 1647-1655),
2014. Date of Publication: 01 Oct 2014.
Publisher
Mosby Inc.
Abstract
Methods: In this randomized pilot study, patients were allocated to
receive fibrinogen concentrate (60 mg/kg) or cryoprecipitate (10 mL/kg) if
bleeding was associated with fibrinogen levels < 1 g/dL after
cardiopulmonary bypass weaning. The primary outcome was postoperative
blood losses during the 48 hours after surgery.

<19>
Accession Number
2014751276
Authors
Takagi H. Goto S.-N. Watanabe T. Mizuno Y. Kawai N. Umemoto T.
Institution
(Takagi, Goto, Watanabe, Mizuno, Kawai, Umemoto) Shizuoka Medical Center,
Department of Cardiovascular Surgery, 762-1 Nagasawa, Shimizu-cho,
Sunto-gun, Shizuoka 411-8611, Japan
Title
A meta-analysis of adjusted hazard ratios from 20 observational studies of
bilateral versus single internal thoracic artery coronary artery bypass
grafting.
Source
Journal of Thoracic and Cardiovascular Surgery. 148 (4) (pp 1282-1290),
2014. Date of Publication: 01 Oct 2014.
Publisher
Mosby Inc.
Abstract
Conclusions: Based on an updated meta-analysis of exclusive adjusted HRs
from 20 observational studies enrolling more than 70,000 patients, BITA
grafting seems to significantly reduce long-term mortality. As the
proportion of men increases, BITA grafting is more beneficial in reducing
mortality.

<20>
Accession Number
2014751202
Authors
Huang J.H. Sunstrom R. Munar M.Y. Cherala G. Legg A. Olyeai A.J. Langley
S.M.
Institution
(Huang, Legg) Division of Pediatric Cardiology, Doernbecher Children's
Hospital, Oregon Health Science University, Portland, United States
(Sunstrom, Langley) Division of Pediatric Cardiac Surgery, Oregon Health
Science University, Doernbecher Children's Hospital, Portland, OR, United
States
(Munar, Cherala, Olyeai) College of Pharmacy, Oregon State University,
Corvallis, OR, United States
Title
Are children undergoing cardiac surgery receiving antibiotics at
subtherapeutic levels?.
Source
Journal of Thoracic and Cardiovascular Surgery. 148 (4) (pp 1591-1596),
2014. Date of Publication: 01 Oct 2014.
Publisher
Mosby Inc.
Abstract
Conclusions: Our model predicts which patients undergoing cardiac surgery
with cardiopulmonary will have subtherapeutic cefuroxime levels. This
nomogram enables providers to determine when to administer additional
antibiotics in patients receiving large additional volumes during cardiac
surgeries. This rational approach to perioperative antibiotic dosing may
result in a reduction in postoperative infection in this vulnerable
patient population.

<21>
Accession Number
2014751221
Authors
Roshanali F. Shoar S. Shoar N. Naderan M. Alaeddini F. Mandegar M.H.
Institution
(Roshanali, Shoar, Alaeddini) Department of Cardiology, Day General
Hospital, Tehran, Iran, Islamic Republic of
(Shoar, Mandegar) Department of Cardiology and Cardiac Surgery, Day
General Hospital, No. 1434873111, Tavanir St, Vali e Asr Ave, Tehran,
Iran, Islamic Republic of
(Shoar, Naderan) Department of Surgery, Shariati Hospital, Tehran
University of Medical Sciences, Tehran, Iran, Islamic Republic of
(Shoar) School of Medicine, Kashan University of Medical Sciences, Kashan,
Iran, Islamic Republic of
Title
Low-dose dobutamine stress echocardiography cannot predict mitral
regurgitation reversibility after coronary artery bypass grafting.
Source
Journal of Thoracic and Cardiovascular Surgery. 148 (4) (pp 1323-1327),
2014. Date of Publication: 01 Oct 2014.
Publisher
Mosby Inc.
Abstract
Conclusions: Despite its utility in selecting CABG patients with moderate
ischemic MR for valve repair from a short-term perspective, the use of DSE
cannot predict the long-term outcomes of these patients.

<22>
Accession Number
2014782073
Authors
Sako E.Y. Brooks M.M. Hardison R.M. Schaff H. Frye R.L.
Institution
(Sako) Department of Cardiothoracic Surgery, University of Texas Health
Science Center at San Antonio, Mail Code 7841, 7703 Floyd Curl Dr, San
Antonio, TX 78229-3900, United States
(Brooks, Hardison) University of Pittsburgh, Pittsburgh, PA, United States
(Schaff, Frye) Mayo Clinic, Rochester, MN, United States
Title
Coronary artery bypass in patients with type 2 diabetes: Experience from
the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial.
Source
Journal of Thoracic and Cardiovascular Surgery. 148 (4) (pp 1268-1272),
2014. Date of Publication: 01 Oct 2014.
Publisher
Mosby Inc.
Abstract
Conclusions: BARI 2D showed that early CABG in patients with type 2
diabetes and myocardial ischemia and multivessel disease reduced the
subsequent myocardial infarction rates. The present results have
demonstrated that this was achieved using off-pump surgery in certain
cases, standard myocardial protection, and routine use of the internal
mammary artery or other arterial grafts.

<23>
Accession Number
2014775396
Authors
Aiyagari R. Rhodes J.F. Shrader P. Radtke W.A. Bandisode V.M. Bergersen L.
Gillespie M.J. Gray R.G. Guey L.T. Hill K.D. Hirsch R. Kim D.W. Lee K.-J.
Pelech A.N. Ringewald J. Takao C. Vincent J.A. Ohye R.G.
Institution
(Aiyagari) Division of Pediatric Cardiology, University of Michigan
Medical School, 1540 E Hospital Drive, Ann Arbor, MI 48109-4204, United
States
(Rhodes, Hill) Duke University Medical Center, Durham, NC, United States
(Shrader, Guey) New England Research Institute, Watertown, MA, United
States
(Radtke) Nemours Cardiac Center, Wilmington, DE, United States
(Bandisode) Department of Pediatrics, Medical University of South
Carolina, Charleston, SC, United States
(Bergersen) Department of Cardiology, Children's Hospital Boston, Boston,
MA, United States
(Gillespie) Division of Pediatric Cardiology, Children's Hospital of
Philadelphia, Philadelphia, PA, United States
(Gray) Division of Pediatric Cardiology, University of Utah, Salt Lake
City, UT, United States
(Hirsch) Cincinnati Children's Hospital Medical Center, Cincinnati, OH,
United States
(Kim) Children's Healthcare of Atlanta, Emory University, Atlanta, GA,
United States
(Lee) Hospital for Sick Children, Toronto, ON, Canada
(Pelech) Department of Pediatrics, Medical College of Wisconsin,
Milwaukee, WI, United States
(Ringewald) Division of Cardiology, All Children's Hospital, St
Petersburg, FL, United States
(Takao) Division of Pediatric Cardiology, Children's Hospital Los Angeles,
Los Angeles, CA, United States
(Vincent) Division of Cardiology, New York-Presbyterian Morgan Stanley
Children's Hospital, New York, NY, United States
(Ohye) Section of Pediatric Cardiovascular Surgery, University of Michigan
Medical School, Ann Arbor, MI, United States
Title
Impact of pre-stage II hemodynamics and pulmonary artery anatomy on
12-month outcomes in the Pediatric Heart Network Single Ventricle
Reconstruction trial.
Source
Journal of Thoracic and Cardiovascular Surgery. 148 (4) (pp 1467-1474),
2014. Date of Publication: 01 Oct 2014.
Publisher
Mosby Inc.
Abstract
Conclusions: Compared with the RVPAS subjects, the MBTS subjects had more
hemodynamic abnormalities related to shunt physiology, and the RVPAS
subjects had more shunt or pulmonary obstruction of a severe degree and
inferior pulmonary artery growth at pre-stage II catheterization. A lower
body surface area, greater ventricular end-diastolic pressure, and lower
superior vena cava saturation were associated with worse 12-month
transplant-free survival.

<24>
Accession Number
2014862280
Authors
Pibarot P. Weissman N.J. Stewart W.J. Hahn R.T. Lindman B.R. McAndrew T.
Kodali S.K. Mack M.J. Thourani V.H. Miller D.C. Svensson L.G. Herrmann
H.C. Smith C.R. Rodes-Cabau J. Webb J. Lim S. Xu K. Hueter I. Douglas P.S.
Leon M.B.
Institution
(Pibarot, Rodes-Cabau) Quebec Heart and Lung Institute, Institut
Universitaire de Cardiologie et de Pneumologie de Quebec, Laval
University, 2725 Chemin Ste-Foy, Quebec, QC G1V-4G5, Canada
(Weissman) Medstar Health Research Institute, Washington, DC, United
States
(Stewart) Department of Cardiovascular Medicine, Cleveland Clinic,
Cleveland, OH, United States
(Hahn, Kodali, Smith, Hueter, Leon) Columbia University Medical Center,
New York-Presbyterian Hospital, New York, NY, United States
(Hahn, McAndrew, Kodali, Smith, Xu, Leon) Cardiovascular Research
Foundation, New York, NY, United States
(Lindman) Washington University School of Medicine, St. Louis, MI, United
States
(Mack) Baylor Healthcare System, Dallas, TX, United States
(Thourani) Emory University School of Medicine, Atlanta, GA, United States
(Miller) Stanford University School of Medicine, Stanford, CA, United
States
(Svensson) Department of Thoracic and Cardiovascular Surgery, Cleveland
Clinic, Cleveland, OH, United States
(Herrmann) Hospital of the University of Pennsylvania, Philadelphia, PA,
United States
(Webb) University of British Columbia, St. Paul's Hospital, Vancouver,
Canada
(Lim) University of Virginia Medical Center, Charlottesville, VA, United
States
(Douglas) Duke University Medical Center, Duke Clinical Research
Institute, Durham, NC, United States
Title
Incidence and sequelae of prosthesis-patient mismatch in transcatheter
versus surgical valve replacement in high-risk patients with severe aortic
stenosis: A PARTNER trial cohort-a analysis.
Source
Journal of the American College of Cardiology. 64 (13) (pp 1323-1334),
2014. Date of Publication: 30 Sep 2014.
Publisher
Elsevier USA
Abstract
Conclusions In patients with severe aortic stenosis and high surgical
risk, PPM is more frequent and more often severe after SAVR than TAVR.
Patients with PPM after SAVR have worse survival and less LV mass
regression than those without PPM. Severe PPM also has a significant
impact on survival after TAVR in the subset of patients with no
post-procedural aortic regurgitation. TAVR may be preferable to SAVR in
patients with a small aortic annulus who are susceptible to PPM to avoid
its adverse impact on LV mass regression and survival. (The PARTNER Trial:
Placement of AoRTic TraNscathetER Valve Trial; NCT00530894).

<25>
Accession Number
2014857922
Authors
Montalescot G. Van't Hof A.W. Lapostolle F. Silvain J. Lassen J.F.
Bolognese L. Cantor W.J. Cequier A. Chettibi M. Goodman S.G. Hammett C.J.
Huber K. Janzon M. Merkely B. Storey R.F. Zeymer U. Stibbe O. Ecollan P.
Heutz W.M.J.M. Swahn E. Collet J.-P. Willems F.F. Baradat C. Licour M.
Tsatsaris A. Vicaut E. Hamm C.W.
Institution
(Montalescot, Silvain, Collet) Allies in Cardiovascular Trials Initiatives
and Organized Networks (ACTION) Study Group, Institut de Cardiologie,
Centre Hospitalier Universitaire Pitie-Salpetriere, 47 Blvd. de l'H.pital,
75013 Paris, France
(Stibbe) Service Medical D'Urgence, Brigade de Sapeurs Pompiers de Paris,
France
(Ecollan) Service Mobile D'Urgence et de Reanimation, CHU
Pitie-Salpetriere AP-HP, France
(Vicaut) Unite de Recherche Clinique, H.pital Lariboisiere, Paris, France
(Lapostolle) Service D'Aide Medicale Urgente 93, H.pital Avicenne,
Bobigny, France
(Baradat, Licour, Tsatsaris) AstraZeneca, Rueil Malmaison, France
(Van't Hof) Department of Cardiology, Isala Clinics, Zwolle, Netherlands
(Heutz) Regionale Ambulance Voorziening Gelderland-Midden, Netherlands
(Willems) Department of Cardiology, Rijnstate Ziekenhuis, Arnheim,
Netherlands
(Lassen) Department of Cardiology B, Aarhus University Hospital, Skejby,
Aarhus, Denmark
(Bolognese) Cardiovascular and Neurologic Department, Azienda Ospedaliera
Arezzo, Arezzo, Italy
(Cantor) Southlake Regional Health Centre, United States
(Goodman) Canadian Heart Research Centre, Division of Cardiology,
University of Toronto, Toronto, Canada
(Cequier) Heart Disease Institute, Hospital Universitario de Bellvitge,
University of Barcelona, Barcelona, Spain
(Chettibi) Centre Hospito-universitaire Franz Fanon, Blida, Algeria
(Hammett) Department of Cardiology, Royal Brisbane and Women's Hospital,
Brisbane, QLD, Australia
(Huber) Third Department of Medicine, Cardiology and Intensive Care
Medicine, Wilhelminenspital, Vienna, Austria
(Janzon, Swahn) Departments of Cardiology and Medical and Health Sciences,
Linkoping University, Linkoping, Sweden
(Merkely) Heart and Vascular Center, Semmelweis University, Budapest,
Hungary
(Storey) Department of Cardiovascular Science, University of Sheffield,
Sheffield, United Kingdom
(Zeymer) Klinikum Ludwigshafen and Institut Fur Herzinfarktforschung
Ludwigshafen, Ludwigshafen, Germany
(Hamm) Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim,
Germany
Title
Prehospital ticagrelor in ST-segment elevation myocardial infarction.
Source
New England Journal of Medicine. 371 (11) (pp 1016-1027), 2014. Date of
Publication: 11 Sep 2014.
Publisher
Massachussetts Medical Society
Abstract
Conclusions: Prehospital administration of ticagrelor in patients with
acute STEMI appeared to be safe but did not improve pre-PCI coronary
reperfusion.

<26>
Accession Number
2014853057
Authors
Chang S.J. Choi S. Kim S.-A. Song M.
Institution
(Chang) Department of Nursing Science, Chungbuk National University,
Cheongju, South Korea
(Choi) College of Nursing, Jeju National University, Jeju, South Korea
(Kim) College of Nursing, Seoul National University, Seoul, South Korea
(Song) College of Nursing, Research Institute of Nursing Science, Seoul
National University, 28 Yougon-dong, Chongro-gu, Seoul, South Korea
Title
Intervention strategies based on information-motivation-behavioral skills
model for health behavior change: A systematic review.
Source
Asian Nursing Research. 8 (3) (pp 172-181), 2014. Date of Publication: 01
Sep 2014.
Publisher
Korean Society of Nursing Science (635-4 Yeoksam-dong Kangnam-gu, Seoul
135-703, South Korea. E-mail: kaneditor@kan.or.kr)
Abstract
Purpose This study systematically reviewed research on behavioral
interventions based on the information-motivation-behavioral skills (IMB)
model to investigate specific intervention strategies that focus on
information, motivation, and behavioral skills and to evaluate their
effectiveness for people with chronic diseases.

<27>
Accession Number
2014851895
Authors
Silvestri L. Weir I. Gregori D. Taylor N. Zandstra D.F. Van Saene J.J.M.
Van Saene H.K.F.
Institution
(Silvestri) Department of Emergency, Unit of Anesthesia and Intensive
Care, Presidio Ospedaliero, Gorizia 34170, Italy
(Weir) Department of Cardiothoracic Surgery, London Chest Hospital,
London, United Kingdom
(Gregori) Department of Cardiological, Thoracic and Vascular Sciences,
Unit of Biostatistics, Epidemiology and Public Health, University of
Padua, Padua, Italy
(Taylor, Van Saene, Van Saene) Institute of Ageing and Chronic Disease,
University of Liverpool, Liverpool, United Kingdom
(Zandstra) Department of Intensive Care, Onze Lieve Vrouwe Gasthuis,
Amsterdam, Netherlands
Title
Effectiveness of oral chlorhexidine on nosocomial pneumonia, causative
micro-organisms and mortality in critically ill patients: A systematic
review and meta-analysis.
Source
Minerva Anestesiologica. 80 (7) (pp 805-820), 2014. Date of Publication:
01 Jul 2014.
Publisher
Edizioni Minerva Medica
Abstract
We carried out a systematic review and meta-analysis of randomized trials
to explore the effectiveness of oral chlorhexidine on nosocomial
pneumonia, causative bacteria, and mortality. PubMed, Embase, and the
Cochrane Register of Controlled Trials were searched for randomized trials
in critically ill patients receiving oral chlorhexidine. Odds ratios (OR)
were pooled with the random effects model. Twenty-two randomized trials
including 4277 patients were identified. Chlorhexidine significantly
reduced the incidence of nosocomial pneumonia (OR 0.66; 95% confidence
interval [CI] 0.51-0.85) and ventilator-associated pneumonia (OR 0.68, 95%
CI 0.53-0.87). There was a significant reduction of nosocomial pneumonia
due to both Gram-positive (OR 0.41; 95% CI 0.19-0.85) and Gram-negative
(OR 0.68; 95% CI 0.51-0.90) bacteria, but only pneumonia due to "normal"
flora (OR 0.51; 95% CI 0.33-0.80). The subgroup analysis revealed a
significant benefit of chlorhexidine on nosocomial pneumonia in surgical
patients only (OR 0.52; 95% CI 0.33-0.82). Mortality was not affected.
This review indicates that in critically ilL mainly surgical, patients,
oral chlorhexidine reduces nosocomial pneumonia, ventilator-associated
pneumonia, nosocomial pneumonia due to Gram-positive and Gram-negative
bacteria, and due to "normal" flora, without affecting mortality. Further
studies should explore the efficacy of oral chlorhexidine in non-surgical
critically ill population.

<28>
Accession Number
2014857744
Authors
Varenhorst C. Alstrom U. Braun O.O. Storey R.F. Mahaffey K.W. Bertilsson
M. Cannon C.P. Scirica B.M. Himmelmann A. James S.K. Wallentin L. Held C.
Institution
(Varenhorst, James, Wallentin, Held) Department of Medical Sciences,
Cardiology, Uppsala University, Uppsala, Sweden
(Varenhorst, Bertilsson, James, Wallentin, Held) Uppsala Clinical Research
Center, Uppsala University, Uppsala, Sweden
(Alstrom) Department of Cardiac and Thoracic Anaesthesia and Surgery,
Uppsala University, Uppsala, Sweden
(Braun) Department of Cardiology, Lund University, Lund, Sweden
(Storey) Department of Cardiovascular Science, University of Sheffield,
Sheffield, United Kingdom
(Mahaffey) Department of Medicine, Stanford University, Stanford, CA,
United States
(Cannon, Scirica) TIMI Study Group, Brigham and Women's Hospital, Harvard
Medical School, Boston, MA, United States
(Himmelmann) AstraZeneca R and D, Molndal, Sweden
Title
Causes of mortality with ticagrelor compared with clopidogrel in acute
coronary syndromes.
Source
Heart. 100 (22) (pp 1762-1769), 2014. Date of Publication: 01 Nov 2014.
Publisher
BMJ Publishing Group
Abstract
Objective: To describe specific causes of death and evaluate whether
bleeding events and infection contributed to mortality in all
ticagrelor-treated and clopidogrel-treated patients with acute coronary
syndromes. Methods: In the PLATelet inhibition and patient Outcomes
(PLATO) trial, ticagrelor signi ficantly reduced rates of vascular and
total death compared with clopidogrel. In the 905 patients who died
postenrolment in the PLATO trial (n=18 624), reviewers, blinded to study
treatment, subclassified direct causes of death and evaluated whether
infection or bleeding events contributed to fatal events. Results: Among
vascular deaths, there were significantly fewer sudden deaths (63 (0.7%)
vs 98 (1.1%), p<0.01) but no significant difference in deaths caused by
acute myocardial infarction (179 (1.9%) vs 194 (2.1%), p=0.43) or heart
failure (31 (0.3%) vs 42 (0.5%), p=0.20) with ticagrelor compared with
clopidogrel. For non-vascular deaths, there was no difference between
treatments in deaths directly caused by infection. Although, patients
treated with ticagrelor were at lower risk for death where infection was
either a direct cause or contributed to death (51 (0.5%) vs 76 (0.8%), HR
0.67 (0.47 to 0.95), p<0.05) but not for bleeding (42 (0.5%) vs 42 (0.5%),
HR 0.99 (0.65 to 1.53), p=0.98). Conclusions: In this post hoc analysis,
ticagrelor compared with clopidogrel reduced total and cardiovascular
mortality, which appeared to be mainly mediated by a reduction in sudden
death. Importantly, bleeding causing or contributing to death did not
differ between treatments. Clinical trial registration number NCT00391872
(http://www.clinicaltrial.gov).

<29>
Accession Number
71673956
Authors
Valero A. Westerhout K.Y. Van De Wetering G. Perez-Alcantara F. Azpeitia
A. Najib M.
Institution
(Valero) Hospital Clinic, Universitari De Barcelona, Barcelona, Spain
(Westerhout, Van De Wetering) Pharmerit International, Rotterdam,
Netherlands
(Perez-Alcantara) Oblikue Consulting, Barcelona, Spain
(Azpeitia) Stallergenes Iberica S.A, Barcelona, Spain
(Najib) Stallergenes, Antony, France
Title
Cost-effectiveness analysis of allergen immunotherapy in patients with
grass pollen-induced allergic rhinitis in Spain.
Source
Value in Health. Conference: ISPOR 17th Annual European Congress Amsterdam
Netherlands. Conference Start: 20141108 Conference End: 20141112.
Conference Publication: (var.pagings). 17 (7) (pp A598), 2014. Date of
Publication: November 2014.
Publisher
Elsevier Ltd
Abstract
Objectives: To determine the relative impact of treatment with Oralair,
Grazax, Pangramin, Pollinex Quattro, and symptomatic drug treatment (SDT)
on clinical effects and health care costs in patients with grass
pollen-induced allergic rhinitis (AR) in Spain. Methods: The effects of
three years of drug treatment on qualityadjusted life years (QALYs) and
costs were assessed using a Markov model with a nine-year time horizon.
Symptom score data were extracted, and the relative efficacy on QALYs was
assessed through a network meta-analysis (i. e. indirect comparison) of
3-year, placebo-controlled, clinical trial data. Patient symptom scores
were translated into the impact on quality of life by means of published
sources. Costs associated with drug treatment and other health care
resources were calculated. The incremental costs and QALYs gained were
generated accordingly. The uncertainty around the model outcomes was
determined by means of sensitivity analyses. Results: The base case
analysis over 9 years estimated incremental QALYs of 0.005 (95%CI: -0.024;
0.038), 0.016 (95%CI: -0.034; 0.063), 0.059 (95%CI: 0.024; 0.107), and
0.143 (95%CI: 0.102; 0.195) when Oralair was compared to Grazax,
Pangramin, Pollinex Quattro and SDT, respectively. Corresponding
incremental costs were - 1,063 (95%CI: - 1,306; - 779), 109 (95%CI: 206;
428), 572 (95%CI: 321; 864), and 1,360 (95%CI: 1,110; 1,649). Hence,
Oralair was predicted as dominant relative to Grazax, while ICERs of
6,931/QALY, 9,703/QALY, and 9,517/QALY were estimated relative to
Pangramin, Pollinex Quattro, and SDT, respectively. Apart from drug costs,
the sensitivity analyses suggest that results were mostly driven by
drug-specific symptom score values, duration of the pollen season, and
inputs for immunotherapy discontinuation. At a willingness-to-pay
threshold of 20,000, the probability of Oralair being the most
cost-effective treatment option is 65%. Conclusions: Oralair is
cost-effective relative to Grazax, Pangramin, Pollinex Quattro and SDT in
grass pollen-induced AR in Spain. Findings are confirmed by extensive
sensitivity analyses.

<30>
Accession Number
71670280
Title
22nd European Conference on General Thoracic Surgery.
Source
Interactive Cardiovascular and Thoracic Surgery. Conference: 22nd European
Conference on General Thoracic Surgery Copenhagen Denmark. Conference
Start: 20140615 Conference End: 20140618. Conference Publication:
(var.pagings). 18 , 2014. Date of Publication: June 2014.
Publisher
Oxford University Press
Abstract
The proceedings contain 233 papers. The topics discussed include:
treatment of primary spontaneous pneumothorax with thin catheter drainage
associated with Heimlich valve: comparative analysis; optimization of
chest stabilization methods for acute respiratory distress-syndrome
prophylaxy and treatment in patients with craniothoracic trauma; novel
approaches to complex chest wall reconstruction using a combination of two
titanium-based plating-systems: a case report; use of intraoperative
ultrasound probe to detect vascular injury by bullet during endoscopic
removal of chest wall bullet; successful treatment of 13 years chronic
postpneumonectomy empyema with bronchopleural fistula in a patient with
clagett-window; long-term results of different surgical correction
techniques in diaphragmatic eventration; a meta-analysis of debulking
surgery versus surgical biopsy for unresectable thymoma; and mediastinal
bronchogenic cyst with acute cardiac dysfunction: a two-stage surgical
approach.

<31>
Accession Number
71670261
Authors
Hamaji M. Omasa M. Kojima F. Sozu T. Sato T. Chen F. Sonobe M. Date H.
Institution
(Hamaji, Omasa, Kojima, Chen, Sonobe, Date) Thoracic Surgery, Kyoto
University, Kyoto, Japan
(Sozu, Sato) Biostatistics, Kyoto University, School of Publec Health,
Kyoto, Japan
Title
A meta-analysis of debulking surgery versus surgical biopsy for
unresectable thymoma.
Source
Interactive Cardiovascular and Thoracic Surgery. Conference: 22nd European
Conference on General Thoracic Surgery Copenhagen Denmark. Conference
Start: 20140615 Conference End: 20140618. Conference Publication:
(var.pagings). 18 (pp S57-S58), 2014. Date of Publication: June 2014.
Publisher
Oxford University Press
Abstract
Objectives: Observational studies on long-term outcomes following
debulking surgery or surgical biopsy for unresectable thymoma showed
various results. This meta-analysis was designed to determine the effect
of debulking surgery against surgical biopsy on mortality rate in patients
with unresectable thymoma. Methods: The PubMed database was queried for
studies published in the English language on unresecable thymoma and
overall survival. We compared mortality rates following surgery between
patients undergoing debulking surgery and patients undergoing surgical
biopsy for unresectable thymoma. A meta-analysis was performed using the
Mantel-Haenszel method and potential publication bias was evaluated with a
funnel plot of precision. Results: No randomized trials on this topic were
identified. Thirteen retrospective observational studies containing a
total of 314 patients with the number of deaths and person-year
information were suitable for analysis. One hundred and seventy-two
patients (54.8%) underwent debulking surgery and 142 (45.2%) underwent
surgical biopsy. The pooled hazard ratio was 0.451 (95% confidence
interval: 0.336-0.605, P < 0.001), favouring debulking surgery compared
with surgical biopsy. The funnel plot of precision demonstrated no
important publication bias. Conclusions: Our results suggested that
debulking surgery for unresectable thymoma may be associated with improved
mortality and may be considered for patients with unresectable thymoma if
possible.

<32>
Accession Number
71670260
Authors
Liao H. Liu L.
Institution
(Liao, Liu) Department of Thoracic Surgery, West China Hospital, Sichuan
University, Chengdu, China
Title
Comparison of video-assisted thoracoscopic thymectomy and open thymectomy
to treat myasthenia gravis: A meta-analysis.
Source
Interactive Cardiovascular and Thoracic Surgery. Conference: 22nd European
Conference on General Thoracic Surgery Copenhagen Denmark. Conference
Start: 20140615 Conference End: 20140618. Conference Publication:
(var.pagings). 18 (pp S57), 2014. Date of Publication: June 2014.
Publisher
Oxford University Press
Abstract
Objectives: Video-assisted thoracoscopic thymectomy (VATT) is widely used
to treat myasthenia gravis (MG), but it is still controversial. We
performed a meta-analysis of studies that compared safety and efficacy of
VATT and open thymectomy in order to determine which is the better choice.
Methods: Fourteen studies were included in the meta-analysis. Two authors
independently reviewed each study and extracted data on perioperative
mortality, overall morbidity, complete stable remission (CSR), occurrence
of MG crises, operative time, intraoperative blood loss and postoperative
hospital stay. Results: VATT was superior to open thymectomy in CSR (RR
1.30, 95% CI 1.06-1.59, P = 0.01), overall morbidity (RR 0.62, 95% CI
0.41-0.95, P = 0.03) and occurrence of MG crisis (RR 0.31, 95% CI
0.17-0.55, P < 0.001 [ACR1]), but the two techniques did not differ
significantly in mortality (P = 0.47). Compared with the open thymectomy
group, operative time is significantly longer in VATT group (SMD 0.79, 95%
CI 0.09 to 1.49, P = 0.03) while intraoperative blood loss is less (SMD
-2.07, 95% CI -2.36 to -1.77, P < 0.001) and postoperative hospital stay
is shorter (SMD -0.70, 95% CI -1.17 to -0.23, P = 0.004) There is no
difference between the two groups of thymo-fatty tissue resected. However
substantial heterogeneity was found in operative time (chi² =
108.50, I2 = 93%), post-hospital stay (chi² = 13.39, I2 = 78%)
and intraoperative blood loss (chi² = 188.78, I2 = 98%).
Conclusions: These results suggest that VATT is associated with greater
efficacy and safety than open thymectomy, making it potentially a better
choice of surgical approach for myasthenia gravis patients.

<33>
Accession Number
71670232
Authors
Guo W. Ma X. Yang S. Xiang J. Chen H. Li H.
Institution
(Guo, Ma, Yang, Xiang, Chen, Li) Thoracic Surgery, Fudan University,
Shanghai Cancer Center, Shanghai, China
Title
Combined thoracoscopic-laparoscopic oesophagectomy versus open
oesophagectomy: A meta-analysis of outcomes.
Source
Interactive Cardiovascular and Thoracic Surgery. Conference: 22nd European
Conference on General Thoracic Surgery Copenhagen Denmark. Conference
Start: 20140615 Conference End: 20140618. Conference Publication:
(var.pagings). 18 (pp S50), 2014. Date of Publication: June 2014.
Publisher
Oxford University Press
Abstract
Objectives: To evaluate the outcomes of combined
thoracoscopic-laparoscopic oesophagectomy and open oesophagectomy.
Methods: We searched PubMed and Web of Science. Studies comparing combined
thoracoscopic-laparoscopic oesophagectomy with open oesophagectomy were
included in the meta-analysis. Pooling was conducted using a
random-effects model if P < 0.10 or I2 >50% for heterogeneity. Eleven
studies involving 1266 patients were included. Intervention: Combined
thoracoscopic-laparoscopic oesophagectomy and open oesophagectomy. Main
Outcome Measurements: Total complication rate, 30-day mortality rate,
anastomotic leakage, anastomotic stricture, pulmonary infection,
arrhythmia, recurrent laryngeal nerve injury, pulmonary embolism, and
blood loss. Results: Meta-analysis showed that there were no significant
differences between the two groups in total complication rate, 30-day
mortality rate, anastomotic leakage, anastomotic stricture, pulmonary
infection, arrhythmia, recurrent laryngeal nerve injury, pulmonary
embolism, or blood loss (P > 0.05). However, the combined
thoracoscopic-laparoscopic oesophagectomy group had lower pulmonary
embolism rates and less blood loss. Limitations: The range of
complications does not completely coincide in the different reports.
Conclusions: Combined thoracoscopic-laparoscopic oesophagectomy shows
similar efficacy for oesophageal neoplasms compared to open
oesophagectomy, and combined thoracoscopic-laparoscopic oesophagectomy has
lower pulmonary embolism rates and less blood loss during surgery.

<34>
Accession Number
71670227
Authors
Milosevic M. Migliore M. Lees B. Treasure T.
Institution
(Milosevic) Institute for Pulmonary Diseases of Vojvodina, University of
Novi Sad, Novi Sad, Serbia
(Migliore) Thoracic Surgery, University of Catania, Catania, Italy
(Lees) Cteu, Royal Brompton Hospital, London, United Kingdom
(Treasure) Clinical Operational Research Unit, University College London,
London, United Kingdom
Title
Pulmicc international: A randomized controlled trial of pulmonary
metastasectomy in colorectal cancer: Work in progress.
Source
Interactive Cardiovascular and Thoracic Surgery. Conference: 22nd European
Conference on General Thoracic Surgery Copenhagen Denmark. Conference
Start: 20140615 Conference End: 20140618. Conference Publication:
(var.pagings). 18 (pp S49), 2014. Date of Publication: June 2014.
Publisher
Oxford University Press
Abstract
Objectives: To adequately inform patients with lung metastases of the
effect of metastasectomy we need evidence-based estimates of the survival
after metastasectomy compared with the course of the disease without
surgery. There have been no control data in over 100 studies since the
1960s but increasingly sophisticated means of analysis have shown
recurrence free survival is probably largely confined to people with a
solitary metastasis and an interval since primary resection counted in
years. Therefore, we cannot know from observational data whether survival
is a result of surgery or is due to systematic selection of those with the
best natural prognosis. Advanced colorectal cancer predominately affects
the liver, abdomen and pelvis; it is rare for pulmonary disease to
contribute to the clinical picture. There is no palliative role for lung
metastasectomy in asymptomatic patients. The patient's only gain is hope
of cure. If that is not attained by pulmonary metastasectomy, patients
should be informed and spared unavailing surgery. Methods: We are
recruiting to a randomized trial in which patients are evaluated according
to protocol in Stage 1 and fully informed individualized decisions can be
made for or against metastasectomy. If benefit is uncertain, random
allocation to active monitoring only, or active monitoring plus
metastasectomy, is offered in Stage 2 of the study. Survival, lung
function, and quality of life are measured for up to 5 years from
randomization. Results: Over 240 patients have been enrolled into Stage 1
and more than 60 have been randomized into Stage 2 from centres in the UK,
Serbia and Italy. Conclusions: Amongst patients made aware of the
uncertain benefit of surgery, randomization as a means of treatment
allocation has been found to be acceptable. The Data Monitoring Committee,
at the time of submission, recommends that the study continues as planned.

<35>
Accession Number
71670189
Authors
Hansen H.J. Laursen L. Konge L. Jensen T. Ravn J. Petersen R.H.
Institution
(Hansen, Laursen, Ravn, Petersen) Department of Cardiothoracic Surgery
2152, Rigshospitalet, Copenhagen, Denmark
(Konge) Centre for Clinical Education, University of Copenhagen, Capital
Region of Denmark, Copenhagen, Denmark
(Jensen) Department of Environmental Medicine, Faculty of Health Sciences,
Odense, Denmark
Title
Is long-term overall mortality after lobectomy for lung cancer affected by
the approach?.
Source
Interactive Cardiovascular and Thoracic Surgery. Conference: 22nd European
Conference on General Thoracic Surgery Copenhagen Denmark. Conference
Start: 20140615 Conference End: 20140618. Conference Publication:
(var.pagings). 18 (pp S39), 2014. Date of Publication: June 2014.
Publisher
Oxford University Press
Abstract
Objectives: Evidence supports the short-term benefits of a video-assisted
thoracoscopic surgery (VATS) approach in lobectomy over traditional open
thoracotomy. The remaining question is whether the approach affects
long-term overall mortality after lung cancer surgery as indicated by
several meta-analyses. Methods: This study is based on a prospectively
collected regional centre database including 1339 patients [774 (57.8%)
VATS and 565 (42.2%) thoracotomies] who underwent lobectomy or
bi-lobectomy for lung cancer from 2005 to 2011. The open approach was
performed as a muscle sparring thoracotomy leaving the latissimus muscle
untouched. All patients operated before 2009 were restaged to the 2009
edition of the IASLC lung cancer classification. Data on death until
January 3rd 2013, type of surgical approach, tumour stage (split into IA,
IB, IIA ...IV), modified Charlson comorbidity index excluding age, tumour
stage and smoking, FEV1 (per litre), age and sex were used to analyse
mortality hazard using Cox multivariate regression analysis. Results:
Median follow-up was 1200 days (3.3 years) with 275 deaths in the VATS
group (35.5%) and 295 in the thoracotomy group (52.2%). In the Cox
multivariate regression analysis the hazard ratio for death among patients
with thoracotomy compared to VATS was 1.07 (95% CI 0.90-1.27) after
adjustment for cancer stage, Charlson comorbidity index, age, FEV1 and
sex. Conclusions: This study indicates that a thoracotomy approach for
lobectomy for lung cancer independently increases the mortality by 7%.
Although not significant, it supports findings in current published
meta-analyses. Other factors have higher impact on mortality, but they
cannot be changed at the time of surgery or by the surgeon.

<36>
Accession Number
71670160
Authors
Kowalewski M. Lewandowska M.A. Kowalewski J.
Institution
(Kowalewski, Lewandowska, Kowalewski) Department of Thoracic Surgery and
Tumors, Collegium Medicum, Nicoalus Copernicus University in Torun,
Bydgoszcz, Poland
Title
Different measures to prevent atrial fibrillation in patients undergoing
pulmonary resection for lung cancer: Evidence from a comprehensive network
meta-analysis of randomized and observational studies.
Source
Interactive Cardiovascular and Thoracic Surgery. Conference: 22nd European
Conference on General Thoracic Surgery Copenhagen Denmark. Conference
Start: 20140615 Conference End: 20140618. Conference Publication:
(var.pagings). 18 (pp S32), 2014. Date of Publication: June 2014.
Publisher
Oxford University Press
Abstract
Objectives: Atrial fibrillation (AF) after pulmonary resections for lung
cancer, although transient in most cases, occurs in up to 30% following
lobectomy and up to 65% after pneumonectomy and might, in turn, lead to
serious adverse events including stroke, myocardial infarction and death.
Different preventive measures have been investigated; however, because of
paucity of evidence from randomized studies, straightforward
recommendations are still uncertain. We aimed to perform a
Bayesian-framework mixed treatments comparison (network) meta-analysis of
both randomized controlled (RCTs) and observational studies, to
investigate the net-relative benefit of diverse drugs in prevention of
atrial fibrillation following pulmonary resections for lung cancer
Methods: We screened Medline, Google Scholar, EMBASE and Cochrane CENTRAL
registries for randomized and observational studies comparing drugs to
each other and/or to placebo. Studies with postoperative AF as
prespecified end-point were retrieved for detailed abstraction. Primary
outcome was assessed at longest available follow-up. Results: Overall 15
studies (13 RCTs) were identified, enrolling 1753 patients. Beta-blockers,
atrial natriuretic peptide and flecainide were associated with significant
relative reduction in odds of postoperative AF, OR (2.5-97.5% CrI) of 0.34
(0.02-0.92); 0.35 (0.00-0.94) and 0.11 (0.00-0.46) respectively; digoxin
was found to increase these odds. Addition of observational data allowed
for identification of amiodarone as another potentially preventive
treatment OR (2.5-97.5% CrI) 0.28 (0.03-0.69). Bayesian posterior
probability curves revealed the ranking among treatments with flecainide,
beta-blockers, ANP and amiodarone being associated with the highest
probability to reduce the odds of AF, magnesium and calcium blockers with
virtually no effect and digoxin found inferior to placebo. Conclusions:
Beta-blockers and flecainide are effective in reducing the incidence of
postoperative AF in patients after pulmonary resections which is not the
case with digoxin; data on remaining treatments are sparse and preclude
drawing definite conclusions.

<37>
Accession Number
71670104
Authors
De Waele M. Schieman C. Finley C.J. Schneider L. Schnurr T. Farrokhyar F.
Hanna W.C. Nair P. Shargall Y.
Institution
(De Waele, Schieman, Schneider, Schnurr, Farrokhyar, Hanna, Shargall)
Thoracic Surgery, McMaster University, Hamilton, Canada
(Finley) Surgery, McMaster University, Hamilton, Canada
(Nair) Respirology, McMaster University, Hamilton, Canada
Title
Does the usage of a digital chest drainage system reduce pleural
inflammation and volume of pleural effusion after major lung resections
for cancer? A prospective, randomized study.
Source
Interactive Cardiovascular and Thoracic Surgery. Conference: 22nd European
Conference on General Thoracic Surgery Copenhagen Denmark. Conference
Start: 20140615 Conference End: 20140618. Conference Publication:
(var.pagings). 18 (pp S15), 2014. Date of Publication: June 2014.
Publisher
Oxford University Press
Abstract
Objectives: Excessive amounts of pleural effusion are a common cause for
delay in chest tube removal following lung resection. Digital pleural
drainage systems are increasingly used, with assumed superiority over
traditional analogue systems in the management of postoperative air leak.
The effect of the system type on pleural effusion and inflammation has not
been studied. We hypothesized that digital systems, introducing
intermittent, balanced suction would be associated with less pleural
inflammation and effusion formation. Methods: One hundred and three
patients, enrolled in a prospective, randomized controlled study, received
either analogue (n = 50) or digital (n = 53) drainage systems following
lung resection for malignancy. Chest tubes were removed according to an a
priori defined protocol. Inflammatory mediators (interleukin-6, 8, 10,
1Ra, TNF-alpha) in pleural fluid and sputum were collected and analysed.
The primary outcome was to observe differences in pleural effusion volume.
Secondary outcomes were duration of chest tube in situ, air-leak
incidence, length of hospital stay and degree of pleural inflammation.
Results: Mean age was 66.7 years, 50.5% male. A trend for shorter chest
tube duration was found with the digital system (P = 0.055). There was no
difference in total amount of fluid drained or length of hospital stay.
Incidence of prolonged postoperative air leak was significantly higher
when using the analogue system (9 vs 2; P = 0.025). Video-assisted
procedures were superior to open on all outcomes (P < 0.001). Lobectomy
was associated with longer chest tube duration (P = 0.001) and increased
fluid drainage when compared to sublobar resection (P < 0.001), regardless
of drainage system. Comparison of inflammatory mediator levels revealed no
difference. Conclusions: Digital drainage systems are superior in regards
to incidence of postoperative air leak and chest tube duration.
Inflammatory mediators and total pleural effusion volume are not
correlated with the type of drainage system utilized. Minimally invasive
procedures and sublobar resections have less effusion formation and
shorter duration of chest tube.

<38>
Accession Number
71666339
Authors
Palii I. Vataman E. Revenco N. Maniuc L. Vataman M. Repin O.
Institution
(Palii) Paediatric Cardiology, Institute of Mother and Child, Chisinau,
Moldova
(Vataman) Laboratory of Heart Failure, Institute of Cardiology, Chisinau,
Moldova
(Revenco) Department of Paediatric SUMF, SUMF Nicolae Testemitanu,
Chisinau, Moldova
(Maniuc, Repin) Congenital Heart Diseases, Cardiac Surgery Centre,
Chisinau, Moldova
(Vataman) Department of Echocardiography, Diagnostic German Centre,
Chisinau, Moldova
Title
Outcome research in 77 patients with pulmonary arterial hypertension
receiving sildenafil: A double-blind, randomised controlled study.
Source
Archives of Disease in Childhood. Conference: 5th Congress of the European
Academy of Paediatric Societies, EAPS 2014 Barcelona Spain. Conference
Start: 20141017 Conference End: 20141021. Conference Publication:
(var.pagings). 99 (pp A31), 2014. Date of Publication: October 2014.
Publisher
BMJ Publishing Group
Abstract
Purpose PAH resulting from CHD - a major cause of postoperative morbidity
and death. Sildenafil: selective inhibitor of phosphodiesterase-5 - an
effective and promising pulmonary vasodilator, with minors reverse
effects. Methods This monocentric, randomised placebo-controlled study
evaluated the efficacy, safety, tolerability of oral Sildenafil in
children with severe PAH secondary congenital shunts (simple (14
patients), mixed (35), complex (28)). 77 PAH patients (35 - repaired
shunts, 31 - palliative, 11 inoperable) assigned to placebo or Sildenafil
- dose of 1-2 mg/kg/day each 8h: 6-12 months. Sildenafil group - 38 (mean
age 19, 9 + 5, 3 months: 16 boys/22 girls); placebo - 39 (mean age 21, 7 +
7, 8 months: 22 boys/17 girls). Research protocol: FC NYHA; 6-min walk
test; O2 saturation; echocardiography PAPm, myocardial performance index
(MPI/Tei index), right cardiac catheterisation - PVRI; questionnaire for
adverse reactions was available. Results Sildenafil patients improved FC
from 3,16 + 0, 1-2, 15 + 0,1 (p < 0,001); effort tolerance (+152,5 + 17,4m
- 6 months and +184,3 + 21,2 m - 12 months of treatment), (p < 0,001); O2
saturation (+3,1 + 0,5%) but placebo (+0,6 + 0,3%), (p < 0,001); PAPm
decreased: 22,0 + 2,22 at 6 months with 19,03 + 2,3 mmHg - 12 months (p <
0,001); PVRI decreased: 2,45 + 0,19 UWood m2 (p < 0,001); Tei index with
0,15 + 0,01(-31%) to initial (p < 0,001). In placebo group only PVRI
diminished from 6,4 + 0,1 to 5,7 + 0,3 UW/m2 (p < 0,05). No death in the
Sildenafil group, but 5 in placebo. Conclusions Sildenafil - efficient in
treating severe PAH secondary to congenital shunts, but even more
effective in children after cardiac surgery. Sildenafil improves FC,
effort tolerability, O2 saturation, RV global function, diminishing PAPm
and PVRI comparing with placebo. Sildenafil has good safety, tolerability,
favourable impact on life quality - insignificant adverse reactions.

<39>
Accession Number
71665973
Authors
Salvatici M. Cardinale D. Facchi G. Colombo A. Spaggiari L. Sandri M.T.
Institution
(Salvatici, Facchi, Sandri) Div. di Medicina di Laboratorio, Istituto
Europeo di Oncologia, Milano, Italy
(Cardinale) U. di Cardioncologia, Istituto Europeo di Oncologia, Milano,
Italy
(Colombo) U. di Cardiologia, Istituto Europeo di Oncologia, Milano, Italy
(Spaggiari) Div. di Chirurgia Toracica, Istituto Europeo di Oncologia,
Milano, Italy
Title
Ntprobnp identifies patients at high risk of postoperative atrial
fibrillation suitable of preventive therapy.
Source
Biochimica Clinica. Conference: 46 Congresso Nazionale della Societa
Italiana di Biochimica Clinica e Biologia Molecolare Clinica (SIBioC -
Medicina di Laboratorio) Roma Italy. Conference Start: 20141013 Conference
End: 20141015. Conference Publication: (var.pagings). 38 (5) (pp 488),
2014. Date of Publication: 2014.
Publisher
Biomedia
Abstract
Background: Postoperative atrial fibrillation (AF) is one of the most
frequent complications of thoracic surgery for lung cancer, with an
incidence ranging from 8 to 42%. In some studies, postoperative AF has
been found to be a benign and self-limiting complication, whereas, in
others, it has been related to significantly increased morbidity and
mortality. The development of postoperative AF is associated with a
prolonged length of hospitalization and high related costs. The
identification of patients at high risk that could benefit from preventive
strategies, represents a clear need. Several risk indexes have been
evaluated, and recently the N-terminal pro-BNP (NT-proBNP) has emerged as
an early marker predictive of post-operative AF in different surgical
settings. This study was aimed at the evaluation of the efficacy of
treatment with a betablocker or angiotensin receptor blocker, in patients
with elevated perioperative values of Nt-proBNP at higher risk for AF.
Methods: We conducted a prospective randomized controlled study in
patients undergoing elective thoracic surgery for lung cancer. Patients
with elevated perioperative values of NT-proBNP were randomized to receive
a cardio protective therapy (Metoprolol or Losartan) or no therapy
(control subjects). The primary end point was a decrease of the incidence
of postoperative AF. Results: Of the 1116 cancer patients undergoing
thoracic surgery enrolled from April 2008 to June 2013, 315 showed a
perioperative NT-proBNP increase and were randomized to receive Metoprolol
n=104 or Losartan n=101, while 110 represented the control group. All
patients remained under continuous ECG monitoring until discharge.
Sixty-three patients (20%) develop a postoperative AF. A significant
reduction of postoperative AF events was observed in treated patients: 7%
(=7 patients) and 11% (=12 patients) in the groups receiving metoprolol or
losartan respectively, compared to 40% (n=44) in the control group (P
<0.001). Conclusions: In patients undergoing elective thoracic surgery for
lung cancer, a perioperative increased value of Nt-proBNP could represent
an early marker useful to candidate patients to receive a therapy with
betablocker or angiotensin to prevent the development of a postoperative
AF.

<40>
Accession Number
71665026
Authors
Zhifeng H. Shaoyi Z. Wen L. Mingjie M. Xinquan C. Zuan L. Huade C. Han-Xi
C. Lianghua M. Hanhua L.
Institution
(Zhifeng, Shaoyi, Wen, Zuan, Huade, Han-Xi, Lianghua, Hanhua) Department
of Burns surgery, Guangdong General Hospital, Guangdong Academy of Medical
Sciences, China
(Mingjie, Xinquan) Department of Cardiovascular Surgery, Guangdong General
Hospital, Guangdong Cardiovascular Institute, China
Title
A prospective randomized controlled study on median sternotomy closure
with titanium plate fixation in high risk patients.
Source
Journal of the American College of Cardiology. Conference: 25th Great Wall
International Congress of Cardiology, Asia Pacific Heart Congress 2014,
and the International Congress Cardiovascular Prevention and
Rehabilitation 2014 Beijing China. Conference Start: 20141016 Conference
End: 20141019. Conference Publication: (var.pagings). 64 (16 SUPPL. 1) (pp
C201-C202), 2014. Date of Publication: 21 Oct 2014.
Publisher
Elsevier USA
Abstract
Objectives: Median sternotomy remains the preferred technique for access
in open heart surgery. Conventional standard for sternal closure remains
fixation with 5-11 stainless steel wires. This may sometimes put too much
mechanical stress on the wires, leading to wire movement or fracture,
sternal instability, mal-union or nonunion, and even complicated sternal
wound infection and mediastinitis. We studied the sternal closure with
titanium plate fixation in high-risk patients to see if it could prevent
sternal dehiscence and offer cost-effectiveness. Methods: Our prospective,
randomized, controlled study enrolled the open cardiac surgery patients
who were admitted in the Guangdong Provincial Cardiovascular Institute
from January 2010 to December 2013. Two hundred patients who were
determined preoperatively to be at high risk were randomly assigned to
sternal closure with rigid plate fixation (Group R, n=100) or wire
cerclage controlled group (Group C, n=100). High risk factor including
insulin-dependent mellitus diabetes, obesity, immunosuppression, chronic
obstructive pulmonary disease, sternal osteoporosis, irradiation of the
operated area, use of bilateral internal thoracic arteries as bypass
grafts, decreased or increased body mass and renalfailure. Statistical
calculations were based on sternal fixation, wound healing, development of
infection, sternal healing and long-term follow-up. Age and risk factors
of two groups has no difference. Results: The Group R and the Group C of
non healing wounds was significantly different (2%&12%, P=0.007).
Non-healing wounds were observed in 2 patients in Group R. As wound
culture was positive for Staphylococcus aureus, systemic vancomycin
treatment was initiated. For the treatment, surgical debridement and
sternal reconstruction was performed along with bilateral pectoralis major
flap. All patients in Group R were discharged postoperatively. In Group C,
non-healing wounds and sternal movement were identified in 12 patients, of
whom 6 had sternal dehiscence caused by wire cutting through the sternum
and 8 had evidence of Methicillin-resistant Staphylococcus aureus by wound
culture. The patients with second operation was required in all 12
patients with non-healing wounds, of whom 4 were referred for sternal
fixation and 8 referred for flap operation. All patients in Group C were
discharged postoperatively. The 4 - 36 months follow-up showed the sternum
was healed in either group. Two patients in Group C reported incision pain
caused by broken wire after 6 months postoperatively and had the wire
removed, and another two patients were referred for wire removal with no
microbiological evidence of infection in the first year after surgery.
Conclusions: Rigid sternal fixation using titanium plate and screw
provides better sternal stability and is an effective way to prevent
sternal dehiscence and wound infection in high-risk patients. Long-term
follow-up showed acceptably low risk of rejection and relative safety.

<41>
Accession Number
71664810
Authors
Kang S. Zhuang S.-W. Liu X.-B.
Institution
(Kang, Zhuang, Liu) Shanghai East Hospital, Tongji University, China
Title
Fractional flow reserve guides treatment with left main coronary disease:
A systematic review for clinical trials.
Source
Journal of the American College of Cardiology. Conference: 25th Great Wall
International Congress of Cardiology, Asia Pacific Heart Congress 2014,
and the International Congress Cardiovascular Prevention and
Rehabilitation 2014 Beijing China. Conference Start: 20141016 Conference
End: 20141019. Conference Publication: (var.pagings). 64 (16 SUPPL. 1) (pp
C153), 2014. Date of Publication: 21 Oct 2014.
Publisher
Elsevier USA
Abstract
Objectives: To assess clinical outcomes of fractional flow reserve (FFR)
guiding pharmacologic therapy vs left main coronary artery (LMCA)
revascularization for LMCA disease. Methods: We searched the MEDLINE,
PUBMED, Cochrane databases, Google, OVID medline (all from their inception
to October 2013). Studies had to include the patients with LMCA disease
underwent FFR guiding assigned to pharmacologic therapy or LM
revascularization. All studies had to report clinical outcomes during a
follow-up of at least 10 months. Data was extracted from the follow-up
angiographic LM-related ischemia events, cardiac death events and
non-cardiac death events. Results: Our search identified 8 prospective
clinical trials, which compared pharmacologic therapy with LM
revascularization in 595 patients with LMCA disease. Between pharmacologic
therapy group and LM revascularization group there were 7.9% vs 2.1%,
pooled RR 2.70 (95% CI, 1.22 to 5.95; P=0.014) for LM-related ischemia
events, and 1.1% vs 2.5%, pooled RR 0.53 (95% CI, 0.19 to 1.54; P=0.246)
for cardiac death outcomes, and 1.4% vs 5.4%, pooled RR 0.28 (95% CI, 0.12
to 0.70; P=0.006) for non-cardiac death events, and there was not
significant heterogeneity across these studies (P>0.05), further it
occurred to less non-cardiac death events in percutaneous coronary
intervention (PCI) group compared with coronary artery bypass grafting
(CABG) group. Conclusions: Follow-up LM-related ischemia events approve of
FFR-guiding LM revascularization compared with pharmacologic therapy for
LMCA disease, there is not different of cardiac death events between the
two groups, but pharmacologic therapy has less non-cardiac death events
than LM revascularization, and PCI treatment with LMCA disease seems to be
less non-cardiac death events compared with CABG.

<42>
Accession Number
71664778
Authors
Yanfei W. Xinwei J.
Institution
(Yanfei, Xinwei) Affiliated Hospital, Hebei University, China
Title
The correlation between balloon release pressure and no-reflow in acute
myocardial infarction undergoing direct PCI.
Source
Journal of the American College of Cardiology. Conference: 25th Great Wall
International Congress of Cardiology, Asia Pacific Heart Congress 2014,
and the International Congress Cardiovascular Prevention and
Rehabilitation 2014 Beijing China. Conference Start: 20141016 Conference
End: 20141019. Conference Publication: (var.pagings). 64 (16 SUPPL. 1) (pp
C146), 2014. Date of Publication: 21 Oct 2014.
Publisher
Elsevier USA
Abstract
Objectives: Balloon release pressure may increase the incidence of no
reflow after direct percutaneous coronary intervention (PCI). This
randomized controlled study designed to analyze the correlation between
balloon release pressure and no-reflow in acute myocardial infarction
(AMI) patients undergone direct PCI. Methods: There were 156 acute
myocardial infarction patients underwent PCI from January 1 2010 to
December 31 2012 were divided into two groups according to the stents
inflation pressure. They were conventional pressure group and high
pressure group. After PCI, angiography was operated to assess the
thrombolysis in myocardial infarction (TIMI) grade with related artery.
Examinations were undertaken on all patients before and after operation
including cardiac enzymes, total cholesterol, low-density lipoprotein,
blood glucose, homocysteine, b-thromboglobulin (b-TG), Hamilton depression
scale (HAMD) and Self-rating anxiety scale (SAS). After interventional
therapy, afore-mentioned parameters in conventional pressure group and
high pressure group were analyzed. Results: The results showed that CK-MB,
HAMD, SAS have significant difference (P<0.05) in all patients after PCI,
especially in CK-MB of high pressure group (25.7+7.6 vs. 76.7+11.8U/L).
Furthermore, CK-MB, HAMD, SAS, b-TG were comparative before PCI but they
have significant changes (P<0.05) after intervention done. No-reflow
phenomenon occurred in 13 patients in high pressure group, which was
severely higher than conventional pressure group (17.11 vs. 6.25%,
P<0.05). Conclusions: In stent implantation, using a pressure less than
1823.4 kPa balloon to release pressure may be the better choice to reduce
the occurrence rate of no reflow during direct PCI.